Incidental Mutation 'R4378:Zfp612'
ID 325197
Institutional Source Beutler Lab
Gene Symbol Zfp612
Ensembl Gene ENSMUSG00000044676
Gene Name zinc finger protein 612
Synonyms B230354B21Rik
MMRRC Submission 041121-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4378 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 110806378-110819373 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 110815683 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 258 (V258F)
Ref Sequence ENSEMBL: ENSMUSP00000062474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058804] [ENSMUST00000165700] [ENSMUST00000212754]
AlphaFold A0A1D5RMC2
Predicted Effect possibly damaging
Transcript: ENSMUST00000058804
AA Change: V258F

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000062474
Gene: ENSMUSG00000044676
AA Change: V258F

DomainStartEndE-ValueType
KRAB 11 71 2e-32 SMART
low complexity region 135 146 N/A INTRINSIC
ZnF_C2H2 225 247 1.45e-2 SMART
ZnF_C2H2 253 275 2.67e-1 SMART
ZnF_C2H2 281 303 1.4e-4 SMART
ZnF_C2H2 309 331 2.91e-2 SMART
ZnF_C2H2 337 359 3.16e-3 SMART
ZnF_C2H2 365 387 4.17e-3 SMART
ZnF_C2H2 393 415 1.82e-3 SMART
ZnF_C2H2 421 443 3.69e-4 SMART
ZnF_C2H2 449 471 3.69e-4 SMART
ZnF_C2H2 477 499 1.58e-3 SMART
ZnF_C2H2 505 527 4.87e-4 SMART
ZnF_C2H2 533 555 1.38e-3 SMART
ZnF_C2H2 561 583 5.06e-2 SMART
ZnF_C2H2 589 611 5.9e-3 SMART
ZnF_C2H2 617 639 9.44e-2 SMART
ZnF_C2H2 645 667 1.03e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000165700
Predicted Effect possibly damaging
Transcript: ENSMUST00000212754
AA Change: V297F

