Incidental Mutation 'R4360:Fmo2'
ID 324840
Institutional Source Beutler Lab
Gene Symbol Fmo2
Ensembl Gene ENSMUSG00000040170
Gene Name flavin containing monooxygenase 2
Synonyms 2310042I22Rik, 2310008D08Rik
MMRRC Submission 041111-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R4360 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 162701886-162726295 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 162709583 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 268 (N268S)
Ref Sequence ENSEMBL: ENSMUSP00000107135 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045902] [ENSMUST00000111510]
AlphaFold Q8K2I3
Predicted Effect probably damaging
Transcript: ENSMUST00000045902
AA Change: N268S

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000044405
Gene: ENSMUSG00000040170
AA Change: N268S

DomainStartEndE-ValueType
Pfam:FMO-like 2 533 8.7e-296 PFAM
Pfam:Pyr_redox_2 3 230 6.4e-12 PFAM
Pfam:Pyr_redox_3 6 220 4.4e-10 PFAM
Pfam:K_oxygenase 69 233 2.2e-11 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111510
AA Change: N268S

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000107135
Gene: ENSMUSG00000040170
AA Change: N268S

DomainStartEndE-ValueType
Pfam:FMO-like 2 533 8.7e-296 PFAM
Pfam:Pyr_redox_2 4 446 1.3e-6 PFAM
Pfam:Pyr_redox_3 6 220 8e-17 PFAM
Pfam:NAD_binding_8 7 72 4.3e-6 PFAM
Pfam:K_oxygenase 78 333 1.3e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194061
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194197
Meta Mutation Damage Score 0.1474 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930578I07Rik T C 14: 67,175,850 (GRCm39) noncoding transcript Het
Adgra3 T C 5: 50,147,552 (GRCm39) E496G possibly damaging Het
Atg14 C G 14: 47,805,827 (GRCm39) E13Q probably benign Het
BC023105 G T 18: 60,575,073 (GRCm39) noncoding transcript Het
Chd6 A G 2: 160,791,776 (GRCm39) V2527A possibly damaging Het
Csn1s2a G T 5: 87,929,700 (GRCm39) V100L possibly damaging Het
Fah G A 7: 84,238,856 (GRCm39) L330F probably damaging Het
Foxg1 CCAGCAGCAGCAGCAGCAGC CCAGCAGCAGCAGCAGC 12: 49,431,475 (GRCm39) probably benign Het
Frmd4a A T 2: 4,606,052 (GRCm39) H287L probably damaging Het
G2e3 T A 12: 51,410,197 (GRCm39) probably benign Het
Gm1758 A T 16: 14,324,215 (GRCm39) noncoding transcript Het
Gm7204 T C 16: 48,039,196 (GRCm39) noncoding transcript Het
Gm829 T C 4: 45,718,819 (GRCm39) noncoding transcript Het
Hspa14 A G 2: 3,503,560 (GRCm39) V116A possibly damaging Het
Hspa4 T C 11: 53,155,919 (GRCm39) Y662C probably damaging Het
Islr T A 9: 58,064,887 (GRCm39) N207Y probably damaging Het
Lipc T C 9: 70,759,864 (GRCm39) probably benign Het
Ncor2 A G 5: 125,106,036 (GRCm39) S1546P probably damaging Het
Or13a25 T C 7: 140,247,730 (GRCm39) F170L probably damaging Het
Or56a3 A C 7: 104,735,460 (GRCm39) E179A probably damaging Het
Or7g18 G A 9: 18,787,013 (GRCm39) C127Y probably damaging Het
Parp4 A G 14: 56,866,661 (GRCm39) D1075G possibly damaging Het
Pkp2 A G 16: 16,086,546 (GRCm39) I736V probably benign Het
Plekha8 T C 6: 54,599,171 (GRCm39) I235T probably benign Het
Polq A G 16: 36,880,701 (GRCm39) D955G probably benign Het
Pramel16 A G 4: 143,677,433 (GRCm39) F49L possibly damaging Het
Psmd1 A G 1: 86,061,459 (GRCm39) K890E probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Scpep1 A G 11: 88,821,070 (GRCm39) Y366H possibly damaging Het
