Incidental Mutation 'R4379:Zmynd8'
| ID |
325227 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zmynd8
|
| Ensembl Gene |
ENSMUSG00000039671 |
| Gene Name |
zinc finger, MYND-type containing 8 |
| Synonyms |
ZMYND8, RACK7, 1110013E22Rik, 2010005I16Rik, Prkcbp1, 3632413B07Rik |
| MMRRC Submission |
041677-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4379 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
165626072-165740896 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to T
at 165649858 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136211
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018050]
[ENSMUST00000018050]
[ENSMUST00000088113]
[ENSMUST00000088113]
[ENSMUST00000088113]
[ENSMUST00000088113]
[ENSMUST00000099084]
[ENSMUST00000099084]
[ENSMUST00000109266]
[ENSMUST00000109266]
[ENSMUST00000109269]
[ENSMUST00000109269]
[ENSMUST00000170272]
[ENSMUST00000170272]
[ENSMUST00000177633]
[ENSMUST00000177633]
|
| AlphaFold |
A2A484 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000018050
|
| SMART Domains |
Protein: ENSMUSP00000018050
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
90 |
131 |
2.23e-11 |
SMART |
|
BROMO
|
147 |
254 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
275 |
349 |
4e-12 |
PFAM |
|
Pfam:DUF3544
|
412 |
624 |
9.8e-112 |
PFAM |
|
internal_repeat_2
|
640 |
701 |
9.06e-5 |
PROSPERO |
|
low complexity region
|
770 |
805 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
875 |
887 |
N/A |
INTRINSIC |
|
coiled coil region
|
916 |
978 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
988 |
1022 |
2.2e-7 |
PFAM |
|
low complexity region
|
1055 |
1075 |
N/A |
INTRINSIC |
|
low complexity region
|
1142 |
1156 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000018050
|
| SMART Domains |
Protein: ENSMUSP00000018050
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
90 |
131 |
2.23e-11 |
SMART |
|
BROMO
|
147 |
254 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
275 |
349 |
4e-12 |
PFAM |
|
Pfam:DUF3544
|
412 |
624 |
9.8e-112 |
PFAM |
|
internal_repeat_2
|
640 |
701 |
9.06e-5 |
PROSPERO |
|
low complexity region
|
770 |
805 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
875 |
887 |
N/A |
INTRINSIC |
|
coiled coil region
|
916 |
978 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
988 |
1022 |
2.2e-7 |
PFAM |
|
low complexity region
|
1055 |
1075 |
N/A |
INTRINSIC |
|
low complexity region
|
1142 |
1156 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000088113
|
| SMART Domains |
Protein: ENSMUSP00000085436
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
271 |
346 |
2.7e-11 |
PFAM |
|
Pfam:DUF3544
|
408 |
617 |
2.1e-102 |
PFAM |
|
internal_repeat_2
|
635 |
696 |
4.2e-5 |
PROSPERO |
|
low complexity region
|
765 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
863 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1070 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000088113
|
| SMART Domains |
Protein: ENSMUSP00000085436
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
271 |
346 |
2.7e-11 |
PFAM |
|
Pfam:DUF3544
|
408 |
617 |
2.1e-102 |
PFAM |
|
internal_repeat_2
|
635 |
696 |
4.2e-5 |
PROSPERO |
|
low complexity region
|
765 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
863 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1070 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000088113
|
| SMART Domains |
Protein: ENSMUSP00000085436
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
271 |
346 |
2.7e-11 |
PFAM |
|
Pfam:DUF3544
|
408 |
617 |
2.1e-102 |
PFAM |
|
internal_repeat_2
|
635 |
696 |
4.2e-5 |
PROSPERO |
|
low complexity region
|
765 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
863 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1070 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000088113
|
| SMART Domains |
Protein: ENSMUSP00000085436
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
271 |
346 |
2.7e-11 |
PFAM |
|
Pfam:DUF3544
|
408 |
617 |
2.1e-102 |
PFAM |
|
internal_repeat_2
|
635 |
696 |
4.2e-5 |
PROSPERO |
|
low complexity region
|
765 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
863 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1070 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000099084
