Incidental Mutation 'R4324:Cdk14'
ID 323953
Institutional Source Beutler Lab
Gene Symbol Cdk14
Ensembl Gene ENSMUSG00000028926
Gene Name cyclin dependent kinase 14
Synonyms Pftk1
MMRRC Submission 041095-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4324 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 4853384-5430251 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 5086532 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 263 (K263*)
Ref Sequence ENSEMBL: ENSMUSP00000111112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030763] [ENSMUST00000115450] [ENSMUST00000115451] [ENSMUST00000115452]
AlphaFold O35495
Predicted Effect probably null
Transcript: ENSMUST00000030763
AA Change: K281*
SMART Domains Protein: ENSMUSP00000030763
Gene: ENSMUSG00000028926
AA Change: K281*

DomainStartEndE-ValueType
low complexity region 119 127 N/A INTRINSIC
S_TKc 135 419 3.63e-85 SMART
Predicted Effect probably null
Transcript: ENSMUST00000115450
AA Change: K235*
SMART Domains Protein: ENSMUSP00000111110
Gene: ENSMUSG00000028926
AA Change: K235*

DomainStartEndE-ValueType
low complexity region 73 81 N/A INTRINSIC
S_TKc 89 373 3.63e-85 SMART
Predicted Effect probably null
Transcript: ENSMUST00000115451
AA Change: K235*
SMART Domains Protein: ENSMUSP00000111111
Gene: ENSMUSG00000028926
AA Change: K235*

DomainStartEndE-ValueType
low complexity region 73 81 N/A INTRINSIC
S_TKc 89 373 3.63e-85 SMART
Predicted Effect probably null
Transcript: ENSMUST00000115452
AA Change: K263*
SMART Domains Protein: ENSMUSP00000111112
Gene: ENSMUSG00000028926
AA Change: K263*

