Incidental Mutation 'R4381:Tstd2'
ID 325323
Institutional Source Beutler Lab
Gene Symbol Tstd2
Ensembl Gene ENSMUSG00000035495
Gene Name thiosulfate sulfurtransferase (rhodanese)-like domain containing 2
Synonyms
MMRRC Submission 041122-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.153) question?
Stock # R4381 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 46114746-46138694 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 46119933 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 340 (K340E)
Ref Sequence ENSEMBL: ENSMUSP00000103401 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107770] [ENSMUST00000107772] [ENSMUST00000107773]
AlphaFold Q3U269
Predicted Effect probably benign
Transcript: ENSMUST00000107770
AA Change: K340E

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000103399
Gene: ENSMUSG00000035495
AA Change: K340E

DomainStartEndE-ValueType
low complexity region 44 64 N/A INTRINSIC
RHOD 290 392 2.25e-11 SMART
Pfam:Rhodanese_C 396 459 2.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107772
AA Change: K340E

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000103401
Gene: ENSMUSG00000035495
AA Change: K340E

DomainStartEndE-ValueType
low complexity region 44 64 N/A INTRINSIC
RHOD 290 392 2.25e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000107773
SMART Domains Protein: ENSMUSP00000103402
Gene: ENSMUSG00000028328

DomainStartEndE-ValueType
Pfam:Tropomodulin 3 143 6.3e-64 PFAM
PDB:1IO0|A 160 344 1e-115 PDB
SCOP:d1a4ya_ 181 312 3e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157444
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160008
Meta Mutation Damage Score 0.0577 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency 95% (41/43)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk1 C T 3: 127,523,022 (GRCm39) V7M probably damaging Het
Dlgap2 A G 8: 14,896,502 (GRCm39) I993V probably benign Het
Dst T C 1: 34,202,316 (GRCm39) S215P probably damaging Het
Eml5 A G 12: 98,782,214 (GRCm39) I1359T possibly damaging Het
Eps15 G A 4: 109,223,727 (GRCm39) probably benign Het
Gpr158 T A 2: 21,832,403 (GRCm39) W1168R probably damaging Het
Ighv1-62-1 T A 12: 115,350,613 (GRCm39) H18L probably benign Het
Il18r1 A G 1: 40,510,950 (GRCm39) I12V probably benign Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Mib2 G C 4: 155,742,069 (GRCm39) A234G possibly damaging Het
Mtpap T C 18: 4,383,223 (GRCm39) F200S probably benign Het
Nacad T A 11: 6,550,204 (GRCm39) T996S probably benign Het
Nek9 T A 12: 85,376,632 (GRCm39) T250S probably damaging Het
Nif3l1 A C 1: 58,494,738 (GRCm39) probably benign Het
Nipbl A G 15: 8,388,690 (GRCm39) V310A probably benign Het
Or10al3 G T 17: 38,011,790 (GRCm39) E76D probably damaging Het
Or7g34 A G 9: 19,478,038 (GRCm39) L211P probably benign Het
Pbrm1 T C 14: 30,747,513 (GRCm39) V33A probably benign Het
Pcdha4 A G 18: 37,085,928 (GRCm39) E37G probably damaging Het
Pdgfc A G 3: 81,116,558 (GRCm39) K304R probably damaging Het
Peak1 G T 9: 56,165,711 (GRCm39) A739E probably benign Het
Pla2g4c A T 7: 13,079,990 (GRCm39) N433Y probably damaging Het
Polrmt A C 10: 79,577,642 (GRCm39) L319R possibly damaging Het
Prkaa1 A T 15: 5,206,289 (GRCm39) T373S probably benign Het
Qars1 G A 9: 108,387,382 (GRCm39) probably benign Het
Ranbp1 G A 16: 18,065,208 (GRCm39) L33F probably damaging Het
Rpgrip1 C T 14: 52,387,906 (GRCm39) P1094L possibly damaging Het
Taf1d T A 9: 15,223,277 (GRCm39) probably benign Het
Vmn2r45 A T 7: 8,474,912 (GRCm39) C705* probably null Het
Vrk3 C T 7: 44,424,866 (GRCm39) T427M probably benign Het
Zdhhc16 A G 19: 41,929,093 (GRCm39) Y232C possibly damaging Het
Zfp1 T A 8: 112,397,083 (GRCm39) L354Q probably damaging Het
Zyg11a G A 4: 108,058,517 (GRCm39) A341V possibly damaging Het
Other mutations in Tstd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00232:Tstd2 APN 4 46,120,002 (GRCm39) unclassified probably benign
IGL02832:Tstd2 APN 4 46,124,949 (GRCm39) missense probably damaging 1.00
curative UTSW 4 46,116,960 (GRCm39) missense probably damaging 1.00
R1991:Tstd2 UTSW 4 46,120,563 (GRCm39) missense probably benign 0.00
R2154:Tstd2 UTSW 4 46,129,235 (GRCm39) missense probably damaging 0.98
R4643:Tstd2 UTSW 4 46,129,297 (GRCm39) missense possibly damaging 0.92
R4961:Tstd2 UTSW 4 46,120,467 (GRCm39) missense probably damaging 1.00
R5282:Tstd2 UTSW 4 46,120,461 (GRCm39) missense probably damaging 1.00
R5396:Tstd2 UTSW 4 46,135,542 (GRCm39) missense probably benign 0.00
R7196:Tstd2 UTSW 4 46,119,955 (GRCm39) missense probably damaging 1.00
R7535:Tstd2 UTSW 4 46,116,960 (GRCm39) missense probably damaging 1.00
R7991:Tstd2 UTSW 4 46,133,646 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AACATAAATCCCTCGGCCGG -3'
(R):5'- CCAGCTCTTGAGGTTAAAGGGTG -3'

Sequencing Primer
(F):5'- CGGCTAGTGGTGAGCAGG -3'
(R):5'- CTCTTGAGGTTAAAGGGTGAGAGTG -3'
Posted On 2015-07-06