Incidental Mutation 'R4373:Vmn2r16'
ID 326056
Institutional Source Beutler Lab
Gene Symbol Vmn2r16
Ensembl Gene ENSMUSG00000092080
Gene Name vomeronasal 2, receptor 16
Synonyms EG384220
MMRRC Submission 041675-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.154) question?
Stock # R4373 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 109478247-109512347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 109511667 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 625 (I625F)
Ref Sequence ENSEMBL: ENSMUSP00000127838 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165180]
AlphaFold A0A3B2WCY4
Predicted Effect probably damaging
Transcript: ENSMUST00000165180
AA Change: I625F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: I625F

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 76 425 2.3e-28 PFAM
Pfam:NCD3G 509 563 8.2e-19 PFAM
Pfam:7tm_3 596 831 3.5e-56 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck5 A G 15: 76,478,535 (GRCm39) probably benign Het
Akr1b1 A C 6: 34,281,202 (GRCm39) probably benign Het
Armh4 T A 14: 50,007,893 (GRCm39) T527S probably damaging Het
Asns A T 6: 7,677,978 (GRCm39) S367T probably damaging Het
BC034090 T C 1: 155,101,904 (GRCm39) N120S probably benign Het
Bub1 A T 2: 127,647,156 (GRCm39) probably benign Het
Csf1 T A 3: 107,664,055 (GRCm39) T38S probably damaging Het
Ctsz T C 2: 174,270,378 (GRCm39) E268G possibly damaging Het
Dach1 G A 14: 98,065,186 (GRCm39) T685I possibly damaging Het
Dclre1a A G 19: 56,533,874 (GRCm39) L240S probably benign Het
Ercc1 G A 7: 19,081,057 (GRCm39) probably benign Het
Esam C T 9: 37,445,492 (GRCm39) T71I probably benign Het
Espl1 A G 15: 102,221,424 (GRCm39) I944V probably damaging Het
Gde1 A G 7: 118,297,781 (GRCm39) L35P possibly damaging Het
Gm10382 A G 5: 125,466,647 (GRCm39) probably benign Het
H2-M10.6 T C 17: 37,123,958 (GRCm39) Y141H probably damaging Het
Hk1 C A 10: 62,151,319 (GRCm39) K10N probably damaging Het
Lamc3 A G 2: 31,788,244 (GRCm39) K135E probably damaging Het
Lrtm2 A G 6: 119,297,489 (GRCm39) F184S probably damaging Het
Marchf11 A G 15: 26,309,532 (GRCm39) E62G probably damaging Het
Mtcl1 T A 17: 66,687,074 (GRCm39) T611S probably benign Het
Myc A T 15: 61,861,513 (GRCm39) H373L probably damaging Het
Myh6 T A 14: 55,199,565 (GRCm39) I249F probably damaging Het
Naaa T C 5: 92,426,002 (GRCm39) probably benign Het
Nfib A G 4: 82,241,895 (GRCm39) V432A probably damaging Het
Nmt1 A G 11: 102,934,026 (GRCm39) K55R probably damaging Het
Opa3 C T 7: 18,978,699 (GRCm39) R55W probably damaging Het
Or4c122 T C 2: 89,079,589 (GRCm39) R150G possibly damaging Het
Pfn4 T A 12: 4,820,182 (GRCm39) D10E probably damaging Het
Pld5 T A 1: 175,967,583 (GRCm39) I91F probably damaging Het
Plec A C 15: 76,067,317 (GRCm39) S1350A probably damaging Het
Polq G T 16: 36,833,543 (GRCm39) V79F probably damaging Het
Ppp1r16b T C 2: 158,603,685 (GRCm39) Y537H probably damaging Het
Prdm8 T C 5: 98,334,367 (GRCm39) S645P probably damaging Het
Rgs1 T C 1: 144,123,644 (GRCm39) T94A probably benign Het
Rpl11 G A 4: 135,778,454 (GRCm39) probably benign Het
Sanbr A T 11: 23,565,265 (GRCm39) probably null Het
Scamp3 G A 3: 89,089,234 (GRCm39) probably null Het
