Mutagenetix > Incidental Mutations

Incidental Mutation 'R4330:Vmn1r78'

324564

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r78

Ensembl Gene

ENSMUSG00000061602

Gene Name

vomeronasal 1 receptor 78

Synonyms

V1rg7

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R4330 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

12150257-12159959 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 12152459 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000077186 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000078039] [ENSMUST00000078039] [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]

Predicted Effect

probably null
Transcript: ENSMUST00000078039

SMART Domains

Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	304	5.7e-8	PFAM
Pfam:V1R	12	301	1.5e-29	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000078039

SMART Domains

Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	304	5.7e-8	PFAM
Pfam:V1R	12	301	1.5e-29	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000078039

SMART Domains

Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	304	5.7e-8	PFAM
Pfam:V1R	12	301	1.5e-29	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000078039

SMART Domains

Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	304	5.7e-8	PFAM
Pfam:V1R	12	301	1.5e-29	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209489

Predicted Effect

probably benign
Transcript: ENSMUST00000228244

Predicted Effect

probably benign
Transcript: ENSMUST00000228664

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arl6ip1	AAAATAAATAAATAAATAAATAAATA	AAAATAAATAAATAAATAAATAAATAAATA	7: 118,121,899		probably benign	Het
Cdh10	G	A	15: 18,999,959	V497I	probably damaging	Het
Chd4	T	C	6: 125,101,602	V229A	probably benign	Het
Cnr2	T	A	4: 135,916,926	I105N	possibly damaging	Het
Dnaic1	A	G	4: 41,637,966	T701A	probably damaging	Het
Eri1	G	A	8: 35,469,229	R313*	probably null	Het
Gm5346	T	A	8: 43,626,250	K312N	probably benign	Het
Hrh3	T	C	2: 180,099,872		probably benign	Het
Hs3st5	T	A	10: 36,832,730	V87D	probably benign	Het
Jmy	G	C	13: 93,498,882	P142R	probably damaging	Het
Jmy	C	A	13: 93,499,273	D12Y	probably damaging	Het
Mfsd4a	A	C	1: 132,053,553	M320R	possibly damaging	Het
Myocd	A	T	11: 65,223,764	H49Q	probably benign	Het
Nlk	A	G	11: 78,590,948	I229T	possibly damaging	Het
Rabl2	T	C	15: 89,586,934	D66G	probably benign	Het
Ramp1	C	T	1: 91,223,345	T144I	possibly damaging	Het
Rhbdf2	T	C	11: 116,601,956	K413R	probably benign	Het
Scpep1	G	A	11: 88,935,903	Q236*	probably null	Het
Stil	A	G	4: 115,004,979	R40G	probably damaging	Het
Syt7	T	C	19: 10,421,798	V86A	probably damaging	Het
Ubr2	A	T	17: 46,967,278	L711Q	probably null	Het
Zfp280d	C	T	9: 72,295,979	T3I	possibly damaging	Het
Zscan25	T	A	5: 145,290,551	F342I	probably damaging	Het

Other mutations in Vmn1r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01129:Vmn1r78	APN	7	12153238	missense	probably benign	0.10
IGL02019:Vmn1r78	APN	7	12152707	missense	probably damaging	0.99
IGL02143:Vmn1r78	APN	7	12152480	missense	probably benign
IGL02154:Vmn1r78	APN	7	12152545	missense	probably benign	0.22
IGL02290:Vmn1r78	APN	7	12153155	missense	probably damaging	1.00
IGL03012:Vmn1r78	APN	7	12153364	missense	probably benign	0.32
IGL03256:Vmn1r78	APN	7	12152798	missense	probably damaging	1.00
IGL03373:Vmn1r78	APN	7	12153343	missense	possibly damaging	0.86
IGL03384:Vmn1r78	APN	7	12153209	missense	possibly damaging	0.94
R0016:Vmn1r78	UTSW	7	12153352	missense	probably benign	0.02
R1445:Vmn1r78	UTSW	7	12152581	missense	possibly damaging	0.64
R1748:Vmn1r78	UTSW	7	12153323	missense	probably damaging	1.00
R2017:Vmn1r78	UTSW	7	12153343	missense	possibly damaging	0.86
R2032:Vmn1r78	UTSW	7	12153283	missense	probably benign	0.00
R2198:Vmn1r78	UTSW	7	12152560	missense	probably benign	0.06
R4564:Vmn1r78	UTSW	7	12152558	missense	probably damaging	1.00
R4769:Vmn1r78	UTSW	7	12152798	missense	probably damaging	1.00
R4801:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4802:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R5648:Vmn1r78	UTSW	7	12152766	missense	possibly damaging	0.92
R6561:Vmn1r78	UTSW	7	12152899	missense	probably damaging	1.00
R6869:Vmn1r78	UTSW	7	12152749	missense	probably benign	0.01
R6945:Vmn1r78	UTSW	7	12152905	missense	probably benign	0.01
R7793:Vmn1r78	UTSW	7	12153314	missense	probably benign	0.01
R7954:Vmn1r78	UTSW	7	12153300	nonsense	probably null
Z1088:Vmn1r78	UTSW	7	12152714	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACTGTGTCTGTCCATTCATGATTAGG -3'
(R):5'- GCAGTTAGCAAAAGTCAAGTGC -3'

Sequencing Primer
(F):5'- AAAGACTGTCCTGGAACTGTCTCTG -3'
(R):5'- GTGCTTTATAATCACATCTTTGGGC -3'

Posted On

2015-06-24