Incidental Mutation 'R4357:Or4f60'
ID 324586
Institutional Source Beutler Lab
Gene Symbol Or4f60
Ensembl Gene ENSMUSG00000074946
Gene Name olfactory receptor family 4 subfamily F member 60
Synonyms GA_x6K02T2Q125-73119859-73118924, MOR245-23, Olfr1313
MMRRC Submission 041109-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R4357 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 111901991-111902928 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111902583 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 115 (L115P)
Ref Sequence ENSEMBL: ENSMUSP00000148886 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099599] [ENSMUST00000213577] [ENSMUST00000216071]
AlphaFold Q7TQW8
Predicted Effect probably damaging
Transcript: ENSMUST00000099599
AA Change: L115P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097194
Gene: ENSMUSG00000074946
AA Change: L115P

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 2.2e-41 PFAM
Pfam:7tm_1 41 286 2.8e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213577
AA Change: L115P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216071
AA Change: L115P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam20 A G 8: 41,248,084 (GRCm39) T65A possibly damaging Het
Alpk1 C T 3: 127,523,022 (GRCm39) V7M probably damaging Het
Ap4m1 A G 5: 138,171,311 (GRCm39) E125G probably damaging Het
Atp13a2 C A 4: 140,729,215 (GRCm39) D599E probably benign Het
Brme1 T C 8: 84,886,221 (GRCm39) L59P probably benign Het
Camkv G A 9: 107,825,145 (GRCm39) G354E probably benign Het
Casp8ap2 T A 4: 32,646,150 (GRCm39) M1741K probably benign Het
Chtf18 T C 17: 25,938,106 (GRCm39) D119G probably benign Het
Cnga1 T A 5: 72,775,595 (GRCm39) D42V probably damaging Het
Cysltr2 T C 14: 73,267,084 (GRCm39) I209V probably benign Het
Defa27 A T 8: 21,805,608 (GRCm39) Q16L probably null Het
Dnaja3 T C 16: 4,517,731 (GRCm39) I321T probably damaging Het
Eef2 GCCC GCCCC 10: 81,014,601 (GRCm39) probably null Het
Eif2ak3 T A 6: 70,861,859 (GRCm39) I467N probably damaging Het
Eif5b T A 1: 38,089,339 (GRCm39) V1105E probably damaging Het
Gfod2 T C 8: 106,444,177 (GRCm39) N122S possibly damaging Het
Gm10803 A G 2: 93,394,350 (GRCm39) R41G unknown Het
Gm38392 A T 3: 88,154,741 (GRCm39) I221N probably damaging Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Hsd17b6 G T 10: 127,829,637 (GRCm39) probably null Het
Ids C A X: 69,389,950 (GRCm39) G506C probably damaging Het
Ifna15 G T 4: 88,476,079 (GRCm39) T135N probably benign Het
Igsf9b G A 9: 27,220,774 (GRCm39) V47I possibly damaging Het
Kif24 A G 4: 41,413,827 (GRCm39) probably null Het
Lats2 A G 14: 57,936,840 (GRCm39) S550P probably damaging Het
Lmo7 A G 14: 102,125,091 (GRCm39) R406G probably null Het
Lpcat2 C A 8: 93,599,734 (GRCm39) P234Q probably benign Het
Lrp10 C T 14: 54,705,823 (GRCm39) R338C probably damaging Het
Lrrfip2 A G 9: 111,028,755 (GRCm39) E326G probably damaging Het
Megf8 T A 7: 25,055,174 (GRCm39) I1969N probably benign Het
Mib1 A G 18: 10,751,844 (GRCm39) N242S probably benign Het
Ngf A G 3: 102,427,521 (GRCm39) E94G probably benign Het
Oas2 C T 5: 120,876,734 (GRCm39) probably null Het
Odf2 A G 2: 29,782,256 (GRCm39) T75A probably benign Het
