Mutagenetix > Incidental Mutation

Incidental Mutation 'R4321:Itpr3'

323849

Institutional Source

Beutler Lab

Gene Symbol

Itpr3

Ensembl Gene

ENSMUSG00000042644

Gene Name

inositol 1,4,5-triphosphate receptor 3

Synonyms

tf, Ip3r3, Itpr-3

MMRRC Submission

041662-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4321 (G1)

Quality Score

169

Status

Validated

Chromosome

Chromosomal Location

27057304-27122223 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 27111974 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 1752 (E1752G)

Ref Sequence

ENSEMBL: ENSMUSP00000038150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049308]

AlphaFold

P70227

PDB Structure

Crystal structure of the ligand binding suppressor domain of type 3 inositol 1,4,5-trisphosphate receptor [X-RAY DIFFRACTION]

Predicted Effect

probably benign
Transcript: ENSMUST00000049308
AA Change: E1752G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000038150
Gene: ENSMUSG00000042644
AA Change: E1752G

Domain	Start	End	E-Value	Type
MIR	113	167	7.75e-6	SMART
MIR	174	224	1.16e-4	SMART
MIR	232	288	1.21e-7	SMART
MIR	295	402	9.38e-14	SMART
Pfam:RYDR_ITPR	473	670	7.8e-64	PFAM
low complexity region	881	889	N/A	INTRINSIC
Pfam:RYDR_ITPR	1175	1333	5.8e-16	PFAM
low complexity region	1549	1567	N/A	INTRINSIC
low complexity region	1831	1851	N/A	INTRINSIC
Pfam:RIH_assoc	1863	1973	2.6e-34	PFAM
transmembrane domain	2203	2225	N/A	INTRINSIC
Pfam:Ion_trans	2235	2527	8.1e-20	PFAM
coiled coil region	2631	2660	N/A	INTRINSIC

Meta Mutation Damage Score

0.4730

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

95% (56/59)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9330159F19Rik	A	T	10: 29,224,891 (GRCm38)	D420V	probably damaging	Het
Als2	A	C	1: 59,167,454 (GRCm38)		probably benign	Het
Ankrd9	A	G	12: 110,976,640 (GRCm38)	L287P	probably damaging	Het
Aoc1l1	T	A	6: 48,976,522 (GRCm38)	D460E	probably damaging	Het
Bbof1	A	T	12: 84,427,128 (GRCm38)	R411*	probably null	Het
Camta2	A	T	11: 70,678,325 (GRCm38)	L598Q	probably damaging	Het
Ccdc178	T	A	18: 22,033,543 (GRCm38)	K530*	probably null	Het
Cep85	G	A	4: 134,132,285 (GRCm38)	T689I	probably damaging	Het
Clvs1	T	C	4: 9,282,029 (GRCm38)		probably benign	Het
Cpped1	T	C	16: 11,887,746 (GRCm38)	T65A	probably benign	Het
Daxx	T	C	17: 33,911,406 (GRCm38)	Y132H	possibly damaging	Het
