Incidental Mutation 'R4398:Ythdc1'
ID 325581
Institutional Source Beutler Lab
Gene Symbol Ythdc1
Ensembl Gene ENSMUSG00000035851
Gene Name YTH domain containing 1
Synonyms A730098D12Rik
MMRRC Submission 041130-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.968) question?
Stock # R4398 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 86952080-86984518 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) G to T at 86983679 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000122491 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038384] [ENSMUST00000119339] [ENSMUST00000120498] [ENSMUST00000156363]
AlphaFold E9Q5K9
Predicted Effect unknown
Transcript: ENSMUST00000038384
AA Change: R708L
SMART Domains Protein: ENSMUSP00000039133
Gene: ENSMUSG00000035851
AA Change: R708L

DomainStartEndE-ValueType
SCOP:d1qbkb_ 225 249 6e-3 SMART
low complexity region 269 280 N/A INTRINSIC
low complexity region 316 330 N/A INTRINSIC
Pfam:YTH 356 494 5e-42 PFAM
low complexity region 516 540 N/A INTRINSIC
low complexity region 609 622 N/A INTRINSIC
low complexity region 625 645 N/A INTRINSIC
low complexity region 682 736 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000119339
AA Change: R682L
SMART Domains Protein: ENSMUSP00000113000
Gene: ENSMUSG00000035851
AA Change: R682L

DomainStartEndE-ValueType
SCOP:d1qbkb_ 225 249 6e-3 SMART
low complexity region 269 280 N/A INTRINSIC
Pfam:YTH 337 478 4.4e-44 PFAM
low complexity region 498 522 N/A INTRINSIC
low complexity region 583 596 N/A INTRINSIC
low complexity region 599 619 N/A INTRINSIC
low complexity region 656 710 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000120498
AA Change: R700L
SMART Domains Protein: ENSMUSP00000113951
Gene: ENSMUSG00000035851
AA Change: R700L

DomainStartEndE-ValueType
SCOP:d1qbkb_ 225 249 6e-3 SMART
low complexity region 269 280 N/A INTRINSIC
low complexity region 316 330 N/A INTRINSIC
Pfam:YTH 355 496 4.6e-44 PFAM
low complexity region 516 540 N/A INTRINSIC
low complexity region 601 614 N/A INTRINSIC
low complexity region 617 637 N/A INTRINSIC
low complexity region 674 728 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123625
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124123
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151489
Predicted Effect probably benign
Transcript: ENSMUST00000156363
SMART Domains Protein: ENSMUSP00000122491
Gene: ENSMUSG00000035851

