Incidental Mutation 'R4387:Meig1'
ID 326251
Institutional Source Beutler Lab
Gene Symbol Meig1
Ensembl Gene ENSMUSG00000026650
Gene Name meiosis expressed gene 1
Synonyms Meg1
MMRRC Submission 041681-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R4387 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 3410080-3423685 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 3410278 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 74 (E74G)
Ref Sequence ENSEMBL: ENSMUSP00000110736 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064685] [ENSMUST00000115081] [ENSMUST00000115082] [ENSMUST00000115083] [ENSMUST00000115084] [ENSMUST00000144584]
AlphaFold Q61845
Predicted Effect probably damaging
Transcript: ENSMUST00000064685
AA Change: E74G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000070310
Gene: ENSMUSG00000026650
AA Change: E74G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 87 1.4e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115081
AA Change: E74G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110733
Gene: ENSMUSG00000026650
AA Change: E74G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 86 6.3e-43 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115082
AA Change: E74G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110734
Gene: ENSMUSG00000026650
AA Change: E74G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 87 1.4e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115083
AA Change: E74G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110735
Gene: ENSMUSG00000026650
AA Change: E74G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 87 1.4e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115084
AA Change: E74G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110736
Gene: ENSMUSG00000026650
AA Change: E74G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 87 1.4e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144584
SMART Domains Protein: ENSMUSP00000123118
Gene: ENSMUSG00000026650

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 65 6.1e-29 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit male sterility with arrested spermatogenesis, absent sperm flagellum, and deformed sperm heads. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik T A 13: 77,464,693 (GRCm39) probably null Het
Adprm C T 11: 66,929,019 (GRCm39) R324K probably benign Het
Brd10 A G 19: 29,782,715 (GRCm39) probably benign Het
Calcr T A 6: 3,707,581 (GRCm39) N240Y probably damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cd209b A G 8: 3,975,960 (GRCm39) L67P probably damaging Het
Cp T C 3: 20,031,366 (GRCm39) V601A probably damaging Het
Cyp2a5 A G 7: 26,540,479 (GRCm39) D364G probably damaging Het
Eno4 T A 19: 58,941,640 (GRCm39) V187D probably benign Het
Fbxl7 C A 15: 26,543,345 (GRCm39) S434I probably damaging Het
Fbxw24 A T 9: 109,439,053 (GRCm39) L174Q probably damaging Het
Fryl T A 5: 73,243,903 (GRCm39) R91S possibly damaging Het
Gabrd A G 4: 155,473,389 (GRCm39) probably null Het
Gtpbp2 A G 17: 46,477,284 (GRCm39) D383G probably benign Het
Igf1r A G 7: 67,819,757 (GRCm39) I356V probably benign Het
Kcnc1 C A 7: 46,047,126 (GRCm39) R9S possibly damaging Het
Lipi T A 16: 75,370,843 (GRCm39) I125F probably damaging Het
Mgat4d A T 8: 84,098,335 (GRCm39) Q366L probably damaging Het
Mrpl1 A G 5: 96,386,778 (GRCm39) N256D possibly damaging Het
Nlrp4e A G 7: 23,000,902 (GRCm39) K66E probably benign Het
Nlrp4e A G 7: 23,020,652 (GRCm39) I380V probably benign Het
Nphp3 A G 9: 103,907,219 (GRCm39) T740A possibly damaging Het
Or5an1c A G 19: 12,218,503 (GRCm39) V174A probably damaging Het
Or8k33 T C 2: 86,384,298 (GRCm39) T57A probably damaging Het
Or8k40 T A 2: 86,584,464 (GRCm39) D206V probably benign Het
Pde5a T C 3: 122,523,001 (GRCm39) I36T probably benign Het
Pign A T 1: 105,449,785 (GRCm39) L914M possibly damaging Het
Ppm1b A G 17: 85,322,847 (GRCm39) D382G probably benign Het
Psd3 T C 8: 68,453,413 (GRCm39) Y282C probably damaging Het
Ptprt A T 2: 161,769,570 (GRCm39) Y432N probably damaging Het
Rbbp6 T C 7: 122,596,534 (GRCm39) probably null Het
Recql4 A G 15: 76,590,158 (GRCm39) S659P probably benign Het
Rpl7a-ps3 G A 15: 36,308,429 (GRCm39) noncoding transcript Het
Shoc1 A T 4: 59,060,915 (GRCm39) C953S possibly damaging Het
Slit3 T C 11: 35,574,875 (GRCm39) V1063A probably benign Het
Spdye4a A G 5: 143,211,378 (GRCm39) V62A probably benign Het
Ttc6 G A 12: 57,689,836 (GRCm39) G509S probably benign Het
Ush2a C T 1: 188,175,628 (GRCm39) T1242M probably benign Het
Wwc2 T C 8: 48,284,681 (GRCm39) S1155G unknown Het
Zfp551 A T 7: 12,152,568 (GRCm39) I55N probably damaging Het
Other mutations in Meig1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00955:Meig1 APN 2 3,410,311 (GRCm39) missense probably damaging 1.00
IGL01311:Meig1 APN 2 3,410,245 (GRCm39) missense possibly damaging 0.78
IGL02329:Meig1 APN 2 3,410,288 (GRCm39) missense probably damaging 0.97
IGL02730:Meig1 APN 2 3,412,947 (GRCm39) missense probably damaging 1.00
R1119:Meig1 UTSW 2 3,410,311 (GRCm39) missense probably damaging 1.00
R1681:Meig1 UTSW 2 3,410,311 (GRCm39) missense probably damaging 1.00
R2155:Meig1 UTSW 2 3,410,290 (GRCm39) missense probably benign 0.08
R4787:Meig1 UTSW 2 3,410,251 (GRCm39) missense possibly damaging 0.95
R4814:Meig1 UTSW 2 3,412,959 (GRCm39) missense probably benign 0.14
R5145:Meig1 UTSW 2 3,410,263 (GRCm39) missense probably damaging 0.98
R5694:Meig1 UTSW 2 3,412,999 (GRCm39) missense probably damaging 0.99
R7843:Meig1 UTSW 2 3,410,248 (GRCm39) missense probably damaging 1.00
R7974:Meig1 UTSW 2 3,412,911 (GRCm39) nonsense probably null
R8061:Meig1 UTSW 2 3,410,240 (GRCm39) missense not run
R9704:Meig1 UTSW 2 3,410,336 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CAATTCAAGGTTTCAAGGTGGGTG -3'
(R):5'- TGTACTCCACGCTCCAAGAG -3'

Sequencing Primer
(F):5'- CAAGGTTTCAAGGTGGGTGTTTATG -3'
(R):5'- GGCAAGGACTTTAAAACTTAATCTCG -3'
Posted On 2015-07-06