Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00336:Olfr1442'

3235

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr1442

Ensembl Gene

ENSMUSG00000044441

Gene Name

olfactory receptor 1442

Synonyms

GA_x6K02T2RE5P-3000589-3001527, MOR202-9

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL00336

Quality Score

Status

Chromosome

Chromosomal Location

12670439-12677277 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 12674560 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 118 (Y118*)

Ref Sequence

ENSEMBL: ENSMUSP00000146650 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049724] [ENSMUST00000057924] [ENSMUST00000207341] [ENSMUST00000208494] [ENSMUST00000208657] [ENSMUST00000213486] [ENSMUST00000215134]

AlphaFold

Q0VEV7

Predicted Effect

probably benign
Transcript: ENSMUST00000049724

SMART Domains

Protein: ENSMUSP00000059886
Gene: ENSMUSG00000045030

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	2.4e-50	PFAM
Pfam:7TM_GPCR_Srsx	33	303	1.5e-6	PFAM
Pfam:7tm_1	39	288	8.6e-22	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000057924
AA Change: Y118*

SMART Domains

Protein: ENSMUSP00000050632
Gene: ENSMUSG00000044441
AA Change: Y118*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	7.9e-49	PFAM
Pfam:7TM_GPCR_Srsx	33	303	1.6e-6	PFAM
Pfam:7tm_1	39	288	1.6e-19	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000207341
AA Change: Y118*

Predicted Effect

probably null
Transcript: ENSMUST00000208494
AA Change: Y118*

Predicted Effect

probably null
Transcript: ENSMUST00000208657
AA Change: Y118*

Predicted Effect

probably benign
Transcript: ENSMUST00000213486

Predicted Effect

probably benign
Transcript: ENSMUST00000215134

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010111I01Rik	A	T	13: 63,015,423	D86V	possibly damaging	Het
A430033K04Rik	A	G	5: 138,647,104	Y417C	probably damaging	Het
Adam28	T	A	14: 68,622,120	H548L	possibly damaging	Het
AF529169	T	C	9: 89,603,143	D67G	probably damaging	Het
Agbl3	A	T	6: 34,846,836	D812V	probably damaging	Het
Aox1	T	A	1: 58,059,044	L305Q	probably damaging	Het
Arhgef38	A	G	3: 133,132,051	V706A	probably benign	Het
Arl15	A	G	13: 114,154,752	I171V	probably benign	Het
Cacna1s	C	A	1: 136,084,273	Y237*	probably null	Het
Ccnt1	T	C	15: 98,565,109	T61A	possibly damaging	Het
Col25a1	T	A	3: 130,181,784		probably benign	Het
Col4a1	T	A	8: 11,240,077		probably benign	Het
Dcun1d1	T	C	3: 35,916,306	E130G	possibly damaging	Het
Dnah7b	G	A	1: 46,142,149	M1065I	probably benign	Het
Ephb2	T	G	4: 136,657,484	K872T	probably damaging	Het
Fga	G	A	3: 83,031,674	G452D	probably damaging	Het
Flrt1	T	A	19: 7,096,912	N90I	probably damaging	Het
Fut10	T	A	8: 31,195,291		probably null	Het
Gm4553	T	C	7: 142,165,227	S155G	unknown	Het
Gpr137b	T	C	13: 13,374,415		probably benign	Het
Gprc5d	G	A	6: 135,116,490	Q140*	probably null	Het
Ifi27l2b	T	C	12: 103,451,217	K237R	unknown	Het
Ipo8	A	T	6: 148,782,786	M836K	possibly damaging	Het
Kcnq4	G	A	4: 120,698,016	Q657*	probably null	Het
Lama1	A	T	17: 67,813,948	H2693L	probably benign	Het
Lrrc23	A	G	6: 124,778,926	W40R	probably damaging	Het
Morn2	C	A	17: 80,295,504		probably benign	Het
Ms4a6b	T	A	19: 11,529,490	N214K	possibly damaging	Het
Nags	A	T	11: 102,149,066	S527C	probably damaging	Het
Ndst1	C	T	18: 60,707,956	G218D	probably damaging	Het
Olfr1097	C	T	2: 86,890,245	C310Y	probably benign	Het
Olfr16	G	A	1: 172,957,478	V228M	probably benign	Het
Oxa1l	G	T	14: 54,363,345	G92*	probably null	Het
Parp16	A	T	9: 65,229,963	E157V	probably damaging	Het
Pcdh17	A	T	14: 84,447,544	I484F	probably damaging	Het
Pex16	A	G	2: 92,379,235	R263G	probably benign	Het
Pkd1l3	G	A	8: 109,630,237	E765K	possibly damaging	Het
Plce1	T	C	19: 38,651,906	V532A	probably damaging	Het
Polq	A	G	16: 37,065,247		probably benign	Het
Pramel5	T	C	4: 144,271,621	T351A	probably damaging	Het
Prokr1	A	T	6: 87,588,611	I84N	probably damaging	Het
Prss30	A	T	17: 23,973,721	S162T	probably benign	Het
Ranbp2	A	G	10: 58,451,984	K25E	probably damaging	Het
Rapsn	A	G	2: 91,035,860	T22A	probably damaging	Het
Rhoj	G	T	12: 75,308,906	G9V	probably damaging	Het
Rnf213	A	G	11: 119,449,343	R3467G	probably benign	Het
Rreb1	C	A	13: 37,929,646	S327*	probably null	Het
Scn5a	G	A	9: 119,486,224	P1806L	probably damaging	Het
Sema6a	C	A	18: 47,289,975		probably null	Het
Stag3	G	A	5: 138,297,659	E416K	probably benign	Het
Stpg1	T	A	4: 135,529,545	S216T	possibly damaging	Het
Tfeb	C	A	17: 47,791,664	N426K	probably benign	Het
Trp53bp1	G	T	2: 121,256,579	Q199K	possibly damaging	Het
Ubr4	A	G	4: 139,428,566	D2234G	probably damaging	Het
Ush1c	T	G	7: 46,196,770	Q866P	probably benign	Het
Vdr	T	A	15: 97,884,854	D29V	probably damaging	Het
Vps13c	T	C	9: 67,945,942	V2439A	probably benign	Het
Xirp2	T	C	2: 67,512,598	S1728P	possibly damaging	Het
Zfp9	A	G	6: 118,464,475	S409P	probably damaging	Het