Dock7	T	C	4: 99,072,454 (GRCm38)	E279G	probably damaging	Het
Dok7	A	T	5: 35,079,797 (GRCm38)		probably benign	Het
Dthd1	A	T	5: 62,818,690 (GRCm38)	I236F	probably damaging	Het
Egf	A	G	3: 129,706,134 (GRCm38)	C285R	probably damaging	Het
Epha4	T	A	1: 77,507,213 (GRCm38)		probably null	Het
Fbxw13	A	C	9: 109,181,435 (GRCm38)	I378M	probably benign	Het
Gaa	A	T	11: 119,270,137 (GRCm38)	N2I	probably benign	Het
Gad1	G	A	2: 70,589,830 (GRCm38)	D353N	probably damaging	Het
Ggcx	A	G	6: 72,428,820 (GRCm38)	S545G	probably benign	Het
Gm2663	G	T	6: 40,997,596 (GRCm38)	Q87K	probably damaging	Het
Golga4	A	G	9: 118,556,435 (GRCm38)	E847G	probably damaging	Het
Hipk3	C	A	2: 104,446,571 (GRCm38)	V388L	probably damaging	Het
Ibtk	T	C	9: 85,735,072 (GRCm38)	D149G	possibly damaging	Het
Ice1	A	T	13: 70,603,110 (GRCm38)	V1619E	possibly damaging	Het
Itsn1	G	A	16: 91,818,552 (GRCm38)		probably benign	Het
Kprp	G	A	3: 92,824,856 (GRCm38)	R296W	probably damaging	Het
Lama1	G	A	17: 67,771,083 (GRCm38)	G1171D	probably benign	Het
Lonp2	A	G	8: 86,665,728 (GRCm38)	H474R	probably damaging	Het
Mark1	G	T	1: 184,898,674 (GRCm38)	D746E	possibly damaging	Het
Mlxipl	C	T	5: 135,135,450 (GRCm38)	Q167*	probably null	Het
Myo3a	A	T	2: 22,267,155 (GRCm38)	N162Y	probably damaging	Het
Myo5a	T	G	9: 75,217,530 (GRCm38)	V1787G	probably damaging	Het
Myorg	C	T	4: 41,498,767 (GRCm38)	V288I	probably benign	Het
Nrxn3	A	T	12: 90,199,231 (GRCm38)	E227V	probably damaging	Het
Orc1	G	A	4: 108,588,776 (GRCm38)	M30I	probably benign	Het
Pira13	A	G	7: 3,822,755 (GRCm38)	S372P	possibly damaging	Het
Rufy2	A	G	10: 62,982,680 (GRCm38)	D5G	probably damaging	Het
Rufy4	T	C	1: 74,147,663 (GRCm38)	C537R	probably damaging	Het
Rufy4	A	T	1: 74,132,784 (GRCm38)	D222V	possibly damaging	Het
Septin1	G	A	7: 127,217,028 (GRCm38)	P77S	probably damaging	Het
Slamf1	T	C	1: 171,775,126 (GRCm38)		probably null	Het
Sox6	A	G	7: 115,580,563 (GRCm38)		probably null	Het
Spef2	A	T	15: 9,679,343 (GRCm38)	I636K	possibly damaging	Het
Tshz2	T	A	2: 169,885,545 (GRCm38)	I218N	possibly damaging	Het
Txnl1	T	C	18: 63,679,490 (GRCm38)	T78A	possibly damaging	Het
Ulk4	T	G	9: 121,073,996 (GRCm38)	R1138S	probably benign	Het
Vamp8	A	C	6: 72,385,553 (GRCm38)	V88G	possibly damaging	Het
Vmn2r63	A	G	7: 42,926,982 (GRCm38)	F469S	probably benign	Het
Zfp850	A	C	7: 27,989,400 (GRCm38)	F461C	probably damaging	Het

