Incidental Mutation 'R4322:Vmn1r203'
ID 323884
Institutional Source Beutler Lab
Gene Symbol Vmn1r203
Ensembl Gene ENSMUSG00000069289
Gene Name vomeronasal 1 receptor 203
Synonyms V1rh11
MMRRC Submission 041093-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R4322 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 22708221-22709156 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 22708408 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 63 (N63I)
Ref Sequence ENSEMBL: ENSMUSP00000154399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091729] [ENSMUST00000227520] [ENSMUST00000228889]
AlphaFold Q8R273
Predicted Effect probably damaging
Transcript: ENSMUST00000091729
AA Change: N63I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000089322
Gene: ENSMUSG00000069289
AA Change: N63I

DomainStartEndE-ValueType
transmembrane domain 19 41 N/A INTRINSIC
Pfam:V1R 43 304 5.8e-35 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137651
Predicted Effect probably damaging
Transcript: ENSMUST00000227520
AA Change: N63I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228889
AA Change: N63I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 94% (48/51)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actrt2 G A 4: 154,751,701 (GRCm39) A145V probably damaging Het
Allc C A 12: 28,604,023 (GRCm39) L353F probably benign Het
Alx3 C T 3: 107,502,691 (GRCm39) P67L probably benign Het
Arhgef10l C A 4: 140,270,037 (GRCm39) G882V probably benign Het
Asb13 G T 13: 3,695,012 (GRCm39) R160L possibly damaging Het
Atxn7l2 A T 3: 108,113,148 (GRCm39) D218E probably damaging Het
Bdp1 T A 13: 100,228,731 (GRCm39) N299I probably damaging Het
Ccdc80 G T 16: 44,915,951 (GRCm39) V236L probably damaging Het
Cdhr2 A T 13: 54,881,534 (GRCm39) I1085L probably benign Het
Csn2 C T 5: 87,845,886 (GRCm39) probably null Het
Dnajb14 G A 3: 137,591,060 (GRCm39) G54S probably damaging Het
Fyb1 T A 15: 6,610,300 (GRCm39) L291Q possibly damaging Het
Ggcx A G 6: 72,405,803 (GRCm39) S545G probably benign Het
Gm12250 G A 11: 58,079,126 (GRCm39) noncoding transcript Het
Hipk3 C A 2: 104,276,916 (GRCm39) V388L probably damaging Het
Hjurp G C 1: 88,204,937 (GRCm39) probably benign Het
Kng1 A C 16: 22,898,270 (GRCm39) M557L probably benign Het
Lilrb4a T C 10: 51,367,707 (GRCm39) F83S probably damaging Het
Lmcd1 A G 6: 112,292,724 (GRCm39) E192G possibly damaging Het
Lrp2 C A 2: 69,256,335 (GRCm39) E4602* probably null Het
Mc4r T C 18: 66,992,121 (GRCm39) R331G probably benign Het
Mybpc3 A G 2: 90,954,306 (GRCm39) D393G possibly damaging Het
Or2y1f G A 11: 49,184,503 (GRCm39) M118I probably damaging Het
Or4c10b A G 2: 89,712,078 (GRCm39) K303E probably benign Het
Or5p69 C T 7: 107,967,555 (GRCm39) P286L probably damaging Het
Orc1 G A 4: 108,445,973 (GRCm39) M30I probably benign Het
Pira13 A G 7: 3,825,754 (GRCm39) S372P possibly damaging Het
Pot1a T C 6: 25,745,929 (GRCm39) T591A probably benign Het
Rnf125 G A 18: 21,110,817 (GRCm39) R25K probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Sh3rf2 A T 18: 42,244,464 (GRCm39) H310L probably damaging Het