DomainStartEndE-ValueType
low complexity region 101 109 N/A INTRINSIC
S_TKc 117 401 3.63e-85 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133465
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134867
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156660
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afp A G 5: 90,655,764 (GRCm39) D583G probably benign Het
Alg9 T G 9: 50,716,643 (GRCm39) H22Q probably damaging Het
Aqp6 G A 15: 99,499,291 (GRCm39) M1I probably null Het
Arhgef10 T A 8: 14,990,335 (GRCm39) I270N possibly damaging Het
Asb13 G T 13: 3,695,012 (GRCm39) R160L possibly damaging Het
Atg10 T A 13: 91,189,085 (GRCm39) D75V probably damaging Het
Atxn7l2 A T 3: 108,113,148 (GRCm39) D218E probably damaging Het
Ccdc191 A G 16: 43,767,872 (GRCm39) E624G probably damaging Het
Cdan1 T C 2: 120,555,460 (GRCm39) I760M probably damaging Het
Cdk5rap2 A T 4: 70,271,851 (GRCm39) I287N probably damaging Het
Cdkn2aip A T 8: 48,165,208 (GRCm39) S168R probably benign Het
Dnah17 C T 11: 117,985,039 (GRCm39) V1555M probably benign Het
Dsel T C 1: 111,789,123 (GRCm39) T471A probably damaging Het
Dzank1 T C 2: 144,330,618 (GRCm39) E478G possibly damaging Het
Enc1 T C 13: 97,382,405 (GRCm39) F305S probably benign Het
Epn1 T A 7: 5,100,210 (GRCm39) M441K probably benign Het
Fbxw24 C T 9: 109,434,013 (GRCm39) probably null Het
Gad1 G A 2: 70,420,174 (GRCm39) D353N probably damaging Het
Ggcx A G 6: 72,405,803 (GRCm39) S545G probably benign Het
H2-K2 C T 17: 34,219,014 (GRCm39) V30M possibly damaging Het
Hipk3 C A 2: 104,276,916 (GRCm39) V388L probably damaging Het
Krt82 T A 15: 101,450,182 (GRCm39) M505L probably benign Het
Man2a1 A G 17: 64,973,788 (GRCm39) I355V probably benign Het
Or5p53 C T 7: 107,532,900 (GRCm39) P58S probably damaging Het
Pcbp3 G A 10: 76,599,177 (GRCm39) R109* probably null Het
Pcgf1 T C 6: 83,056,938 (GRCm39) probably null Het
Plekhm2 A T 4: 141,359,168 (GRCm39) V533E possibly damaging Het
Prss3 T G 6: 41,350,779 (GRCm39) D237A probably benign Het
Rnf125 G A 18: 21,110,817 (GRCm39) R25K probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Shc4 T A 2: 125,520,670 (GRCm39) M260L probably benign Het
Spag6l T C 16: 16,605,099 (GRCm39) Y151C probably benign Het
Stac3 C T 10: 127,339,118 (GRCm39) P76S probably damaging Het
Trpc7 T C 13: 57,035,169 (GRCm39) I255V probably damaging Het
Ttn T C 2: 76,738,923 (GRCm39) E3872G probably benign Het
Uqcrfs1 A G 13: 30,725,141 (GRCm39) V133A probably benign Het
Vmn2r52 T A 7: 9,904,940 (GRCm39) T300S possibly damaging Het
Wipi1 A T 11: 109,494,662 (GRCm39) I57N possibly damaging Het
Other mutations in Cdk14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00678:Cdk14 APN 5 5,299,237 (GRCm39) splice site probably benign
IGL01376:Cdk14 APN 5 5,060,839 (GRCm39) missense probably damaging 1.00
IGL02102:Cdk14 APN 5 5,430,083 (GRCm39) missense probably benign 0.01
IGL02179:Cdk14 APN 5 5,153,845 (GRCm39) missense probably damaging 1.00
IGL02423:Cdk14 APN 5 4,938,905 (GRCm39) missense probably benign 0.00
IGL03081:Cdk14 APN 5 4,999,527 (GRCm39) splice site probably benign
IGL02988:Cdk14 UTSW 5 5,086,484 (GRCm39) missense probably damaging 1.00
R0465:Cdk14 UTSW 5 5,143,019 (GRCm39) missense probably damaging 1.00
R0630:Cdk14 UTSW 5 5,185,422 (GRCm39) splice site probably benign
R1452:Cdk14 UTSW 5 4,938,927 (GRCm39) missense possibly damaging 0.85
R1601:Cdk14 UTSW 5 5,185,378 (GRCm39) missense probably damaging 1.00
R1629:Cdk14 UTSW 5 5,153,807 (GRCm39) missense probably benign 0.18
R1659:Cdk14 UTSW 5 4,999,571 (GRCm39) missense probably benign 0.08
R1809:Cdk14 UTSW 5 5,060,901 (GRCm39) missense probably damaging 0.98
R2013:Cdk14 UTSW 5 5,143,047 (GRCm39) missense probably damaging 1.00
R2015:Cdk14 UTSW 5 5,430,082 (GRCm39) missense probably benign
R2256:Cdk14 UTSW 5 4,938,924 (GRCm39) missense probably benign
R2257:Cdk14 UTSW 5 4,938,924 (GRCm39) missense probably benign
R2908:Cdk14 UTSW 5 5,299,051 (GRCm39) missense probably benign 0.33
R4432:Cdk14 UTSW 5 5,086,427 (GRCm39) missense probably damaging 1.00
R4907:Cdk14 UTSW 5 5,299,140 (GRCm39) missense probably damaging 0.96
R5426:Cdk14 UTSW 5 4,938,975 (GRCm39) missense possibly damaging 0.93
R5708:Cdk14 UTSW 5 5,316,036 (GRCm39) intron probably benign
R6006:Cdk14 UTSW 5 5,299,211 (GRCm39) start codon destroyed probably null 0.33
R6120:Cdk14 UTSW 5 4,944,029 (GRCm39) missense probably damaging 0.96
R7048:Cdk14 UTSW 5 5,143,005 (GRCm39) missense probably damaging 1.00
R7104:Cdk14 UTSW 5 5,245,325 (GRCm39) missense possibly damaging 0.92
R7712:Cdk14 UTSW 5 5,430,061 (GRCm39) missense possibly damaging 0.86
R8046:Cdk14 UTSW 5 5,299,159 (GRCm39) missense possibly damaging 0.86
R8121:Cdk14 UTSW 5 5,277,195 (GRCm39) missense possibly damaging 0.92
R8195:Cdk14 UTSW 5 5,277,159 (GRCm39) splice site probably null
R8279:Cdk14 UTSW 5 5,316,125 (GRCm39) intron probably benign
R8312:Cdk14 UTSW 5 4,944,141 (GRCm39) missense probably benign 0.03
R8543:Cdk14 UTSW 5 5,430,079 (GRCm39) missense probably benign 0.02
R8728:Cdk14 UTSW 5 5,470,117 (GRCm39) synonymous silent
R8862:Cdk14 UTSW 5 5,060,862 (GRCm39) missense probably benign 0.01
R8914:Cdk14 UTSW 5 5,086,515 (GRCm39) missense possibly damaging 0.93
R8956:Cdk14 UTSW 5 5,277,182 (GRCm39) missense probably damaging 1.00
R9111:Cdk14 UTSW 5 5,315,985 (GRCm39) missense possibly damaging 0.93
R9649:Cdk14 UTSW 5 5,423,477 (GRCm39) missense probably benign 0.07
R9796:Cdk14 UTSW 5 5,316,012 (GRCm39) missense probably benign 0.10
Z1176:Cdk14 UTSW 5 5,185,322 (GRCm39) nonsense probably null
Z1177:Cdk14 UTSW 5 4,938,894 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- CATAGGCAAGACTCCTGCAC -3'
(R):5'- AGTCAGGAGATTCTAAAGTGGTTG -3'

Sequencing Primer
(F):5'- AAGACTCCTGCACCATTAATCTTTG -3'
(R):5'- GCTTTATTTGCAGTATGAATGACTTG -3'
Posted On 2015-06-24