Incidental Mutation 'R4387:Meig1'
ID |
326251 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Meig1
|
Ensembl Gene |
ENSMUSG00000026650 |
Gene Name |
meiosis expressed gene 1 |
Synonyms |
Meg1 |
MMRRC Submission |
041681-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.076)
|
Stock # |
R4387 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
2 |
Chromosomal Location |
3410080-3423685 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 3410278 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 74
(E74G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000110736
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064685]
[ENSMUST00000115081]
[ENSMUST00000115082]
[ENSMUST00000115083]
[ENSMUST00000115084]
[ENSMUST00000144584]
|
AlphaFold |
Q61845 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000064685
AA Change: E74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000070310 Gene: ENSMUSG00000026650 AA Change: E74G
Domain | Start | End | E-Value | Type |
Pfam:Meiosis_expr
|
11 |
87 |
1.4e-42 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000115081
AA Change: E74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000110733 Gene: ENSMUSG00000026650 AA Change: E74G
Domain | Start | End | E-Value | Type |
Pfam:Meiosis_expr
|
11 |
86 |
6.3e-43 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000115082
AA Change: E74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000110734 Gene: ENSMUSG00000026650 AA Change: E74G
Domain | Start | End | E-Value | Type |
Pfam:Meiosis_expr
|
11 |
87 |
1.4e-42 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000115083
AA Change: E74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000110735 Gene: ENSMUSG00000026650 AA Change: E74G
Domain | Start | End | E-Value | Type |
Pfam:Meiosis_expr
|
11 |
87 |
1.4e-42 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000115084
AA Change: E74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000110736 Gene: ENSMUSG00000026650 AA Change: E74G
Domain | Start | End | E-Value | Type |
Pfam:Meiosis_expr
|
11 |
87 |
1.4e-42 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000144584
|
SMART Domains |
Protein: ENSMUSP00000123118 Gene: ENSMUSG00000026650
Domain | Start | End | E-Value | Type |
Pfam:Meiosis_expr
|
11 |
65 |
6.1e-29 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.7%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit male sterility with arrested spermatogenesis, absent sperm flagellum, and deformed sperm heads. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2210408I21Rik |
T |
A |
13: 77,464,693 (GRCm39) |
|
probably null |
Het |
Adprm |
C |
T |
11: 66,929,019 (GRCm39) |
R324K |
probably benign |
Het |
Brd10 |
A |
G |
19: 29,782,715 (GRCm39) |
|
probably benign |
Het |
Calcr |
T |
A |
6: 3,707,581 (GRCm39) |
N240Y |
probably damaging |
Het |
Cd109 |
CATTTATTTATTTATTTATTTATTTATTTATTTAT |
CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT |
9: 78,619,782 (GRCm39) |
|
probably benign |
Het |
Cd209b |
A |
G |
8: 3,975,960 (GRCm39) |
L67P |
probably damaging |
Het |
Cp |
T |
C |
3: 20,031,366 (GRCm39) |
V601A |
probably damaging |
Het |
Cyp2a5 |
A |
G |
7: 26,540,479 (GRCm39) |
D364G |
probably damaging |
Het |
Eno4 |
T |
A |
19: 58,941,640 (GRCm39) |
V187D |
probably benign |
Het |
Fbxl7 |
C |
A |
15: 26,543,345 (GRCm39) |
S434I |
probably damaging |
Het |
Fbxw24 |
A |
T |
9: 109,439,053 (GRCm39) |
L174Q |
probably damaging |
Het |
Fryl |
T |
A |
5: 73,243,903 (GRCm39) |
R91S |
possibly damaging |
Het |
Gabrd |
A |
G |
4: 155,473,389 (GRCm39) |
|
