Incidental Mutation 'R4378:Nars1'
ID 325217
Institutional Source Beutler Lab
Gene Symbol Nars1
Ensembl Gene ENSMUSG00000024587
Gene Name asparaginyl-tRNA synthetase 1
Synonyms Nars, ASNRS
MMRRC Submission 041121-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.967) question?
Stock # R4378 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 64632726-64649586 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 64634424 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 500 (Y500H)
Ref Sequence ENSEMBL: ENSMUSP00000025483 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025483]
AlphaFold Q8BP47
Predicted Effect probably damaging
Transcript: ENSMUST00000025483
AA Change: Y500H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000025483
Gene: ENSMUSG00000024587
AA Change: Y500H

DomainStartEndE-ValueType
coiled coil region 80 112 N/A INTRINSIC
Pfam:tRNA_anti-codon 139 219 1.2e-12 PFAM
Pfam:tRNA-synt_2 236 554 1.8e-108 PFAM
Meta Mutation Damage Score 0.8841 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 96% (47/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,243,644 (GRCm39) K1836E probably benign Het
Adora1 A G 1: 134,130,948 (GRCm39) F241S probably damaging Het
Akt1s1 C T 7: 44,503,384 (GRCm39) T168M probably damaging Het
Amigo1 C T 3: 108,099,069 (GRCm39) probably benign Het
Amigo2 A G 15: 97,143,859 (GRCm39) F188L possibly damaging Het
Armc2 T C 10: 41,869,078 (GRCm39) T29A possibly damaging Het
Axl G A 7: 25,458,262 (GRCm39) A822V probably benign Het
Borcs5 T C 6: 134,621,292 (GRCm39) V21A probably benign Het
Cdc42ep3 A G 17: 79,642,408 (GRCm39) S171P probably benign Het
Cmas T C 6: 142,718,011 (GRCm39) probably benign Het
Cyp4f40 A G 17: 32,887,003 (GRCm39) N158S probably null Het
Dnah6 G T 6: 73,095,009 (GRCm39) N2139K probably benign Het
Elmo1 A T 13: 20,557,286 (GRCm39) H409L possibly damaging Het
Exoc1l A G 5: 76,648,380 (GRCm39) K62R probably damaging Het
Exoc4 T A 6: 33,792,622 (GRCm39) V584E probably damaging Het
Gm9116 A G 3: 93,817,786 (GRCm39) noncoding transcript Het
Gxylt2 A G 6: 100,710,161 (GRCm39) S101G probably benign Het
Hsph1 C A 5: 149,559,472 (GRCm39) E24* probably null Het
Ighv1-56 C T 12: 115,206,568 (GRCm39) E50K probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lrriq1 A T 10: 103,038,225 (GRCm39) D859E probably damaging Het
Mapk7 G A 11: 61,384,493 (GRCm39) S71L probably damaging Het
Or1j1 T C 2: 36,702,481 (GRCm39) M208V probably benign Het
Or5d20-ps1 G T 2: 87,931,829 (GRCm39) N167K unknown Het
Phc1 T C 6: 122,311,966 (GRCm39) N64S possibly damaging Het
Ppp4r3b T A 11: 29,159,450 (GRCm39) N180K possibly damaging Het
Primpol G A 8: 47,029,218 (GRCm39) probably benign Het
Prtg T C 9: 72,750,042 (GRCm39) S149P possibly damaging Het
Qrich2 T C 11: 116,337,741 (GRCm39) S1916G probably damaging Het
Rps6ka5 A T 12: 100,564,196 (GRCm39) Y218N probably damaging Het
Setbp1 T C 18: 78,899,833 (GRCm39) D1278G possibly damaging Het
Sirt1 C T 10: 63,174,728 (GRCm39) A8T probably benign Het
Sobp C T 10: 42,897,300 (GRCm39) V762I probably damaging Het
