Incidental Mutation 'R4398:Or13a20'
ID 325586
Institutional Source Beutler Lab
Gene Symbol Or13a20
Ensembl Gene ENSMUSG00000094819
Gene Name olfactory receptor family 13 subfamily A member 20
Synonyms MOR253-5, GA_x6K02T2PBJ9-42798103-42799038, Olfr53, IE12
MMRRC Submission 041130-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R4398 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 140226365-140232832 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 140232741 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 283 (V283A)
Ref Sequence ENSEMBL: ENSMUSP00000081494 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084456] [ENSMUST00000211057] [ENSMUST00000211399]
AlphaFold Q8VGL8
Predicted Effect possibly damaging
Transcript: ENSMUST00000084456
AA Change: V283A

PolyPhen 2 Score 0.648 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000081494
Gene: ENSMUSG00000094819
AA Change: V283A

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.5e-51 PFAM
Pfam:7TM_GPCR_Srsx 37 208 9.7e-7 PFAM
Pfam:7tm_1 43 292 1.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211057
Predicted Effect probably benign
Transcript: ENSMUST00000211399
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency 96% (53/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 C A 15: 94,231,576 (GRCm39) R871L possibly damaging Het
Adcy5 G A 16: 35,089,363 (GRCm39) C520Y probably damaging Het
AI661453 G A 17: 47,779,042 (GRCm39) probably benign Het
Bptf T C 11: 107,001,670 (GRCm39) K481E probably damaging Het
Cnot10 T A 9: 114,460,949 (GRCm39) K74* probably null Het
Ctc1 C T 11: 68,913,697 (GRCm39) P200S probably damaging Het
Dact1 T C 12: 71,363,959 (GRCm39) Y210H probably damaging Het
Dbn1 T C 13: 55,623,194 (GRCm39) T430A probably benign Het
Dmd A C X: 82,765,624 (GRCm39) T657P probably benign Het
Efnb2 C T 8: 8,670,832 (GRCm39) R256H possibly damaging Het
Eif4a1 T C 11: 69,560,070 (GRCm39) I116M possibly damaging Het
F730035P03Rik A T 7: 99,429,475 (GRCm39) noncoding transcript Het
Fbn1 C T 2: 125,239,701 (GRCm39) V329I probably benign Het
Gpr20 G A 15: 73,568,125 (GRCm39) T88I probably benign Het
Herc1 T G 9: 66,386,735 (GRCm39) V3783G probably benign Het
Khdc1a A G 1: 21,420,617 (GRCm39) D79G possibly damaging Het
Klk1b16 A T 7: 43,790,851 (GRCm39) I218F probably damaging Het
Malrd1 C T 2: 16,155,594 (GRCm39) T2001I unknown Het
Mia3 A G 1: 183,111,733 (GRCm39) S556P probably damaging Het
Myo3a T A 2: 22,467,854 (GRCm39) D369E probably benign Het
Nelfa T C 5: 34,058,623 (GRCm39) D279G possibly damaging Het
Ntrk3 A T 7: 77,900,517 (GRCm39) C607* probably null Het
Pclo A T 5: 14,825,380 (GRCm39) Q1371L probably damaging Het
Pdzd2 A T 15: 12,376,061 (GRCm39) V1358E probably benign Het
Pgr T C 9: 8,903,750 (GRCm39) probably null Het
Prag1 A G 8: 36,570,809 (GRCm39) D464G probably damaging Het
Prickle4 A G 17: 48,001,456 (GRCm39) probably benign Het
Prim2 A G 1: 33,551,192 (GRCm39) Y309H probably damaging Het
Prkaa1 A G 15: 5,206,642 (GRCm39) Q464R possibly damaging Het
Rab36 G A 10: 74,880,328 (GRCm39) V63I probably damaging Het
Rint1 T A 5: 23,999,445 (GRCm39) I78K possibly damaging Het
Rnf130 T A 11: 49,962,205 (GRCm39) F217Y probably benign Het
Smad7 T C 18: 75,527,234 (GRCm39) V360A probably damaging Het
