Incidental Mutation 'R4384:Ncapg2'
ID 326125
Institutional Source Beutler Lab
Gene Symbol Ncapg2
Ensembl Gene ENSMUSG00000042029
Gene Name non-SMC condensin II complex, subunit G2
Synonyms 5830426I05Rik, Mtb, mCAP-G2, Luzp5
MMRRC Submission 042002-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4384 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 116368969-116427152 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 116403497 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000081889 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084828]
AlphaFold Q6DFV1
Predicted Effect probably null
Transcript: ENSMUST00000084828
SMART Domains Protein: ENSMUSP00000081889
Gene: ENSMUSG00000042029

DomainStartEndE-ValueType
low complexity region 14 25 N/A INTRINSIC
Pfam:Condensin2nSMC 212 361 7.2e-62 PFAM
Meta Mutation Damage Score 0.9507 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 97% (56/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
PHENOTYPE: Homozygous null embryos exhibit impaired inner cell mass expansion and die shortly after implantation and prior to gastrulation and blood cell development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acer2 T A 4: 86,792,805 (GRCm39) V27E possibly damaging Het
Adam23 T C 1: 63,605,787 (GRCm39) Y624H probably damaging Het
Arhgef10 T A 8: 14,980,157 (GRCm39) C132* probably null Het
Boc A T 16: 44,311,545 (GRCm39) L726H probably damaging Het
Brip1 A T 11: 86,039,255 (GRCm39) D426E possibly damaging Het
Cadps2 T A 6: 23,412,987 (GRCm39) Q654L probably benign Het
Calr3 T A 8: 73,182,008 (GRCm39) D120V probably damaging Het
Cntnap3 A G 13: 64,896,274 (GRCm39) Y1067H probably damaging Het
Csnk1g1 T C 9: 65,927,190 (GRCm39) V119A probably damaging Het
Ddias G A 7: 92,507,431 (GRCm39) T828I probably damaging Het
Dennd4c A G 4: 86,729,687 (GRCm39) Y763C probably damaging Het
Dscam T A 16: 96,510,416 (GRCm39) I948F probably damaging Het
E030018B13Rik A G 7: 63,569,141 (GRCm39) probably benign Het
E2f8 G A 7: 48,516,847 (GRCm39) T844I possibly damaging Het
Eps8 T A 6: 137,476,590 (GRCm39) H603L probably benign Het
Esrrg G A 1: 187,775,908 (GRCm39) C122Y probably damaging Het
Frmd4a C T 2: 4,599,374 (GRCm39) R467* probably null Het
Gad2 G A 2: 22,575,422 (GRCm39) V509I probably benign Het
Gpat4 A G 8: 23,664,602 (GRCm39) I446T probably benign Het
Klhl12 T G 1: 134,415,392 (GRCm39) D435E probably damaging Het
Luc7l T C 17: 26,498,936 (GRCm39) probably benign Het
Marchf2 C A 17: 33,915,167 (GRCm39) M142I probably benign Het
Marf1 T A 16: 13,960,505 (GRCm39) Y513F possibly damaging Het
Mdm2 T C 10: 117,532,344 (GRCm39) D114G possibly damaging Het
Med1 G A 11: 98,043,688 (GRCm39) probably benign Het
Meikin C T 11: 54,308,613 (GRCm39) Q404* probably null Het
Myh9 A T 15: 77,675,912 (GRCm39) probably benign Het
Mylip T C 13: 45,543,434 (GRCm39) M1T probably null Het
Nmd3 T C 3: 69,631,731 (GRCm39) probably benign Het
Nwd2 T A 5: 63,963,914 (GRCm39) L1166H probably damaging Het
Or1j13 A G 2: 36,370,010 (GRCm39) L44P probably damaging Het
Or8b48 T C 9: 38,493,349 (GRCm39) Y259H probably damaging Het
Rubcn A G 16: 32,677,272 (GRCm39) I71T probably damaging Het
Rwdd3 T C 3: 120,952,406 (GRCm39) probably benign Het