Sptan1 T C 2: 29,915,581 (GRCm39) S1994P probably damaging Het
Taok3 T C 5: 117,347,636 (GRCm39) I87T probably damaging Het
Tecta T C 9: 42,278,004 (GRCm39) Y1168C probably damaging Het
Trhr A G 15: 44,061,023 (GRCm39) Y181C probably damaging Het
Ube4b C T 4: 149,468,255 (GRCm39) D174N probably damaging Het
Ubr4 C T 4: 139,137,751 (GRCm39) H1067Y possibly damaging Het
Vmn2r86 A G 10: 130,288,469 (GRCm39) I344T possibly damaging Het
Vmn2r88 T A 14: 51,650,746 (GRCm39) L153* probably null Het
Zfp516 T A 18: 83,005,305 (GRCm39) D736E probably benign Het
Zfp612 G T 8: 110,815,683 (GRCm39) V258F possibly damaging Het
Other mutations in Nars1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01012:Nars1 APN 18 64,638,039 (GRCm39) missense probably damaging 1.00
IGL01962:Nars1 APN 18 64,643,554 (GRCm39) missense probably benign 0.00
IGL01968:Nars1 APN 18 64,640,929 (GRCm39) missense probably damaging 1.00
IGL02288:Nars1 APN 18 64,643,606 (GRCm39) splice site probably benign
IGL02366:Nars1 APN 18 64,636,599 (GRCm39) missense possibly damaging 0.70
IGL02948:Nars1 APN 18 64,638,266 (GRCm39) missense possibly damaging 0.66
FR4976:Nars1 UTSW 18 64,643,516 (GRCm39) critical splice donor site probably benign
R0591:Nars1 UTSW 18 64,633,638 (GRCm39) missense probably damaging 1.00
R1654:Nars1 UTSW 18 64,645,120 (GRCm39) missense probably damaging 1.00
R1691:Nars1 UTSW 18 64,649,485 (GRCm39) critical splice donor site probably null
R1954:Nars1 UTSW 18 64,633,635 (GRCm39) missense probably damaging 1.00
R2006:Nars1 UTSW 18 64,638,099 (GRCm39) missense probably damaging 1.00
R2516:Nars1 UTSW 18 64,638,087 (GRCm39) missense probably damaging 1.00
R3433:Nars1 UTSW 18 64,642,374 (GRCm39) missense probably damaging 1.00
R4667:Nars1 UTSW 18 64,638,302 (GRCm39) missense possibly damaging 0.93
R4737:Nars1 UTSW 18 64,649,498 (GRCm39) missense probably benign
R4877:Nars1 UTSW 18 64,633,643 (GRCm39) nonsense probably null
R5950:Nars1 UTSW 18 64,643,556 (GRCm39) missense possibly damaging 0.91
R6434:Nars1 UTSW 18 64,640,872 (GRCm39) missense probably benign 0.01
R6920:Nars1 UTSW 18 64,634,471 (GRCm39) missense probably damaging 0.99
R7082:Nars1 UTSW 18 64,637,425 (GRCm39) missense possibly damaging 0.68
R7132:Nars1 UTSW 18 64,640,841 (GRCm39) critical splice donor site probably null
R7504:Nars1 UTSW 18 64,645,093 (GRCm39) missense probably benign 0.22
R8120:Nars1 UTSW 18 64,637,422 (GRCm39) missense probably benign 0.19
R8343:Nars1 UTSW 18 64,637,458 (GRCm39) missense probably benign 0.01
R8429:Nars1 UTSW 18 64,634,391 (GRCm39) missense probably damaging 1.00
R8929:Nars1 UTSW 18 64,644,895 (GRCm39) missense probably benign
R9321:Nars1 UTSW 18 64,637,950 (GRCm39) missense probably damaging 1.00
R9397:Nars1 UTSW 18 64,642,327 (GRCm39) missense probably benign 0.30
Predicted Primers PCR Primer
(F):5'- CGAAACTGACGTATAACTGGGC -3'
(R):5'- TGAGTACTACTTGAACTTTGCGTAG -3'

Sequencing Primer
(F):5'- CTGACGTATAACTGGGCTAAAGAC -3'
(R):5'- GAACTTTGCGTAGTCACATAGC -3'
Posted On 2015-07-06