|
| SMART Domains |
Protein: ENSMUSP00000096683
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
65 |
106 |
2.23e-11 |
SMART |
|
BROMO
|
122 |
229 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
250 |
324 |
4.1e-12 |
PFAM |
|
Pfam:DUF3544
|
387 |
599 |
1e-111 |
PFAM |
|
internal_repeat_2
|
615 |
676 |
4.95e-5 |
PROSPERO |
|
low complexity region
|
745 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
819 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
880 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
902 |
914 |
N/A |
INTRINSIC |
|
coiled coil region
|
943 |
1005 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
1015 |
1049 |
2.3e-7 |
PFAM |
|
low complexity region
|
1082 |
1102 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1183 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000099084
|
| SMART Domains |
Protein: ENSMUSP00000096683
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
65 |
106 |
2.23e-11 |
SMART |
|
BROMO
|
122 |
229 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
250 |
324 |
4.1e-12 |
PFAM |
|
Pfam:DUF3544
|
387 |
599 |
1e-111 |
PFAM |
|
internal_repeat_2
|
615 |
676 |
4.95e-5 |
PROSPERO |
|
low complexity region
|
745 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
819 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
880 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
902 |
914 |
N/A |
INTRINSIC |
|
coiled coil region
|
943 |
1005 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
1015 |
1049 |
2.3e-7 |
PFAM |
|
low complexity region
|
1082 |
1102 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1183 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109266
|
| SMART Domains |
Protein: ENSMUSP00000104889
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
11 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
110 |
151 |
2.23e-11 |
SMART |
|
BROMO
|
167 |
274 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
295 |
369 |
4.1e-12 |
PFAM |
|
Pfam:DUF3544
|
432 |
644 |
1e-111 |
PFAM |
|
internal_repeat_2
|
660 |
721 |
8.36e-5 |
PROSPERO |
|
low complexity region
|
790 |
825 |
N/A |
INTRINSIC |
|
low complexity region
|
873 |
888 |
N/A |
INTRINSIC |
|
low complexity region
|
895 |
907 |
N/A |
INTRINSIC |
|
coiled coil region
|
936 |
998 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
1008 |
1042 |
2.3e-7 |
PFAM |
|
low complexity region
|
1075 |
1095 |
N/A |
INTRINSIC |
|
low complexity region
|
1162 |
1176 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109266
|
| SMART Domains |
Protein: ENSMUSP00000104889
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
11 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
110 |
151 |
2.23e-11 |
SMART |
|
BROMO
|
167 |
274 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
295 |
369 |
4.1e-12 |
PFAM |
|
Pfam:DUF3544
|
432 |
644 |
1e-111 |
PFAM |
|
internal_repeat_2
|
660 |
721 |
8.36e-5 |
PROSPERO |
|
low complexity region
|
790 |
825 |
N/A |
INTRINSIC |
|
low complexity region
|
873 |
888 |
N/A |
INTRINSIC |
|
low complexity region
|
895 |
907 |
N/A |
INTRINSIC |
|
coiled coil region
|
936 |
998 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
1008 |
1042 |
2.3e-7 |
PFAM |
|
low complexity region
|
1075 |
1095 |
N/A |
INTRINSIC |
|
low complexity region
|
1162 |
1176 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109269
|
| SMART Domains |
Protein: ENSMUSP00000104892
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
41 |
60 |
N/A |
INTRINSIC |
|
PHD
|
94 |
135 |
2.23e-11 |
SMART |
|
BROMO
|
151 |
258 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
280 |
355 |
6.6e-11 |
PFAM |
|
Pfam:DUF3544
|
417 |
626 |
2.6e-102 |
PFAM |
|
internal_repeat_2
|
644 |
705 |
6.15e-5 |
PROSPERO |
|
low complexity region
|
774 |
809 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
924 |
N/A |
INTRINSIC |
|
low complexity region
|
931 |
943 |
N/A |
INTRINSIC |
|
coiled coil region
|
972 |
1034 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1131 |
N/A |
INTRINSIC |
|
low complexity region
|
1198 |
1212 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109269
|
| SMART Domains |
Protein: ENSMUSP00000104892
