Incidental Mutation 'R4275:D3Ertd751e'
ID 324745
Institutional Source Beutler Lab
Gene Symbol D3Ertd751e
Ensembl Gene ENSMUSG00000025766
Gene Name DNA segment, Chr 3, ERATO Doi 751, expressed
Synonyms 4930415G15Rik, 2810009O15Rik
MMRRC Submission 041646-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock # R4275 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 41742611-41803320 bp(+) (GRCm38)
Type of Mutation utr 3 prime
DNA Base Change (assembly) C to A at 41756154 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000142037 (fasta)
AlphaFold Q8BGN2
Predicted Effect probably benign
Transcript: ENSMUST00000026867
Predicted Effect probably benign
Transcript: ENSMUST00000026868
Predicted Effect probably benign
Transcript: ENSMUST00000108065
Predicted Effect probably benign
Transcript: ENSMUST00000119572
Predicted Effect probably benign
Transcript: ENSMUST00000120167
Predicted Effect probably benign
Transcript: ENSMUST00000143841
Predicted Effect probably benign
Transcript: ENSMUST00000146165
Predicted Effect probably benign
Transcript: ENSMUST00000192193
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192799
Predicted Effect probably benign
Transcript: ENSMUST00000193075
Predicted Effect probably benign
Transcript: ENSMUST00000193228
Predicted Effect probably benign
Transcript: ENSMUST00000194346
Predicted Effect probably benign
Transcript: ENSMUST00000195882
Predicted Effect probably benign
Transcript: ENSMUST00000195030
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 98% (43/44)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cacna1e T C 1: 154,493,325 Y322C probably damaging Het
Camsap2 A G 1: 136,270,876 V1462A probably benign Het
Dhcr7 C T 7: 143,843,227 A152V probably damaging Het
Enpep A T 3: 129,332,278 N68K probably benign Het
Fam126b T C 1: 58,529,933 T440A probably benign Het
Fam131b G A 6: 42,321,307 L43F probably damaging Het
Fbxl5 T A 5: 43,762,772 probably benign Het
Hspg2 C T 4: 137,518,940 R1010C probably damaging Het
Igf2 T C 7: 142,655,786 M46V probably benign Het
Kntc1 T A 5: 123,767,779 Y367N probably damaging Het
Mapk8ip2 T C 15: 89,458,995 W647R probably damaging Het
Mettl21c C T 1: 44,010,556 V110I probably damaging Het
Mrgprh T C 17: 12,877,227 L118P probably damaging Het
Myadm A G 7: 3,297,102 T127A probably benign Het
Myh10 A T 11: 68,751,940 probably null Het
Nadk T A 4: 155,584,255 Y128N probably benign Het
Olfr1089 T C 2: 86,733,592 T7A probably damaging Het
Olfr996 T C 2: 85,579,863 V208A probably benign Het
Papolg A G 11: 23,868,378 I500T probably benign Het
Pkhd1 A T 1: 20,058,384 C4032S probably benign Het
Rnase1 A T 14: 51,145,870 L9Q probably damaging Het
Rspry1 G T 8: 94,649,761 V304L probably benign Het
Sall2 C A 14: 52,313,803 R643L probably damaging Het
Scpep1 T C 11: 88,947,142 probably null Het
Serpina3m T A 12: 104,389,116 I14N probably damaging Het
Smg6 A C 11: 74,993,874 probably benign Het
Suz12 T C 11: 80,030,053 M593T probably damaging Het
Tmem139 A G 6: 42,264,105 E208G probably damaging Het
Tnxb A G 17: 34,698,231 Y2200C probably damaging Het
Usp19 T G 9: 108,498,694 V911G probably damaging Het
Vipr1 T C 9: 121,664,618 L245P probably damaging Het
Vmn2r105 T A 17: 20,228,640 I92F probably damaging Het
Zfp518b A G 5: 38,671,728 V978A probably damaging Het
Zfp651 T A 9: 121,766,539 V576D probably damaging Het
Other mutations in D3Ertd751e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01329:D3Ertd751e APN 3 41748697 missense probably benign 0.04
IGL02484:D3Ertd751e APN 3 41753720 splice site probably null
IGL02587:D3Ertd751e APN 3 41753852 missense probably benign
IGL03173:D3Ertd751e APN 3 41756062 missense probably damaging 1.00
IGL03304:D3Ertd751e APN 3 41746729 critical splice donor site probably null
Terre UTSW 3 41758409 splice site probably null
R0239:D3Ertd751e UTSW 3 41753878 missense probably damaging 1.00
R0239:D3Ertd751e UTSW 3 41753878 missense probably damaging 1.00
R6350:D3Ertd751e UTSW 3 41753843 missense probably damaging 1.00
R7001:D3Ertd751e UTSW 3 41758409 splice site probably null
R7134:D3Ertd751e UTSW 3 41753777 critical splice donor site probably null
R7179:D3Ertd751e UTSW 3 41748708 missense probably damaging 0.96
R7318:D3Ertd751e UTSW 3 41802551 splice site probably null
R7358:D3Ertd751e UTSW 3 41746565 missense probably damaging 0.99
R7632:D3Ertd751e UTSW 3 41753728 missense probably benign 0.00
R7896:D3Ertd751e UTSW 3 41756073 missense probably benign 0.01
R7952:D3Ertd751e UTSW 3 41748661 splice site probably null
R8714:D3Ertd751e UTSW 3 41746563 nonsense probably null
Predicted Primers PCR Primer
(F):5'- GAATGTTGTTCTACCACCAGTG -3'
(R):5'- TGCCTTAGCAGATATAGATAGTCTC -3'

Sequencing Primer
(F):5'- TTGTTCTACCACCAGTGTGACAAAAC -3'
(R):5'- GATTTCAAGTGTGGAGAGG -3'
Posted On 2015-06-24