Mutagenetix > Incidental Mutation

Incidental Mutation 'R0013:Olfr73'

32612

Institutional Source

Beutler Lab

Gene Symbol

Olfr73

Ensembl Gene

ENSMUSG00000075140

Gene Name

olfactory receptor 73

Synonyms

MOR174-9, GA_x6K02T2Q125-49527073-49526132, mOR-EG

MMRRC Submission

038308-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.584) question?

Stock #

R0013 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

88032288-88037699 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 88034266 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 291 (Y291C)

Ref Sequence

ENSEMBL: ENSMUSP00000149472 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099838] [ENSMUST00000129056]

AlphaFold

Q920P2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000099838
AA Change: Y291C

PolyPhen 2 Score 0.783 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000097426
Gene: ENSMUSG00000075140
AA Change: Y291C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	309	6e-48	PFAM
Pfam:7tm_1	42	291	6.1e-13	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000129056
AA Change: Y291C

PolyPhen 2 Score 0.783 (Sensitivity: 0.85; Specificity: 0.93)

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.8%

Validation Efficiency

94% (79/84)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610028H24Rik	A	G	10: 76,457,512	M156V	probably benign	Het
Adnp2	A	T	18: 80,129,745	V483D	probably damaging	Het
Aff1	G	T	5: 103,828,484	E491*	probably null	Het
Agl	A	T	3: 116,776,608	C911*	probably null	Het
Akt2	A	G	7: 27,636,058	D284G	probably damaging	Het
Alox15	A	G	11: 70,349,635	M240T	possibly damaging	Het
Antxr2	A	G	5: 97,979,985	V229A	probably damaging	Het
Arap2	G	A	5: 62,683,484	L680F	probably damaging	Het
Btaf1	A	G	19: 36,958,373	T188A	probably benign	Het
Btnl6	G	A	17: 34,515,531	Q86*	probably null	Het
C2cd3	T	A	7: 100,416,062	L685H	probably damaging	Het
Cdh23	T	C	10: 60,413,173	T878A	possibly damaging	Het
Clec4b2	T	C	6: 123,202,149	Y137H	probably damaging	Het
Dchs1	T	A	7: 105,755,836	T2500S	possibly damaging	Het
Def6	A	G	17: 28,217,092	Y75C	probably damaging	Het
Dhx33	A	T	11: 70,993,635	F448L	probably damaging	Het
Dner	C	T	1: 84,494,893		probably benign	Het
Dnmbp	G	A	19: 43,902,231	P366S	probably benign	Het
Eif4g3	T	C	4: 138,175,848	C1160R	possibly damaging	Het
Elmod1	G	A	9: 53,912,901		probably benign	Het
Faah	C	A	4: 116,004,391	L305F	probably damaging	Het
Fam71b	A	G	11: 46,406,804	T312A	unknown	Het
Flt1	A	G	5: 147,571,014		probably benign	Het
Fyco1	A	T	9: 123,822,406	N1196K	probably benign	Het
Galnt18	T	C	7: 111,554,457	N320S	probably damaging	Het
Glp2r	C	A	11: 67,709,712	G437V	possibly damaging	Het
Gm4884	T	C	7: 41,044,292	S562P	probably damaging	Het
Gm9936	A	G	5: 114,857,347		probably benign	Het
Gpn2	C	A	4: 133,584,792	P112T	probably damaging	Het
Grm4	A	G	17: 27,431,575	Y816H	probably benign	Het
Helz2	A	T	2: 181,240,959	S14T	probably benign	Het
Htt	T	C	5: 34,820,104	L778P	probably benign	Het
Il11ra1	T	C	4: 41,765,060	S129P	probably damaging	Het
Ints11	T	C	4: 155,887,168	F315S	probably damaging	Het
Itga11	A	T	9: 62,776,613	N1059Y	possibly damaging	Het
Jak3	A	G	8: 71,684,327	S716G	probably damaging	Het
Kcns1	G	T	2: 164,168,643	D65E	probably benign	Het
Kdm5d	A	T	Y: 941,715	K1305N	probably benign	Het
Kif26a	G	T	12: 112,177,880	V1523L	probably benign	Het
Mboat7	A	G	7: 3,683,822	S340P	probably damaging	Het
Mctp2	T	C	7: 72,229,408	I234V	probably benign	Het
Mex3c	G	A	18: 73,590,551	A572T	probably benign	Het
Mpp3	C	A	11: 102,005,425	R424L	probably benign	Het
Mroh4	T	A	15: 74,608,237		probably benign	Het
Myo9a	A	T	9: 59,860,206		probably benign	Het
Myog	T	A	1: 134,290,235	H60Q	probably damaging	Het
Nlrp9a	T	A	7: 26,571,225		probably null	Het
Notch1	A	G	2: 26,473,818	V868A	possibly damaging	Het
Olfr352	A	G	2: 36,870,160	N198S	probably damaging	Het
Olfr59	T	A	11: 74,289,051	I135N	possibly damaging	Het
Olfr980	A	T	9: 40,006,355	I198N	probably damaging	Het
Pink1	T	C	4: 138,317,401	T342A	probably benign	Het
Plb1	T	A	5: 32,349,615		probably benign	Het
Plec	T	C	15: 76,178,246	D2524G	probably damaging	Het
Plekhg4	G	T	8: 105,375,396	E6*	probably null	Het
Polq	T	C	16: 37,061,839	F1455S	possibly damaging	Het
Ppm1e	A	G	11: 87,249,058		probably benign	Het
Prkaca	G	A	8: 83,988,303	M119I	possibly damaging	Het
Prss46	G	T	9: 110,850,055	S108I	probably damaging	Het
Ptma	C	T	1: 86,529,776		probably benign	Het
Rab11fip4	C	T	11: 79,689,653	T437M	probably benign	Het
Rngtt	T	A	4: 33,379,409	M437K	probably benign	Het
Rrn3	T	A	16: 13,813,113	D604E	possibly damaging	Het
Scn4a	A	G	11: 106,348,405		probably benign	Het
Sis	A	G	3: 72,910,476	L1468P	possibly damaging	Het
Slit3	A	G	11: 35,707,918	M1450V	probably benign	Het
Smg5	T	C	3: 88,349,233	S269P	probably benign	Het
Sntg1	T	C	1: 8,463,462	T323A	probably damaging	Het
Son	C	T	16: 91,651,662	T37I	probably damaging	Het
Stk17b	T	C	1: 53,764,132	I41M	probably benign	Het
Tgm5	T	A	2: 121,076,882	Y120F	probably damaging	Het
Tppp	A	G	13: 74,021,360	K73R	possibly damaging	Het
Ttn	C	A	2: 76,739,158	K27130N	probably damaging	Het
Ttn	C	T	2: 76,907,752	V4148I	probably benign	Het
Uba7	A	T	9: 107,978,249	Y375F	probably damaging	Het
Ugcg	T	C	4: 59,213,931	L171P	possibly damaging	Het
Vsig2	T	C	9: 37,542,576		probably benign	Het
Zcchc11	T	A	4: 108,530,955		probably benign	Het
Zfp839	T	A	12: 110,868,386	S692T	possibly damaging	Het

