Incidental Mutation 'R4322:Vmn1r203'
ID |
323884 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r203
|
Ensembl Gene |
ENSMUSG00000069289 |
Gene Name |
vomeronasal 1 receptor 203 |
Synonyms |
V1rh11 |
MMRRC Submission |
041093-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.080)
|
Stock # |
R4322 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
13 |
Chromosomal Location |
22708221-22709156 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 22708408 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Isoleucine
at position 63
(N63I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000154399
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000091729]
[ENSMUST00000227520]
[ENSMUST00000228889]
|
AlphaFold |
Q8R273 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000091729
AA Change: N63I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000089322 Gene: ENSMUSG00000069289 AA Change: N63I
Domain | Start | End | E-Value | Type |
transmembrane domain
|
19 |
41 |
N/A |
INTRINSIC |
Pfam:V1R
|
43 |
304 |
5.8e-35 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137651
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000227520
AA Change: N63I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000228889
AA Change: N63I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
Validation Efficiency |
94% (48/51) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 37 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Actrt2 |
G |
A |
4: 154,751,701 (GRCm39) |
A145V |
probably damaging |
Het |
Allc |
C |
A |
12: 28,604,023 (GRCm39) |
L353F |
probably benign |
Het |
Alx3 |
C |
T |
3: 107,502,691 (GRCm39) |
P67L |
probably benign |
Het |
Arhgef10l |
C |
A |
4: 140,270,037 (GRCm39) |
G882V |
probably benign |
Het |
Asb13 |
G |
T |
13: 3,695,012 (GRCm39) |
R160L |
possibly damaging |
Het |
Atxn7l2 |
A |
T |
3: 108,113,148 (GRCm39) |
D218E |
probably damaging |
Het |
Bdp1 |
T |
A |
13: 100,228,731 (GRCm39) |
N299I |
probably damaging |
Het |
Ccdc80 |
G |
T |
16: 44,915,951 (GRCm39) |
V236L |
probably damaging |
Het |
Cdhr2 |
A |
T |
13: 54,881,534 (GRCm39) |
I1085L |
probably benign |
Het |
Csn2 |
C |
T |
5: 87,845,886 (GRCm39) |
|
probably null |
Het |
Dnajb14 |
G |
A |
3: 137,591,060 (GRCm39) |
G54S |
probably damaging |
Het |
Fyb1 |
T |
A |
15: 6,610,300 (GRCm39) |
L291Q |
possibly damaging |
Het |
Ggcx |
A |
G |
6: 72,405,803 (GRCm39) |
S545G |
probably benign |
Het |
Gm12250 |
G |
A |
11: 58,079,126 (GRCm39) |
|
noncoding transcript |
Het |
Hipk3 |
C |
A |
2: 104,276,916 (GRCm39) |
V388L |
probably damaging |
Het |
Hjurp |
G |
C |
1: 88,204,937 (GRCm39) |
|
probably benign |
Het |
Kng1 |
A |
C |
16: 22,898,270 (GRCm39) |
M557L |
probably benign |
Het |
Lilrb4a |
T |
C |
10: 51,367,707 (GRCm39) |
F83S |
probably damaging |
Het |
Lmcd1 |
A |
G |
6: 112,292,724 (GRCm39) |
E192G |
possibly damaging |
Het |
Lrp2 |
C |
A |
2: 69,256,335 (GRCm39) |
E4602* |
probably null |
Het |
Mc4r |
T |
C |
18: 66,992,121 (GRCm39) |
R331G |
probably benign |
Het |
Mybpc3 |
A |
G |
2: 90,954,306 (GRCm39) |
D393G |
possibly damaging |
Het |
Or2y1f |
G |
A |
11: 49,184,503 (GRCm39) |
M118I |
probably damaging |
Het |
Or4c10b |
A |
G |
2: 89,712,078 (GRCm39) |
K303E |
probably benign |
Het |
Or5p69 |
C |
T |
7: 107,967,555 (GRCm39) |
P286L |
probably damaging |
Het |
Orc1 |
G |
A |
4: 108,445,973 (GRCm39) |
M30I |
probably benign |
Het |
Pira13 |
A |
G |
7: 3,825,754 (GRCm39) |
S372P |
possibly damaging |
Het |
Pot1a |
T |
C |
6: 25,745,929 (GRCm39) |
T591A |
probably benign |
Het |
Rnf125 |
G |
A |
18: 21,110,817 (GRCm39) |
R25K |
probably benign |
Het |
Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
Sh3rf2 |
A |
T |
18: 42,244,464 (GRCm39) |
H310L |
probably damaging |
