|Institutional Source||Beutler Lab|
|Gene Name||collectin sub-family member 10|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0004 (G1)|
|Chromosomal Location||54410774-54466358 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to T at 54410875 bp|
|Amino Acid Change||Arginine to Leucine at position 33 (R33L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000037867 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000036737]|
|Predicted Effect||possibly damaging
AA Change: R33L
PolyPhen 2 Score 0.571 (Sensitivity: 0.88; Specificity: 0.91)
AA Change: R33L
|Meta Mutation Damage Score||0.1330|
|Coding Region Coverage||
|Validation Efficiency||98% (63/64)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Colec10||
(F):5'- TGCTTATGGAGAGGTTTGCACTGAC -3'
(R):5'- CCATCTAAACGCACTGGAAGAGGG -3'
(F):5'- GAGGTTTGCACTGACCTGAATATC -3'
(R):5'- GGGTCCTCAGTGTTCGACATC -3'