Sp110 A C 1: 85,505,050 (GRCm39) F434C probably benign Het
Stag1 A G 9: 100,838,659 (GRCm39) probably benign Het
Tlr12 T A 4: 128,509,988 (GRCm39) D754V probably benign Het
Tmf1 G A 6: 97,155,857 (GRCm39) P43L probably damaging Het
Togaram1 A G 12: 65,027,630 (GRCm39) N873S probably benign Het
Tsn C T 1: 118,238,799 (GRCm39) probably benign Het
Ubn1 A G 16: 4,882,289 (GRCm39) K250R probably damaging Het
Vmn1r25 A T 6: 57,955,812 (GRCm39) V159D probably damaging Het
Vmn2r89 T C 14: 51,689,551 (GRCm39) L18P probably damaging Het
Vps8 T G 16: 21,323,216 (GRCm39) N689K probably damaging Het
Ythdc1 T A 5: 86,963,513 (GRCm39) D30E possibly damaging Het
Ythdc1 G T 5: 86,983,679 (GRCm39) probably benign Het
Zfp407 G A 18: 84,580,856 (GRCm39) Q86* probably null Het
Zfp521 C T 18: 13,979,601 (GRCm39) E271K probably benign Het
Other mutations in Or13a20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01017:Or13a20 APN 7 140,232,389 (GRCm39) missense probably benign 0.00
IGL01071:Or13a20 APN 7 140,232,827 (GRCm39) missense possibly damaging 0.76
IGL02590:Or13a20 APN 7 140,232,305 (GRCm39) splice site probably null
IGL02694:Or13a20 APN 7 140,232,093 (GRCm39) missense probably damaging 0.99
R0071:Or13a20 UTSW 7 140,232,170 (GRCm39) missense probably benign 0.00
R0071:Or13a20 UTSW 7 140,232,170 (GRCm39) missense probably benign 0.00
R0089:Or13a20 UTSW 7 140,232,224 (GRCm39) missense probably damaging 0.99
R0586:Or13a20 UTSW 7 140,231,976 (GRCm39) missense probably benign 0.35
R1209:Or13a20 UTSW 7 140,231,927 (GRCm39) missense probably benign 0.03
R1491:Or13a20 UTSW 7 140,232,650 (GRCm39) missense probably damaging 1.00
R1781:Or13a20 UTSW 7 140,232,419 (GRCm39) missense probably damaging 0.99
R4060:Or13a20 UTSW 7 140,232,033 (GRCm39) missense probably damaging 1.00
R4231:Or13a20 UTSW 7 140,232,653 (GRCm39) missense probably damaging 1.00
R4236:Or13a20 UTSW 7 140,232,653 (GRCm39) missense probably damaging 1.00
R4299:Or13a20 UTSW 7 140,232,156 (GRCm39) missense probably benign 0.00
R4675:Or13a20 UTSW 7 140,232,074 (GRCm39) missense probably damaging 1.00
R4937:Or13a20 UTSW 7 140,232,534 (GRCm39) missense probably benign 0.00
R5854:Or13a20 UTSW 7 140,232,491 (GRCm39) missense probably benign 0.03
R6124:Or13a20 UTSW 7 140,232,507 (GRCm39) missense probably damaging 1.00
R7092:Or13a20 UTSW 7 140,232,150 (GRCm39) missense probably benign 0.16
R7167:Or13a20 UTSW 7 140,232,466 (GRCm39) nonsense probably null
R7846:Or13a20 UTSW 7 140,232,374 (GRCm39) missense probably damaging 0.96
R7896:Or13a20 UTSW 7 140,232,814 (GRCm39) missense probably benign 0.00
R8080:Or13a20 UTSW 7 140,232,387 (GRCm39) missense probably benign 0.05
R8847:Or13a20 UTSW 7 140,232,326 (GRCm39) missense possibly damaging 0.80
R8926:Or13a20 UTSW 7 140,232,113 (GRCm39) missense probably benign 0.03
R9391:Or13a20 UTSW 7 140,232,272 (GRCm39) missense probably damaging 0.99
R9414:Or13a20 UTSW 7 140,232,263 (GRCm39) missense probably damaging 0.96
R9484:Or13a20 UTSW 7 140,231,904 (GRCm39) missense probably benign 0.00
Z1177:Or13a20 UTSW 7 140,232,700 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- TGTCTTTCTGGGAGGCATCAAC -3'
(R):5'- ATGCTCCATGAAGCTGCTC -3'

Sequencing Primer
(F):5'- GGGAGGCATCAACTTCATGTTAACC -3'
(R):5'- CTCCATGAAGCTGCTCTTAGGAAAG -3'
Posted On 2015-07-06