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 96% (47/49)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,243,644 (GRCm39) K1836E probably benign Het
Adora1 A G 1: 134,130,948 (GRCm39) F241S probably damaging Het
Akt1s1 C T 7: 44,503,384 (GRCm39) T168M probably damaging Het
Amigo1 C T 3: 108,099,069 (GRCm39) probably benign Het
Amigo2 A G 15: 97,143,859 (GRCm39) F188L possibly damaging Het
Armc2 T C 10: 41,869,078 (GRCm39) T29A possibly damaging Het
Axl G A 7: 25,458,262 (GRCm39) A822V probably benign Het
Borcs5 T C 6: 134,621,292 (GRCm39) V21A probably benign Het
Cdc42ep3 A G 17: 79,642,408 (GRCm39) S171P probably benign Het
Cmas T C 6: 142,718,011 (GRCm39) probably benign Het
Cyp4f40 A G 17: 32,887,003 (GRCm39) N158S probably null Het
Dnah6 G T 6: 73,095,009 (GRCm39) N2139K probably benign Het
Elmo1 A T 13: 20,557,286 (GRCm39) H409L possibly damaging Het
Exoc1l A G 5: 76,648,380 (GRCm39) K62R probably damaging Het
Exoc4 T A 6: 33,792,622 (GRCm39) V584E probably damaging Het
Gm9116 A G 3: 93,817,786 (GRCm39) noncoding transcript Het
Gxylt2 A G 6: 100,710,161 (GRCm39) S101G probably benign Het
Hsph1 C A 5: 149,559,472 (GRCm39) E24* probably null Het
Ighv1-56 C T 12: 115,206,568 (GRCm39) E50K probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lrriq1 A T 10: 103,038,225 (GRCm39) D859E probably damaging Het
Mapk7 G A 11: 61,384,493 (GRCm39) S71L probably damaging Het
Nars1 A G 18: 64,634,424 (GRCm39) Y500H probably damaging Het
Or1j1 T C 2: 36,702,481 (GRCm39) M208V probably benign Het
Or5d20-ps1 G T 2: 87,931,829 (GRCm39) N167K unknown Het
Phc1 T C 6: 122,311,966 (GRCm39) N64S possibly damaging Het
Ppp4r3b T A 11: 29,159,450 (GRCm39) N180K possibly damaging Het
Primpol G A 8: 47,029,218 (GRCm39) probably benign Het
Prtg T C 9: 72,750,042 (GRCm39) S149P possibly damaging Het
Qrich2 T C 11: 116,337,741 (GRCm39) S1916G probably damaging Het
Rps6ka5 A T 12: 100,564,196 (GRCm39) Y218N probably damaging Het
Setbp1 T C 18: 78,899,833 (GRCm39) D1278G possibly damaging Het
Sirt1 C T 10: 63,174,728 (GRCm39) A8T probably benign Het
Sobp C T 10: 42,897,300 (GRCm39) V762I probably damaging Het
Sptan1 T C 2: 29,915,581 (GRCm39) S1994P probably damaging Het
Taok3 T C 5: 117,347,636 (GRCm39) I87T probably damaging Het
Tecta T C 9: 42,278,004 (GRCm39) Y1168C probably damaging Het
Trhr A G 15: 44,061,023 (GRCm39) Y181C probably damaging Het
Ube4b C T 4: 149,468,255 (GRCm39) D174N probably damaging Het
Ubr4 C T 4: 139,137,751 (GRCm39) H1067Y possibly damaging Het
Vmn2r86 A G 10: 130,288,469 (GRCm39) I344T possibly damaging Het
Vmn2r88 T A 14: 51,650,746 (GRCm39) L153* probably null Het
Zfp516 T A 18: 83,005,305 (GRCm39) D736E probably benign Het
Other mutations in Zfp612
AlleleSourceChrCoordTypePredicted EffectPPH Score
H8562:Zfp612 UTSW 8 110,816,670 (GRCm39) missense probably damaging 1.00
R1920:Zfp612 UTSW 8 110,815,095 (GRCm39) missense probably benign 0.03
R2994:Zfp612 UTSW 8 110,816,049 (GRCm39) missense probably damaging 1.00
R4281:Zfp612 UTSW 8 110,816,691 (GRCm39) missense probably damaging 0.98
R4492:Zfp612 UTSW 8 110,815,929 (GRCm39) missense probably damaging 0.99
R4748:Zfp612 UTSW 8 110,815,304 (GRCm39) missense probably benign 0.37
R4890:Zfp612 UTSW 8 110,816,576 (GRCm39) nonsense probably null
R5200:Zfp612 UTSW 8 110,816,532 (GRCm39) nonsense probably null
R5443:Zfp612 UTSW 8 110,816,227 (GRCm39) missense possibly damaging 0.85
R5864:Zfp612 UTSW 8 110,816,358 (GRCm39) missense probably damaging 1.00
R6177:Zfp612 UTSW 8 110,816,606 (GRCm39) missense probably damaging 1.00
R6435:Zfp612 UTSW 8 110,815,952 (GRCm39) missense probably damaging 0.99
R6601:Zfp612 UTSW 8 110,816,181 (GRCm39) missense possibly damaging 0.92
R7082:Zfp612 UTSW 8 110,816,337 (GRCm39) missense probably damaging 1.00
R7083:Zfp612 UTSW 8 110,815,768 (GRCm39) missense probably damaging 1.00
R8837:Zfp612 UTSW 8 110,815,603 (GRCm39) missense probably damaging 1.00
R9323:Zfp612 UTSW 8 110,815,372 (GRCm39) missense probably benign
R9394:Zfp612 UTSW 8 110,810,993 (GRCm39) missense probably damaging 1.00
RF007:Zfp612 UTSW 8 110,816,174 (GRCm39) nonsense probably null
RF008:Zfp612 UTSW 8 110,816,193 (GRCm39) missense probably damaging 1.00
Z1176:Zfp612 UTSW 8 110,815,495 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCTTCCAGAGATCTGTGATG -3'
(R):5'- GATGCTGAATCAGTTTTGCGTTAAC -3'

Sequencing Primer
(F):5'- TAAAGCCAAGTTCGTCTGGC -3'
(R):5'- CGTTAACATTGAAGGCTTTCCCACAG -3'
Posted On 2015-07-06