Incidental Mutation 'R0004:Klra1'
ID 32386
Institutional Source Beutler Lab
Gene Symbol Klra1
Ensembl Gene ENSMUSG00000079853
Gene Name killer cell lectin-like receptor, subfamily A, member 1
Synonyms Ly49A, Ly49o<129>
MMRRC Submission 038300-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R0004 (G1)
Quality Score 167
Status Validated
Chromosome 6
Chromosomal Location 130340881-130363837 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 130349836 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 201 (Y201N)
Ref Sequence ENSEMBL: ENSMUSP00000032288 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032288]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000032288
AA Change: Y201N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000032288
Gene: ENSMUSG00000079853
AA Change: Y201N

DomainStartEndE-ValueType
Blast:CLECT 73 118 9e-8 BLAST
CLECT 139 254 4.02e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127570
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.1%
Validation Efficiency 98% (63/64)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adal T C 2: 120,982,966 (GRCm39) I86T probably damaging Het
Aff3 T C 1: 38,308,807 (GRCm39) D376G possibly damaging Het
Akap11 A T 14: 78,752,380 (GRCm39) H164Q possibly damaging Het
Akap12 A T 10: 4,303,220 (GRCm39) D10V probably damaging Het
Arhgap32 T C 9: 32,063,294 (GRCm39) V101A probably damaging Het
Atm A T 9: 53,364,828 (GRCm39) probably benign Het
Ccdc18 A G 5: 108,309,566 (GRCm39) D387G possibly damaging Het
Ccdc38 A T 10: 93,409,964 (GRCm39) Q261L probably damaging Het
Cd180 T G 13: 102,839,216 (GRCm39) V33G probably benign Het
Cd207 G A 6: 83,651,230 (GRCm39) Q242* probably null Het
Cnp T C 11: 100,467,633 (GRCm39) F192S probably damaging Het
Colec10 G T 15: 54,274,271 (GRCm39) R33L possibly damaging Het
Csn1s1 A T 5: 87,819,390 (GRCm39) M16L probably benign Het
Dnah10 A T 5: 124,803,966 (GRCm39) M98L probably benign Het
Dnah17 T C 11: 117,950,918 (GRCm39) I2902V possibly damaging Het
Dtnb A G 12: 3,646,635 (GRCm39) probably benign Het
Epha5 T C 5: 84,479,701 (GRCm39) Y101C probably damaging Het
Ephb2 T A 4: 136,384,835 (GRCm39) M860L probably damaging Het
Fbxw18 T C 9: 109,530,381 (GRCm39) T77A probably damaging Het
Fgfbp3 A G 19: 36,896,082 (GRCm39) S179P possibly damaging Het
Foxp2 A G 6: 15,197,095 (GRCm39) T45A possibly damaging Het
Gckr A T 5: 31,454,933 (GRCm39) probably benign Het
Glce T A 9: 61,975,861 (GRCm39) Q213L probably damaging Het
Gm1965 A C 6: 89,123,469 (GRCm39) H84P unknown Het
Hbegf A G 18: 36,640,559 (GRCm39) V166A probably damaging Het
Helb G T 10: 119,944,886 (GRCm39) H217N probably damaging Het
Ino80 G A 2: 119,213,441 (GRCm39) R1249C probably damaging Het
Kansl2 A G 15: 98,418,257 (GRCm39) L392P probably damaging Het
Klra3 A G 6: 130,300,650 (GRCm39) S240P probably damaging Het
Liph T A 16: 21,802,944 (GRCm39) R42* probably null Het
Lrp1 A T 10: 127,377,694 (GRCm39) probably null Het
Luc7l2 A T 6: 38,566,169 (GRCm39) K52M probably damaging Het
Mecom G A 3: 30,034,060 (GRCm39) P215S probably damaging Het
Myo1g T A 11: 6,465,901 (GRCm39) T395S probably damaging Het
Ndst4 T A 3: 125,364,475 (GRCm39) M384K probably benign Het
Ndufb2 C T 6: 39,573,438 (GRCm39) T51I possibly damaging Het
Nell1 C A 7: 50,210,507 (GRCm39) probably benign Het
