Incidental Mutation 'R4382:Scgb2b12'
ID 325372
Institutional Source Beutler Lab
Gene Symbol Scgb2b12
Ensembl Gene ENSMUSG00000097982
Gene Name secretoglobin, family 2B, member 12
Synonyms Gm9138, Abpbg12
MMRRC Submission 041679-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R4382 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 32024711-32026670 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 32024870 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 112 (E112D)
Ref Sequence ENSEMBL: ENSMUSP00000138687 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000183195]
AlphaFold S4R2L0
Predicted Effect probably benign
Transcript: ENSMUST00000183195
AA Change: E112D

PolyPhen 2 Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000138687
Gene: ENSMUSG00000097982
AA Change: E112D

DomainStartEndE-ValueType
low complexity region 3 12 N/A INTRINSIC
Pfam:Feld-I_B 24 90 2.1e-34 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm2 T A 4: 144,281,596 (GRCm39) T399S possibly damaging Het
Acp2 T C 2: 91,038,454 (GRCm39) S309P possibly damaging Het
Adam23 T C 1: 63,605,787 (GRCm39) Y624H probably damaging Het
B4galnt4 T C 7: 140,650,449 (GRCm39) V772A probably damaging Het
Boc A T 16: 44,311,545 (GRCm39) L726H probably damaging Het
Calr3 T A 8: 73,182,008 (GRCm39) D120V probably damaging Het
Ccdc92b G A 11: 74,520,842 (GRCm39) S48N probably damaging Het
Ceacam12 C T 7: 17,799,959 (GRCm39) probably benign Het
Clca3a1 T A 3: 144,466,483 (GRCm39) M1L probably benign Het
Cnot1 T C 8: 96,496,407 (GRCm39) T300A probably damaging Het
Col12a1 A T 9: 79,538,023 (GRCm39) Y2514* probably null Het
Col6a6 G A 9: 105,660,889 (GRCm39) R407W probably damaging Het
Csnk1g1 T C 9: 65,927,190 (GRCm39) V119A probably damaging Het
Cspg4b T C 13: 113,459,288 (GRCm39) I1273T probably benign Het
Ddx60 G A 8: 62,402,012 (GRCm39) probably null Het
Dnajb12 A T 10: 59,733,321 (GRCm39) K372N probably benign Het
Fhl5 A C 4: 25,200,118 (GRCm39) C239G probably benign Het
Gad2 G A 2: 22,575,422 (GRCm39) V509I probably benign Het
Glrb T A 3: 80,786,946 (GRCm39) R72S probably damaging Het
Gm6811 T C 17: 21,314,865 (GRCm39) noncoding transcript Het
Hecw1 C T 13: 14,490,749 (GRCm39) D748N probably damaging Het
Hk2 A T 6: 82,712,322 (GRCm39) L542Q probably null Het
Iglc1 A T 16: 18,880,508 (GRCm39) C104* probably null Het
Kel T A 6: 41,675,334 (GRCm39) T306S probably benign Het
Lpo T C 11: 87,713,027 (GRCm39) D25G probably benign Het
Mboat7 T A 7: 3,691,545 (GRCm39) Y109F possibly damaging Het
Myh15 T G 16: 48,963,306 (GRCm39) N1082K probably benign Het
Nagk A G 6: 83,774,993 (GRCm39) E90G probably benign Het
Nagpa A T 16: 5,021,819 (GRCm39) F10I possibly damaging Het
Or9a4 T A 6: 40,548,998 (GRCm39) L226H probably damaging Het
Otog T A 7: 45,939,122 (GRCm39) C2051S probably damaging Het
Ptpn6 A G 6: 124,704,361 (GRCm39) V315A possibly damaging Het
Rbp3 G C 14: 33,677,253 (GRCm39) E400D probably benign Het
Rnf41 T C 10: 128,272,392 (GRCm39) S140P probably benign Het
Ros1 C T 10: 51,997,055 (GRCm39) V1206I possibly damaging Het
Serpinb3b T A 1: 107,083,273 (GRCm39) M210L probably damaging Het
Sipa1l1 A G 12: 82,493,596 (GRCm39) R1672G possibly damaging Het
Smc5 A G 19: 23,246,210 (GRCm39) S70P probably benign Het
Spen C T 4: 141,200,450 (GRCm39) G2703S possibly damaging Het
Stard9 C G 2: 120,464,703 (GRCm39) A56G probably damaging Het
Wtap A G 17: 13,194,307 (GRCm39) S87P probably damaging Het
Zzef1 T G 11: 72,765,938 (GRCm39) S1488R probably benign Het
Other mutations in Scgb2b12
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4206:Scgb2b12 UTSW 7 32,026,063 (GRCm39) missense probably damaging 1.00
R4755:Scgb2b12 UTSW 7 32,024,956 (GRCm39) missense probably benign 0.03
R7157:Scgb2b12 UTSW 7 32,026,102 (GRCm39) missense probably benign 0.00
R7387:Scgb2b12 UTSW 7 32,026,060 (GRCm39) missense probably benign 0.02
R9256:Scgb2b12 UTSW 7 32,026,054 (GRCm39) missense probably damaging 1.00
R9289:Scgb2b12 UTSW 7 32,026,060 (GRCm39) missense probably benign 0.22
Predicted Primers PCR Primer
(F):5'- TGTTCAGCACATAGACACAGG -3'
(R):5'- GGGACCTGAATCACTGCATG -3'

Sequencing Primer
(F):5'- CACAGGTCACAGAACAGAGTTGC -3'
(R):5'- AATCACTGCATGGGATTTTCTTC -3'
Posted On 2015-07-06