Incidental Mutation 'R4345:Pdzd8'
ID 324318
Institutional Source Beutler Lab
Gene Symbol Pdzd8
Ensembl Gene ENSMUSG00000074746
Gene Name PDZ domain containing 8
Synonyms A630041P07Rik, Pdzk8
MMRRC Submission 041666-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4345 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 59296084-59345780 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 59300128 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 947 (T947A)
Ref Sequence ENSEMBL: ENSMUSP00000096880 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026084] [ENSMUST00000099274]
AlphaFold B9EJ80
Predicted Effect probably benign
Transcript: ENSMUST00000026084
SMART Domains Protein: ENSMUSP00000026084
Gene: ENSMUSG00000025094

DomainStartEndE-ValueType
Pfam:MFS_1 22 428 6.8e-40 PFAM
Pfam:Sugar_tr 26 284 5.9e-10 PFAM
Pfam:MFS_2 127 457 4.3e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000099274
AA Change: T947A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000096880
Gene: ENSMUSG00000074746
AA Change: T947A

DomainStartEndE-ValueType
transmembrane domain 2 24 N/A INTRINSIC
low complexity region 75 90 N/A INTRINSIC
PDZ 374 448 2.02e-10 SMART
low complexity region 582 596 N/A INTRINSIC
low complexity region 802 814 N/A INTRINSIC
C1 834 884 8.31e-8 SMART
coiled coil region 1021 1057 N/A INTRINSIC
Meta Mutation Damage Score 0.0582 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 96% (47/49)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asap2 T C 12: 21,230,831 (GRCm38) W449R probably damaging Het
Astn1 T A 1: 158,502,032 (GRCm38) probably null Het
BC005561 A G 5: 104,521,449 (GRCm38) E1279G probably benign Het
C3ar1 T C 6: 122,850,700 (GRCm38) D186G probably damaging Het
Fbf1 A G 11: 116,147,742 (GRCm38) V851A probably benign Het
Foxp4 G A 17: 47,874,648 (GRCm38) T500M unknown Het
Gm5878 G A 6: 85,125,651 (GRCm38) R31* probably null Het
Gramd4 T C 15: 86,134,893 (GRCm38) S581P probably damaging Het
Heatr5b A T 17: 78,760,511 (GRCm38) V1816E possibly damaging Het
Igf2r C T 17: 12,709,511 (GRCm38) E982K possibly damaging Het
Il1r1 A G 1: 40,297,924 (GRCm38) D224G probably benign Het
Kcnv1 G A 15: 45,114,444 (GRCm38) T66M probably damaging Het
Lactb2 T A 1: 13,660,350 (GRCm38) Y34F probably damaging Het
Lepr G A 4: 101,765,152 (GRCm38) probably null Het
Loxhd1 A G 18: 77,399,001 (GRCm38) I1261V possibly damaging Het
Map4k3 A G 17: 80,597,551 (GRCm38) probably null Het
Mcee T C 7: 64,411,938 (GRCm38) L109P probably damaging Het
Mier3 A G 13: 111,705,283 (GRCm38) D124G probably damaging Het
Mrpl43 T C 19: 45,006,110 (GRCm38) Y64C probably damaging Het
Nfasc A G 1: 132,631,705 (GRCm38) F229S probably damaging Het
Nsd3 G C 8: 25,641,317 (GRCm38) G233R probably benign Het
Olfr1065 T A 2: 86,445,845 (GRCm38) I46F probably damaging Het
Olfr320 A G 11: 58,683,945 (GRCm38) D24G possibly damaging Het
Plod3 G C 5: 136,988,146 (GRCm38) A50P probably benign Het