Or5w11 T A 2: 87,458,810 (GRCm39) M1K probably null Het
Pi4ka T A 16: 17,185,303 (GRCm39) I266F probably benign Het
Prps2 T A X: 166,146,545 (GRCm39) K176* probably null Het
Psmd2 T G 16: 20,475,402 (GRCm39) D393E probably benign Het
Rabep2 A G 7: 126,047,397 (GRCm39) I753T probably damaging Het
Rara A C 11: 98,858,937 (GRCm39) I129L probably damaging Het
Rasgrf2 C A 13: 92,038,796 (GRCm39) D1017Y probably damaging Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Spmip4 T C 6: 50,551,190 (GRCm39) T420A probably benign Het
Spsb1 T C 4: 149,991,232 (GRCm39) H112R probably damaging Het
Sptlc1 A T 13: 53,528,068 (GRCm39) I32K probably damaging Het
Srd5a3 T A 5: 76,295,547 (GRCm39) F79Y probably damaging Het
Ssrp1 A T 2: 84,871,495 (GRCm39) M306L probably benign Het
Sulf2 T C 2: 165,919,497 (GRCm39) E817G probably benign Het
Tiam2 C A 17: 3,501,128 (GRCm39) D922E probably damaging Het
Tle4 A G 19: 14,445,625 (GRCm39) V207A probably benign Het
Ttll12 A T 15: 83,465,958 (GRCm39) C413S probably damaging Het
Usp45 T A 4: 21,834,350 (GRCm39) Y809* probably null Het
Vmn2r59 G A 7: 41,661,644 (GRCm39) P724S probably damaging Het
Vrk3 C T 7: 44,424,866 (GRCm39) T427M probably benign Het
Other mutations in Or4f60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00895:Or4f60 APN 2 111,902,100 (GRCm39) missense probably damaging 0.98
IGL01790:Or4f60 APN 2 111,902,266 (GRCm39) missense probably benign 0.00
IGL02054:Or4f60 APN 2 111,902,269 (GRCm39) missense probably benign 0.43
IGL03387:Or4f60 APN 2 111,902,007 (GRCm39) missense probably benign 0.00
R1891:Or4f60 UTSW 2 111,902,739 (GRCm39) missense probably damaging 1.00
R2509:Or4f60 UTSW 2 111,902,837 (GRCm39) missense probably benign
R2520:Or4f60 UTSW 2 111,902,013 (GRCm39) missense probably benign 0.00
R3084:Or4f60 UTSW 2 111,902,320 (GRCm39) nonsense probably null
R3085:Or4f60 UTSW 2 111,902,320 (GRCm39) nonsense probably null
R3086:Or4f60 UTSW 2 111,902,320 (GRCm39) nonsense probably null
R4700:Or4f60 UTSW 2 111,902,097 (GRCm39) missense possibly damaging 0.54
R5366:Or4f60 UTSW 2 111,902,823 (GRCm39) missense possibly damaging 0.91
R5372:Or4f60 UTSW 2 111,902,454 (GRCm39) missense probably benign 0.03
R5643:Or4f60 UTSW 2 111,902,013 (GRCm39) missense probably benign 0.00
R5644:Or4f60 UTSW 2 111,902,013 (GRCm39) missense probably benign 0.00
R5681:Or4f60 UTSW 2 111,902,722 (GRCm39) missense probably benign 0.38
R6004:Or4f60 UTSW 2 111,902,371 (GRCm39) missense probably damaging 1.00
R6609:Or4f60 UTSW 2 111,902,509 (GRCm39) missense probably benign 0.01
R7056:Or4f60 UTSW 2 111,902,662 (GRCm39) missense probably benign
R7066:Or4f60 UTSW 2 111,902,541 (GRCm39) missense probably damaging 1.00
R7417:Or4f60 UTSW 2 111,902,445 (GRCm39) missense probably benign 0.01
R8942:Or4f60 UTSW 2 111,902,802 (GRCm39) missense probably damaging 1.00
R9261:Or4f60 UTSW 2 111,902,718 (GRCm39) missense probably damaging 1.00
R9423:Or4f60 UTSW 2 111,902,808 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- CCAATAGCTGACCACAGAGAGG -3'
(R):5'- AGCATGATGGGAAACTGTCTC -3'

Sequencing Primer
(F):5'- CTGACCACAGAGAGGTAAATTTAC -3'
(R):5'- AACTGTCTCATAATTTTCACTGTGGC -3'
Posted On 2015-06-24