DomainStartEndE-ValueType
SCOP:d1qbkb_ 237 261 8e-3 SMART
low complexity region 281 292 N/A INTRINSIC
Pfam:YTH 350 488 3e-42 PFAM
low complexity region 510 525 N/A INTRINSIC
Meta Mutation Damage Score 0.1509 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency 96% (53/55)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 C A 15: 94,231,576 (GRCm39) R871L possibly damaging Het
Adcy5 G A 16: 35,089,363 (GRCm39) C520Y probably damaging Het
AI661453 G A 17: 47,779,042 (GRCm39) probably benign Het
Bptf T C 11: 107,001,670 (GRCm39) K481E probably damaging Het
Cnot10 T A 9: 114,460,949 (GRCm39) K74* probably null Het
Ctc1 C T 11: 68,913,697 (GRCm39) P200S probably damaging Het
Dact1 T C 12: 71,363,959 (GRCm39) Y210H probably damaging Het
Dbn1 T C 13: 55,623,194 (GRCm39) T430A probably benign Het
Dmd A C X: 82,765,624 (GRCm39) T657P probably benign Het
Efnb2 C T 8: 8,670,832 (GRCm39) R256H possibly damaging Het
Eif4a1 T C 11: 69,560,070 (GRCm39) I116M possibly damaging Het
F730035P03Rik A T 7: 99,429,475 (GRCm39) noncoding transcript Het
Fbn1 C T 2: 125,239,701 (GRCm39) V329I probably benign Het
Gpr20 G A 15: 73,568,125 (GRCm39) T88I probably benign Het
Herc1 T G 9: 66,386,735 (GRCm39) V3783G probably benign Het
Khdc1a A G 1: 21,420,617 (GRCm39) D79G possibly damaging Het
Klk1b16 A T 7: 43,790,851 (GRCm39) I218F probably damaging Het
Malrd1 C T 2: 16,155,594 (GRCm39) T2001I unknown Het
Mia3 A G 1: 183,111,733 (GRCm39) S556P probably damaging Het
Myo3a T A 2: 22,467,854 (GRCm39) D369E probably benign Het
Nelfa T C 5: 34,058,623 (GRCm39) D279G possibly damaging Het
Ntrk3 A T 7: 77,900,517 (GRCm39) C607* probably null Het
Or13a20 T C 7: 140,232,741 (GRCm39) V283A possibly damaging Het
Pclo A T 5: 14,825,380 (GRCm39) Q1371L probably damaging Het
Pdzd2 A T 15: 12,376,061 (GRCm39) V1358E probably benign Het
Pgr T C 9: 8,903,750 (GRCm39) probably null Het
Prag1 A G 8: 36,570,809 (GRCm39) D464G probably damaging Het
Prickle4 A G 17: 48,001,456 (GRCm39) probably benign Het
Prim2 A G 1: 33,551,192 (GRCm39) Y309H probably damaging Het
Prkaa1 A G 15: 5,206,642 (GRCm39) Q464R possibly damaging Het
Rab36 G A 10: 74,880,328 (GRCm39) V63I probably damaging Het
Rint1 T A 5: 23,999,445 (GRCm39) I78K possibly damaging Het
Rnf130 T A 11: 49,962,205 (GRCm39) F217Y probably benign Het
Smad7 T C 18: 75,527,234 (GRCm39) V360A probably damaging Het
Sp110 A C 1: 85,505,050 (GRCm39) F434C probably benign Het
Stag1 A G 9: 100,838,659 (GRCm39) probably benign Het
Tlr12 T A 4: 128,509,988 (GRCm39) D754V probably benign Het
Tmf1 G A 6: 97,155,857 (GRCm39) P43L probably damaging Het
Togaram1 A G 12: 65,027,630 (GRCm39) N873S probably benign Het
Tsn C T 1: 118,238,799 (GRCm39) probably benign Het
Ubn1 A G 16: 4,882,289 (GRCm39) K250R probably damaging Het
Vmn1r25 A T 6: 57,955,812 (GRCm39) V159D probably damaging Het
Vmn2r89 T C 14: 51,689,551 (GRCm39) L18P probably damaging Het
Vps8 T G 16: 21,323,216 (GRCm39) N689K probably damaging Het
Zfp407 G A 18: 84,580,856 (GRCm39) Q86* probably null Het
Zfp521 C T 18: 13,979,601 (GRCm39) E271K probably benign Het
Other mutations in Ythdc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00676:Ythdc1 APN 5 86,979,670 (GRCm39) missense probably damaging 1.00
IGL02222:Ythdc1 APN 5 86,975,902 (GRCm39) missense possibly damaging 0.72
R0091:Ythdc1 UTSW 5 86,968,560 (GRCm39) intron probably benign
R0311:Ythdc1 UTSW 5 86,983,564 (GRCm39) missense probably damaging 0.97
R0349:Ythdc1 UTSW 5 86,983,579 (GRCm39) missense probably damaging 1.00
R0630:Ythdc1 UTSW 5 86,957,207 (GRCm39) splice site probably benign
R1662:Ythdc1 UTSW 5 86,975,981 (GRCm39) critical splice donor site probably null
R1907:Ythdc1 UTSW 5 86,978,489 (GRCm39) missense probably damaging 1.00
R2100:Ythdc1 UTSW 5 86,964,544 (GRCm39) missense possibly damaging 0.62
R2911:Ythdc1 UTSW 5 86,964,418 (GRCm39) missense possibly damaging 0.95
R3692:Ythdc1 UTSW 5 86,970,526 (GRCm39) missense probably damaging 0.98
R4042:Ythdc1 UTSW 5 86,964,383 (GRCm39) missense probably benign 0.03
R4398:Ythdc1 UTSW 5 86,963,513 (GRCm39) missense possibly damaging 0.95
R4608:Ythdc1 UTSW 5 86,970,667 (GRCm39) missense probably damaging 0.97
R4806:Ythdc1 UTSW 5 86,970,704 (GRCm39) missense probably damaging 0.99
R5291:Ythdc1 UTSW 5 86,983,547 (GRCm39) missense probably damaging 1.00
R5761:Ythdc1 UTSW 5 86,983,810 (GRCm39) utr 3 prime probably benign
R6180:Ythdc1 UTSW 5 86,975,953 (GRCm39) missense possibly damaging 0.91
R6249:Ythdc1 UTSW 5 86,979,815 (GRCm39) missense possibly damaging 0.94
R6560:Ythdc1 UTSW 5 86,964,467 (GRCm39) missense probably benign 0.06
R7145:Ythdc1 UTSW 5 86,964,467 (GRCm39) missense probably benign 0.06
R8072:Ythdc1 UTSW 5 86,969,133 (GRCm39) nonsense probably null
R8225:Ythdc1 UTSW 5 86,964,797 (GRCm39) missense possibly damaging 0.73
R8225:Ythdc1 UTSW 5 86,964,796 (GRCm39) missense possibly damaging 0.91
R8229:Ythdc1 UTSW 5 86,957,167 (GRCm39) intron probably benign
R8246:Ythdc1 UTSW 5 86,965,181 (GRCm39) missense possibly damaging 0.94
R8284:Ythdc1 UTSW 5 86,964,325 (GRCm39) missense probably benign 0.18
R8385:Ythdc1 UTSW 5 86,975,961 (GRCm39) missense possibly damaging 0.77
R8546:Ythdc1 UTSW 5 86,974,607 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- CTTTACCAGACAACTGATAAAAGGG -3'
(R):5'- TGAGCTTTAAGTCGACAGCTG -3'

Sequencing Primer
(F):5'- TCATATAAAGTTTTGCTTTGCTGATC -3'
(R):5'- CTTCAGTCAGTGCTTCCAA -3'
Posted On 2015-07-06