Incidental Mutation 'R4369:Trgv4'
ID 325914
Institutional Source Beutler Lab
Gene Symbol Trgv4
Ensembl Gene ENSMUSG00000076745
Gene Name T cell receptor gamma, variable 4
Synonyms Tcrg-V4
MMRRC Submission 041116-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R4369 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 19369151-19369676 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19369567 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 104 (Y104H)
Ref Sequence ENSEMBL: ENSMUSP00000100335 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103554] [ENSMUST00000103555] [ENSMUST00000198330]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000103554
AA Change: Y104H

PolyPhen 2 Score 0.056 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000100335
Gene: ENSMUSG00000076745
AA Change: Y104H

DomainStartEndE-ValueType
IGv 57 137 5.79e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103555
SMART Domains Protein: ENSMUSP00000100336
Gene: ENSMUSG00000076746

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IG 40 134 2.94e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197661
Predicted Effect probably benign
Transcript: ENSMUST00000198330
SMART Domains Protein: ENSMUSP00000142811
Gene: ENSMUSG00000076746

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IG 27 121 1.2e-3 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730596B20Rik A T 6: 52,156,042 (GRCm39) probably benign Het
A730018C14Rik T C 12: 112,382,048 (GRCm39) noncoding transcript Het
Abcc1 T G 16: 14,278,857 (GRCm39) S1056A possibly damaging Het
Akr1c19 A T 13: 4,283,779 (GRCm39) K4* probably null Het
Amph T A 13: 19,321,870 (GRCm39) S516R probably benign Het
Apoh T C 11: 108,288,205 (GRCm39) F108L probably damaging Het
Arg2 T C 12: 79,196,746 (GRCm39) S156P probably damaging Het
AU018091 A T 7: 3,207,815 (GRCm39) L582* probably null Het
Bckdk C T 7: 127,505,591 (GRCm39) A238V probably benign Het
Bean1 T A 8: 104,943,742 (GRCm39) V275D probably damaging Het
Brpf3 C T 17: 29,055,594 (GRCm39) A1181V probably damaging Het
Cfb T C 17: 35,079,290 (GRCm39) K287R probably damaging Het
Cpd T C 11: 76,688,537 (GRCm39) N912D possibly damaging Het
Cyp4f14 T C 17: 33,128,232 (GRCm39) N261S probably benign Het
Dennd3 T C 15: 73,412,658 (GRCm39) I440T probably damaging Het
Dhx38 C T 8: 110,279,763 (GRCm39) V976I probably damaging Het
Dpep2 T G 8: 106,711,707 (GRCm39) L573F probably benign Het
Ebag9 T C 15: 44,491,865 (GRCm39) S86P probably benign Het
Epha1 T C 6: 42,342,391 (GRCm39) Y319C probably damaging Het
Eps8l3 T C 3: 107,798,330 (GRCm39) Y466H possibly damaging Het
Ercc6 A G 14: 32,239,164 (GRCm39) E84G probably damaging Het
Ffar1 A G 7: 30,560,033 (GRCm39) I288T probably benign Het
Flnb C T 14: 7,942,216 (GRCm38) T2398I probably benign Het
Galnt15 T C 14: 31,751,496 (GRCm39) F16S possibly damaging Het
Golgb1 A G 16: 36,737,269 (GRCm39) E2172G probably damaging Het
Lhx4 T A 1: 155,580,560 (GRCm39) H161L probably benign Het
Lrp1 T C 10: 127,386,155 (GRCm39) N3457S possibly damaging Het
Map7d1 A T 4: 126,128,866 (GRCm39) S436T probably damaging Het
Nmral1 T C 16: 4,532,394 (GRCm39) Y139C probably damaging Het
Noc2l A G 4: 156,321,853 (GRCm39) D84G possibly damaging Het
Or2a25 T A 6: 42,889,211 (GRCm39) Y251* probably null Het
Or5p79 C T 7: 108,221,096 (GRCm39) L26F probably benign Het
Osbpl11 T C 16: 33,045,018 (GRCm39) S386P probably damaging Het
Papss2 A G 19: 32,618,791 (GRCm39) H283R probably damaging Het
Pcdha11 T C 18: 37,139,796 (GRCm39) V475A possibly damaging Het
Pglyrp3 T C 3: 91,935,386 (GRCm39) I212T probably damaging Het
Pkhd1l1 C T 15: 44,368,949 (GRCm39) R865W probably benign Het
Prdm9 T C 17: 15,764,708 (GRCm39) T691A probably benign Het
Rnf121 T C 7: 101,673,313 (GRCm39) D206G probably benign Het
Rnf122 T A 8: 31,602,177 (GRCm39) M1K probably null Het
Shank2 T C 7: 143,733,518 (GRCm39) S22P probably damaging Het
Smg6 C T 11: 74,823,269 (GRCm39) R175* probably null Het
Speer3 C G 5: 13,846,394 (GRCm39) A238G possibly damaging Het
Thsd7a C T 6: 12,468,907 (GRCm39) C557Y probably damaging Het
Tiam2 A G 17: 3,464,242 (GRCm39) probably benign Het
Ttn C T 2: 76,594,345 (GRCm39) W18788* probably null Het
Vmn2r82 A T 10: 79,231,914 (GRCm39) I638F probably benign Het
Zswim6 A G 13: 107,863,229 (GRCm39) noncoding transcript Het
Other mutations in Trgv4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01569:Trgv4 APN 13 19,369,678 (GRCm39) unclassified probably benign
IGL02821:Trgv4 APN 13 19,369,422 (GRCm39) missense possibly damaging 0.60
IGL03269:Trgv4 APN 13 19,369,622 (GRCm39) missense probably damaging 1.00
R0102:Trgv4 UTSW 13 19,369,370 (GRCm39) missense possibly damaging 0.74
R0104:Trgv4 UTSW 13 19,369,480 (GRCm39) missense probably damaging 1.00
R4856:Trgv4 UTSW 13 19,369,236 (GRCm39) missense probably benign 0.01
R4886:Trgv4 UTSW 13 19,369,236 (GRCm39) missense probably benign 0.01
R6575:Trgv4 UTSW 13 19,369,250 (GRCm39) missense probably benign 0.03
R8894:Trgv4 UTSW 13 19,369,627 (GRCm39) missense probably damaging 1.00
R9031:Trgv4 UTSW 13 19,369,169 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TTGCAGTTGGACATGGGAAG -3'
(R):5'- TGCCCAAGCTAAGAAGGATG -3'

Sequencing Primer
(F):5'- AAGTTGGAGCAACCTGAAATATC -3'
(R):5'- GCCGTAGGAACAGTAGTA -3'
Posted On 2015-07-06