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
41 |
60 |
N/A |
INTRINSIC |
|
PHD
|
94 |
135 |
2.23e-11 |
SMART |
|
BROMO
|
151 |
258 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
280 |
355 |
6.6e-11 |
PFAM |
|
Pfam:DUF3544
|
417 |
626 |
2.6e-102 |
PFAM |
|
internal_repeat_2
|
644 |
705 |
6.15e-5 |
PROSPERO |
|
low complexity region
|
774 |
809 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
924 |
N/A |
INTRINSIC |
|
low complexity region
|
931 |
943 |
N/A |
INTRINSIC |
|
coiled coil region
|
972 |
1034 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1131 |
N/A |
INTRINSIC |
|
low complexity region
|
1198 |
1212 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152682
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000170272
|
| SMART Domains |
Protein: ENSMUSP00000128680
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
65 |
106 |
2.23e-11 |
SMART |
|
BROMO
|
122 |
229 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
250 |
324 |
1.1e-11 |
PFAM |
|
Pfam:DUF3544
|
387 |
599 |
1.9e-111 |
PFAM |
|
internal_repeat_2
|
615 |
676 |
7.92e-5 |
PROSPERO |
|
low complexity region
|
745 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
828 |
843 |
N/A |
INTRINSIC |
|
low complexity region
|
850 |
862 |
N/A |
INTRINSIC |
|
coiled coil region
|
891 |
953 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
963 |
997 |
1.1e-6 |
PFAM |
|
low complexity region
|
1030 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1117 |
1131 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000170272
|
| SMART Domains |
Protein: ENSMUSP00000128680
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
65 |
106 |
2.23e-11 |
SMART |
|
BROMO
|
122 |
229 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
250 |
324 |
1.1e-11 |
PFAM |
|
Pfam:DUF3544
|
387 |
599 |
1.9e-111 |
PFAM |
|
internal_repeat_2
|
615 |
676 |
7.92e-5 |
PROSPERO |
|
low complexity region
|
745 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
828 |
843 |
N/A |
INTRINSIC |
|
low complexity region
|
850 |
862 |
N/A |
INTRINSIC |
|
coiled coil region
|
891 |
953 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
963 |
997 |
1.1e-6 |
PFAM |
|
low complexity region
|
1030 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1117 |
1131 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000177633
|
| SMART Domains |
Protein: ENSMUSP00000136211
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
270 |
344 |
9.6e-12 |
PFAM |
|
Pfam:DUF3544
|
407 |
619 |
1.8e-111 |
PFAM |
|
internal_repeat_2
|
635 |
696 |
6.45e-5 |
PROSPERO |
|
low complexity region
|
765 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
863 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
973 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
983 |
1017 |
6.7e-7 |
PFAM |
|
low complexity region
|
1050 |
1070 |
N/A |
INTRINSIC |
|
low complexity region
|
1137 |
1151 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000177633
|
| SMART Domains |
Protein: ENSMUSP00000136211
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
270 |
344 |
9.6e-12 |
PFAM |
|
Pfam:DUF3544
|
407 |
619 |
1.8e-111 |
PFAM |
|
internal_repeat_2
|
635 |
696 |
6.45e-5 |
PROSPERO |
|
low complexity region
|
765 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
863 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
973 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
983 |
1017 |
6.7e-7 |
PFAM |
|
low complexity region
|
1050 |
1070 |
N/A |
INTRINSIC |
|
low complexity region
|
1137 |
1151 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.4%
|
| Validation Efficiency |
95% (53/56) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 52 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1b |
C |
A |
5: 8,915,875 (GRCm39) |
H1252Q |
probably benign |
Het |
| Adcy3 |
T |
C |
12: 4,184,558 (GRCm39) |
L78P |
probably damaging |
Het |
| Agmat |
G |
T |
4: 141,484,802 (GRCm39) |
A282S |
probably benign |
Het |
| Akap8 |
G |
T |
17: 32,525,534 (GRCm39) |
T515K |
probably damaging |
Het |
| Akap8l |
T |
C |
17: 32,540,488 (GRCm39) |
|
probably benign |
Het |
| Alpk1 |
C |
T |
3: 127,523,022 (GRCm39) |
V7M |
probably damaging |
Het |
| AW209491 |
T |
C |
13: 14,812,412 (GRCm39) |
*422Q |
