Incidental Mutation 'R4333:Or10d1c'
ID 323665
Institutional Source Beutler Lab
Gene Symbol Or10d1c
Ensembl Gene ENSMUSG00000057424
Gene Name olfactory receptor family 10 subfamily D member 1C
Synonyms GA_x6K02T2PVTD-32678895-32677963, Olfr934, MOR224-6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R4333 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38893406-38894338 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38893884 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 152 (I152T)
Ref Sequence ENSEMBL: ENSMUSP00000150864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074211] [ENSMUST00000214324] [ENSMUST00000216238] [ENSMUST00000216823]
AlphaFold Q9EQ87
Predicted Effect possibly damaging
Transcript: ENSMUST00000074211
AA Change: I152T

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000073835
Gene: ENSMUSG00000057424
AA Change: I152T

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.7e-48 PFAM
Pfam:7TM_GPCR_Srsx 33 222 7.2e-9 PFAM
Pfam:7tm_1 39 286 5.4e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214324
AA Change: I152T

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect probably benign
Transcript: ENSMUST00000216238
Predicted Effect possibly damaging
Transcript: ENSMUST00000216823
AA Change: I152T

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb C T 10: 10,318,246 (GRCm39) V193I possibly damaging Het
Cadps C T 14: 12,467,031 (GRCm38) R967H probably damaging Het
Cwh43 A G 5: 73,598,722 (GRCm39) D647G probably damaging Het
Dab2ip T A 2: 35,551,632 (GRCm39) *164R probably null Het
Ddx18 A T 1: 121,492,331 (GRCm39) D125E probably benign Het
Fbxw7 T C 3: 84,879,802 (GRCm39) C375R probably damaging Het
Iqca1l A G 5: 24,749,368 (GRCm39) L710P probably damaging Het
Khnyn A G 14: 56,131,499 (GRCm39) D536G probably damaging Het
Lamp3 T C 16: 19,492,186 (GRCm39) I353V probably benign Het
Med13 A G 11: 86,179,009 (GRCm39) F1429S probably benign Het
Mybl1 T C 1: 9,742,523 (GRCm39) K621E probably damaging Het
Myo19 G A 11: 84,799,114 (GRCm39) A816T probably benign Het
Or51h7 A T 7: 102,591,176 (GRCm39) L203I possibly damaging Het
Rnf2 T C 1: 151,348,827 (GRCm39) T98A possibly damaging Het
Samm50 A G 15: 84,087,031 (GRCm39) K280R probably benign Het
Satb2 T C 1: 56,884,745 (GRCm39) N511S probably damaging Het
Tbc1d19 A G 5: 54,029,619 (GRCm39) T327A possibly damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Vmn2r7 T C 3: 64,598,199 (GRCm39) N786S probably damaging Het
Other mutations in Or10d1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02156:Or10d1c APN 9 38,893,842 (GRCm39) missense possibly damaging 0.71
R1061:Or10d1c UTSW 9 38,893,779 (GRCm39) missense probably damaging 1.00
R1604:Or10d1c UTSW 9 38,893,914 (GRCm39) missense probably benign 0.01
R1776:Or10d1c UTSW 9 38,894,190 (GRCm39) missense probably damaging 1.00
R3499:Or10d1c UTSW 9 38,893,761 (GRCm39) missense probably damaging 1.00
R3761:Or10d1c UTSW 9 38,893,662 (GRCm39) missense possibly damaging 0.94
R3876:Or10d1c UTSW 9 38,894,166 (GRCm39) missense probably damaging 1.00
R4191:Or10d1c UTSW 9 38,894,313 (GRCm39) missense probably benign 0.01
R4192:Or10d1c UTSW 9 38,894,313 (GRCm39) missense probably benign 0.01
R4876:Or10d1c UTSW 9 38,893,922 (GRCm39) nonsense probably null
R5539:Or10d1c UTSW 9 38,893,573 (GRCm39) missense possibly damaging 0.85
R6916:Or10d1c UTSW 9 38,894,200 (GRCm39) missense probably benign 0.14
R7097:Or10d1c UTSW 9 38,893,914 (GRCm39) missense probably benign 0.01
R7338:Or10d1c UTSW 9 38,893,816 (GRCm39) missense probably damaging 0.99
R8116:Or10d1c UTSW 9 38,894,169 (GRCm39) missense probably damaging 1.00
R9350:Or10d1c UTSW 9 38,894,081 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- CCTCAGTAGAGCGGATCTGAAG -3'
(R):5'- GAGCCATCTCCTATACAGGCTG -3'

Sequencing Primer
(F):5'- CTCAGTAGAGCGGATCTGAAGAATGG -3'
(R):5'- ATCTCCTATACAGGCTGTGTTTG -3'
Posted On 2015-06-24