Incidental Mutation 'R4398:Cnot10'
ID 325592
Institutional Source Beutler Lab
Gene Symbol Cnot10
Ensembl Gene ENSMUSG00000056167
Gene Name CCR4-NOT transcription complex, subunit 10
Synonyms 2600001P13Rik
MMRRC Submission 041130-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4398 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 114414946-114469252 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 114460949 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 74 (K74*)
Ref Sequence ENSEMBL: ENSMUSP00000148963 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070117] [ENSMUST00000213955] [ENSMUST00000215155] [ENSMUST00000216785] [ENSMUST00000217148]
AlphaFold Q8BH15
Predicted Effect probably null
Transcript: ENSMUST00000070117
AA Change: K74*
SMART Domains Protein: ENSMUSP00000064840
Gene: ENSMUSG00000056167
AA Change: K74*

DomainStartEndE-ValueType
Blast:TPR 27 60 2e-10 BLAST
coiled coil region 73 107 N/A INTRINSIC
TPR 110 143 4.32e1 SMART
low complexity region 182 198 N/A INTRINSIC
TPR 293 326 3.37e-2 SMART
TPR 355 388 6.75e1 SMART
low complexity region 496 508 N/A INTRINSIC
TPR 643 676 7.87e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213539
Predicted Effect probably null
Transcript: ENSMUST00000213955
AA Change: K74*
Predicted Effect probably null
Transcript: ENSMUST00000215155
AA Change: K74*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215701
Predicted Effect probably null
Transcript: ENSMUST00000216785
AA Change: K74*
Predicted Effect probably null
Transcript: ENSMUST00000217148
AA Change: K74*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217296
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency 96% (53/55)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 C A 15: 94,231,576 (GRCm39) R871L possibly damaging Het
Adcy5 G A 16: 35,089,363 (GRCm39) C520Y probably damaging Het
AI661453 G A 17: 47,779,042 (GRCm39) probably benign Het
Bptf T C 11: 107,001,670 (GRCm39) K481E probably damaging Het
Ctc1 C T 11: 68,913,697 (GRCm39) P200S probably damaging Het
Dact1 T C 12: 71,363,959 (GRCm39) Y210H probably damaging Het
Dbn1 T C 13: 55,623,194 (GRCm39) T430A probably benign Het
Dmd A C X: 82,765,624 (GRCm39) T657P probably benign Het
Efnb2 C T 8: 8,670,832 (GRCm39) R256H possibly damaging Het
Eif4a1 T C 11: 69,560,070 (GRCm39) I116M possibly damaging Het
F730035P03Rik A T 7: 99,429,475 (GRCm39) noncoding transcript Het
Fbn1 C T 2: 125,239,701 (GRCm39) V329I probably benign Het
Gpr20 G A 15: 73,568,125 (GRCm39) T88I probably benign Het
Herc1 T G 9: 66,386,735 (GRCm39) V3783G probably benign Het
Khdc1a A G 1: 21,420,617 (GRCm39) D79G possibly damaging Het
Klk1b16 A T 7: 43,790,851 (GRCm39) I218F probably damaging Het
Malrd1 C T 2: 16,155,594 (GRCm39) T2001I unknown Het
Mia3 A G 1: 183,111,733 (GRCm39) S556P probably damaging Het
Myo3a T A 2: 22,467,854 (GRCm39) D369E probably benign Het
Nelfa T C 5: 34,058,623 (GRCm39) D279G possibly damaging Het
Ntrk3 A T 7: 77,900,517 (GRCm39) C607* probably null Het
Or13a20 T C 7: 140,232,741 (GRCm39) V283A possibly damaging Het
Pclo A T 5: 14,825,380 (GRCm39) Q1371L probably damaging Het
Pdzd2 A T 15: 12,376,061 (GRCm39) V1358E probably benign Het
Pgr T C 9: 8,903,750 (GRCm39) probably null Het
Prag1 A G 8: 36,570,809 (GRCm39) D464G probably damaging Het
Prickle4 A G 17: 48,001,456 (GRCm39) probably benign Het
Prim2 A G 1: 33,551,192 (GRCm39) Y309H probably damaging Het
Prkaa1 A G 15: 5,206,642 (GRCm39) Q464R possibly damaging Het
Rab36 G A 10: 74,880,328 (GRCm39) V63I probably damaging Het
Rint1 T A 5: 23,999,445 (GRCm39) I78K possibly damaging Het
Rnf130 T A 11: 49,962,205 (GRCm39) F217Y probably benign Het
Smad7 T C 18: 75,527,234 (GRCm39) V360A probably damaging Het
Sp110 A C 1: 85,505,050 (GRCm39) F434C probably benign Het
Stag1 A G 9: 100,838,659 (GRCm39) probably benign Het
Tlr12 T A 4: 128,509,988 (GRCm39) D754V probably benign Het
Tmf1 G A 6: 97,155,857 (GRCm39) P43L probably damaging Het
Togaram1 A G 12: 65,027,630 (GRCm39) N873S probably benign Het