Other mutations in Itpr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00715:Itpr3	APN	17	27,083,629 (GRCm38)	missense	probably benign	0.05
IGL00980:Itpr3	APN	17	27,110,956 (GRCm38)	missense	probably benign
IGL01151:Itpr3	APN	17	27,091,529 (GRCm38)	missense	probably damaging	1.00
IGL01289:Itpr3	APN	17	27,099,765 (GRCm38)	missense	probably damaging	0.99
IGL01403:Itpr3	APN	17	27,118,595 (GRCm38)	missense	probably damaging	0.97
IGL01666:Itpr3	APN	17	27,117,178 (GRCm38)	missense	probably benign	0.02
IGL01897:Itpr3	APN	17	27,111,262 (GRCm38)	missense	probably damaging	1.00
IGL02003:Itpr3	APN	17	27,121,475 (GRCm38)	missense	probably damaging	1.00
IGL02012:Itpr3	APN	17	27,104,095 (GRCm38)	missense	probably benign
IGL02063:Itpr3	APN	17	27,120,023 (GRCm38)	missense	probably benign	0.01
IGL02146:Itpr3	APN	17	27,117,275 (GRCm38)	missense	probably damaging	1.00
IGL02158:Itpr3	APN	17	27,098,442 (GRCm38)	missense	probably damaging	1.00
IGL02177:Itpr3	APN	17	27,099,614 (GRCm38)	missense	possibly damaging	0.74
IGL02247:Itpr3	APN	17	27,098,179 (GRCm38)	missense	probably damaging	1.00
IGL02606:Itpr3	APN	17	27,114,512 (GRCm38)	splice site	probably benign
IGL02651:Itpr3	APN	17	27,106,398 (GRCm38)	missense	probably damaging	0.99
IGL02902:Itpr3	APN	17	27,104,556 (GRCm38)	missense	probably benign	0.21
IGL03001:Itpr3	APN	17	27,089,612 (GRCm38)	splice site	probably benign
IGL03004:Itpr3	APN	17	27,097,978 (GRCm38)	missense	possibly damaging	0.90
IGL03065:Itpr3	APN	17	27,091,933 (GRCm38)	missense	probably damaging	1.00
IGL03117:Itpr3	APN	17	27,119,266 (GRCm38)	missense	probably damaging	1.00
IGL03181:Itpr3	APN	17	27,111,268 (GRCm38)	missense	probably benign
IGL03404:Itpr3	APN	17	27,091,518 (GRCm38)	missense	probably damaging	1.00
Allure	UTSW	17	27,107,303 (GRCm38)	missense	probably damaging	1.00
alopecia	UTSW	17	27,095,478 (GRCm38)	missense	probably damaging	0.98
Beauty	UTSW	17	27,106,342 (GRCm38)	missense	probably damaging	1.00
Opuesto	UTSW	17	27,087,592 (GRCm38)	missense	probably damaging	1.00
Paradox	UTSW	17	27,098,171 (GRCm38)	missense	probably damaging	1.00
Pulchritude	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R0010:Itpr3	UTSW	17	27,120,977 (GRCm38)	missense	probably damaging	1.00
R0055:Itpr3	UTSW	17	27,098,322 (GRCm38)	missense	probably damaging	1.00
R0068:Itpr3	UTSW	17	27,104,060 (GRCm38)	splice site	probably benign
R0068:Itpr3	UTSW	17	27,104,060 (GRCm38)	splice site	probably benign
R0104:Itpr3	UTSW	17	27,095,992 (GRCm38)	missense	probably benign	0.01
R0195:Itpr3	UTSW	17	27,114,114 (GRCm38)	missense	probably damaging	1.00
R0212:Itpr3	UTSW	17	27,089,319 (GRCm38)	missense	probably damaging	1.00
R0454:Itpr3	UTSW	17	27,113,819 (GRCm38)	missense	probably benign
R0485:Itpr3	UTSW	17	27,111,929 (GRCm38)	missense	probably damaging	0.98
R0501:Itpr3	UTSW	17	27,107,289 (GRCm38)	missense	probably benign	0.09
R0781:Itpr3	UTSW	17	27,110,555 (GRCm38)	missense	probably benign	0.00
R0890:Itpr3	UTSW	17	27,089,011 (GRCm38)	nonsense	probably null
R1028:Itpr3	UTSW	17	27,091,369 (GRCm38)	missense	probably benign	0.04
R1144:Itpr3	UTSW	17	27,114,923 (GRCm38)	missense	probably benign	0.01
R1347:Itpr3	UTSW	17	27,111,561 (GRCm38)	missense	probably benign	0.02
R1347:Itpr3	UTSW	17	27,111,561 (GRCm38)	missense	probably benign	0.02
R1458:Itpr3	UTSW	17	27,118,372 (GRCm38)	missense	probably benign	0.01
R1463:Itpr3	UTSW	17	27,117,154 (GRCm38)	splice site	probably benign
R1472:Itpr3	UTSW	17	27,114,225 (GRCm38)	missense	probably benign	0.09
R1529:Itpr3	UTSW	17	27,105,485 (GRCm38)	splice site	probably null
R1533:Itpr3	UTSW	17	27,095,560 (GRCm38)	missense	possibly damaging	0.71
R1537:Itpr3	UTSW	17	27,114,147 (GRCm38)	missense	possibly damaging	0.96
R1618:Itpr3	UTSW	17	27,116,607 (GRCm38)	critical splice acceptor site	probably null
R1672:Itpr3	UTSW	17	27,089,013 (GRCm38)	missense	probably benign
R1726:Itpr3	UTSW	17	27,111,690 (GRCm38)	missense	probably damaging	0.96
R1865:Itpr3	UTSW	17	27,120,023 (GRCm38)	missense	probably benign	0.01
R1940:Itpr3	UTSW	17	27,111,217 (GRCm38)	missense	probably damaging	1.00