probably null |
Het |
Gtpbp2 |
A |
G |
17: 46,477,284 (GRCm39) |
D383G |
probably benign |
Het |
Igf1r |
A |
G |
7: 67,819,757 (GRCm39) |
I356V |
probably benign |
Het |
Kcnc1 |
C |
A |
7: 46,047,126 (GRCm39) |
R9S |
possibly damaging |
Het |
Lipi |
T |
A |
16: 75,370,843 (GRCm39) |
I125F |
probably damaging |
Het |
Mgat4d |
A |
T |
8: 84,098,335 (GRCm39) |
Q366L |
probably damaging |
Het |
Mrpl1 |
A |
G |
5: 96,386,778 (GRCm39) |
N256D |
possibly damaging |
Het |
Nlrp4e |
A |
G |
7: 23,000,902 (GRCm39) |
K66E |
probably benign |
Het |
Nlrp4e |
A |
G |
7: 23,020,652 (GRCm39) |
I380V |
probably benign |
Het |
Nphp3 |
A |
G |
9: 103,907,219 (GRCm39) |
T740A |
possibly damaging |
Het |
Or5an1c |
A |
G |
19: 12,218,503 (GRCm39) |
V174A |
probably damaging |
Het |
Or8k33 |
T |
C |
2: 86,384,298 (GRCm39) |
T57A |
probably damaging |
Het |
Or8k40 |
T |
A |
2: 86,584,464 (GRCm39) |
D206V |
probably benign |
Het |
Pde5a |
T |
C |
3: 122,523,001 (GRCm39) |
I36T |
probably benign |
Het |
Pign |
A |
T |
1: 105,449,785 (GRCm39) |
L914M |
possibly damaging |
Het |
Ppm1b |
A |
G |
17: 85,322,847 (GRCm39) |
D382G |
probably benign |
Het |
Psd3 |
T |
C |
8: 68,453,413 (GRCm39) |
Y282C |
probably damaging |
Het |
Ptprt |
A |
T |
2: 161,769,570 (GRCm39) |
Y432N |
probably damaging |
Het |
Rbbp6 |
T |
C |
7: 122,596,534 (GRCm39) |
|
probably null |
Het |
Recql4 |
A |
G |
15: 76,590,158 (GRCm39) |
S659P |
probably benign |
Het |
Rpl7a-ps3 |
G |
A |
15: 36,308,429 (GRCm39) |
|
noncoding transcript |
Het |
Shoc1 |
A |
T |
4: 59,060,915 (GRCm39) |
C953S |
possibly damaging |
Het |
Slit3 |
T |
C |
11: 35,574,875 (GRCm39) |
V1063A |
probably benign |
Het |
Spdye4a |
A |
G |
5: 143,211,378 (GRCm39) |
V62A |
probably benign |
Het |
Ttc6 |
G |
A |
12: 57,689,836 (GRCm39) |
G509S |
probably benign |
Het |
Ush2a |
C |
T |
1: 188,175,628 (GRCm39) |
T1242M |
probably benign |
Het |
Wwc2 |
T |
C |
8: 48,284,681 (GRCm39) |
S1155G |
unknown |
Het |
Zfp551 |
A |
T |
7: 12,152,568 (GRCm39) |
I55N |
probably damaging |
Het |
|
Other mutations in Meig1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00955:Meig1
|
APN |
2 |
3,410,311 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01311:Meig1
|
APN |
2 |
3,410,245 (GRCm39) |
missense |
possibly damaging |
0.78 |
IGL02329:Meig1
|
APN |
2 |
3,410,288 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02730:Meig1
|
APN |
2 |
3,412,947 (GRCm39) |
missense |
probably damaging |
1.00 |
R1119:Meig1
|
UTSW |
2 |
3,410,311 (GRCm39) |
missense |
probably damaging |
1.00 |
R1681:Meig1
|
UTSW |
2 |
3,410,311 (GRCm39) |
missense |
probably damaging |
1.00 |
R2155:Meig1
|
UTSW |
2 |
3,410,290 (GRCm39) |
missense |
probably benign |
0.08 |
R4787:Meig1
|
UTSW |
2 |
3,410,251 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4814:Meig1
|
UTSW |
2 |
3,412,959 (GRCm39) |
missense |
probably benign |
0.14 |
R5145:Meig1
|
UTSW |
2 |
3,410,263 (GRCm39) |
missense |
probably damaging |
0.98 |
R5694:Meig1
|
UTSW |
2 |
3,412,999 (GRCm39) |
missense |
probably damaging |
0.99 |
R7843:Meig1
|
UTSW |
2 |
3,410,248 (GRCm39) |
missense |
probably damaging |
1.00 |
R7974:Meig1
|
UTSW |
2 |
3,412,911 (GRCm39) |
nonsense |
probably null |
|
R8061:Meig1
|
UTSW |
2 |
3,410,240 (GRCm39) |
missense |
not run |
|
R9704:Meig1
|
UTSW |
2 |
3,410,336 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
PCR Primer
(F):5'- CAATTCAAGGTTTCAAGGTGGGTG -3'
(R):5'- TGTACTCCACGCTCCAAGAG -3'
Sequencing Primer
(F):5'- CAAGGTTTCAAGGTGGGTGTTTATG -3'
(R):5'- GGCAAGGACTTTAAAACTTAATCTCG -3'
|
Posted On |
2015-07-06 |