probably null |
Het |
| Cdan1 |
A |
G |
2: 120,557,099 (GRCm39) |
F576L |
probably damaging |
Het |
| Cers5 |
A |
G |
15: 99,649,134 (GRCm39) |
F45L |
probably damaging |
Het |
| Dst |
A |
G |
1: 34,267,056 (GRCm39) |
I5011V |
probably benign |
Het |
| Dst |
T |
C |
1: 34,202,316 (GRCm39) |
S215P |
probably damaging |
Het |
| En1 |
A |
G |
1: 120,531,084 (GRCm39) |
N108S |
possibly damaging |
Het |
| Entrep3 |
A |
T |
3: 89,093,064 (GRCm39) |
D274V |
probably damaging |
Het |
| Fancd2 |
T |
C |
6: 113,538,677 (GRCm39) |
S591P |
probably benign |
Het |
| Glt1d1 |
T |
C |
5: 127,771,346 (GRCm39) |
V279A |
possibly damaging |
Het |
| Gm10051 |
C |
T |
5: 133,504,287 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr158 |
G |
T |
2: 21,830,025 (GRCm39) |
G690V |
probably damaging |
Het |
| Grm7 |
G |
T |
6: 110,623,309 (GRCm39) |
V161F |
probably damaging |
Het |
| Grm7 |
T |
A |
6: 111,223,335 (GRCm39) |
N458K |
probably benign |
Het |
| Hibadh |
G |
A |
6: 52,597,027 (GRCm39) |
S139L |
probably damaging |
Het |
| Hivep1 |
C |
T |
13: 42,308,906 (GRCm39) |
S382F |
probably damaging |
Het |
| Ift74 |
A |
G |
4: 94,568,171 (GRCm39) |
N403D |
probably benign |
Het |
| Igkv4-81 |
A |
G |
6: 68,967,933 (GRCm39) |
L56S |
probably damaging |
Het |
| Igsf9b |
G |
A |
9: 27,220,774 (GRCm39) |
V47I |
possibly damaging |
Het |
| Klk14 |
G |
A |
7: 43,341,501 (GRCm39) |
C51Y |
probably damaging |
Het |
| Lmbr1l |
G |
T |
15: 98,807,144 (GRCm39) |
C212* |
probably null |
Het |
| Lrp10 |
C |
T |
14: 54,705,823 (GRCm39) |
R338C |
probably damaging |
Het |
| Lrrc34 |
A |
G |
3: 30,685,524 (GRCm39) |
L275P |
probably damaging |
Het |
| Mgam2-ps |
T |
C |
6: 40,810,793 (GRCm39) |
|
noncoding transcript |
Het |
| Mief1 |
T |
G |
15: 80,132,160 (GRCm39) |
M77R |
possibly damaging |
Het |
| Neurod6 |
T |
C |
6: 55,656,257 (GRCm39) |
T127A |
probably damaging |
Het |
| Nif3l1 |
A |
C |
1: 58,494,738 (GRCm39) |
|
probably benign |
Het |
| Nlrp12 |
T |
A |
7: 3,288,554 (GRCm39) |
T653S |
probably benign |
Het |
| Nol7 |
G |
T |
13: 43,555,051 (GRCm39) |
W228L |
probably damaging |
Het |
| Nrp1 |
G |
A |
8: 129,194,948 (GRCm39) |
R468H |
probably damaging |
Het |
| Or5ac15 |
C |
T |
16: 58,940,027 (GRCm39) |
M135I |
probably benign |
Het |
| Or7g34 |
A |
G |
9: 19,478,038 (GRCm39) |
L211P |
probably benign |
Het |
| Pbrm1 |
A |
T |
14: 30,789,663 (GRCm39) |
H785L |
probably damaging |
Het |
| Pus7 |
T |
C |
5: 23,953,864 (GRCm39) |
|
probably benign |
Het |
| Qser1 |
G |
T |
2: 104,596,404 (GRCm39) |
|
probably null |
Het |
| Rrm1 |
T |
C |
7: 102,095,800 (GRCm39) |
V51A |
probably damaging |
Het |
| Setbp1 |
T |
C |
18: 79,129,896 (GRCm39) |
N112S |
probably damaging |
Het |
| Svil |
C |
T |
18: 5,046,909 (GRCm39) |
H52Y |
probably damaging |
Het |
| Taf1d |
T |
A |
9: 15,223,277 (GRCm39) |
|
probably benign |
Het |
| Tle1 |
ACAGGTTTCTTCAGGTTTCTT |
ACAGGTTTCTT |
4: 72,036,400 (GRCm39) |
|
probably benign |
Het |
| Treml1 |
A |
G |
17: 48,667,424 (GRCm39) |
Y103C |
probably damaging |
Het |
| Trim28 |
A |
T |
7: 12,763,407 (GRCm39) |
D516V |
probably damaging |
Het |
| Usp34 |
T |
A |
11: 23,334,499 (GRCm39) |
N1164K |
possibly damaging |
Het |
| Vmn2r115 |
A |
G |
17: 23,564,197 (GRCm39) |
Y123C |
possibly damaging |
Het |
| Vrk3 |
C |
T |
7: 44,424,866 (GRCm39) |
T427M |
probably benign |
Het |
| Zfp28 |
C |
T |
7: 6,396,441 (GRCm39) |
T292I |
probably benign |
Het |
| Zscan4d |
A |
G |
7: 10,898,905 (GRCm39) |
V124A |
probably benign |
Het |
|
| Other mutations in Zmynd8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01288:Zmynd8
|
APN |
2 |
165,654,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01311:Zmynd8
|
APN |
2 |
165,647,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02317:Zmynd8
|
APN |
2 |
165,662,492 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02548:Zmynd8
|
APN |
2 |
165,675,325 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Zmynd8
|
APN |
2 |
165,694,070 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02933:Zmynd8
|
APN |
2 |
165,670,238 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
cain
|
UTSW |
2 |
165,699,973 (GRCm39) |
critical splice donor site |
probably null |
|
|