Pno1 A G 11: 17,209,095 (GRCm38) S158P possibly damaging Het
Prr14l A G 5: 32,828,576 (GRCm38) S1192P probably damaging Het
Setbp1 T A 18: 79,086,579 (GRCm38) E146V probably damaging Het
Slc9a5 T C 8: 105,349,455 (GRCm38) S27P probably benign Het
Sri G T 5: 8,059,427 (GRCm38) probably null Het
Stard9 G A 2: 120,701,946 (GRCm38) V2895I probably benign Het
Tgfbrap1 T C 1: 43,056,706 (GRCm38) D524G probably benign Het
Them4 A G 3: 94,329,865 (GRCm38) T211A possibly damaging Het
Trpm3 A T 19: 22,897,697 (GRCm38) S568C probably damaging Het
Ttl T C 2: 129,075,858 (GRCm38) L80P probably damaging Het
Ttn G T 2: 76,756,316 (GRCm38) N13423K possibly damaging Het
Usp10 T A 8: 119,954,814 (GRCm38) L670Q probably damaging Het
Usp4 T A 9: 108,368,023 (GRCm38) probably benign Het
Vmn1r72 T A 7: 11,670,036 (GRCm38) T162S possibly damaging Het
Zmym5 T C 14: 56,796,626 (GRCm38) N376S probably benign Het
Zswim6 G T 13: 107,726,931 (GRCm38) noncoding transcript Het
Other mutations in Pdzd8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01293:Pdzd8 APN 19 59,299,786 (GRCm38) missense probably damaging 1.00
IGL01321:Pdzd8 APN 19 59,301,529 (GRCm38) missense probably benign
IGL01865:Pdzd8 APN 19 59,299,645 (GRCm38) missense possibly damaging 0.92
IGL02044:Pdzd8 APN 19 59,315,292 (GRCm38) missense possibly damaging 0.85
IGL02119:Pdzd8 APN 19 59,300,490 (GRCm38) missense possibly damaging 0.95
IGL02186:Pdzd8 APN 19 59,300,628 (GRCm38) missense probably damaging 1.00
IGL02389:Pdzd8 APN 19 59,301,393 (GRCm38) missense probably benign 0.00
IGL02479:Pdzd8 APN 19 59,299,783 (GRCm38) nonsense probably null
IGL02713:Pdzd8 APN 19 59,345,458 (GRCm38) missense probably damaging 0.98
IGL02958:Pdzd8 APN 19 59,300,372 (GRCm38) nonsense probably null
IGL02966:Pdzd8 APN 19 59,300,859 (GRCm38) missense probably damaging 1.00
IGL03166:Pdzd8 APN 19 59,300,508 (GRCm38) missense probably damaging 1.00
citadel UTSW 19 59,299,525 (GRCm38) makesense probably null
Eleventh_hour UTSW 19 59,305,230 (GRCm38) missense probably damaging 1.00
keep UTSW 19 59,301,351 (GRCm38) nonsense probably null
Stronghold UTSW 19 59,345,352 (GRCm38) nonsense probably null
R0018:Pdzd8 UTSW 19 59,300,673 (GRCm38) missense probably damaging 1.00
R0038:Pdzd8 UTSW 19 59,299,596 (GRCm38) missense possibly damaging 0.54
R0196:Pdzd8 UTSW 19 59,301,131 (GRCm38) missense probably benign 0.00
R0233:Pdzd8 UTSW 19 59,300,379 (GRCm38) missense probably damaging 0.99
R0233:Pdzd8 UTSW 19 59,300,379 (GRCm38) missense probably damaging 0.99
R0418:Pdzd8 UTSW 19 59,300,929 (GRCm38) missense probably damaging 1.00
R0736:Pdzd8 UTSW 19 59,344,933 (GRCm38) missense probably damaging 0.99
R1456:Pdzd8 UTSW 19 59,300,472 (GRCm38) missense probably benign 0.01
R1709:Pdzd8 UTSW 19 59,301,339 (GRCm38) missense probably benign
R1965:Pdzd8 UTSW 19 59,300,122 (GRCm38) missense probably benign 0.37
R2155:Pdzd8 UTSW 19 59,300,421 (GRCm38) missense probably damaging 1.00