Het |
Shld2 |
G |
T |
14: 33,981,632 (GRCm39) |
T502K |
probably damaging |
Het |
Srgap1 |
T |
C |
10: 121,705,711 (GRCm39) |
K238E |
probably damaging |
Het |
Ssc5d |
C |
T |
7: 4,931,449 (GRCm39) |
R219C |
probably damaging |
Het |
Them5 |
C |
A |
3: 94,253,463 (GRCm39) |
H158N |
probably damaging |
Het |
Vps41 |
T |
A |
13: 19,007,960 (GRCm39) |
F264L |
probably damaging |
Het |
Vtn |
A |
T |
11: 78,390,916 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Vmn1r203 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01356:Vmn1r203
|
APN |
13 |
22,708,947 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01527:Vmn1r203
|
APN |
13 |
22,708,447 (GRCm39) |
missense |
possibly damaging |
0.89 |
IGL01808:Vmn1r203
|
APN |
13 |
22,708,717 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01887:Vmn1r203
|
APN |
13 |
22,709,046 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02340:Vmn1r203
|
APN |
13 |
22,708,997 (GRCm39) |
nonsense |
probably null |
|
IGL02543:Vmn1r203
|
APN |
13 |
22,709,074 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02684:Vmn1r203
|
APN |
13 |
22,708,539 (GRCm39) |
missense |
possibly damaging |
0.95 |
BB005:Vmn1r203
|
UTSW |
13 |
22,708,705 (GRCm39) |
missense |
probably benign |
0.01 |
BB015:Vmn1r203
|
UTSW |
13 |
22,708,705 (GRCm39) |
missense |
probably benign |
0.01 |
PIT4519001:Vmn1r203
|
UTSW |
13 |
22,708,765 (GRCm39) |
missense |
probably benign |
0.01 |
R0544:Vmn1r203
|
UTSW |
13 |
22,708,443 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1365:Vmn1r203
|
UTSW |
13 |
22,708,756 (GRCm39) |
missense |
probably benign |
0.00 |
R1396:Vmn1r203
|
UTSW |
13 |
22,708,678 (GRCm39) |
missense |
probably benign |
0.01 |
R1794:Vmn1r203
|
UTSW |
13 |
22,708,521 (GRCm39) |
missense |
probably damaging |
1.00 |
R2010:Vmn1r203
|
UTSW |
13 |
22,708,617 (GRCm39) |
missense |
possibly damaging |
0.56 |
R2169:Vmn1r203
|
UTSW |
13 |
22,708,905 (GRCm39) |
nonsense |
probably null |
|
R2333:Vmn1r203
|
UTSW |
13 |
22,709,113 (GRCm39) |
missense |
probably damaging |
1.00 |
R2418:Vmn1r203
|
UTSW |
13 |
22,709,004 (GRCm39) |
missense |
possibly damaging |
0.57 |
R2419:Vmn1r203
|
UTSW |
13 |
22,709,004 (GRCm39) |
missense |
possibly damaging |
0.57 |
R4460:Vmn1r203
|
UTSW |
13 |
22,708,852 (GRCm39) |
missense |
probably damaging |
0.98 |
R4686:Vmn1r203
|
UTSW |
13 |
22,708,528 (GRCm39) |
missense |
probably damaging |
1.00 |
R5526:Vmn1r203
|
UTSW |
13 |
22,708,273 (GRCm39) |
missense |
probably benign |
0.01 |
R6240:Vmn1r203
|
UTSW |
13 |
22,708,899 (GRCm39) |
missense |
possibly damaging |
0.89 |
R6607:Vmn1r203
|
UTSW |
13 |
22,708,891 (GRCm39) |
missense |
probably benign |
0.23 |
R7575:Vmn1r203
|
UTSW |
13 |
22,708,588 (GRCm39) |
missense |
probably benign |
0.12 |
R7928:Vmn1r203
|
UTSW |
13 |
22,708,705 (GRCm39) |
missense |
probably benign |
0.01 |
R8375:Vmn1r203
|
UTSW |
13 |
22,709,154 (GRCm39) |
makesense |
probably null |
|
R8421:Vmn1r203
|
UTSW |
13 |
22,709,154 (GRCm39) |
makesense |
probably null |
|
R8424:Vmn1r203
|
UTSW |
13 |
22,709,004 (GRCm39) |
missense |
probably damaging |
1.00 |
R8845:Vmn1r203
|
UTSW |
13 |
22,708,720 (GRCm39) |
missense |
possibly damaging |
0.81 |
R8933:Vmn1r203
|
UTSW |
13 |
22,708,691 (GRCm39) |
missense |
possibly damaging |
0.69 |
R8956:Vmn1r203
|
UTSW |
13 |
22,709,004 (GRCm39) |
missense |
possibly damaging |
0.57 |
R9493:Vmn1r203
|
UTSW |
13 |
22,708,423 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Vmn1r203
|
UTSW |
13 |
22,708,579 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Predicted Primers |
PCR Primer
(F):5'- GTCTACAATTGAAGAGGTTTCCTTCC -3'
(R):5'- ATGATGATGGCCTGGACCAC -3'
Sequencing Primer
(F):5'- GAAGAGGTTTCCTTCCAAAAGTG -3'
(R):5'- TGGCCTGGACCACAGTAAG -3'
|
Posted On |
2015-06-24 |