Mutagenetix > Incidental Mutation

Incidental Mutation 'R4275:Vmn2r105'

324774

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r105

Ensembl Gene

ENSMUSG00000091670

Gene Name

vomeronasal 2, receptor 105

Synonyms

EG627743

MMRRC Submission

041646-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4275 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20428492-20455134 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20448902 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 92 (I92F)

Ref Sequence

ENSEMBL: ENSMUSP00000129762 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167382]

AlphaFold

E9Q3A5

Predicted Effect

probably damaging
Transcript: ENSMUST00000167382
AA Change: I92F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: I92F

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	85	469	6.5e-42	PFAM
Pfam:NCD3G	512	565	3.2e-21	PFAM
Pfam:7tm_3	598	833	2.5e-51	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.7%

Validation Efficiency

98% (43/44)

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cacna1e	T	C	1: 154,369,071 (GRCm39)	Y322C	probably damaging	Het
Camsap2	A	G	1: 136,198,614 (GRCm39)	V1462A	probably benign	Het
D3Ertd751e	C	A	3: 41,710,589 (GRCm39)		probably benign	Het
Dhcr7	C	T	7: 143,396,964 (GRCm39)	A152V	probably damaging	Het
Enpep	A	T	3: 129,125,927 (GRCm39)	N68K	probably benign	Het
Fam131b	G	A	6: 42,298,241 (GRCm39)	L43F	probably damaging	Het
Fbxl5	T	A	5: 43,920,114 (GRCm39)		probably benign	Het
Hspg2	C	T	4: 137,246,251 (GRCm39)	R1010C	probably damaging	Het
Hycc2	T	C	1: 58,569,092 (GRCm39)	T440A	probably benign	Het
Igf2	T	C	7: 142,209,523 (GRCm39)	M46V	probably benign	Het
Kntc1	T	A	5: 123,905,842 (GRCm39)	Y367N	probably damaging	Het
Mapk8ip2	T	C	15: 89,343,198 (GRCm39)	W647R	probably damaging	Het
Mettl21c	C	T	1: 44,049,716 (GRCm39)	V110I	probably damaging	Het
Mrgprh	T	C	17: 13,096,114 (GRCm39)	L118P	probably damaging	Het
Myadm	A	G	7: 3,345,618 (GRCm39)	T127A	probably benign	Het
Myh10	A	T	11: 68,642,766 (GRCm39)		probably null	Het
Nadk	T	A	4: 155,668,712 (GRCm39)	Y128N	probably benign	Het
Or5g27	T	C	2: 85,410,207 (GRCm39)	V208A	probably benign	Het
Or8k39	T	C	2: 86,563,936 (GRCm39)	T7A	probably damaging	Het
Papolg	A	G	11: 23,818,378 (GRCm39)	I500T	probably benign	Het
Pkhd1	A	T	1: 20,128,608 (GRCm39)	C4032S	probably benign	Het
Rnase1	A	T	14: 51,383,327 (GRCm39)	L9Q	probably damaging	Het
Rspry1	G	T	8: 95,376,389 (GRCm39)	V304L	probably benign	Het
Sall2	C	A	14: 52,551,260 (GRCm39)	R643L	probably damaging	Het
Scpep1	T	C	11: 88,837,968 (GRCm39)		probably null	Het
Serpina3m	T	A	12: 104,355,375 (GRCm39)	I14N	probably damaging	Het
Smg6	A	C	11: 74,884,700 (GRCm39)		probably benign	Het
Suz12	T	C	11: 79,920,879 (GRCm39)	M593T	probably damaging	Het
Tmem139	A	G	6: 42,241,039 (GRCm39)	E208G	probably damaging	Het
Tnxb	A	G	17: 34,917,205 (GRCm39)	Y2200C	probably damaging	Het
Usp19	T	G	9: 108,375,893 (GRCm39)	V911G	probably damaging	Het
Vipr1	T	C	9: 121,493,684 (GRCm39)	L245P	probably damaging	Het
Zbtb47	T	A	9: 121,595,605 (GRCm39)	V576D	probably damaging	Het
Zfp518b	A	G	5: 38,829,071 (GRCm39)	V978A	probably damaging	Het