Sgsm1 TTTTATATT TTT 5: 113,405,989 (GRCm39) probably benign Het
Sirpb1b A T 3: 15,613,821 (GRCm39) I87K probably damaging Het
Slc14a2 G A 18: 78,250,283 (GRCm39) R62C probably damaging Het
Stat4 T C 1: 52,111,100 (GRCm39) probably null Het
Tex9 A T 9: 72,387,877 (GRCm39) probably null Het
Tsku T C 7: 98,002,038 (GRCm39) T98A probably benign Het
Ttc23l CT CTTGGATT 15: 10,537,648 (GRCm39) probably benign Het
Ttc23l G A 15: 10,537,652 (GRCm39) S206L probably benign Het
Vmn2r116 A C 17: 23,620,395 (GRCm39) I710L probably benign Het
Xpo4 G A 14: 57,828,479 (GRCm39) Q794* probably null Het
Zfp112 T A 7: 23,824,473 (GRCm39) I147N probably damaging Het
Zmiz1 T C 14: 25,636,434 (GRCm39) S140P probably damaging Het
Other mutations in Vmn2r16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01116:Vmn2r16 APN 5 109,488,294 (GRCm39) missense probably damaging 1.00
IGL01374:Vmn2r16 APN 5 109,478,283 (GRCm39) missense probably benign 0.00
IGL01391:Vmn2r16 APN 5 109,511,627 (GRCm39) missense possibly damaging 0.50
IGL01419:Vmn2r16 APN 5 109,510,267 (GRCm39) splice site probably benign
IGL01634:Vmn2r16 APN 5 109,488,177 (GRCm39) missense probably benign 0.00
IGL01845:Vmn2r16 APN 5 109,511,762 (GRCm39) missense probably damaging 1.00
IGL01875:Vmn2r16 APN 5 109,478,277 (GRCm39) missense probably benign 0.01
IGL01910:Vmn2r16 APN 5 109,487,951 (GRCm39) missense probably damaging 1.00
IGL02217:Vmn2r16 APN 5 109,487,676 (GRCm39) missense probably damaging 0.98
IGL02327:Vmn2r16 APN 5 109,487,987 (GRCm39) missense probably benign 0.01
IGL02491:Vmn2r16 APN 5 109,487,703 (GRCm39) nonsense probably null
IGL02531:Vmn2r16 APN 5 109,488,134 (GRCm39) missense probably damaging 0.99
IGL02680:Vmn2r16 APN 5 109,487,948 (GRCm39) missense probably benign 0.44
IGL02884:Vmn2r16 APN 5 109,508,757 (GRCm39) missense possibly damaging 0.94
IGL03084:Vmn2r16 APN 5 109,478,292 (GRCm39) missense probably damaging 0.99
IGL03096:Vmn2r16 APN 5 109,487,751 (GRCm39) missense probably damaging 0.99
IGL03355:Vmn2r16 APN 5 109,511,580 (GRCm39) missense possibly damaging 0.74
R0280:Vmn2r16 UTSW 5 109,488,005 (GRCm39) missense possibly damaging 0.88
R0594:Vmn2r16 UTSW 5 109,511,762 (GRCm39) missense probably damaging 1.00
R1016:Vmn2r16 UTSW 5 109,487,754 (GRCm39) missense probably damaging 1.00
R1109:Vmn2r16 UTSW 5 109,487,652 (GRCm39) missense probably damaging 0.98
R1248:Vmn2r16 UTSW 5 109,508,643 (GRCm39) missense probably benign 0.10
R1626:Vmn2r16 UTSW 5 109,511,443 (GRCm39) missense probably damaging 1.00
R1909:Vmn2r16 UTSW 5 109,511,853 (GRCm39) missense probably benign 0.01
R1929:Vmn2r16 UTSW 5 109,487,124 (GRCm39) missense possibly damaging 0.92
R1982:Vmn2r16 UTSW 5 109,511,890 (GRCm39) missense probably benign 0.01
R3038:Vmn2r16 UTSW 5 109,487,199 (GRCm39) missense probably damaging 1.00
R3437:Vmn2r16 UTSW 5 109,478,362 (GRCm39) missense probably damaging 0.99
R3734:Vmn2r16 UTSW 5 109,478,280 (GRCm39) missense probably benign 0.11
R3820:Vmn2r16 UTSW 5 109,510,143 (GRCm39) missense probably benign 0.36
R3873:Vmn2r16 UTSW 5 109,488,177 (GRCm39) missense probably benign 0.33
R4165:Vmn2r16 UTSW 5 109,478,427 (GRCm39) missense possibly damaging 0.80