R2023:Itpr3	UTSW	17	27,102,811 (GRCm38)	missense	possibly damaging	0.76
R2063:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2064:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2065:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2067:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2068:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2219:Itpr3	UTSW	17	27,115,053 (GRCm38)	missense	probably benign
R2248:Itpr3	UTSW	17	27,115,059 (GRCm38)	missense	probably damaging	1.00
R2291:Itpr3	UTSW	17	27,113,579 (GRCm38)	missense	possibly damaging	0.92
R2320:Itpr3	UTSW	17	27,095,915 (GRCm38)	missense	probably benign
R2864:Itpr3	UTSW	17	27,091,551 (GRCm38)	missense	probably benign	0.01
R2865:Itpr3	UTSW	17	27,091,551 (GRCm38)	missense	probably benign	0.01
R3778:Itpr3	UTSW	17	27,095,472 (GRCm38)	missense	possibly damaging	0.57
R3881:Itpr3	UTSW	17	27,113,840 (GRCm38)	missense	probably benign	0.01
R3979:Itpr3	UTSW	17	27,091,572 (GRCm38)	missense	probably damaging	1.00
R3979:Itpr3	UTSW	17	27,085,131 (GRCm38)	missense	probably benign	0.23
R4224:Itpr3	UTSW	17	27,107,258 (GRCm38)	missense	probably damaging	1.00
R4259:Itpr3	UTSW	17	27,106,324 (GRCm38)	missense	probably damaging	1.00
R4466:Itpr3	UTSW	17	27,106,342 (GRCm38)	missense	probably damaging	1.00
R4493:Itpr3	UTSW	17	27,104,612 (GRCm38)	missense	probably damaging	1.00
R4597:Itpr3	UTSW	17	27,093,283 (GRCm38)	missense	probably damaging	1.00
R4823:Itpr3	UTSW	17	27,085,147 (GRCm38)	missense	probably benign	0.30
R4921:Itpr3	UTSW	17	27,098,005 (GRCm38)	missense	probably damaging	1.00
R4974:Itpr3	UTSW	17	27,083,608 (GRCm38)	missense	probably damaging	0.96
R5063:Itpr3	UTSW	17	27,089,911 (GRCm38)	missense	possibly damaging	0.94
R5079:Itpr3	UTSW	17	27,098,423 (GRCm38)	missense	probably damaging	1.00
R5303:Itpr3	UTSW	17	27,116,689 (GRCm38)	missense	probably benign	0.38
R5518:Itpr3	UTSW	17	27,087,592 (GRCm38)	missense	probably damaging	1.00
R5521:Itpr3	UTSW	17	27,107,334 (GRCm38)	missense	probably benign	0.09
R5566:Itpr3	UTSW	17	27,115,952 (GRCm38)	missense	possibly damaging	0.71
R5567:Itpr3	UTSW	17	27,103,906 (GRCm38)	missense	possibly damaging	0.66
R5579:Itpr3	UTSW	17	27,113,519 (GRCm38)	missense	probably damaging	1.00
R5610:Itpr3	UTSW	17	27,118,566 (GRCm38)	missense	probably benign	0.42
R5658:Itpr3	UTSW	17	27,107,878 (GRCm38)	missense	possibly damaging	0.74
R5856:Itpr3	UTSW	17	27,106,405 (GRCm38)	missense	probably damaging	1.00
R5872:Itpr3	UTSW	17	27,086,976 (GRCm38)	missense	probably benign	0.02
R5878:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R5889:Itpr3	UTSW	17	27,115,065 (GRCm38)	missense	probably damaging	0.99
R5907:Itpr3	UTSW	17	27,117,893 (GRCm38)	missense	probably damaging	1.00
R5930:Itpr3	UTSW	17	27,110,921 (GRCm38)	missense	possibly damaging	0.49
R5987:Itpr3	UTSW	17	27,104,601 (GRCm38)	missense	probably damaging	1.00
R6029:Itpr3	UTSW	17	27,098,171 (GRCm38)	missense	probably damaging	1.00
R6195:Itpr3	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R6213:Itpr3	UTSW	17	27,111,200 (GRCm38)	missense	probably benign	0.03
R6233:Itpr3	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R6376:Itpr3	UTSW	17	27,095,475 (GRCm38)	missense	possibly damaging	0.94
R6514:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6515:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6516:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6955:Itpr3	UTSW	17	27,121,467 (GRCm38)	missense	probably damaging	1.00
R7002:Itpr3	UTSW	17	27,110,580 (GRCm38)	missense	probably benign	0.00
R7064:Itpr3	UTSW	17	27,089,295 (GRCm38)	missense	probably damaging	1.00
R7257:Itpr3	UTSW	17	27,118,561 (GRCm38)	missense	probably benign	0.00
R7349:Itpr3	UTSW	17	27,107,812 (GRCm38)	splice site	probably null
R7469:Itpr3	UTSW	17	27,121,054 (GRCm38)	missense	possibly damaging	0.74
R7493:Itpr3	UTSW	17	27,094,800 (GRCm38)	missense	probably benign	0.09
R7510:Itpr3	UTSW	17	27,089,039 (GRCm38)	missense	probably damaging	0.97
R7565:Itpr3	UTSW	17	27,110,888 (GRCm38)	missense	probably benign	0.01
R7616:Itpr3	UTSW	17	27,088,977 (GRCm38)	missense	probably damaging	1.00
