Incidental Mutation 'R4275:Or5g27'
ID 324743
Institutional Source Beutler Lab
Gene Symbol Or5g27
Ensembl Gene ENSMUSG00000111179
Gene Name olfactory receptor family 5 subfamily G member 27
Synonyms MOR175-4, GA_x6K02T2Q125-47058060-47059004, Olfr996
MMRRC Submission 041646-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R4275 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85409559-85410626 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85410207 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 208 (V208A)
Ref Sequence ENSEMBL: ENSMUSP00000076330 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077075]
AlphaFold Q7TRA0
Predicted Effect probably benign
Transcript: ENSMUST00000077075
AA Change: V208A

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000076330
Gene: ENSMUSG00000111179
AA Change: V208A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.2e-52 PFAM
Pfam:7tm_1 41 290 2.7e-16 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 98% (43/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cacna1e T C 1: 154,369,071 (GRCm39) Y322C probably damaging Het
Camsap2 A G 1: 136,198,614 (GRCm39) V1462A probably benign Het
D3Ertd751e C A 3: 41,710,589 (GRCm39) probably benign Het
Dhcr7 C T 7: 143,396,964 (GRCm39) A152V probably damaging Het
Enpep A T 3: 129,125,927 (GRCm39) N68K probably benign Het
Fam131b G A 6: 42,298,241 (GRCm39) L43F probably damaging Het
Fbxl5 T A 5: 43,920,114 (GRCm39) probably benign Het
Hspg2 C T 4: 137,246,251 (GRCm39) R1010C probably damaging Het
Hycc2 T C 1: 58,569,092 (GRCm39) T440A probably benign Het
Igf2 T C 7: 142,209,523 (GRCm39) M46V probably benign Het
Kntc1 T A 5: 123,905,842 (GRCm39) Y367N probably damaging Het
Mapk8ip2 T C 15: 89,343,198 (GRCm39) W647R probably damaging Het
Mettl21c C T 1: 44,049,716 (GRCm39) V110I probably damaging Het
Mrgprh T C 17: 13,096,114 (GRCm39) L118P probably damaging Het
Myadm A G 7: 3,345,618 (GRCm39) T127A probably benign Het
Myh10 A T 11: 68,642,766 (GRCm39) probably null Het
Nadk T A 4: 155,668,712 (GRCm39) Y128N probably benign Het
Or8k39 T C 2: 86,563,936 (GRCm39) T7A probably damaging Het
Papolg A G 11: 23,818,378 (GRCm39) I500T probably benign Het
Pkhd1 A T 1: 20,128,608 (GRCm39) C4032S probably benign Het
Rnase1 A T 14: 51,383,327 (GRCm39) L9Q probably damaging Het
Rspry1 G T 8: 95,376,389 (GRCm39) V304L probably benign Het
Sall2 C A 14: 52,551,260 (GRCm39) R643L probably damaging Het
Scpep1 T C 11: 88,837,968 (GRCm39) probably null Het
Serpina3m T A 12: 104,355,375 (GRCm39) I14N probably damaging Het
Smg6 A C 11: 74,884,700 (GRCm39) probably benign Het
Suz12 T C 11: 79,920,879 (GRCm39) M593T probably damaging Het
Tmem139 A G 6: 42,241,039 (GRCm39) E208G probably damaging Het
Tnxb A G 17: 34,917,205 (GRCm39) Y2200C probably damaging Het
Usp19 T G 9: 108,375,893 (GRCm39) V911G probably damaging Het
Vipr1 T C 9: 121,493,684 (GRCm39) L245P probably damaging Het
Vmn2r105 T A 17: 20,448,902 (GRCm39) I92F probably damaging Het
Zbtb47 T A 9: 121,595,605 (GRCm39) V576D probably damaging Het
Zfp518b A G 5: 38,829,071 (GRCm39) V978A probably damaging Het
Other mutations in Or5g27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01550:Or5g27 APN 2 85,409,875 (GRCm39) nonsense probably null
IGL01972:Or5g27 APN 2 85,410,117 (GRCm39) missense probably damaging 1.00
IGL02102:Or5g27 APN 2 85,410,017 (GRCm39) missense probably damaging 0.98
IGL03159:Or5g27 APN 2 85,410,284 (GRCm39) missense probably damaging 0.99
R0539:Or5g27 UTSW 2 85,410,119 (GRCm39) missense probably damaging 0.99
R4561:Or5g27 UTSW 2 85,409,964 (GRCm39) missense probably damaging 0.99
R4953:Or5g27 UTSW 2 85,410,069 (GRCm39) nonsense probably null
R5794:Or5g27 UTSW 2 85,409,685 (GRCm39) missense probably benign 0.03
R6061:Or5g27 UTSW 2 85,409,886 (GRCm39) missense possibly damaging 0.48
R6695:Or5g27 UTSW 2 85,409,793 (GRCm39) missense probably damaging 1.00
R6981:Or5g27 UTSW 2 85,409,825 (GRCm39) missense probably benign 0.06
R7030:Or5g27 UTSW 2 85,409,746 (GRCm39) missense possibly damaging 0.56
R7399:Or5g27 UTSW 2 85,409,640 (GRCm39) missense probably benign 0.00
R8914:Or5g27 UTSW 2 85,410,056 (GRCm39) missense possibly damaging 0.72
R9594:Or5g27 UTSW 2 85,409,882 (GRCm39) nonsense probably null
R9686:Or5g27 UTSW 2 85,410,340 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CAGCCATATGTAAGCCCTTGC -3'
(R):5'- TTCAAGGAGGAACTGACATTGG -3'

Sequencing Primer
(F):5'- GCCTTATGCCATTGCTCTTATAAG -3'
(R):5'- GACATTGGGTCTAACATAGATGAAG -3'
Posted On 2015-06-24