Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00391:Hrasls5'

3262

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Hrasls5

Ensembl Gene

ENSMUSG00000024973

Gene Name

HRAS-like suppressor family, member 5

Synonyms

4921526K24Rik, 1700086E08Rik, 1700055A14Rik, iNAT

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00391

Quality Score

Status

Chromosome

Chromosomal Location

7612541-7639642 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 7619266 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000118096 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025929] [ENSMUST00000148558]

Predicted Effect

probably benign
Transcript: ENSMUST00000025929

SMART Domains

Protein: ENSMUSP00000025929
Gene: ENSMUSG00000024973

Domain	Start	End	E-Value	Type
Pfam:LRAT	139	261	1.6e-39	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131326

Predicted Effect

probably benign
Transcript: ENSMUST00000148558

SMART Domains

Protein: ENSMUSP00000118096
Gene: ENSMUSG00000024973

Domain	Start	End	E-Value	Type
Pfam:LRAT	144	261	1.9e-37	PFAM
low complexity region	294	305	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl3	G	A	5: 81,724,224	V990M	probably damaging	Het
Ap4b1	A	G	3: 103,821,542	T499A	probably benign	Het
Cacna2d4	T	C	6: 119,337,933		probably benign	Het
Ccr5	T	A	9: 124,124,406	D15E	possibly damaging	Het
Clca4b	A	G	3: 144,915,561	V584A	possibly damaging	Het
Cmtr1	T	C	17: 29,674,262	M85T	probably damaging	Het
Col6a3	T	A	1: 90,828,255	H104L	probably damaging	Het
Coq9	A	T	8: 94,850,517	K170M	probably damaging	Het
Elmod1	A	G	9: 53,924,398		probably null	Het
Fam47e	A	C	5: 92,579,663	E143D	probably damaging	Het
Faxc	A	G	4: 21,948,725	K146E	probably damaging	Het
Gm5346	A	T	8: 43,625,629	F519L	probably damaging	Het
Myo7b	A	C	18: 32,021,556		probably benign	Het
Nmur1	G	A	1: 86,386,471	R381C	probably damaging	Het
Nsd2	T	G	5: 33,855,733	D469E	probably damaging	Het
Osbpl6	G	A	2: 76,590,439	C786Y	probably damaging	Het
Osgin2	T	C	4: 16,006,439	Y85C	probably damaging	Het
Otof	A	G	5: 30,375,623	C1587R	probably damaging	Het
Plekha2	A	G	8: 25,057,327	V247A	probably damaging	Het
Plppr5	A	T	3: 117,671,943	N281I	possibly damaging	Het
Popdc3	A	G	10: 45,317,826		probably null	Het
Ppp1r12a	A	G	10: 108,198,848	N85D	probably damaging	Het
Serpinb8	A	G	1: 107,606,984	S262G	probably benign	Het
Sspo	G	A	6: 48,497,386	G4780R	probably damaging	Het
Ush2a	A	G	1: 188,916,061	E4621G	probably damaging	Het

Other mutations in Hrasls5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00757:Hrasls5	APN	19	7614559	missense	possibly damaging	0.48
R0330:Hrasls5	UTSW	19	7637298	splice site	probably null
R1144:Hrasls5	UTSW	19	7613330	missense	probably benign	0.00
R1294:Hrasls5	UTSW	19	7614650	splice site	probably benign
R1453:Hrasls5	UTSW	19	7639634	unclassified	probably benign
R2069:Hrasls5	UTSW	19	7612638	missense	possibly damaging	0.83
R2258:Hrasls5	UTSW	19	7612746	missense	probably damaging	1.00
R2260:Hrasls5	UTSW	19	7612746	missense	probably damaging	1.00
R5478:Hrasls5	UTSW	19	7614671	intron	probably benign
R6151:Hrasls5	UTSW	19	7619291	missense	probably damaging	1.00
R6274:Hrasls5	UTSW	19	7637466	missense	probably damaging	1.00
R6746:Hrasls5	UTSW	19	7613330	missense	probably benign	0.00
R6823:Hrasls5	UTSW	19	7639496	unclassified	probably benign
R6912:Hrasls5	UTSW	19	7639465	unclassified	probably benign
R7100:Hrasls5	UTSW	19	7639558	missense	unknown
R7241:Hrasls5	UTSW	19	7614581	missense	probably benign	0.01

Posted On

2012-04-20