R7728:Itpr3	UTSW	17	27,098,114 (GRCm38)	missense	probably damaging	1.00
R7779:Itpr3	UTSW	17	27,096,063 (GRCm38)	missense	probably damaging	1.00
R7788:Itpr3	UTSW	17	27,118,597 (GRCm38)	nonsense	probably null
R7871:Itpr3	UTSW	17	27,117,179 (GRCm38)	missense	probably damaging	1.00
R7889:Itpr3	UTSW	17	27,116,777 (GRCm38)	missense	probably damaging	1.00
R7966:Itpr3	UTSW	17	27,112,028 (GRCm38)	critical splice donor site	probably null
R8065:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R8067:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R8230:Itpr3	UTSW	17	27,107,737 (GRCm38)	critical splice donor site	probably null
R8263:Itpr3	UTSW	17	27,115,913 (GRCm38)	nonsense	probably null
R8264:Itpr3	UTSW	17	27,104,112 (GRCm38)	synonymous	silent
R8269:Itpr3	UTSW	17	27,093,284 (GRCm38)	missense	possibly damaging	0.60
R8271:Itpr3	UTSW	17	27,087,648 (GRCm38)	missense	probably damaging	1.00
R8316:Itpr3	UTSW	17	27,106,225 (GRCm38)	missense	possibly damaging	0.50
R8354:Itpr3	UTSW	17	27,115,919 (GRCm38)	missense	possibly damaging	0.74
R8413:Itpr3	UTSW	17	27,111,926 (GRCm38)	missense	probably damaging	1.00
R8437:Itpr3	UTSW	17	27,107,303 (GRCm38)	missense	probably damaging	1.00
R8676:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8679:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8846:Itpr3	UTSW	17	27,112,022 (GRCm38)	missense	probably damaging	1.00
R8884:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8885:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8886:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8887:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8888:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8891:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8896:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8975:Itpr3	UTSW	17	27,116,654 (GRCm38)	missense	possibly damaging	0.56
R9025:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9026:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9063:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9087:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9088:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9089:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9090:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9091:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9200:Itpr3	UTSW	17	27,107,662 (GRCm38)	missense	probably damaging	0.99
R9270:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9271:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9294:Itpr3	UTSW	17	27,111,217 (GRCm38)	missense	probably damaging	1.00
R9389:Itpr3	UTSW	17	27,095,925 (GRCm38)	missense	possibly damaging	0.84
R9433:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9434:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9443:Itpr3	UTSW	17	27,105,549 (GRCm38)	missense	probably damaging	1.00
R9472:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9474:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9475:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9476:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9477:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9507:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9508:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9511:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9694:Itpr3	UTSW	17	27,115,953 (GRCm38)	missense	probably damaging	0.99
R9789:Itpr3	UTSW	17	27,089,941 (GRCm38)	missense	probably benign	0.15
V7732:Itpr3	UTSW	17	27,111,026 (GRCm38)	splice site	probably null
V7732:Itpr3	UTSW	17	27,111,024 (GRCm38)	splice site	probably benign
Z1088:Itpr3	UTSW	17	27,113,528 (GRCm38)	missense	possibly damaging	0.50
Z1177:Itpr3	UTSW	17	27,119,987 (GRCm38)	missense	probably damaging	1.00
Z1177:Itpr3	UTSW	17	27,114,929 (GRCm38)	missense	probably damaging	1.00
Z31818:Itpr3	UTSW	17	27,095,478 (GRCm38)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- GCTGGCTCTTGCTTCAAAC -3'
(R):5'- CTCTGAAATGCCAGAAGAGTAGAC -3'

Sequencing Primer
(F):5'- GGCTCTTGCTTCAAACCGCTG -3'
(R):5'- TGCCAGAAGAGTAGACCTAGG -3'

Posted On

2015-06-24