Incidental Mutation 'R4320:Tsen15'
ID 323760
Institutional Source Beutler Lab
Gene Symbol Tsen15
Ensembl Gene ENSMUSG00000014980
Gene Name tRNA splicing endonuclease subunit 15
Synonyms 5730449L18Rik
MMRRC Submission 041661-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.926) question?
Stock # R4320 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 152246486-152262433 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 152259460 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 66 (D66E)
Ref Sequence ENSEMBL: ENSMUSP00000015124 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000015124] [ENSMUST00000162371]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000015124
AA Change: D66E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000015124
Gene: ENSMUSG00000014980
AA Change: D66E

DomainStartEndE-ValueType
Pfam:Sen15 62 163 8.4e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159270
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159717
Predicted Effect probably damaging
Transcript: ENSMUST00000162371
AA Change: D66E

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000124391
Gene: ENSMUSG00000014980
AA Change: D66E

DomainStartEndE-ValueType
Pfam:Sen15 62 127 4.1e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163027
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188105
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 96% (46/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ank3 G A 10: 69,740,076 (GRCm39) V826I possibly damaging Het
Arid4a T A 12: 71,116,769 (GRCm39) I609N possibly damaging Het
Asb13 G T 13: 3,695,012 (GRCm39) R160L possibly damaging Het
Brix1 A T 15: 10,483,398 (GRCm39) M91K probably damaging Het
Ccdc191 A G 16: 43,767,872 (GRCm39) E624G probably damaging Het
Cdh10 A G 15: 18,985,251 (GRCm39) D305G probably benign Het
Daxx T C 17: 34,130,393 (GRCm39) L136P probably damaging Het
Fmo1 A T 1: 162,661,200 (GRCm39) L361Q probably damaging Het
Ggcx A G 6: 72,405,803 (GRCm39) S545G probably benign Het
Gm5114 T G 7: 39,057,051 (GRCm39) Y856S probably damaging Het
Grk5 C T 19: 61,080,383 (GRCm39) R576* probably null Het
Hipk3 C A 2: 104,276,916 (GRCm39) V388L probably damaging Het
Htr1f T C 16: 64,747,050 (GRCm39) I81V possibly damaging Het
Kprp G A 3: 92,732,163 (GRCm39) R296W probably damaging Het
Mtf2 T A 5: 108,234,891 (GRCm39) C3S probably damaging Het
Mtmr3 T C 11: 4,437,947 (GRCm39) R836G probably benign Het
Ntrk2 A G 13: 59,007,960 (GRCm39) N241D possibly damaging Het
Or12j2 T A 7: 139,916,219 (GRCm39) I148N possibly damaging Het
Or2y1f G A 11: 49,184,503 (GRCm39) M118I probably damaging Het
Or7g25 A C 9: 19,160,052 (GRCm39) I214M probably damaging Het
Or7g28 G T 9: 19,272,254 (GRCm39) Y132* probably null Het
Orc1 G A 4: 108,445,973 (GRCm39) M30I probably benign Het
Pax2 T A 19: 44,823,838 (GRCm39) F366I probably damaging Het
Pira13 A G 7: 3,825,754 (GRCm39) S372P possibly damaging Het
Plekha5 A G 6: 140,489,543 (GRCm39) K316E possibly damaging Het
Ppp4r4 T A 12: 103,564,502 (GRCm39) N8K probably damaging Het
Rnf125 G A 18: 21,110,817 (GRCm39) R25K probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Septin1 G A 7: 126,816,200 (GRCm39) P77S probably damaging Het
Sostdc1 C A 12: 36,367,419 (GRCm39) S198R probably benign Het
Sox6 A G 7: 115,179,798 (GRCm39) probably null Het
Spef2 A T 15: 9,679,429 (GRCm39) I636K possibly damaging Het
Stat4 A G 1: 52,113,866 (GRCm39) N192S probably benign Het
Thoc1 A G 18: 9,960,493 (GRCm39) H66R probably benign Het
Tpr A G 1: 150,299,325 (GRCm39) E1101G possibly damaging Het
Trpa1 G T 1: 14,944,676 (GRCm39) H1023N probably benign Het
Tssk3 A G 4: 129,382,994 (GRCm39) V226A possibly damaging Het
Ufl1 T A 4: 25,278,601 (GRCm39) probably null Het
Usp3 A G 9: 66,437,530 (GRCm39) C258R possibly damaging Het
Vmn2r117 TC T 17: 23,698,487 (GRCm39) probably null Het
Other mutations in Tsen15
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0110:Tsen15 UTSW 1 152,247,548 (GRCm39) missense probably damaging 1.00
R5284:Tsen15 UTSW 1 152,247,624 (GRCm39) missense probably damaging 0.99
R5288:Tsen15 UTSW 1 152,259,131 (GRCm39) missense probably damaging 1.00
R5719:Tsen15 UTSW 1 152,247,534 (GRCm39) missense probably damaging 0.99
R8704:Tsen15 UTSW 1 152,247,541 (GRCm39) nonsense probably null
R9275:Tsen15 UTSW 1 152,259,098 (GRCm39) missense probably damaging 0.98
R9278:Tsen15 UTSW 1 152,259,098 (GRCm39) missense probably damaging 0.98
RF004:Tsen15 UTSW 1 152,259,470 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCCATGACCTAGTAAGTCCCAATG -3'
(R):5'- AGAGGCAGAGATAAGACCTTACATTC -3'

Sequencing Primer
(F):5'- TGACCTAGTAAGTCCCAATGTAAATC -3'
(R):5'- CCAGAAGATGGTTTATGTCCA -3'
Posted On 2015-06-24