Ryr2 T C 13: 11,620,119 (GRCm39) E3826G probably damaging Het
Sdad1 T C 5: 92,446,116 (GRCm39) Q273R probably benign Het
Sdha A T 13: 74,475,104 (GRCm39) I579K possibly damaging Het
Sema4d A G 13: 51,856,919 (GRCm39) L771P probably damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Slc6a11 A G 6: 114,224,688 (GRCm39) E624G possibly damaging Het
Tada3 G T 6: 113,347,340 (GRCm39) R117S probably damaging Het
Tm9sf3 T C 19: 41,236,372 (GRCm39) M130V probably damaging Het
Trpc1 C A 9: 95,614,161 (GRCm39) M34I probably benign Het
Trpc4ap A G 2: 155,482,427 (GRCm39) V521A possibly damaging Het
Trpm2 A G 10: 77,753,559 (GRCm39) V1315A probably benign Het
Tvp23a A G 16: 10,246,546 (GRCm39) S80P probably benign Het
Usp54 A T 14: 20,600,153 (GRCm39) probably null Het
Vmn2r27 A G 6: 124,201,115 (GRCm39) Y281H probably benign Het
Vwf T A 6: 125,632,079 (GRCm39) I37N unknown Het
Zfp329 G A 7: 12,545,584 (GRCm39) probably benign Het
Zfp616 G T 11: 73,974,005 (GRCm39) L91F possibly damaging Het
Other mutations in Ncapg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01410:Ncapg2 APN 12 116,388,270 (GRCm39) missense possibly damaging 0.54
IGL01694:Ncapg2 APN 12 116,370,850 (GRCm39) utr 5 prime probably benign
IGL01724:Ncapg2 APN 12 116,390,331 (GRCm39) missense probably damaging 1.00
IGL01792:Ncapg2 APN 12 116,389,438 (GRCm39) missense probably damaging 0.99
IGL02098:Ncapg2 APN 12 116,407,952 (GRCm39) missense possibly damaging 0.59
IGL02136:Ncapg2 APN 12 116,424,203 (GRCm39) missense probably benign
IGL02409:Ncapg2 APN 12 116,384,337 (GRCm39) missense probably damaging 1.00
IGL02580:Ncapg2 APN 12 116,384,309 (GRCm39) missense probably damaging 1.00
IGL02653:Ncapg2 APN 12 116,389,526 (GRCm39) critical splice donor site probably null
IGL03073:Ncapg2 APN 12 116,415,894 (GRCm39) missense probably benign 0.01
IGL03114:Ncapg2 APN 12 116,415,993 (GRCm39) splice site probably benign
IGL03199:Ncapg2 APN 12 116,382,856 (GRCm39) missense probably damaging 1.00
IGL03328:Ncapg2 APN 12 116,403,677 (GRCm39) missense possibly damaging 0.90
P0033:Ncapg2 UTSW 12 116,402,255 (GRCm39) missense probably benign 0.03
R0008:Ncapg2 UTSW 12 116,393,455 (GRCm39) missense probably damaging 1.00
R0194:Ncapg2 UTSW 12 116,384,303 (GRCm39) splice site probably null
R0379:Ncapg2 UTSW 12 116,406,695 (GRCm39) missense probably damaging 1.00
R0568:Ncapg2 UTSW 12 116,386,835 (GRCm39) missense probably damaging 1.00
R0771:Ncapg2 UTSW 12 116,376,779 (GRCm39) nonsense probably null
R1016:Ncapg2 UTSW 12 116,402,295 (GRCm39) missense probably damaging 1.00
R1507:Ncapg2 UTSW 12 116,424,186 (GRCm39) missense probably benign 0.00
R1524:Ncapg2 UTSW 12 116,398,198 (GRCm39) splice site probably benign
R1596:Ncapg2 UTSW 12 116,382,856 (GRCm39) missense probably damaging 1.00
R1635:Ncapg2 UTSW 12 116,398,305 (GRCm39) frame shift probably null
R1752:Ncapg2 UTSW 12 116,390,338 (GRCm39) missense probably damaging 1.00
R2164:Ncapg2 UTSW 12 116,414,095 (GRCm39) splice site probably null
R2266:Ncapg2 UTSW 12 116,393,296 (GRCm39) missense probably damaging 1.00
R2366:Ncapg2 UTSW 12 116,384,349 (GRCm39) nonsense probably null
R2924:Ncapg2 UTSW 12 116,402,349 (GRCm39) missense probably benign 0.03
R2925:Ncapg2 UTSW 12 116,402,349 (GRCm39) missense probably benign 0.03