R4575:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4576:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4578:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4637:Vmn2r16 UTSW 5 109,478,280 (GRCm39) missense probably benign 0.00
R4696:Vmn2r16 UTSW 5 109,487,168 (GRCm39) missense probably benign 0.01
R5026:Vmn2r16 UTSW 5 109,508,722 (GRCm39) nonsense probably null
R5180:Vmn2r16 UTSW 5 109,478,391 (GRCm39) missense probably benign 0.01
R5433:Vmn2r16 UTSW 5 109,511,708 (GRCm39) missense probably damaging 1.00
R5955:Vmn2r16 UTSW 5 109,511,613 (GRCm39) missense possibly damaging 0.78
R5958:Vmn2r16 UTSW 5 109,510,153 (GRCm39) missense possibly damaging 0.81
R6353:Vmn2r16 UTSW 5 109,488,119 (GRCm39) missense probably benign 0.33
R6389:Vmn2r16 UTSW 5 109,478,344 (GRCm39) missense probably benign 0.19
R6819:Vmn2r16 UTSW 5 109,488,412 (GRCm39) missense probably benign 0.04
R6994:Vmn2r16 UTSW 5 109,487,969 (GRCm39) missense probably damaging 1.00
R7061:Vmn2r16 UTSW 5 109,511,620 (GRCm39) missense probably damaging 0.99
R7063:Vmn2r16 UTSW 5 109,511,650 (GRCm39) missense probably damaging 1.00
R7220:Vmn2r16 UTSW 5 109,508,772 (GRCm39) missense probably damaging 0.97
R7268:Vmn2r16 UTSW 5 109,488,331 (GRCm39) nonsense probably null
R7420:Vmn2r16 UTSW 5 109,511,736 (GRCm39) missense probably damaging 0.96
R7591:Vmn2r16 UTSW 5 109,510,223 (GRCm39) missense probably damaging 0.99
R7644:Vmn2r16 UTSW 5 109,487,837 (GRCm39) missense probably damaging 1.00
R7939:Vmn2r16 UTSW 5 109,487,705 (GRCm39) missense possibly damaging 0.79
R7977:Vmn2r16 UTSW 5 109,488,015 (GRCm39) missense probably damaging 1.00
R7987:Vmn2r16 UTSW 5 109,488,015 (GRCm39) missense probably damaging 1.00
R8023:Vmn2r16 UTSW 5 109,488,272 (GRCm39) nonsense probably null
R8427:Vmn2r16 UTSW 5 109,488,138 (GRCm39) missense probably benign 0.03
R8436:Vmn2r16 UTSW 5 109,511,649 (GRCm39) missense probably damaging 1.00
R8475:Vmn2r16 UTSW 5 109,487,073 (GRCm39) missense probably benign 0.01
R8554:Vmn2r16 UTSW 5 109,511,997 (GRCm39) missense probably benign 0.13
R8771:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8774:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8774-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8775:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8775-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8777:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8777-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8825:Vmn2r16 UTSW 5 109,487,019 (GRCm39) missense probably benign 0.41
R8865:Vmn2r16 UTSW 5 109,487,910 (GRCm39) missense probably benign 0.33
R8900:Vmn2r16 UTSW 5 109,511,619 (GRCm39) missense probably benign 0.04
R9365:Vmn2r16 UTSW 5 109,488,064 (GRCm39) missense probably damaging 0.99
R9683:Vmn2r16 UTSW 5 109,511,677 (GRCm39) missense probably damaging 1.00
X0027:Vmn2r16 UTSW 5 109,487,175 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r16 UTSW 5 109,511,779 (GRCm39) frame shift probably null
Z1088:Vmn2r16 UTSW 5 109,488,381 (GRCm39) missense probably benign 0.03
Z1177:Vmn2r16 UTSW 5 109,487,864 (GRCm39) missense possibly damaging 0.79
Predicted Primers PCR Primer
(F):5'- ACTGCCTCCAAAGAGCTGTG -3'
(R):5'- ATAGGAATGACCAAGTTAGGTGTCC -3'

Sequencing Primer
(F):5'- CCAAAGAGCTGTGTCATTTCTGGC -3'
(R):5'- ACCAAGTTAGGTGTCCCTGATGC -3'
Posted On 2015-07-06