Incidental Mutation 'R4323:Vmn1r46'
ID 323911
Institutional Source Beutler Lab
Gene Symbol Vmn1r46
Ensembl Gene ENSMUSG00000061653
Gene Name vomeronasal 1 receptor 46
Synonyms V1rb8
MMRRC Submission 041094-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R4323 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 89953153-89954082 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 89953349 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 66 (M66T)
Ref Sequence ENSEMBL: ENSMUSP00000154175 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075797] [ENSMUST00000205088] [ENSMUST00000226715] [ENSMUST00000228231] [ENSMUST00000228349] [ENSMUST00000228401]
AlphaFold Q9EQ45
Predicted Effect probably benign
Transcript: ENSMUST00000075797
AA Change: M66T

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000075197
Gene: ENSMUSG00000061653
AA Change: M66T

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
Pfam:V1R 38 301 5.9e-132 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205088
AA Change: M66T

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000144888
Gene: ENSMUSG00000061653
AA Change: M66T

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
Pfam:V1R 38 301 5.9e-132 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226715
AA Change: M66T

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000228231
AA Change: M66T

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000228349
AA Change: M66T

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000228401
AA Change: M66T

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 95% (59/62)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik A G 4: 62,465,548 (GRCm39) Y414C probably damaging Het
Akr1b1 T C 6: 34,287,862 (GRCm39) T166A probably benign Het
Ankhd1 C T 18: 36,711,686 (GRCm39) S94L probably damaging Het
B4galt3 G T 1: 171,103,515 (GRCm39) M68I possibly damaging Het
Bpnt1 A C 1: 185,088,786 (GRCm39) H312P probably benign Het
Ccdc178 T A 18: 22,166,600 (GRCm39) K530* probably null Het
Ccdc191 A G 16: 43,767,872 (GRCm39) E624G probably damaging Het
Clasp2 T C 9: 113,719,027 (GRCm39) V724A possibly damaging Het
Copa G T 1: 171,946,831 (GRCm39) C1022F probably damaging Het
Cwf19l2 T G 9: 3,430,452 (GRCm39) F261L probably damaging Het
Esr1 G A 10: 4,951,307 (GRCm39) V562M possibly damaging Het
Fap T C 2: 62,333,716 (GRCm39) H643R probably damaging Het
Fbxo38 T A 18: 62,648,232 (GRCm39) M769L probably benign Het
Fgfr1 A G 8: 26,063,915 (GRCm39) N814S probably benign Het
Hipk3 C A 2: 104,276,916 (GRCm39) V388L probably damaging Het
Hspa1l T A 17: 35,196,832 (GRCm39) Y290* probably null Het
Itsn1 G A 16: 91,615,440 (GRCm39) probably benign Het
Jam2 T C 16: 84,619,744 (GRCm39) probably benign Het
Kprp G A 3: 92,732,163 (GRCm39) R296W probably damaging Het
Med23 T C 10: 24,746,603 (GRCm39) I14T probably benign Het
Mitf A G 6: 97,968,910 (GRCm39) Y10C probably benign Het
Mpo T C 11: 87,686,865 (GRCm39) S165P probably damaging Het
Neb T G 2: 52,154,122 (GRCm39) M2330L possibly damaging Het
Nup214 T C 2: 31,884,696 (GRCm39) S486P probably benign Het
Or2y1f G A 11: 49,184,503 (GRCm39) M118I probably damaging Het
Parp6 G A 9: 59,537,969 (GRCm39) V205I possibly damaging Het
Pate2 A T 9: 35,581,767 (GRCm39) probably benign Het
Pdss1 T C 2: 22,802,608 (GRCm39) probably benign Het
Pira13 A G 7: 3,825,754 (GRCm39) S372P possibly damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Septin1 G A 7: 126,816,200 (GRCm39) P77S probably damaging Het
Slitrk3 A G 3: 72,958,118 (GRCm39) L218P probably damaging Het
Sltm T C 9: 70,487,529 (GRCm39) I521T probably benign Het
Smchd1 A G 17: 71,735,270 (GRCm39) I618T probably benign Het
Sox6 A G 7: 115,179,798 (GRCm39) probably null Het
Sp8 A G 12: 118,812,171 (GRCm39) I9V probably benign Het
Usp9y T A Y: 1,434,407 (GRCm39) M352L possibly damaging Het
Vmn2r111 A T 17: 22,792,159 (GRCm39) N32K probably benign Het
Vmn2r63 A G 7: 42,576,406 (GRCm39) F469S probably benign Het
Vps13d T A 4: 144,879,348 (GRCm39) T1486S probably benign Het
Wdr55 A G 18: 36,896,153 (GRCm39) N281S probably benign Het
Zswim6 G A 13: 108,025,938 (GRCm39) noncoding transcript Het
Other mutations in Vmn1r46
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02271:Vmn1r46 APN 6 89,953,886 (GRCm39) missense probably damaging 1.00
IGL02488:Vmn1r46 APN 6 89,953,963 (GRCm39) missense probably benign 0.10
IGL03116:Vmn1r46 APN 6 89,953,898 (GRCm39) missense probably benign 0.16
IGL03270:Vmn1r46 APN 6 89,953,756 (GRCm39) missense probably damaging 1.00
R0109:Vmn1r46 UTSW 6 89,954,044 (GRCm39) missense probably benign 0.03
R0126:Vmn1r46 UTSW 6 89,953,935 (GRCm39) missense probably benign
R0681:Vmn1r46 UTSW 6 89,953,946 (GRCm39) missense probably damaging 1.00
R1501:Vmn1r46 UTSW 6 89,953,198 (GRCm39) missense probably benign 0.03
R1717:Vmn1r46 UTSW 6 89,953,811 (GRCm39) missense probably damaging 1.00
R1937:Vmn1r46 UTSW 6 89,953,716 (GRCm39) missense probably benign 0.00
R5449:Vmn1r46 UTSW 6 89,953,343 (GRCm39) missense probably benign 0.18
R6062:Vmn1r46 UTSW 6 89,953,241 (GRCm39) missense possibly damaging 0.64
R6385:Vmn1r46 UTSW 6 89,953,427 (GRCm39) missense probably damaging 0.99
R6431:Vmn1r46 UTSW 6 89,953,389 (GRCm39) missense probably benign 0.13
R7126:Vmn1r46 UTSW 6 89,953,976 (GRCm39) missense possibly damaging 0.79
R7391:Vmn1r46 UTSW 6 89,953,607 (GRCm39) missense probably benign 0.23
R8700:Vmn1r46 UTSW 6 89,953,325 (GRCm39) missense probably benign 0.04
R8950:Vmn1r46 UTSW 6 89,954,053 (GRCm39) missense probably damaging 0.99
R9046:Vmn1r46 UTSW 6 89,953,585 (GRCm39) missense probably damaging 1.00
Z1088:Vmn1r46 UTSW 6 89,953,723 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTTCCTACCCACATACAATG -3'
(R):5'- AAGGCACCTGAGATGTGATG -3'

Sequencing Primer
(F):5'- GCCAACATATTCTGCACCG -3'
(R):5'- CACCTGAGATGTGATGGGGAG -3'
Posted On 2015-06-24