Incidental Mutation 'R4343:Gm8674'
ID |
324236 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gm8674
|
Ensembl Gene |
ENSMUSG00000093976 |
Gene Name |
predicted gene 8674 |
Synonyms |
|
MMRRC Submission |
041665-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.080)
|
Stock # |
R4343 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
13 |
Chromosomal Location |
50053085-50056359 bp(-) (GRCm39) |
Type of Mutation |
exon |
DNA Base Change (assembly) |
T to A
at 50053742 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Gene Model |
predicted gene model for transcript(s):
|
AlphaFold |
no structure available at present |
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000179367
|
SMART Domains |
Protein: ENSMUSP00000137219 Gene: ENSMUSG00000093976
Domain | Start | End | E-Value | Type |
low complexity region
|
70 |
86 |
N/A |
INTRINSIC |
Pfam:FAM75
|
92 |
444 |
3.6e-27 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.6%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 29 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Cd38 |
A |
C |
5: 44,026,431 (GRCm39) |
I72L |
probably benign |
Het |
Diras1 |
T |
A |
10: 80,858,018 (GRCm39) |
K78* |
probably null |
Het |
Gm5878 |
G |
A |
6: 85,102,633 (GRCm39) |
R31* |
probably null |
Het |
Gnal |
T |
C |
18: 67,268,659 (GRCm39) |
S182P |
probably benign |
Het |
Grik1 |
T |
C |
16: 87,693,140 (GRCm39) |
T932A |
probably benign |
Het |
Igf2r |
C |
T |
17: 12,928,398 (GRCm39) |
E982K |
possibly damaging |
Het |
Lepr |
G |
A |
4: 101,622,349 (GRCm39) |
|
probably null |
Het |
Mical3 |
C |
A |
6: 120,911,799 (GRCm39) |
E1083* |
probably null |
Het |
Mki67 |
A |
G |
7: 135,296,847 (GRCm39) |
V2729A |
probably benign |
Het |
Mmp20 |
GA |
GAA |
9: 7,628,346 (GRCm39) |
|
probably null |
Het |
Myo7b |
A |
G |
18: 32,116,680 (GRCm39) |
F976L |
probably damaging |
Het |
Nfasc |
A |
G |
1: 132,559,443 (GRCm39) |
F229S |
probably damaging |
Het |
Npc1l1 |
G |
A |
11: 6,167,773 (GRCm39) |
T1006I |
probably benign |
Het |
Or5g9 |
T |
A |
2: 85,552,592 (GRCm39) |
V281E |
probably damaging |
Het |
Plekha5 |
A |
G |
6: 140,501,780 (GRCm39) |
E656G |
probably damaging |
Het |
Prep |
C |
A |
10: 44,996,866 (GRCm39) |
S381R |
probably damaging |
Het |
Rab31 |
C |
T |
17: 65,961,414 (GRCm39) |
R192H |
probably benign |
Het |
Rbm5 |
T |
C |
9: 107,629,395 (GRCm39) |
D319G |
probably damaging |
Het |
Rexo2 |
T |
C |
9: 48,380,148 (GRCm39) |
E228G |
possibly damaging |
Het |
Rrn3 |
A |
G |
16: 13,601,986 (GRCm39) |
D80G |
probably benign |
Het |
Slc38a3 |
A |
G |
9: 107,533,671 (GRCm39) |
V224A |
possibly damaging |
Het |
Slc66a2 |
A |
G |
18: 80,327,004 (GRCm39) |
|
probably benign |
Het |
Sycp2 |
T |
C |
2: 178,022,740 (GRCm39) |
T464A |
probably damaging |
Het |
Tpcn1 |
A |
T |
5: 120,698,285 (GRCm39) |
L79H |
probably damaging |
Het |
Trim30a |
T |
C |
7: 104,084,799 (GRCm39) |
Q137R |
probably benign |
Het |
Tyrp1 |
A |
G |
4: 80,768,078 (GRCm39) |
D92G |
possibly damaging |
Het |
Ugt1a6a |
T |
C |
1: 88,066,248 (GRCm39) |
L18P |
probably damaging |
Het |
Ugt2b5 |
A |
T |
5: 87,287,582 (GRCm39) |
V195E |
probably damaging |
Het |
Zmym2 |
T |
A |
14: 57,159,019 (GRCm39) |
M598K |
probably damaging |
Het |
|