Other mutations in Olfr73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03137:Olfr73	APN	2	88034410	missense	probably benign	0.44
IGL03377:Olfr73	APN	2	88034245	missense	probably damaging	1.00
PIT4260001:Olfr73	UTSW	2	88034782	missense	probably damaging	1.00
R0969:Olfr73	UTSW	2	88034248	missense	probably damaging	0.99
R1216:Olfr73	UTSW	2	88034258	missense	probably damaging	0.99
R2148:Olfr73	UTSW	2	88034599	missense	probably damaging	0.99
R2355:Olfr73	UTSW	2	88035035	missense	probably damaging	0.97
R2357:Olfr73	UTSW	2	88034684	missense	probably damaging	1.00
R2994:Olfr73	UTSW	2	88034957	missense	probably damaging	1.00
R3806:Olfr73	UTSW	2	88034567	missense	possibly damaging	0.60
R4618:Olfr73	UTSW	2	88034554	missense	probably benign	0.19
R4975:Olfr73	UTSW	2	88034661	missense	probably benign	0.09
R5753:Olfr73	UTSW	2	88034576	missense	probably damaging	1.00
R6795:Olfr73	UTSW	2	88034324	missense	probably benign	0.02
R8982:Olfr73	UTSW	2	88034269	missense	probably damaging	1.00
R9151:Olfr73	UTSW	2	88034353	missense	probably damaging	0.99
Z1190:Olfr73	UTSW	2	88034663	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGGTGGCACACGCCTTTTttttttt -3'
(R):5'- CAGCAAGTGGACGCCGCAA -3'

Sequencing Primer
(F):5'- CAAACTCAATTTCTACTCTGTTGTG -3'
(R):5'- GCAAAGCCTTCTCCACTTGTG -3'

Posted On

2013-05-09