Tsn C T 1: 118,238,799 (GRCm39) probably benign Het
Ubn1 A G 16: 4,882,289 (GRCm39) K250R probably damaging Het
Vmn1r25 A T 6: 57,955,812 (GRCm39) V159D probably damaging Het
Vmn2r89 T C 14: 51,689,551 (GRCm39) L18P probably damaging Het
Vps8 T G 16: 21,323,216 (GRCm39) N689K probably damaging Het
Ythdc1 T A 5: 86,963,513 (GRCm39) D30E possibly damaging Het
Ythdc1 G T 5: 86,983,679 (GRCm39) probably benign Het
Zfp407 G A 18: 84,580,856 (GRCm39) Q86* probably null Het
Zfp521 C T 18: 13,979,601 (GRCm39) E271K probably benign Het
Other mutations in Cnot10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01313:Cnot10 APN 9 114,460,923 (GRCm39) missense probably benign 0.19
IGL02004:Cnot10 APN 9 114,451,998 (GRCm39) missense probably damaging 1.00
IGL03297:Cnot10 APN 9 114,427,784 (GRCm39) missense possibly damaging 0.87
BB003:Cnot10 UTSW 9 114,446,883 (GRCm39) missense probably damaging 1.00
BB013:Cnot10 UTSW 9 114,446,883 (GRCm39) missense probably damaging 1.00
R0348:Cnot10 UTSW 9 114,427,838 (GRCm39) missense probably benign 0.10
R0390:Cnot10 UTSW 9 114,458,218 (GRCm39) nonsense probably null
R1256:Cnot10 UTSW 9 114,439,749 (GRCm39) missense probably damaging 1.00
R1471:Cnot10 UTSW 9 114,420,619 (GRCm39) missense probably benign 0.00
R1607:Cnot10 UTSW 9 114,458,163 (GRCm39) nonsense probably null
R1721:Cnot10 UTSW 9 114,444,067 (GRCm39) missense probably benign
R1741:Cnot10 UTSW 9 114,426,892 (GRCm39) missense possibly damaging 0.87
R2116:Cnot10 UTSW 9 114,455,504 (GRCm39) missense probably damaging 1.00
R4073:Cnot10 UTSW 9 114,452,015 (GRCm39) missense possibly damaging 0.91
R4074:Cnot10 UTSW 9 114,452,015 (GRCm39) missense possibly damaging 0.91
R4075:Cnot10 UTSW 9 114,452,015 (GRCm39) missense possibly damaging 0.91
R4365:Cnot10 UTSW 9 114,460,949 (GRCm39) nonsense probably null
R4383:Cnot10 UTSW 9 114,460,949 (GRCm39) nonsense probably null
R4385:Cnot10 UTSW 9 114,460,949 (GRCm39) nonsense probably null
R4423:Cnot10 UTSW 9 114,446,988 (GRCm39) missense probably damaging 1.00
R4859:Cnot10 UTSW 9 114,456,532 (GRCm39) missense probably damaging 1.00
R4916:Cnot10 UTSW 9 114,458,202 (GRCm39) missense possibly damaging 0.72
R4927:Cnot10 UTSW 9 114,447,012 (GRCm39) missense probably damaging 1.00
R5153:Cnot10 UTSW 9 114,442,803 (GRCm39) missense probably damaging 1.00
R5677:Cnot10 UTSW 9 114,458,161 (GRCm39) missense probably damaging 1.00
R5702:Cnot10 UTSW 9 114,458,078 (GRCm39) missense probably damaging 0.98
R5790:Cnot10 UTSW 9 114,454,985 (GRCm39) splice site probably null
R6190:Cnot10 UTSW 9 114,461,791 (GRCm39) missense probably damaging 1.00
R6353:Cnot10 UTSW 9 114,426,614 (GRCm39) missense probably damaging 1.00
R6463:Cnot10 UTSW 9 114,454,970 (GRCm39) missense probably damaging 1.00
R6819:Cnot10 UTSW 9 114,444,123 (GRCm39) missense probably benign 0.10
R6849:Cnot10 UTSW 9 114,461,004 (GRCm39) missense probably benign 0.01
R6875:Cnot10 UTSW 9 114,444,175 (GRCm39) missense probably benign 0.00
R7071:Cnot10 UTSW 9 114,446,787 (GRCm39) splice site probably null
R7408:Cnot10 UTSW 9 114,460,894 (GRCm39) missense probably benign 0.33
R7412:Cnot10 UTSW 9 114,454,971 (GRCm39) missense probably damaging 1.00
R7645:Cnot10 UTSW 9 114,442,705 (GRCm39) missense probably benign
R7706:Cnot10 UTSW 9 114,422,506 (GRCm39) missense probably damaging 0.98
R7926:Cnot10 UTSW 9 114,446,883 (GRCm39) missense probably damaging 1.00
R8187:Cnot10 UTSW 9 114,426,556 (GRCm39) nonsense probably null
R8322:Cnot10 UTSW 9 114,456,537 (GRCm39) missense probably damaging 0.99
R8412:Cnot10 UTSW 9 114,439,738 (GRCm39) missense probably benign 0.11
R8904:Cnot10 UTSW 9 114,430,423 (GRCm39) missense probably benign 0.06
R9340:Cnot10 UTSW 9 114,460,897 (GRCm39) missense probably benign 0.01
R9691:Cnot10 UTSW 9 114,420,715 (GRCm39) missense probably damaging 1.00
X0062:Cnot10 UTSW 9 114,444,202 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- CACAGCAGGCAATTCACAGG -3'
(R):5'- GCTATACGTAGGGGACTTCTGC -3'

Sequencing Primer
(F):5'- AAGCTCCTGCGTTGGCTAGATC -3'
(R):5'- CGTAGGGGACTTCTGCTTTAAAAC -3'
Posted On 2015-07-06