Shld2 G T 14: 33,981,632 (GRCm39) T502K probably damaging Het
Srgap1 T C 10: 121,705,711 (GRCm39) K238E probably damaging Het
Ssc5d C T 7: 4,931,449 (GRCm39) R219C probably damaging Het
Them5 C A 3: 94,253,463 (GRCm39) H158N probably damaging Het
Vps41 T A 13: 19,007,960 (GRCm39) F264L probably damaging Het
Vtn A T 11: 78,390,916 (GRCm39) probably benign Het
Other mutations in Vmn1r203
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01356:Vmn1r203 APN 13 22,708,947 (GRCm39) missense probably damaging 1.00
IGL01527:Vmn1r203 APN 13 22,708,447 (GRCm39) missense possibly damaging 0.89
IGL01808:Vmn1r203 APN 13 22,708,717 (GRCm39) missense probably benign 0.02
IGL01887:Vmn1r203 APN 13 22,709,046 (GRCm39) missense probably benign 0.00
IGL02340:Vmn1r203 APN 13 22,708,997 (GRCm39) nonsense probably null
IGL02543:Vmn1r203 APN 13 22,709,074 (GRCm39) missense probably damaging 1.00
IGL02684:Vmn1r203 APN 13 22,708,539 (GRCm39) missense possibly damaging 0.95
BB005:Vmn1r203 UTSW 13 22,708,705 (GRCm39) missense probably benign 0.01
BB015:Vmn1r203 UTSW 13 22,708,705 (GRCm39) missense probably benign 0.01
PIT4519001:Vmn1r203 UTSW 13 22,708,765 (GRCm39) missense probably benign 0.01
R0544:Vmn1r203 UTSW 13 22,708,443 (GRCm39) missense possibly damaging 0.94
R1365:Vmn1r203 UTSW 13 22,708,756 (GRCm39) missense probably benign 0.00
R1396:Vmn1r203 UTSW 13 22,708,678 (GRCm39) missense probably benign 0.01
R1794:Vmn1r203 UTSW 13 22,708,521 (GRCm39) missense probably damaging 1.00
R2010:Vmn1r203 UTSW 13 22,708,617 (GRCm39) missense possibly damaging 0.56
R2169:Vmn1r203 UTSW 13 22,708,905 (GRCm39) nonsense probably null
R2333:Vmn1r203 UTSW 13 22,709,113 (GRCm39) missense probably damaging 1.00
R2418:Vmn1r203 UTSW 13 22,709,004 (GRCm39) missense possibly damaging 0.57
R2419:Vmn1r203 UTSW 13 22,709,004 (GRCm39) missense possibly damaging 0.57
R4460:Vmn1r203 UTSW 13 22,708,852 (GRCm39) missense probably damaging 0.98
R4686:Vmn1r203 UTSW 13 22,708,528 (GRCm39) missense probably damaging 1.00
R5526:Vmn1r203 UTSW 13 22,708,273 (GRCm39) missense probably benign 0.01
R6240:Vmn1r203 UTSW 13 22,708,899 (GRCm39) missense possibly damaging 0.89
R6607:Vmn1r203 UTSW 13 22,708,891 (GRCm39) missense probably benign 0.23
R7575:Vmn1r203 UTSW 13 22,708,588 (GRCm39) missense probably benign 0.12
R7928:Vmn1r203 UTSW 13 22,708,705 (GRCm39) missense probably benign 0.01
R8375:Vmn1r203 UTSW 13 22,709,154 (GRCm39) makesense probably null
R8421:Vmn1r203 UTSW 13 22,709,154 (GRCm39) makesense probably null
R8424:Vmn1r203 UTSW 13 22,709,004 (GRCm39) missense probably damaging 1.00
R8845:Vmn1r203 UTSW 13 22,708,720 (GRCm39) missense possibly damaging 0.81
R8933:Vmn1r203 UTSW 13 22,708,691 (GRCm39) missense possibly damaging 0.69
R8956:Vmn1r203 UTSW 13 22,709,004 (GRCm39) missense possibly damaging 0.57
R9493:Vmn1r203 UTSW 13 22,708,423 (GRCm39) missense probably damaging 1.00
Z1177:Vmn1r203 UTSW 13 22,708,579 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GTCTACAATTGAAGAGGTTTCCTTCC -3'
(R):5'- ATGATGATGGCCTGGACCAC -3'

Sequencing Primer
(F):5'- GAAGAGGTTTCCTTCCAAAAGTG -3'
(R):5'- TGGCCTGGACCACAGTAAG -3'
Posted On 2015-06-24