Other mutations in Vmn2r105

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01433:Vmn2r105	APN	17	20,448,817 (GRCm39)	missense	probably benign	0.01
IGL01909:Vmn2r105	APN	17	20,444,918 (GRCm39)	missense	probably damaging	1.00
IGL01925:Vmn2r105	APN	17	20,428,973 (GRCm39)	missense	possibly damaging	0.94
IGL02021:Vmn2r105	APN	17	20,448,157 (GRCm39)	missense	possibly damaging	0.49
IGL02828:Vmn2r105	APN	17	20,429,345 (GRCm39)	missense	possibly damaging	0.80
IGL02838:Vmn2r105	APN	17	20,447,847 (GRCm39)	missense	probably damaging	1.00
IGL03343:Vmn2r105	APN	17	20,446,631 (GRCm39)	nonsense	probably null
R0096:Vmn2r105	UTSW	17	20,447,741 (GRCm39)	missense	possibly damaging	0.49
R0096:Vmn2r105	UTSW	17	20,447,741 (GRCm39)	missense	possibly damaging	0.49
R0212:Vmn2r105	UTSW	17	20,428,827 (GRCm39)	missense	possibly damaging	0.90
R0268:Vmn2r105	UTSW	17	20,428,938 (GRCm39)	missense	probably benign	0.18
R0271:Vmn2r105	UTSW	17	20,454,965 (GRCm39)	missense	probably damaging	0.96
R0613:Vmn2r105	UTSW	17	20,428,578 (GRCm39)	missense	probably damaging	1.00
R0765:Vmn2r105	UTSW	17	20,448,119 (GRCm39)	missense	probably damaging	0.98
R0765:Vmn2r105	UTSW	17	20,447,973 (GRCm39)	missense	probably benign	0.20
R1162:Vmn2r105	UTSW	17	20,447,973 (GRCm39)	missense	probably benign	0.20
R1263:Vmn2r105	UTSW	17	20,428,584 (GRCm39)	missense	probably damaging	1.00
R1363:Vmn2r105	UTSW	17	20,428,932 (GRCm39)	missense	probably benign	0.00
R1464:Vmn2r105	UTSW	17	20,449,004 (GRCm39)	splice site	probably benign
R2029:Vmn2r105	UTSW	17	20,444,840 (GRCm39)	missense	probably damaging	0.99
R2420:Vmn2r105	UTSW	17	20,448,097 (GRCm39)	missense	probably benign	0.15
R2421:Vmn2r105	UTSW	17	20,448,097 (GRCm39)	missense	probably benign	0.15
R2422:Vmn2r105	UTSW	17	20,448,097 (GRCm39)	missense	probably benign	0.15
R2570:Vmn2r105	UTSW	17	20,447,585 (GRCm39)	missense	probably damaging	1.00
R3847:Vmn2r105	UTSW	17	20,428,952 (GRCm39)	missense	possibly damaging	0.85
R3848:Vmn2r105	UTSW	17	20,428,952 (GRCm39)	missense	possibly damaging	0.85
R4030:Vmn2r105	UTSW	17	20,429,016 (GRCm39)	missense	probably damaging	0.99
R4551:Vmn2r105	UTSW	17	20,446,613 (GRCm39)	missense	probably benign
R4801:Vmn2r105	UTSW	17	20,447,556 (GRCm39)	missense	probably benign	0.00
R4802:Vmn2r105	UTSW	17	20,447,556 (GRCm39)	missense	probably benign	0.00
R4816:Vmn2r105	UTSW	17	20,428,953 (GRCm39)	missense	probably benign	0.27
R4929:Vmn2r105	UTSW	17	20,448,280 (GRCm39)	missense	probably benign	0.44
R5022:Vmn2r105	UTSW	17	20,428,676 (GRCm39)	missense	probably damaging	0.99
R5475:Vmn2r105	UTSW	17	20,455,044 (GRCm39)	missense	probably benign
R5576:Vmn2r105	UTSW	17	20,444,836 (GRCm39)	critical splice donor site	probably null
R5795:Vmn2r105	UTSW	17	20,448,998 (GRCm39)	missense	probably benign	0.00
R5895:Vmn2r105	UTSW	17	20,448,929 (GRCm39)	missense	probably benign	0.10
R6017:Vmn2r105	UTSW	17	20,428,889 (GRCm39)	missense	probably damaging	0.97
R6210:Vmn2r105	UTSW	17	20,448,758 (GRCm39)	missense	probably damaging	1.00
R6491:Vmn2r105	UTSW	17	20,447,992 (GRCm39)	nonsense	probably null
R6542:Vmn2r105	UTSW	17	20,448,803 (GRCm39)	missense	probably benign	0.03
R6729:Vmn2r105	UTSW	17	20,428,605 (GRCm39)	missense	probably damaging	0.99
R7020:Vmn2r105	UTSW	17	20,429,336 (GRCm39)	missense	probably damaging	1.00
R7033:Vmn2r105	UTSW	17	20,428,874 (GRCm39)	missense	probably damaging	0.97
R7488:Vmn2r105	UTSW	17	20,429,045 (GRCm39)	missense	probably damaging	1.00
R7491:Vmn2r105	UTSW	17	20,448,827 (GRCm39)	missense	probably benign	0.02
R7555:Vmn2r105	UTSW	17	20,447,937 (GRCm39)	missense	probably damaging	0.98
R7863:Vmn2r105	UTSW	17	20,428,937 (GRCm39)	missense	probably benign	0.18
R8137:Vmn2r105	UTSW	17	20,454,966 (GRCm39)	missense	probably benign	0.02
R8166:Vmn2r105	UTSW	17	20,428,904 (GRCm39)	missense	probably benign	0.07
R8186:Vmn2r105	UTSW	17	20,444,880 (GRCm39)	nonsense	probably null
R8214:Vmn2r105	UTSW	17	20,448,775 (GRCm39)	missense	probably benign	0.02
R8497:Vmn2r105	UTSW	17	20,455,134 (GRCm39)	start codon destroyed	probably null	0.75
R8850:Vmn2r105	UTSW	17	20,428,872 (GRCm39)	missense	probably damaging	1.00
R8880:Vmn2r105	UTSW	17	20,429,229 (GRCm39)	missense	probably damaging	0.99
R9272:Vmn2r105	UTSW	17	20,447,685 (GRCm39)	missense	probably damaging	1.00
R9506:Vmn2r105	UTSW	17	20,429,404 (GRCm39)	missense	probably benign	0.00
R9549:Vmn2r105	UTSW	17	20,448,023 (GRCm39)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- CCTGTGAGTGCAGCAGTAAAATAC -3'
(R):5'- CCAATAACTTGTAGCAGCAGATCTG -3'

Sequencing Primer
(F):5'- ATGAGCTGTGAGCCACAT -3'
(R):5'- AGATGAATAAAGTATGCCTTGAGC -3'

Posted On

2015-06-24