Slc18a3 A G 14: 32,185,882 (GRCm39) V167A probably benign Het
Sp8 A G 12: 118,812,400 (GRCm39) D85G possibly damaging Het
Stard3nl G A 13: 19,554,654 (GRCm39) S144L probably damaging Het
Stk4 A G 2: 163,930,879 (GRCm39) E160G possibly damaging Het
Tbcb T C 7: 29,926,460 (GRCm39) N119S probably benign Het
Tnc G T 4: 63,935,161 (GRCm39) R592S probably benign Het
Trem3 T A 17: 48,556,801 (GRCm39) S91T probably benign Het
Trpc6 A G 9: 8,610,267 (GRCm39) E245G probably benign Het
Usp40 C T 1: 87,880,083 (GRCm39) R1036H probably damaging Het
Usp47 G T 7: 111,654,139 (GRCm39) G112C probably damaging Het
Wdr35 T C 12: 9,024,149 (GRCm39) probably benign Het
Zc3h14 A G 12: 98,746,456 (GRCm39) K555R probably benign Het
Zfp26 T C 9: 20,349,869 (GRCm39) S232G probably benign Het
Zfp811 T C 17: 33,017,432 (GRCm39) T202A probably benign Het
Other mutations in Fmo2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00715:Fmo2 APN 1 162,716,282 (GRCm39) nonsense probably null
IGL01299:Fmo2 APN 1 162,705,599 (GRCm39) missense probably benign
IGL02617:Fmo2 APN 1 162,704,490 (GRCm39) missense probably damaging 1.00
IGL02994:Fmo2 APN 1 162,708,189 (GRCm39) missense probably damaging 1.00
IGL03270:Fmo2 APN 1 162,709,595 (GRCm39) missense probably damaging 1.00
F5493:Fmo2 UTSW 1 162,708,101 (GRCm39) missense probably benign 0.41
R0058:Fmo2 UTSW 1 162,713,893 (GRCm39) missense probably benign 0.38
R0058:Fmo2 UTSW 1 162,713,893 (GRCm39) missense probably benign 0.38
R0501:Fmo2 UTSW 1 162,704,497 (GRCm39) missense probably benign 0.00
R0658:Fmo2 UTSW 1 162,704,343 (GRCm39) missense possibly damaging 0.57
R0800:Fmo2 UTSW 1 162,704,383 (GRCm39) missense probably benign 0.00
R2223:Fmo2 UTSW 1 162,725,813 (GRCm39) missense probably damaging 1.00
R4523:Fmo2 UTSW 1 162,715,277 (GRCm39) missense probably benign 0.44
R4755:Fmo2 UTSW 1 162,716,374 (GRCm39) missense probably damaging 1.00
R6087:Fmo2 UTSW 1 162,708,002 (GRCm39) missense probably benign 0.45
R6219:Fmo2 UTSW 1 162,708,085 (GRCm39) missense probably damaging 0.97
R6668:Fmo2 UTSW 1 162,704,617 (GRCm39) missense probably benign 0.15
R7042:Fmo2 UTSW 1 162,708,226 (GRCm39) missense probably damaging 1.00
R7291:Fmo2 UTSW 1 162,715,271 (GRCm39) missense probably benign 0.06
R7560:Fmo2 UTSW 1 162,716,318 (GRCm39) missense probably damaging 1.00
R7580:Fmo2 UTSW 1 162,704,613 (GRCm39) missense possibly damaging 0.46
R7657:Fmo2 UTSW 1 162,716,413 (GRCm39) missense probably damaging 1.00
R8757:Fmo2 UTSW 1 162,708,005 (GRCm39) missense probably benign 0.09
R8759:Fmo2 UTSW 1 162,708,005 (GRCm39) missense probably benign 0.09
R8765:Fmo2 UTSW 1 162,707,966 (GRCm39) missense probably benign 0.36
R8925:Fmo2 UTSW 1 162,704,398 (GRCm39) missense probably benign 0.00
R8927:Fmo2 UTSW 1 162,704,398 (GRCm39) missense probably benign 0.00
R9002:Fmo2 UTSW 1 162,705,647 (GRCm39) nonsense probably null
R9141:Fmo2 UTSW 1 162,709,623 (GRCm39) missense probably null 0.01
R9486:Fmo2 UTSW 1 162,708,292 (GRCm39) missense probably damaging 1.00
Z1176:Fmo2 UTSW 1 162,725,843 (GRCm39) missense probably damaging 1.00
Z1176:Fmo2 UTSW 1 162,715,167 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TTGGAATTAGAACTCCAGGATCG -3'
(R):5'- AACACCTTTCATAGCAACTGGTC -3'

Sequencing Primer
(F):5'- GAACTCCAGGATCGATACAATTATAC -3'
(R):5'- GCAACTGGTCAAATTTCACCTG -3'
Posted On 2015-07-06