F5770:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
I1329:Zmynd8
|
UTSW |
2 |
165,670,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0031:Zmynd8
|
UTSW |
2 |
165,662,618 (GRCm39) |
splice site |
probably benign |
|
|
R0267:Zmynd8
|
UTSW |
2 |
165,670,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Zmynd8
|
UTSW |
2 |
165,629,078 (GRCm39) |
splice site |
probably null |
|
|
R1663:Zmynd8
|
UTSW |
2 |
165,649,805 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2212:Zmynd8
|
UTSW |
2 |
165,657,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3412:Zmynd8
|
UTSW |
2 |
165,657,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3413:Zmynd8
|
UTSW |
2 |
165,657,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3749:Zmynd8
|
UTSW |
2 |
165,647,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3820:Zmynd8
|
UTSW |
2 |
165,657,381 (GRCm39) |
nonsense |
probably null |
|
|
R3836:Zmynd8
|
UTSW |
2 |
165,700,019 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3957:Zmynd8
|
UTSW |
2 |
165,654,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4526:Zmynd8
|
UTSW |
2 |
165,649,527 (GRCm39) |
intron |
probably benign |
|
|
R4739:Zmynd8
|
UTSW |
2 |
165,647,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4838:Zmynd8
|
UTSW |
2 |
165,681,954 (GRCm39) |
nonsense |
probably null |
|
|
R4932:Zmynd8
|
UTSW |
2 |
165,676,871 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4933:Zmynd8
|
UTSW |
2 |
165,676,871 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4997:Zmynd8
|
UTSW |
2 |
165,634,736 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5652:Zmynd8
|
UTSW |
2 |
165,649,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5741:Zmynd8
|
UTSW |
2 |
165,681,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6008:Zmynd8
|
UTSW |
2 |
165,684,707 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6242:Zmynd8
|
UTSW |
2 |
165,740,867 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6332:Zmynd8
|
UTSW |
2 |
165,680,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6394:Zmynd8
|
UTSW |
2 |
165,687,943 (GRCm39) |
nonsense |
probably null |
|
|
R6772:Zmynd8
|
UTSW |
2 |
165,649,521 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6970:Zmynd8
|
UTSW |
2 |
165,717,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6986:Zmynd8
|
UTSW |
2 |
165,675,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7229:Zmynd8
|
UTSW |
2 |
165,699,973 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7266:Zmynd8
|
UTSW |
2 |
165,649,492 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7296:Zmynd8
|
UTSW |
2 |
165,681,929 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7642:Zmynd8
|
UTSW |
2 |
165,654,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Zmynd8
|
UTSW |
2 |
165,684,751 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7821:Zmynd8
|
UTSW |
2 |
165,723,000 (GRCm39) |
intron |
probably benign |
|
|
R8135:Zmynd8
|
UTSW |
2 |
165,654,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8828:Zmynd8
|
UTSW |
2 |
165,654,466 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9128:Zmynd8
|
UTSW |
2 |
165,700,058 (GRCm39) |
start codon destroyed |
probably null |
|
|
R9200:Zmynd8
|
UTSW |
2 |
165,682,005 (GRCm39) |
missense |
probably benign |
|
|
R9345:Zmynd8
|
UTSW |
2 |
165,654,668 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9478:Zmynd8
|
UTSW |
2 |
165,649,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9626:Zmynd8
|
UTSW |
2 |
165,654,268 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9649:Zmynd8
|
UTSW |
2 |
165,680,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9759:Zmynd8
|
UTSW |
2 |
165,680,746 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
V7580:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
V7581:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
V7583:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Zmynd8
|
UTSW |
2 |
165,670,091 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Zmynd8
|
UTSW |
2 |
165,670,108 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGACAGTCTCCTTCGGTAAG -3'
(R):5'- AGGCATAATTCATAGCTGTTGC -3'
Sequencing Primer
(F):5'- AGTCTCCTTCGGTAAGAGCGG -3'
(R):5'- TCATAGCTGTTGCAGAGACC -3'
|
| Posted On |
2015-07-06 |
Incidental Mutation