R3077:Pdzd8 UTSW 19 59,305,156 (GRCm38) critical splice donor site probably null
R3411:Pdzd8 UTSW 19 59,345,413 (GRCm38) missense probably damaging 1.00
R4354:Pdzd8 UTSW 19 59,345,481 (GRCm38) missense probably benign
R4504:Pdzd8 UTSW 19 59,345,448 (GRCm38) missense probably damaging 1.00
R4642:Pdzd8 UTSW 19 59,305,230 (GRCm38) missense probably damaging 1.00
R4705:Pdzd8 UTSW 19 59,345,311 (GRCm38) missense possibly damaging 0.80
R4773:Pdzd8 UTSW 19 59,300,860 (GRCm38) missense probably damaging 1.00
R4876:Pdzd8 UTSW 19 59,300,804 (GRCm38) nonsense probably null
R5176:Pdzd8 UTSW 19 59,344,957 (GRCm38) missense probably damaging 1.00
R5267:Pdzd8 UTSW 19 59,301,026 (GRCm38) missense probably damaging 1.00
R5707:Pdzd8 UTSW 19 59,299,625 (GRCm38) missense probably benign 0.00
R5766:Pdzd8 UTSW 19 59,300,540 (GRCm38) missense possibly damaging 0.65
R5903:Pdzd8 UTSW 19 59,345,286 (GRCm38) missense possibly damaging 0.58
R6036:Pdzd8 UTSW 19 59,305,209 (GRCm38) missense probably damaging 1.00
R6036:Pdzd8 UTSW 19 59,305,209 (GRCm38) missense probably damaging 1.00
R6238:Pdzd8 UTSW 19 59,300,562 (GRCm38) missense probably benign 0.05
R6360:Pdzd8 UTSW 19 59,300,983 (GRCm38) missense probably benign 0.10
R6509:Pdzd8 UTSW 19 59,344,866 (GRCm38) missense probably benign 0.01
R6674:Pdzd8 UTSW 19 59,301,369 (GRCm38) missense probably damaging 1.00
R6808:Pdzd8 UTSW 19 59,299,525 (GRCm38) makesense probably null
R6902:Pdzd8 UTSW 19 59,301,397 (GRCm38) missense possibly damaging 0.91
R7017:Pdzd8 UTSW 19 59,345,352 (GRCm38) nonsense probably null
R7088:Pdzd8 UTSW 19 59,344,957 (GRCm38) missense probably damaging 1.00
R7116:Pdzd8 UTSW 19 59,299,693 (GRCm38) missense probably damaging 1.00
R7158:Pdzd8 UTSW 19 59,300,157 (GRCm38) missense probably damaging 1.00
R7237:Pdzd8 UTSW 19 59,345,139 (GRCm38) missense probably damaging 1.00
R7251:Pdzd8 UTSW 19 59,300,645 (GRCm38) missense possibly damaging 0.96
R7314:Pdzd8 UTSW 19 59,301,351 (GRCm38) nonsense probably null
R7699:Pdzd8 UTSW 19 59,344,941 (GRCm38) missense probably damaging 1.00
R7751:Pdzd8 UTSW 19 59,344,776 (GRCm38) missense probably damaging 0.98
R7759:Pdzd8 UTSW 19 59,299,926 (GRCm38) missense probably damaging 1.00
R7784:Pdzd8 UTSW 19 59,327,863 (GRCm38) missense probably damaging 1.00
R7917:Pdzd8 UTSW 19 59,345,086 (GRCm38) missense probably damaging 0.96
R9364:Pdzd8 UTSW 19 59,345,142 (GRCm38) missense probably damaging 1.00
R9368:Pdzd8 UTSW 19 59,300,787 (GRCm38) nonsense probably null
R9406:Pdzd8 UTSW 19 59,344,813 (GRCm38) missense
R9548:Pdzd8 UTSW 19 59,301,394 (GRCm38) missense probably benign 0.13
R9554:Pdzd8 UTSW 19 59,345,142 (GRCm38) missense probably damaging 1.00
R9688:Pdzd8 UTSW 19 59,345,251 (GRCm38) missense probably benign 0.05
R9750:Pdzd8 UTSW 19 59,301,252 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACAGATCACGACCAATTTCCTTTAC -3'
(R):5'- TTGTGGAGCAACTGAGAGGC -3'

Sequencing Primer
(F):5'- ACGACCAATTTCCTTTACTGCAATG -3'
(R):5'- GCGAATAGACCGGACCCTG -3'
Posted On 2015-06-24