Incidental Mutation 'R4373:Or4c122'
ID 326045
Institutional Source Beutler Lab
Gene Symbol Or4c122
Ensembl Gene ENSMUSG00000099486
Gene Name olfactory receptor family 4 subfamily C member 122
Synonyms GA_x6K02T2Q125-50696209-50695274, Olfr1228, MOR233-1
MMRRC Submission 041675-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R4373 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89079065-89080036 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 89079589 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 150 (R150G)
Ref Sequence ENSEMBL: ENSMUSP00000139920 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000190757] [ENSMUST00000215447] [ENSMUST00000216392]
AlphaFold Q8VGM9
Predicted Effect possibly damaging
Transcript: ENSMUST00000190757
AA Change: R150G

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000139920
Gene: ENSMUSG00000099486
AA Change: R150G

DomainStartEndE-ValueType
Pfam:7tm_1 51 298 2.6e-27 PFAM
Pfam:7tm_4 150 292 2.9e-38 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215447
AA Change: R138G

PolyPhen 2 Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216392
AA Change: R138G

PolyPhen 2 Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
Meta Mutation Damage Score 0.3556 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck5 A G 15: 76,478,535 (GRCm39) probably benign Het
Akr1b1 A C 6: 34,281,202 (GRCm39) probably benign Het
Armh4 T A 14: 50,007,893 (GRCm39) T527S probably damaging Het
Asns A T 6: 7,677,978 (GRCm39) S367T probably damaging Het
BC034090 T C 1: 155,101,904 (GRCm39) N120S probably benign Het
Bub1 A T 2: 127,647,156 (GRCm39) probably benign Het
Csf1 T A 3: 107,664,055 (GRCm39) T38S probably damaging Het
Ctsz T C 2: 174,270,378 (GRCm39) E268G possibly damaging Het
Dach1 G A 14: 98,065,186 (GRCm39) T685I possibly damaging Het
Dclre1a A G 19: 56,533,874 (GRCm39) L240S probably benign Het
Ercc1 G A 7: 19,081,057 (GRCm39) probably benign Het
Esam C T 9: 37,445,492 (GRCm39) T71I probably benign Het
Espl1 A G 15: 102,221,424 (GRCm39) I944V probably damaging Het
Gde1 A G 7: 118,297,781 (GRCm39) L35P possibly damaging Het
Gm10382 A G 5: 125,466,647 (GRCm39) probably benign Het
H2-M10.6 T C 17: 37,123,958 (GRCm39) Y141H probably damaging Het
Hk1 C A 10: 62,151,319 (GRCm39) K10N probably damaging Het
Lamc3 A G 2: 31,788,244 (GRCm39) K135E probably damaging Het
Lrtm2 A G 6: 119,297,489 (GRCm39) F184S probably damaging Het
Marchf11 A G 15: 26,309,532 (GRCm39) E62G probably damaging Het
Mtcl1 T A 17: 66,687,074 (GRCm39) T611S probably benign Het
Myc A T 15: 61,861,513 (GRCm39) H373L probably damaging Het
Myh6 T A 14: 55,199,565 (GRCm39) I249F probably damaging Het
Naaa T C 5: 92,426,002 (GRCm39) probably benign Het
Nfib A G 4: 82,241,895 (GRCm39) V432A probably damaging Het
Nmt1 A G 11: 102,934,026 (GRCm39) K55R probably damaging Het
Opa3 C T 7: 18,978,699 (GRCm39) R55W probably damaging Het
Pfn4 T A 12: 4,820,182 (GRCm39) D10E probably damaging Het
Pld5 T A 1: 175,967,583 (GRCm39) I91F probably damaging Het
Plec A C 15: 76,067,317 (GRCm39) S1350A probably damaging Het
Polq G T 16: 36,833,543 (GRCm39) V79F probably damaging Het
Ppp1r16b T C 2: 158,603,685 (GRCm39) Y537H probably damaging Het