Or51k1 A T 7: 103,661,638 (GRCm39) N90K probably benign Het
Oxr1 G A 15: 41,683,936 (GRCm39) S434N possibly damaging Het
Pcdhac2 T A 18: 37,278,290 (GRCm39) S423R probably benign Het
Pcdhb10 T A 18: 37,545,012 (GRCm39) D29E probably benign Het
Pde10a A G 17: 9,200,408 (GRCm39) T1053A probably benign Het
Pkdrej T A 15: 85,702,384 (GRCm39) H1184L probably damaging Het
Prkaa2 C T 4: 104,904,288 (GRCm39) R263Q probably null Het
Prmt9 A G 8: 78,282,411 (GRCm39) I103V possibly damaging Het
Rbm15b T C 9: 106,762,135 (GRCm39) T678A probably benign Het
Ryr2 T C 13: 11,680,805 (GRCm39) Y3180C probably benign Het
Scaf1 T C 7: 44,657,094 (GRCm39) probably benign Het
Scn7a T A 2: 66,518,139 (GRCm39) N1024I possibly damaging Het
Sec23b T C 2: 144,406,482 (GRCm39) probably benign Het
Sf1 C A 19: 6,424,221 (GRCm39) P417Q probably damaging Het
Slc4a3 A T 1: 75,533,653 (GRCm39) probably benign Het
Stk32a T C 18: 43,438,121 (GRCm39) W207R probably damaging Het
Syne1 A T 10: 5,393,132 (GRCm39) probably benign Het
Tecta A T 9: 42,256,774 (GRCm39) V1634E possibly damaging Het
Tenm2 A G 11: 35,914,184 (GRCm39) F2450S probably damaging Het
Tgfb1 T C 7: 25,391,791 (GRCm39) probably benign Het
Tpgs2 A G 18: 25,291,295 (GRCm39) probably benign Het
Washc5 A G 15: 59,239,316 (GRCm39) M149T probably damaging Het
Wrn A T 8: 33,807,588 (GRCm39) V290D probably damaging Het
Zbtb41 A G 1: 139,370,626 (GRCm39) T688A possibly damaging Het
Zfp560 C T 9: 20,259,263 (GRCm39) C533Y probably damaging Het
Zfp791 G A 8: 85,837,495 (GRCm39) A123V probably benign Het
Other mutations in Klra1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01132:Klra1 APN 6 130,341,237 (GRCm39) nonsense probably null
IGL01320:Klra1 APN 6 130,341,224 (GRCm39) missense probably benign 0.02
IGL01322:Klra1 APN 6 130,341,224 (GRCm39) missense probably benign 0.02
IGL02149:Klra1 APN 6 130,352,293 (GRCm39) missense probably damaging 1.00
IGL02666:Klra1 APN 6 130,341,278 (GRCm39) missense probably damaging 1.00
IGL02895:Klra1 APN 6 130,352,203 (GRCm39) missense possibly damaging 0.51
R0408:Klra1 UTSW 6 130,354,737 (GRCm39) missense probably benign 0.13
R0442:Klra1 UTSW 6 130,349,835 (GRCm39) missense probably damaging 1.00
R0498:Klra1 UTSW 6 130,349,782 (GRCm39) critical splice donor site probably null
R0765:Klra1 UTSW 6 130,356,055 (GRCm39) splice site probably benign
R1761:Klra1 UTSW 6 130,349,836 (GRCm39) missense probably damaging 1.00
R1922:Klra1 UTSW 6 130,349,828 (GRCm39) missense probably benign 0.01
R1987:Klra1 UTSW 6 130,354,742 (GRCm39) missense probably benign
R2882:Klra1 UTSW 6 130,354,826 (GRCm39) splice site probably null
R5054:Klra1 UTSW 6 130,352,247 (GRCm39) missense probably damaging 0.99
R5190:Klra1 UTSW 6 130,352,241 (GRCm39) missense probably damaging 1.00
R5572:Klra1 UTSW 6 130,349,802 (GRCm39) missense possibly damaging 0.73
R5825:Klra1 UTSW 6 130,357,592 (GRCm39) missense probably damaging 1.00
R6784:Klra1 UTSW 6 130,349,817 (GRCm39) missense probably benign 0.00
R8957:Klra1 UTSW 6 130,357,609 (GRCm39) missense possibly damaging 0.89
R9154:Klra1 UTSW 6 130,357,607 (GRCm39) missense
Z1176:Klra1 UTSW 6 130,349,814 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCACACTGTGTCTTATGCAACTTGACC -3'
(R):5'- TCGAGCCATGAACCCAGTATCTCAG -3'

Sequencing Primer
(F):5'- AACTTGACCTTCCCCTGAGC -3'
(R):5'- CAGTATCTCAGGACACCTGGAG -3'
Posted On 2013-05-09