Incidental Mutation 'R4364:Lcn10'
ID 325657
Institutional Source Beutler Lab
Gene Symbol Lcn10
Ensembl Gene ENSMUSG00000047356
Gene Name lipocalin 10
Synonyms 9230112J07Rik
MMRRC Submission 041672-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4364 (G1)
Quality Score 147
Status Validated
Chromosome 2
Chromosomal Location 25572738-25576093 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 25574052 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 85 (C85F)
Ref Sequence ENSEMBL: ENSMUSP00000059353 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058912] [ENSMUST00000059693] [ENSMUST00000114197] [ENSMUST00000114199]
AlphaFold Q810Z1
Predicted Effect probably damaging
Transcript: ENSMUST00000058912
AA Change: C85F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000059353
Gene: ENSMUSG00000047356
AA Change: C85F

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Lipocalin 36 169 1.6e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000059693
SMART Domains Protein: ENSMUSP00000055660
Gene: ENSMUSG00000045684

DomainStartEndE-ValueType
Pfam:Lipocalin 7 106 1.4e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114197
SMART Domains Protein: ENSMUSP00000109835
Gene: ENSMUSG00000045684

DomainStartEndE-ValueType
Pfam:Lipocalin 7 106 4.8e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114199
SMART Domains Protein: ENSMUSP00000109837
Gene: ENSMUSG00000045684

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:Lipocalin 33 172 2.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139441
Meta Mutation Damage Score 0.9122 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency 93% (40/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amn A C 12: 111,238,196 (GRCm39) N37H probably damaging Het
Apoa5 A T 9: 46,181,827 (GRCm39) D301V probably damaging Het
Atrn A G 2: 130,812,128 (GRCm39) E691G probably benign Het
Ccer1 CGAGGAGGAGGAGGAGGAGGA CGAGGAGGAGGAGGAGGA 10: 97,530,232 (GRCm39) probably benign Het
Cct2 A G 10: 116,891,056 (GRCm39) V396A probably damaging Het
Dhx35 C T 2: 158,684,272 (GRCm39) Q516* probably null Het
Dop1b A G 16: 93,567,812 (GRCm39) K1413R probably benign Het
Dpp9 T C 17: 56,494,391 (GRCm39) H856R possibly damaging Het
Eif4e2 T C 1: 87,152,093 (GRCm39) F97L probably benign Het
Exoc6b A T 6: 84,980,161 (GRCm39) probably benign Het
Fat1 T A 8: 45,405,999 (GRCm39) S917T probably benign Het
Frem1 A T 4: 82,831,488 (GRCm39) Y2043N probably damaging Het
Galnt14 A G 17: 73,819,154 (GRCm39) I312T probably damaging Het
Glipr1 T C 10: 111,821,542 (GRCm39) N220S possibly damaging Het
Grid1 A G 14: 34,667,989 (GRCm39) E172G probably benign Het
Hspa4l C A 3: 40,721,241 (GRCm39) probably null Het
Il1rl2 G T 1: 40,390,951 (GRCm39) R298L probably benign Het
Il7r T A 15: 9,513,014 (GRCm39) H165L probably damaging Het
Krt87 T G 15: 101,385,395 (GRCm39) M326L probably benign Het
Mideas C T 12: 84,203,245 (GRCm39) G886S probably benign Het
Nup205 C A 6: 35,168,962 (GRCm39) P397Q probably benign Het
Or4d10 A G 19: 12,051,861 (GRCm39) V45A probably benign Het
Or4f17-ps1 G A 2: 111,357,985 (GRCm39) V127M probably benign Het
Or8b12c A T 9: 37,715,486 (GRCm39) H93L probably benign Het
Prkce C T 17: 86,784,279 (GRCm39) T218I probably damaging Het
Rhbdl2 T A 4: 123,703,728 (GRCm39) M1K probably null Het
Ripor2 C T 13: 24,905,694 (GRCm39) P947S probably benign Het
Shoc1 T G 4: 59,082,294 (GRCm39) T445P possibly damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Sptbn5 A G 2: 119,899,136 (GRCm39) L428P probably damaging Het
Syne1 A G 10: 5,303,987 (GRCm39) V789A probably damaging Het
Taar8c C T 10: 23,977,477 (GRCm39) V112M probably benign Het
Tex10 T C 4: 48,468,774 (GRCm39) I51V probably benign Het
Ttll1 T A 15: 83,384,195 (GRCm39) Q144L probably damaging Het
Other mutations in Lcn10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02738:Lcn10 APN 2 25,574,032 (GRCm39) unclassified probably benign
R0030:Lcn10 UTSW 2 25,575,093 (GRCm39) missense probably damaging 1.00
R1832:Lcn10 UTSW 2 25,575,151 (GRCm39) missense probably damaging 1.00
R1931:Lcn10 UTSW 2 25,574,347 (GRCm39) missense probably damaging 1.00
R2890:Lcn10 UTSW 2 25,573,642 (GRCm39) missense probably damaging 1.00
R5511:Lcn10 UTSW 2 25,572,841 (GRCm39) missense probably benign 0.00
R6219:Lcn10 UTSW 2 25,573,587 (GRCm39) nonsense probably null
R8837:Lcn10 UTSW 2 25,575,298 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- TGAATCTCTCAGCTCTGGGC -3'
(R):5'- ATAGAGCCCTCACTGACCTC -3'

Sequencing Primer
(F):5'- GCCTTTGCCCAAATGAGAAGATTC -3'
(R):5'- TCACTTCCCAGGCCAGGTC -3'
Posted On 2015-07-06