Other mutations in Gm8674 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0355:Gm8674
|
UTSW |
13 |
50,055,975 (GRCm39) |
exon |
noncoding transcript |
|
R0357:Gm8674
|
UTSW |
13 |
50,056,149 (GRCm39) |
exon |
noncoding transcript |
|
R0627:Gm8674
|
UTSW |
13 |
50,053,751 (GRCm39) |
exon |
noncoding transcript |
|
R0833:Gm8674
|
UTSW |
13 |
50,058,611 (GRCm39) |
exon |
noncoding transcript |
|
R1300:Gm8674
|
UTSW |
13 |
50,055,758 (GRCm39) |
exon |
noncoding transcript |
|
R1452:Gm8674
|
UTSW |
13 |
50,054,553 (GRCm39) |
exon |
noncoding transcript |
|
R1542:Gm8674
|
UTSW |
13 |
50,054,039 (GRCm39) |
exon |
noncoding transcript |
|
R1613:Gm8674
|
UTSW |
13 |
50,056,474 (GRCm39) |
intron |
noncoding transcript |
|
R1643:Gm8674
|
UTSW |
13 |
50,055,394 (GRCm39) |
exon |
noncoding transcript |
|
R1732:Gm8674
|
UTSW |
13 |
50,055,962 (GRCm39) |
exon |
noncoding transcript |
|
R1824:Gm8674
|
UTSW |
13 |
50,054,844 (GRCm39) |
exon |
noncoding transcript |
|
R1840:Gm8674
|
UTSW |
13 |
50,055,801 (GRCm39) |
exon |
noncoding transcript |
|
R1915:Gm8674
|
UTSW |
13 |
50,054,889 (GRCm39) |
exon |
noncoding transcript |
|
R1934:Gm8674
|
UTSW |
13 |
50,055,471 (GRCm39) |
exon |
noncoding transcript |
|
R2040:Gm8674
|
UTSW |
13 |
50,055,705 (GRCm39) |
exon |
noncoding transcript |
|
R2214:Gm8674
|
UTSW |
13 |
50,055,396 (GRCm39) |
exon |
noncoding transcript |
|
R2421:Gm8674
|
UTSW |
13 |
50,054,699 (GRCm39) |
exon |
noncoding transcript |
|
R3423:Gm8674
|
UTSW |
13 |
50,055,792 (GRCm39) |
exon |
noncoding transcript |
|
R3425:Gm8674
|
UTSW |
13 |
50,055,792 (GRCm39) |
exon |
noncoding transcript |
|
R3886:Gm8674
|
UTSW |
13 |
50,056,199 (GRCm39) |
splice site |
noncoding transcript |
|
R4083:Gm8674
|
UTSW |
13 |
50,055,047 (GRCm39) |
exon |
noncoding transcript |
|
R4570:Gm8674
|
UTSW |
13 |
50,056,570 (GRCm39) |
intron |
noncoding transcript |
|
R4936:Gm8674
|
UTSW |
13 |
50,054,791 (GRCm39) |
exon |
noncoding transcript |
|
R4967:Gm8674
|
UTSW |
13 |
50,056,034 (GRCm39) |
exon |
noncoding transcript |
|
R5065:Gm8674
|
UTSW |
13 |
50,056,613 (GRCm39) |
intron |
noncoding transcript |
|
R5067:Gm8674
|
UTSW |
13 |
50,053,870 (GRCm39) |
exon |
noncoding transcript |
|
R5120:Gm8674
|
UTSW |
13 |
50,055,984 (GRCm39) |
exon |
noncoding transcript |
|
R5208:Gm8674
|
UTSW |
13 |
50,055,957 (GRCm39) |
exon |
noncoding transcript |
|
R5268:Gm8674
|
UTSW |
13 |
50,055,390 (GRCm39) |
exon |
noncoding transcript |
|
R5471:Gm8674
|
UTSW |
13 |
50,054,849 (GRCm39) |
exon |
noncoding transcript |
|
R5773:Gm8674
|
UTSW |
13 |
50,055,912 (GRCm39) |
exon |
noncoding transcript |
|
R5809:Gm8674
|
UTSW |
13 |
50,055,924 (GRCm39) |
exon |
noncoding transcript |
|
R8162:Gm8674
|
UTSW |
13 |
50,054,407 (GRCm39) |
missense |
noncoding transcript |
|
R8239:Gm8674
|
UTSW |
13 |
50,054,262 (GRCm39) |
missense |
noncoding transcript |
|
Z1088:Gm8674
|
UTSW |
13 |
50,055,284 (GRCm39) |
exon |
noncoding transcript |
|
Z1088:Gm8674
|
UTSW |
13 |
50,054,830 (GRCm39) |
exon |
noncoding transcript |
|
|
Predicted Primers |
PCR Primer
(F):5'- GAATTTCTTTCCCCGTGGGC -3'
(R):5'- TGCTGAGCATACAAAGAAAGTCC -3'
Sequencing Primer
(F):5'- CATGTGGAGCTGGTCAAAGCAC -3'
(R):5'- GCATACAAAGAAAGTCCCAACAAGG -3'
|
Posted On |
2015-06-24 |