Prdm8 T C 5: 98,334,367 (GRCm39) S645P probably damaging Het
Rgs1 T C 1: 144,123,644 (GRCm39) T94A probably benign Het
Rpl11 G A 4: 135,778,454 (GRCm39) probably benign Het
Sanbr A T 11: 23,565,265 (GRCm39) probably null Het
Scamp3 G A 3: 89,089,234 (GRCm39) probably null Het
Sgsm1 TTTTATATT TTT 5: 113,405,989 (GRCm39) probably benign Het
Sirpb1b A T 3: 15,613,821 (GRCm39) I87K probably damaging Het
Slc14a2 G A 18: 78,250,283 (GRCm39) R62C probably damaging Het
Stat4 T C 1: 52,111,100 (GRCm39) probably null Het
Tex9 A T 9: 72,387,877 (GRCm39) probably null Het
Tsku T C 7: 98,002,038 (GRCm39) T98A probably benign Het
Ttc23l CT CTTGGATT 15: 10,537,648 (GRCm39) probably benign Het
Ttc23l G A 15: 10,537,652 (GRCm39) S206L probably benign Het
Vmn2r116 A C 17: 23,620,395 (GRCm39) I710L probably benign Het
Vmn2r16 A T 5: 109,511,667 (GRCm39) I625F probably damaging Het
Xpo4 G A 14: 57,828,479 (GRCm39) Q794* probably null Het
Zfp112 T A 7: 23,824,473 (GRCm39) I147N probably damaging Het
Zmiz1 T C 14: 25,636,434 (GRCm39) S140P probably damaging Het
Other mutations in Or4c122
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01804:Or4c122 APN 2 89,079,566 (GRCm39) missense probably benign 0.00
IGL02588:Or4c122 APN 2 89,080,042 (GRCm39) splice site probably benign
R0384:Or4c122 UTSW 2 89,079,414 (GRCm39) missense possibly damaging 0.82
R0600:Or4c122 UTSW 2 89,079,742 (GRCm39) nonsense probably null
R0613:Or4c122 UTSW 2 89,079,469 (GRCm39) missense probably damaging 1.00
R1564:Or4c122 UTSW 2 89,080,016 (GRCm39) missense probably benign 0.00
R2115:Or4c122 UTSW 2 89,079,874 (GRCm39) missense probably damaging 1.00
R2313:Or4c122 UTSW 2 89,079,285 (GRCm39) missense probably damaging 1.00
R3083:Or4c122 UTSW 2 89,079,345 (GRCm39) missense probably damaging 0.96
R3790:Or4c122 UTSW 2 89,079,337 (GRCm39) missense probably benign 0.02
R3948:Or4c122 UTSW 2 89,079,336 (GRCm39) missense possibly damaging 0.95
R4376:Or4c122 UTSW 2 89,079,589 (GRCm39) missense possibly damaging 0.90
R4825:Or4c122 UTSW 2 89,079,034 (GRCm39) splice site probably null
R5022:Or4c122 UTSW 2 89,079,761 (GRCm39) missense probably benign 0.00
R5141:Or4c122 UTSW 2 89,079,473 (GRCm39) nonsense probably null
R5313:Or4c122 UTSW 2 89,079,721 (GRCm39) missense probably benign 0.05
R6010:Or4c122 UTSW 2 89,079,087 (GRCm39) missense probably benign 0.00
R7354:Or4c122 UTSW 2 89,079,031 (GRCm39) splice site probably null
R7548:Or4c122 UTSW 2 89,079,430 (GRCm39) missense probably benign 0.09
R8014:Or4c122 UTSW 2 89,079,343 (GRCm39) missense probably damaging 0.98
R8098:Or4c122 UTSW 2 89,079,652 (GRCm39) missense possibly damaging 0.95
R8280:Or4c122 UTSW 2 89,079,234 (GRCm39) missense probably damaging 0.98
R8554:Or4c122 UTSW 2 89,079,595 (GRCm39) missense possibly damaging 0.48
R8678:Or4c122 UTSW 2 89,079,351 (GRCm39) missense probably damaging 1.00
R8725:Or4c122 UTSW 2 89,079,658 (GRCm39) missense probably benign 0.00
R9039:Or4c122 UTSW 2 89,079,545 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GATGCTGATAGACCCACTGTTAG -3'
(R):5'- CCACTGTCACCCCTAAGATG -3'

Sequencing Primer
(F):5'- TGCTGATAGACCCACTGTTAGAAAAC -3'
(R):5'- CTGTCACCCCTAAGATGATGGTAG -3'
Posted On 2015-07-06