Other mutations in Olfr1442

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00969:Olfr1442	APN	19	12674241	missense	probably damaging	1.00
IGL01788:Olfr1442	APN	19	12675078	missense	probably damaging	0.97
IGL02081:Olfr1442	APN	19	12674816	missense	probably benign
IGL02335:Olfr1442	APN	19	12674238	missense	probably damaging	0.97
IGL02383:Olfr1442	APN	19	12674535	missense	probably benign	0.01
IGL02389:Olfr1442	APN	19	12674535	missense	probably benign	0.00
IGL02484:Olfr1442	APN	19	12674859	missense	possibly damaging	0.56
IGL02682:Olfr1442	APN	19	12674669	missense	probably damaging	0.98
IGL03136:Olfr1442	APN	19	12674967	missense	probably damaging	0.99
R0109:Olfr1442	UTSW	19	12674860	missense	probably benign	0.02
R0109:Olfr1442	UTSW	19	12674860	missense	probably benign	0.02
R0112:Olfr1442	UTSW	19	12674757	missense	probably benign
R4005:Olfr1442	UTSW	19	12674846	missense	probably benign	0.05
R4346:Olfr1442	UTSW	19	12674228	missense	probably benign	0.03
R4611:Olfr1442	UTSW	19	12674954	missense	probably damaging	1.00
R5858:Olfr1442	UTSW	19	12674379	missense	probably damaging	1.00
R5944:Olfr1442	UTSW	19	12674919	missense	probably damaging	1.00
R6406:Olfr1442	UTSW	19	12674820	missense	probably benign	0.21
R6923:Olfr1442	UTSW	19	12675045	missense	possibly damaging	0.94
R7710:Olfr1442	UTSW	19	12674976	missense	probably damaging	1.00
R8699:Olfr1442	UTSW	19	12674882	missense	probably benign	0.21
Z1176:Olfr1442	UTSW	19	12674310	missense	probably benign

Posted On

2012-04-20