Incidental Mutation 'R4366:Or6c210'
ID 325760
Institutional Source Beutler Lab
Gene Symbol Or6c210
Ensembl Gene ENSMUSG00000108114
Gene Name olfactory receptor family 6 subfamily C member 210
Synonyms GA_x6K02T2PULF-11338429-11339364, MOR114-7, Olfr800
MMRRC Submission 041114-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.202) question?
Stock # R4366 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129495677-129496612 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129496400 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 242 (M242L)
Ref Sequence ENSEMBL: ENSMUSP00000151047 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104903] [ENSMUST00000217094]
AlphaFold Q8VFH7
Predicted Effect probably benign
Transcript: ENSMUST00000104903
AA Change: M242L

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000100499
Gene: ENSMUSG00000108114
AA Change: M242L

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 7.3e-43 PFAM
Pfam:7tm_1 38 287 6.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217094
AA Change: M242L

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.7%
Validation Efficiency 95% (57/60)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf5 A C 17: 43,752,860 (GRCm39) T396P probably damaging Het
Apob A T 12: 8,066,083 (GRCm39) I4318F possibly damaging Het
Apol7c T G 15: 77,410,589 (GRCm39) D119A probably benign Het
App G T 16: 84,853,321 (GRCm39) D252E unknown Het
C4a T A 17: 35,033,885 (GRCm39) noncoding transcript Het
Cacna1b T C 2: 24,592,632 (GRCm39) Y515C probably damaging Het
Cacna1f G T X: 7,476,213 (GRCm39) A123S probably damaging Het
Cldn6 G C 17: 23,900,494 (GRCm39) A153P probably benign Het
Cmya5 T C 13: 93,228,464 (GRCm39) N2208S probably benign Het
Csnk1g1 A G 9: 65,927,135 (GRCm39) T101A probably benign Het
Ddx46 T A 13: 55,811,049 (GRCm39) D544E probably benign Het
Dmxl1 T A 18: 50,011,084 (GRCm39) C1080* probably null Het
Dst T C 1: 34,290,959 (GRCm39) S3335P probably damaging Het
Efnb3 T C 11: 69,446,771 (GRCm39) K313R probably damaging Het
Elf2 G A 3: 51,215,570 (GRCm39) Q47* probably null Het
Epc2 A G 2: 49,437,566 (GRCm39) K657E possibly damaging Het
Ephx4 A G 5: 107,551,679 (GRCm39) probably benign Het
Ereg T C 5: 91,234,659 (GRCm39) I24T probably benign Het
Evc2 C A 5: 37,496,013 (GRCm39) A41D possibly damaging Het
Fkbp15 A G 4: 62,254,651 (GRCm39) V283A probably benign Het
Flrt3 T C 2: 140,502,327 (GRCm39) T434A probably damaging Het
Gm572 A G 4: 148,739,322 (GRCm39) D50G possibly damaging Het
Hecw1 C T 13: 14,490,749 (GRCm39) D748N probably damaging Het
Hivep3 A C 4: 119,953,286 (GRCm39) H534P possibly damaging Het
Hspa4l C A 3: 40,721,241 (GRCm39) probably null Het
Ipo7 T C 7: 109,628,919 (GRCm39) M63T possibly damaging Het
Ipo7 A T 7: 109,647,423 (GRCm39) T614S possibly damaging Het
Krt87 T G 15: 101,385,395 (GRCm39) M326L probably benign Het
Mbd5 T A 2: 49,162,978 (GRCm39) N261K probably damaging Het
Mcam T A 9: 44,045,994 (GRCm39) L3Q probably damaging Het
Mcoln3 C A 3: 145,846,247 (GRCm39) T519K possibly damaging Het
Mideas C T 12: 84,203,245 (GRCm39) G886S probably benign Het
Mrgprx1 C A 7: 47,670,941 (GRCm39) A269S probably damaging Het
Mypn T C 10: 63,028,487 (GRCm39) E192G probably benign Het
Nup205 C A 6: 35,168,962 (GRCm39) P397Q probably benign Het
Obsl1 A C 1: 75,464,693 (GRCm39) L1576R possibly damaging Het
