Incidental Mutation 'R4305:Or4k37'
ID 323990
Institutional Source Beutler Lab
Gene Symbol Or4k37
Ensembl Gene ENSMUSG00000095156
Gene Name olfactory receptor family 4 subfamily K member 37
Synonyms GA_x6K02T2Q125-72379864-72380781, MOR248-18, MOR248-14P, Olfr1281
MMRRC Submission 041091-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R4305 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 111158766-111159683 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111159643 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 293 (D293G)
Ref Sequence ENSEMBL: ENSMUSP00000087798 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090326] [ENSMUST00000208176] [ENSMUST00000213551]
AlphaFold Q7TQY6
Predicted Effect probably null
Transcript: ENSMUST00000090326
AA Change: D293G

PolyPhen 2 Score 0.821 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000087798
Gene: ENSMUSG00000095156
AA Change: D293G

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 4.8e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 301 2.6e-6 PFAM
Pfam:7tm_1 41 287 4.8e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000208176
AA Change: D293G

PolyPhen 2 Score 0.821 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect probably benign
Transcript: ENSMUST00000213551
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 92% (36/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik C A 1: 12,042,300 (GRCm39) S440* probably null Het
Abl2 T A 1: 156,469,133 (GRCm39) M695K probably damaging Het
Asap2 T C 12: 21,279,482 (GRCm39) I426T probably damaging Het
Atxn7l1 T C 12: 33,391,991 (GRCm39) M93T probably damaging Het
Ccr5 T C 9: 123,925,111 (GRCm39) L238P possibly damaging Het
Cd27 A G 6: 125,211,633 (GRCm39) V98A probably benign Het
Ceacam23 T A 7: 17,639,118 (GRCm39) Y372N probably benign Het
Cfap47 C G X: 78,541,635 (GRCm39) K469N probably damaging Het
Chrdl2 A G 7: 99,671,229 (GRCm39) T116A probably damaging Het
Epha6 T C 16: 60,346,883 (GRCm39) probably null Het
Garin1b A G 6: 29,326,611 (GRCm39) S243G probably damaging Het
Gart T C 16: 91,430,880 (GRCm39) E394G possibly damaging Het
Krt1 AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC 15: 101,758,813 (GRCm39) probably benign Het
Lpar6 G A 14: 73,476,381 (GRCm39) R114Q probably damaging Het
Med23 G T 10: 24,780,168 (GRCm39) E573* probably null Het
Mtch2 A G 2: 90,689,827 (GRCm39) I183V probably benign Het
Nlrp3 C T 11: 59,438,836 (GRCm39) R138* probably null Het
Notch1 T C 2: 26,367,936 (GRCm39) D657G probably damaging Het
Rbm20 A G 19: 53,831,691 (GRCm39) S642G probably damaging Het
Tex11 C A X: 99,977,021 (GRCm39) A487S possibly damaging Het
Ttn T C 2: 76,748,681 (GRCm39) S4123G probably benign Het
Ugt3a1 A C 15: 9,306,360 (GRCm39) S170R possibly damaging Het
Vmn2r71 G T 7: 85,273,360 (GRCm39) D725Y probably damaging Het
Vps9d1 G T 8: 123,974,976 (GRCm39) probably benign Het
Yeats2 A G 16: 20,027,172 (GRCm39) T808A probably damaging Het
Zdhhc4 C T 5: 143,310,099 (GRCm39) probably benign Het
Other mutations in Or4k37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02426:Or4k37 APN 2 111,158,920 (GRCm39) missense probably damaging 1.00
IGL02550:Or4k37 APN 2 111,158,845 (GRCm39) missense probably damaging 1.00
IGL02553:Or4k37 APN 2 111,159,333 (GRCm39) missense probably benign
IGL02719:Or4k37 APN 2 111,159,590 (GRCm39) nonsense probably null
IGL02750:Or4k37 APN 2 111,159,633 (GRCm39) missense probably damaging 1.00
IGL02873:Or4k37 APN 2 111,159,217 (GRCm39) missense probably benign
IGL03252:Or4k37 APN 2 111,159,125 (GRCm39) nonsense probably null
IGL03375:Or4k37 APN 2 111,159,229 (GRCm39) missense probably damaging 1.00
R0055:Or4k37 UTSW 2 111,158,870 (GRCm39) nonsense probably null
R0368:Or4k37 UTSW 2 111,159,132 (GRCm39) missense probably damaging 0.99
R0497:Or4k37 UTSW 2 111,159,175 (GRCm39) missense probably benign 0.00
R0505:Or4k37 UTSW 2 111,159,673 (GRCm39) missense probably benign 0.00
R1557:Or4k37 UTSW 2 111,158,964 (GRCm39) missense probably damaging 1.00
R1619:Or4k37 UTSW 2 111,159,306 (GRCm39) missense probably benign 0.02
R1691:Or4k37 UTSW 2 111,159,198 (GRCm39) missense probably benign 0.03
R2286:Or4k37 UTSW 2 111,159,252 (GRCm39) missense probably benign 0.01
R4230:Or4k37 UTSW 2 111,159,475 (GRCm39) missense probably damaging 1.00
R4274:Or4k37 UTSW 2 111,159,160 (GRCm39) missense probably damaging 0.98
R4495:Or4k37 UTSW 2 111,159,365 (GRCm39) missense probably benign 0.08
R5307:Or4k37 UTSW 2 111,158,741 (GRCm39) splice site probably null
R6115:Or4k37 UTSW 2 111,159,558 (GRCm39) missense probably benign 0.03
R6615:Or4k37 UTSW 2 111,159,457 (GRCm39) missense probably benign 0.00
R7169:Or4k37 UTSW 2 111,158,943 (GRCm39) missense probably damaging 1.00
R7601:Or4k37 UTSW 2 111,159,565 (GRCm39) missense probably benign 0.12
R8267:Or4k37 UTSW 2 111,159,160 (GRCm39) missense probably benign 0.22
R8447:Or4k37 UTSW 2 111,159,307 (GRCm39) missense possibly damaging 0.81
R8749:Or4k37 UTSW 2 111,158,817 (GRCm39) missense possibly damaging 0.93
R8795:Or4k37 UTSW 2 111,158,881 (GRCm39) nonsense probably null
R9269:Or4k37 UTSW 2 111,159,297 (GRCm39) missense probably damaging 1.00
R9598:Or4k37 UTSW 2 111,159,633 (GRCm39) nonsense probably null
R9679:Or4k37 UTSW 2 111,159,345 (GRCm39) missense probably benign 0.00
Z1177:Or4k37 UTSW 2 111,159,170 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AGATGGCTCATCAAAAGCACTATC -3'
(R):5'- ACCGTGTACAGATAAAACTACTAGC -3'

Sequencing Primer
(F):5'- CCACATGCACATCCCATATCATAGTG -3'
(R):5'- GCAGCAAATTAGAATTAAGATTGGC -3'
Posted On 2015-06-24