|Institutional Source||Beutler Lab|
|Gene Name||kinesin family member 11|
|Synonyms||Eg5, Knsl1, Kifl1|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R4319 (G1)|
|Chromosomal Location||37376403-37421859 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 37384585 bp|
|Amino Acid Change||Valine to Alanine at position 84 (V84A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000012587 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000012587]|
|Predicted Effect||probably damaging
AA Change: V84A
PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
AA Change: V84A
|Meta Mutation Damage Score||0.3698|
|Coding Region Coverage||
|Validation Efficiency||94% (31/33)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Deletion of Kif11 results in early embryonic lethality of homozygotes, with developmental growth arrest at E3.5. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Kif11||
(F):5'- TTGACGGACAAGACCTCCAAG -3'
(R):5'- TTTCCAGTGCCAGTCTGAC -3'
(F):5'- ATACACGTTTGATATGGTACTGATGG -3'
(R):5'- TTACGCGAAGATGGTGC -3'