Ofcc1 A G 13: 40,168,937 (GRCm39) S817P probably benign Het
Or8b12c A T 9: 37,715,486 (GRCm39) H93L probably benign Het
Pcdhgb7 A G 18: 37,887,125 (GRCm39) Y765C possibly damaging Het
Pde7a A G 3: 19,365,026 (GRCm39) probably null Het
Phip C T 9: 82,782,922 (GRCm39) probably benign Het
Rhbdl2 T A 4: 123,703,728 (GRCm39) M1K probably null Het
Ripor2 C T 13: 24,905,694 (GRCm39) P947S probably benign Het
Sf3a3 A G 4: 124,618,932 (GRCm39) T298A probably benign Het
Slc25a29 C T 12: 108,797,097 (GRCm39) probably benign Het
Spinkl T G 18: 44,307,650 (GRCm39) T4P possibly damaging Het
Stk33 G A 7: 108,879,002 (GRCm39) S449L probably benign Het
Suz12 T A 11: 79,892,988 (GRCm39) probably benign Het
Timp2 T A 11: 118,201,497 (GRCm39) I124F probably damaging Het
Tlr1 C T 5: 65,083,180 (GRCm39) D466N probably benign Het
Tmem200b A G 4: 131,649,781 (GRCm39) I234V possibly damaging Het
Ubr1 C A 2: 120,801,084 (GRCm39) probably benign Het
Usp33 C A 3: 152,074,149 (GRCm39) Q332K probably benign Het
Zfr A G 15: 12,156,416 (GRCm39) E634G probably damaging Het
Other mutations in Or6c210
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01322:Or6c210 APN 10 129,495,995 (GRCm39) missense probably benign 0.26
IGL01915:Or6c210 APN 10 129,496,519 (GRCm39) missense probably benign 0.05
IGL02458:Or6c210 APN 10 129,496,475 (GRCm39) missense probably benign 0.38
IGL02721:Or6c210 APN 10 129,495,824 (GRCm39) missense probably benign
R0032:Or6c210 UTSW 10 129,496,269 (GRCm39) missense probably benign 0.05
R0442:Or6c210 UTSW 10 129,495,693 (GRCm39) missense probably benign 0.00
R1564:Or6c210 UTSW 10 129,495,884 (GRCm39) missense probably benign 0.22
R1580:Or6c210 UTSW 10 129,496,184 (GRCm39) missense probably benign 0.10
R1593:Or6c210 UTSW 10 129,496,094 (GRCm39) nonsense probably null
R1911:Or6c210 UTSW 10 129,495,981 (GRCm39) missense probably benign 0.07
R2001:Or6c210 UTSW 10 129,496,290 (GRCm39) missense probably benign 0.02
R2223:Or6c210 UTSW 10 129,495,678 (GRCm39) start codon destroyed probably null 1.00
R3876:Or6c210 UTSW 10 129,496,143 (GRCm39) missense probably benign 0.39
R3884:Or6c210 UTSW 10 129,496,407 (GRCm39) missense probably damaging 1.00
R4689:Or6c210 UTSW 10 129,496,185 (GRCm39) missense probably benign 0.01
R4909:Or6c210 UTSW 10 129,496,589 (GRCm39) missense probably benign 0.01
R5638:Or6c210 UTSW 10 129,495,969 (GRCm39) missense possibly damaging 0.80
R5835:Or6c210 UTSW 10 129,495,803 (GRCm39) missense probably benign 0.39
R5838:Or6c210 UTSW 10 129,495,907 (GRCm39) missense probably benign 0.41
R6150:Or6c210 UTSW 10 129,495,803 (GRCm39) missense probably benign 0.39
R6248:Or6c210 UTSW 10 129,496,532 (GRCm39) missense probably benign 0.39
R8094:Or6c210 UTSW 10 129,495,933 (GRCm39) missense probably damaging 0.99
R9013:Or6c210 UTSW 10 129,495,702 (GRCm39) missense probably damaging 1.00
R9224:Or6c210 UTSW 10 129,496,007 (GRCm39) missense probably damaging 1.00
R9390:Or6c210 UTSW 10 129,495,938 (GRCm39) missense probably benign 0.01
R9726:Or6c210 UTSW 10 129,495,920 (GRCm39) missense possibly damaging 0.67
R9777:Or6c210 UTSW 10 129,495,705 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- CTCAAGCTGGAATTCTGTGACTC -3'
(R):5'- TTGAAGGCCTGCTTGACTTG -3'

Sequencing Primer
(F):5'- GACCATTTTGTCTGTGATGCAAACC -3'
(R):5'- GCTTGACTTGTTTGTTCCTCAATG -3'
Posted On 2015-07-06