Incidental Mutation 'R4360:Olfr679'
ID324854
Institutional Source Beutler Lab
Gene Symbol Olfr679
Ensembl Gene ENSMUSG00000096029
Gene Nameolfactory receptor 679
SynonymsMOR40-2, GA_x6K02T2PBJ9-7714499-7715446
MMRRC Submission 041111-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #R4360 (G1)
Quality Score225
Status Validated
Chromosome7
Chromosomal Location105081205-105090642 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 105086253 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Alanine at position 179 (E179A)
Ref Sequence ENSEMBL: ENSMUSP00000149116 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042676] [ENSMUST00000098158] [ENSMUST00000214328] [ENSMUST00000215704]
Predicted Effect probably benign
Transcript: ENSMUST00000042676
Predicted Effect probably damaging
Transcript: ENSMUST00000098158
AA Change: E179A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000095761
Gene: ENSMUSG00000096029
AA Change: E179A

DomainStartEndE-ValueType
Pfam:7tm_4 35 314 1.2e-73 PFAM
Pfam:7TM_GPCR_Srsx 39 311 6.2e-10 PFAM
Pfam:7tm_1 45 296 1.8e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214328
AA Change: E179A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214738
Predicted Effect probably damaging
Transcript: ENSMUST00000215704
AA Change: E179A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Meta Mutation Damage Score 0.3361 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930578I07Rik T C 14: 66,938,401 noncoding transcript Het
Adgra3 T C 5: 49,990,210 E496G possibly damaging Het
Atg14 C G 14: 47,568,370 E13Q probably benign Het
BC023105 G T 18: 60,442,001 noncoding transcript Het
Chd6 A G 2: 160,949,856 V2527A possibly damaging Het
Csn1s2a G T 5: 87,781,841 V100L possibly damaging Het
Fah G A 7: 84,589,648 L330F probably damaging Het
Fmo2 T C 1: 162,882,014 N268S probably damaging Het
Foxg1 CCAGCAGCAGCAGCAGCAGC CCAGCAGCAGCAGCAGC 12: 49,384,692 probably benign Het
Frmd4a A T 2: 4,601,241 H287L probably damaging Het
G2e3 T A 12: 51,363,414 probably benign Het
Gm1758 A T 16: 14,506,351 noncoding transcript Het
Gm7204 T C 16: 48,218,833 noncoding transcript Het
Gm829 T C 4: 45,718,819 noncoding transcript Het
Hspa14 A G 2: 3,502,523 V116A possibly damaging Het
Hspa4 T C 11: 53,265,092 Y662C probably damaging Het
Islr T A 9: 58,157,604 N207Y probably damaging Het
Lipc T C 9: 70,852,582 probably benign Het
Ncor2 A G 5: 125,028,972 S1546P probably damaging Het
Olfr539 T C 7: 140,667,817 F170L probably damaging Het
Olfr830 G A 9: 18,875,717 C127Y probably damaging Het
Parp4 A G 14: 56,629,204 D1075G possibly damaging Het
Pkp2 A G 16: 16,268,682 I736V probably benign Het
Plekha8 T C 6: 54,622,186 I235T probably benign Het
Polq A G 16: 37,060,339 D955G probably benign Het
Pramef25 A G 4: 143,950,863 F49L possibly damaging Het
Psmd1 A G 1: 86,133,737 K890E probably damaging Het
Rufy4 T C 1: 74,147,663 C537R probably damaging Het
Scpep1 A G 11: 88,930,244 Y366H possibly damaging Het
Slc18a3 A G 14: 32,463,925 V167A probably benign Het
Sp8 A G 12: 118,848,665 D85G possibly damaging Het
Stard3nl G A 13: 19,370,484 S144L probably damaging Het
Stk4 A G 2: 164,088,959 E160G possibly damaging Het
Tbcb T C 7: 30,227,035 N119S probably benign Het
Tnc G T 4: 64,016,924 R592S probably benign Het
Trem3 T A 17: 48,249,773 S91T probably benign Het
Trpc6 A G 9: 8,610,266 E245G probably benign Het
Usp40 C T 1: 87,952,361 R1036H probably damaging Het
Usp47 G T 7: 112,054,932 G112C probably damaging Het
Wdr35 T C 12: 8,974,149 probably benign Het
Zc3h14 A G 12: 98,780,197 K555R probably benign Het
Zfp26 T C 9: 20,438,573 S232G probably benign Het
Zfp811 T C 17: 32,798,458 T202A probably benign Het
Other mutations in Olfr679
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02247:Olfr679 APN 7 105086323 nonsense probably null
IGL02505:Olfr679 APN 7 105086333 missense probably benign
IGL03160:Olfr679 APN 7 105086313 missense probably damaging 1.00
R0079:Olfr679 UTSW 7 105085928 missense probably damaging 1.00
R2126:Olfr679 UTSW 7 105086615 missense probably damaging 1.00
R2185:Olfr679 UTSW 7 105086302 missense possibly damaging 0.79
R3122:Olfr679 UTSW 7 105086178 missense probably benign 0.00
R3828:Olfr679 UTSW 7 105086297 missense probably benign 0.00
R4235:Olfr679 UTSW 7 105085787 missense possibly damaging 0.71
R4485:Olfr679 UTSW 7 105086601 missense probably damaging 1.00
R4790:Olfr679 UTSW 7 105086637 unclassified probably benign
R5542:Olfr679 UTSW 7 105086358 missense probably damaging 1.00
R5599:Olfr679 UTSW 7 105086550 unclassified probably null
R5723:Olfr679 UTSW 7 105091102 missense probably damaging 0.99
R5770:Olfr679 UTSW 7 105090895 missense probably damaging 0.99
R5871:Olfr679 UTSW 7 105086304 missense possibly damaging 0.65
R7231:Olfr679 UTSW 7 105085787 missense possibly damaging 0.94
R7593:Olfr679 UTSW 7 105086165 missense probably benign
R7881:Olfr679 UTSW 7 105086573 missense probably damaging 0.98
R7964:Olfr679 UTSW 7 105086573 missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CAGCTTTCTTGCTATGGAATCTTGC -3'
(R):5'- CCACATGTGCTCAGAGCTTTG -3'

Sequencing Primer
(F):5'- ACATTTATGATCATGGCCTTCGATCG -3'
(R):5'- GCTTTGGCTACAGCACCC -3'
Posted On2015-07-06