Incidental Mutation 'R4397:Aig1'
ID 325543
Institutional Source Beutler Lab
Gene Symbol Aig1
Ensembl Gene ENSMUSG00000019806
Gene Name androgen-induced 1
Synonyms 1500031O19Rik, CGI-103
MMRRC Submission 041685-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4397 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 13522798-13744724 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 13528726 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 237 (S237A)
Ref Sequence ENSEMBL: ENSMUSP00000019942 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019942] [ENSMUST00000105534] [ENSMUST00000162610]
AlphaFold Q9D8B1
Predicted Effect probably benign
Transcript: ENSMUST00000019942
AA Change: S237A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000019942
Gene: ENSMUSG00000019806
AA Change: S237A

DomainStartEndE-ValueType
Pfam:Far-17a_AIG1 12 219 5.6e-77 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105534
SMART Domains Protein: ENSMUSP00000101174
Gene: ENSMUSG00000019806

DomainStartEndE-ValueType
Pfam:Far-17a_AIG1 12 178 3.4e-59 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162174
Predicted Effect probably benign
Transcript: ENSMUST00000162610
SMART Domains Protein: ENSMUSP00000125366
Gene: ENSMUSG00000019806

DomainStartEndE-ValueType
Pfam:Far-17a_AIG1 12 219 5.4e-74 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 96% (55/57)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg4 T G X: 55,977,703 (GRCm39) L2193V probably damaging Het
Agap2 G A 10: 126,926,352 (GRCm39) A866T unknown Het
Baz1b C T 5: 135,273,300 (GRCm39) R1475W probably damaging Het
Bmp1 C T 14: 70,727,982 (GRCm39) probably null Het
Crybg3 A G 16: 59,380,458 (GRCm39) probably benign Het
Dnajc15 T C 14: 78,112,234 (GRCm39) probably null Het
Fam135b T A 15: 71,320,525 (GRCm39) H1334L probably benign Het
Fancg A T 4: 43,008,897 (GRCm39) H113Q probably benign Het
Gfap G A 11: 102,787,810 (GRCm39) A45V probably benign Het
Gjd3 A T 11: 98,873,247 (GRCm39) L199Q probably damaging Het
Gvin-ps3 A G 7: 105,682,130 (GRCm39) noncoding transcript Het
H13 A G 2: 152,519,472 (GRCm39) D65G probably damaging Het
Hcls1 T C 16: 36,757,662 (GRCm39) V5A possibly damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Homer3 G A 8: 70,742,793 (GRCm39) probably null Het
Iqgap3 T C 3: 88,011,665 (GRCm39) Y817H probably damaging Het
Iqsec2 C T X: 150,992,049 (GRCm39) T562I probably damaging Het
Klb A G 5: 65,537,382 (GRCm39) Y904C probably damaging Het
Kremen1 A T 11: 5,149,610 (GRCm39) S354T probably benign Het
Lamc3 A G 2: 31,821,964 (GRCm39) E1304G probably benign Het
Lrp4 T C 2: 91,342,015 (GRCm39) V1876A probably benign Het
Magi3 T C 3: 104,127,030 (GRCm39) T85A probably damaging Het
Map3k12 C T 15: 102,409,694 (GRCm39) A694T probably benign Het
Mex3b T C 7: 82,519,031 (GRCm39) S449P possibly damaging Het
Naip6 C T 13: 100,437,108 (GRCm39) A472T probably benign Het
Nars2 T C 7: 96,622,771 (GRCm39) probably null Het
Nlrp1a T G 11: 70,988,030 (GRCm39) M1046L probably benign Het
Nphs1 T G 7: 30,181,390 (GRCm39) probably null Het
Nup133 G A 8: 124,671,040 (GRCm39) T119M probably benign Het
Or6c201 G T 10: 128,969,450 (GRCm39) N62K possibly damaging Het
Pcdhga9 A T 18: 37,871,694 (GRCm39) I508F probably damaging Het
Phactr3 A G 2: 177,817,199 (GRCm39) probably benign Het
Plcb3 T C 19: 6,943,193 (GRCm39) K155E probably damaging Het
Plxna2 C T 1: 194,431,625 (GRCm39) S538F probably damaging Het
Prss38 T C 11: 59,263,854 (GRCm39) Y286C probably damaging Het
Psg16 T C 7: 16,824,623 (GRCm39) S45P possibly damaging Het
Ptpn21 G T 12: 98,654,507 (GRCm39) P820Q probably damaging Het
Ptpn21 A G 12: 98,681,319 (GRCm39) V105A probably damaging Het
Rnf7 A G 9: 96,360,463 (GRCm39) M58T probably benign Het
Slc25a11 G A 11: 70,535,677 (GRCm39) A287V probably benign Het
Slit2 G T 5: 48,377,423 (GRCm39) probably null Het
Suco A G 1: 161,672,421 (GRCm39) Y460H probably damaging Het
Tnxb C T 17: 34,897,636 (GRCm39) Q804* probably null Het
Trpv6 A G 6: 41,602,172 (GRCm39) I379T possibly damaging Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Virma A G 4: 11,513,901 (GRCm39) E585G possibly damaging Het
Vmn2r79 A G 7: 86,651,099 (GRCm39) H166R possibly damaging Het
Vmn2r88 A T 14: 51,655,435 (GRCm39) D549V probably damaging Het
Other mutations in Aig1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02343:Aig1 APN 10 13,744,418 (GRCm39) missense probably damaging 0.99
IGL02715:Aig1 APN 10 13,744,360 (GRCm39) critical splice donor site probably null
R0697:Aig1 UTSW 10 13,705,069 (GRCm39) missense probably benign 0.01
R1699:Aig1 UTSW 10 13,744,366 (GRCm39) missense possibly damaging 0.85
R1761:Aig1 UTSW 10 13,566,328 (GRCm39) missense probably damaging 1.00
R3934:Aig1 UTSW 10 13,677,656 (GRCm39) missense probably damaging 1.00
R4736:Aig1 UTSW 10 13,677,674 (GRCm39) missense probably damaging 0.97
R4767:Aig1 UTSW 10 13,677,602 (GRCm39) missense probably damaging 1.00
R5081:Aig1 UTSW 10 13,677,644 (GRCm39) missense probably benign 0.01
R5907:Aig1 UTSW 10 13,677,528 (GRCm39) intron probably benign
R7944:Aig1 UTSW 10 13,744,417 (GRCm39) missense probably damaging 1.00
R9105:Aig1 UTSW 10 13,529,339 (GRCm39) missense probably benign 0.10
R9270:Aig1 UTSW 10 13,529,505 (GRCm39) splice site probably null
R9381:Aig1 UTSW 10 13,523,417 (GRCm39) missense probably benign 0.39
R9778:Aig1 UTSW 10 13,528,757 (GRCm39) critical splice acceptor site probably null
X0018:Aig1 UTSW 10 13,566,268 (GRCm39) nonsense probably null
Predicted Primers
Posted On 2015-07-06