R3828:Ncapg2 UTSW 12 116,370,938 (GRCm39) splice site probably benign
R3829:Ncapg2 UTSW 12 116,370,938 (GRCm39) splice site probably benign
R4651:Ncapg2 UTSW 12 116,389,407 (GRCm39) missense probably damaging 1.00
R4701:Ncapg2 UTSW 12 116,404,238 (GRCm39) missense probably benign
R4821:Ncapg2 UTSW 12 116,379,077 (GRCm39) missense probably damaging 0.99
R4845:Ncapg2 UTSW 12 116,404,208 (GRCm39) missense probably damaging 0.96
R5135:Ncapg2 UTSW 12 116,391,406 (GRCm39) missense possibly damaging 0.64
R5294:Ncapg2 UTSW 12 116,391,414 (GRCm39) missense possibly damaging 0.54
R5334:Ncapg2 UTSW 12 116,390,257 (GRCm39) missense probably damaging 1.00
R5588:Ncapg2 UTSW 12 116,376,697 (GRCm39) missense possibly damaging 0.95
R5888:Ncapg2 UTSW 12 116,389,420 (GRCm39) missense possibly damaging 0.84
R5938:Ncapg2 UTSW 12 116,393,277 (GRCm39) missense probably damaging 1.00
R5978:Ncapg2 UTSW 12 116,388,291 (GRCm39) missense possibly damaging 0.68
R6016:Ncapg2 UTSW 12 116,390,227 (GRCm39) missense probably damaging 1.00
R6026:Ncapg2 UTSW 12 116,406,641 (GRCm39) missense possibly damaging 0.73
R6155:Ncapg2 UTSW 12 116,401,631 (GRCm39) missense possibly damaging 0.83
R6509:Ncapg2 UTSW 12 116,391,376 (GRCm39) missense probably damaging 1.00
R6675:Ncapg2 UTSW 12 116,398,281 (GRCm39) missense possibly damaging 0.71
R6912:Ncapg2 UTSW 12 116,390,202 (GRCm39) missense probably benign
R7069:Ncapg2 UTSW 12 116,388,337 (GRCm39) splice site probably null
R7339:Ncapg2 UTSW 12 116,378,454 (GRCm39) missense probably damaging 0.96
R7440:Ncapg2 UTSW 12 116,414,033 (GRCm39) missense possibly damaging 0.89
R7445:Ncapg2 UTSW 12 116,382,888 (GRCm39) missense possibly damaging 0.50
R7704:Ncapg2 UTSW 12 116,382,897 (GRCm39) missense probably damaging 1.00
R8061:Ncapg2 UTSW 12 116,390,197 (GRCm39) missense probably benign
R8132:Ncapg2 UTSW 12 116,407,967 (GRCm39) missense possibly damaging 0.93
R8166:Ncapg2 UTSW 12 116,376,036 (GRCm39) missense probably benign 0.00
R8351:Ncapg2 UTSW 12 116,403,647 (GRCm39) missense possibly damaging 0.80
R8526:Ncapg2 UTSW 12 116,403,679 (GRCm39) missense probably benign 0.00
R8692:Ncapg2 UTSW 12 116,414,049 (GRCm39) missense probably damaging 1.00
R8739:Ncapg2 UTSW 12 116,379,098 (GRCm39) missense possibly damaging 0.75
R8766:Ncapg2 UTSW 12 116,390,356 (GRCm39) missense probably damaging 1.00
R8929:Ncapg2 UTSW 12 116,415,983 (GRCm39) missense probably damaging 1.00
R9046:Ncapg2 UTSW 12 116,376,145 (GRCm39) missense probably benign 0.01
R9187:Ncapg2 UTSW 12 116,402,287 (GRCm39) missense probably damaging 1.00
R9344:Ncapg2 UTSW 12 116,388,273 (GRCm39) missense probably damaging 1.00
R9444:Ncapg2 UTSW 12 116,370,863 (GRCm39) missense probably damaging 1.00
R9580:Ncapg2 UTSW 12 116,424,228 (GRCm39) missense probably damaging 1.00
R9634:Ncapg2 UTSW 12 116,379,077 (GRCm39) missense probably damaging 0.99
R9749:Ncapg2 UTSW 12 116,411,368 (GRCm39) nonsense probably null
X0020:Ncapg2 UTSW 12 116,388,327 (GRCm39) missense probably damaging 1.00
Z1177:Ncapg2 UTSW 12 116,402,225 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTTGTGGGCCTGTAGACAAG -3'
(R):5'- TTCCGAAGCTTCAGATACTCC -3'

Sequencing Primer
(F):5'- AGGCACTTTCCACCTTGTTTTGATG -3'
(R):5'- GAAGCTTCAGATACTCCTCTTCTTGG -3'
Posted On 2015-07-06