Incidental Mutation 'R4358:Zfp951'
ID 324652
Institutional Source Beutler Lab
Gene Symbol Zfp951
Ensembl Gene ENSMUSG00000072774
Gene Name zinc finger protein 951
Synonyms C230055K05Rik
MMRRC Submission 041110-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R4358 (G1)
Quality Score 173
Status Validated
Chromosome 5
Chromosomal Location 104813169-104860070 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 104814675 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 342 (K342E)
Ref Sequence ENSEMBL: ENSMUSP00000140625 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089906] [ENSMUST00000186219]
AlphaFold A0A087WRH0
Predicted Effect probably damaging
Transcript: ENSMUST00000089906
AA Change: K342E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000087350
Gene: ENSMUSG00000072774
AA Change: K342E

DomainStartEndE-ValueType
KRAB 28 90 2e-14 SMART
ZnF_C2H2 176 198 2.79e-4 SMART
ZnF_C2H2 204 226 4.11e-2 SMART
ZnF_C2H2 232 254 3.11e-2 SMART
ZnF_C2H2 260 282 3.16e-3 SMART
ZnF_C2H2 288 310 2.53e-2 SMART
ZnF_C2H2 316 338 2.95e-3 SMART
ZnF_C2H2 344 366 1.18e-2 SMART
ZnF_C2H2 372 394 2.95e-3 SMART
ZnF_C2H2 400 422 2.57e-3 SMART
ZnF_C2H2 428 450 2.4e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000186219
AA Change: K342E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000140625
Gene: ENSMUSG00000072774
AA Change: K342E

DomainStartEndE-ValueType
KRAB 28 90 2e-14 SMART
ZnF_C2H2 176 198 2.79e-4 SMART
ZnF_C2H2 204 226 4.11e-2 SMART
ZnF_C2H2 232 254 3.11e-2 SMART
ZnF_C2H2 260 282 3.16e-3 SMART
ZnF_C2H2 288 310 2.53e-2 SMART
ZnF_C2H2 316 338 2.95e-3 SMART
ZnF_C2H2 344 366 1.18e-2 SMART
ZnF_C2H2 372 394 2.95e-3 SMART
ZnF_C2H2 400 422 2.57e-3 SMART
ZnF_C2H2 428 450 2.4e-3 SMART
Meta Mutation Damage Score 0.2586 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 98% (48/49)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk1 C T 3: 127,729,373 V7M probably damaging Het
Birc6 T A 17: 74,619,668 probably null Het
Chil3 G A 3: 106,160,499 Q117* probably null Het
Daglb T C 5: 143,473,134 probably benign Het
Dnah11 G A 12: 118,125,843 R1163* probably null Het
Ftsj3 G A 11: 106,253,676 A134V probably benign Het
G530012D18Rik G C 1: 85,577,202 probably benign Het
Gfod2 T C 8: 105,717,545 N122S possibly damaging Het
Golga4 A G 9: 118,551,878 E507G probably benign Het
Ids C A X: 70,346,344 G506C probably damaging Het
Ifna15 G T 4: 88,557,842 T135N probably benign Het
Igsf9b G A 9: 27,309,478 V47I possibly damaging Het
Kif24 A G 4: 41,413,827 probably null Het
L3hypdh A T 12: 72,077,424 D247E probably damaging Het
Lama2 A T 10: 26,984,493 N2999K probably damaging Het
Lpcat2 C A 8: 92,873,106 P234Q probably benign Het
Lrp10 C T 14: 54,468,366 R338C probably damaging Het
Mcm9 A C 10: 53,537,653 C444G probably benign Het
Mecom G A 3: 29,979,785 Q246* probably null Het
Mib1 A G 18: 10,751,844 N242S probably benign Het
Olfr13 T A 6: 43,174,226 M80K probably damaging Het
Olfr943 G A 9: 39,184,568 C127Y probably damaging Het
P3h4 A G 11: 100,413,626 F263S probably damaging Het
Pcsk1 T C 13: 75,112,719 S354P possibly damaging Het
Pms2 T A 5: 143,925,926 F617Y probably damaging Het
Prps2 T A X: 167,363,549 K176* probably null Het
Psmd13 G T 7: 140,889,505 probably benign Het
Pygl G A 12: 70,195,690 S573L probably damaging Het
Rapgef3 A G 15: 97,748,648 V794A probably benign Het
Rasgrf2 C A 13: 91,890,677 D1017Y probably damaging Het
Rb1cc1 A G 1: 6,245,637 D555G probably damaging Het
Rptor G T 11: 119,671,345 E111D probably damaging Het
Sall4 T C 2: 168,755,480 E480G probably benign Het
Scn4a G A 11: 106,348,857 probably null Het
Scn8a G A 15: 100,940,133 A94T probably benign Het
Slc26a6 T A 9: 108,861,783 C636S probably benign Het
Slc38a11 T C 2: 65,358,116 K103R probably benign Het
Sned1 T C 1: 93,274,659 L675P probably benign Het
Spsb1 T C 4: 149,906,775 H112R probably damaging Het
Tmem132d G A 5: 127,984,341 T399M possibly damaging Het
Zfp939 A G 7: 39,473,720 noncoding transcript Het
Other mutations in Zfp951
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01897:Zfp951 APN 5 104815283 missense probably benign 0.00
R0594:Zfp951 UTSW 5 104814572 missense possibly damaging 0.67
R1056:Zfp951 UTSW 5 104815285 missense possibly damaging 0.90
R1857:Zfp951 UTSW 5 104814857 missense probably damaging 0.97
R1967:Zfp951 UTSW 5 104817000 missense possibly damaging 0.65
R2422:Zfp951 UTSW 5 104815277 missense probably benign 0.14
R4671:Zfp951 UTSW 5 104814701 missense probably benign 0.01
R5539:Zfp951 UTSW 5 104814846 missense probably damaging 0.99
R5634:Zfp951 UTSW 5 104815289 missense probably benign 0.00
R7894:Zfp951 UTSW 5 104814972 missense probably benign 0.00
R8058:Zfp951 UTSW 5 104814446 missense probably damaging 1.00
R8125:Zfp951 UTSW 5 104815303 nonsense probably null
Z1177:Zfp951 UTSW 5 104828955 start codon destroyed probably null 0.01
Predicted Primers PCR Primer
(F):5'- TCTCCAGTATGTGTCCTTTCATGG -3'
(R):5'- ACATACTGGAGAAAAGCCCTTT -3'

Sequencing Primer
(F):5'- CCACATTGGTTACATGCATAGGGC -3'
(R):5'- AAAGCCCTTTGAGTGTAGCC -3'
Posted On 2015-06-24