Incidental Mutation 'R4389:Vmn1r66'
| ID |
326333 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r66
|
| Ensembl Gene |
ENSMUSG00000043066 |
| Gene Name |
vomeronasal 1 receptor 66 |
| Synonyms |
V1re11 |
| MMRRC Submission |
041126-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
R4389 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
10007755-10009278 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 10008715 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 106
(L106*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153860
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060374]
[ENSMUST00000227719]
[ENSMUST00000228086]
[ENSMUST00000228622]
|
| AlphaFold |
Q8K4I0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000060374
AA Change: L106*
|
| SMART Domains |
Protein: ENSMUSP00000055861
Gene: ENSMUSG00000043066
AA Change: L106*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
39 |
295 |
4.5e-28 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226202
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000227719
AA Change: L106*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000228086
AA Change: L106*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000228622
AA Change: L106*
|
| Meta Mutation Damage Score |
0.9653 |
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.7%
- 10x: 96.6%
- 20x: 92.6%
|
| Validation Efficiency |
87% (26/30) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 22 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
A |
C |
11: 9,247,878 (GRCm39) |
T2542P |
probably damaging |
Het |
| Adprm |
C |
T |
11: 66,929,019 (GRCm39) |
R324K |
probably benign |
Het |
| Cd109 |
CATTTATTTATTTATTTATTTATTTATTTATTTAT |
CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT |
9: 78,619,782 (GRCm39) |
|
probably benign |
Het |
| Cd209b |
A |
G |
8: 3,975,960 (GRCm39) |
L67P |
probably damaging |
Het |
| Cfap54 |
T |
A |
10: 92,803,362 (GRCm39) |
K1560M |
probably benign |
Het |
| Ctps1 |
T |
C |
4: 120,415,987 (GRCm39) |
D212G |
probably damaging |
Het |
| Ercc6 |
T |
A |
14: 32,296,865 (GRCm39) |
L1285* |
probably null |
Het |
| Gzma |
G |
T |
13: 113,234,922 (GRCm39) |
|
probably null |
Het |
| Kng2 |
T |
C |
16: 22,843,618 (GRCm39) |
I120M |
possibly damaging |
Het |
| Lhx3 |
C |
T |
2: 26,091,102 (GRCm39) |
|
probably benign |
Het |
| Mtfr1l |
T |
C |
4: 134,259,953 (GRCm39) |
|
probably benign |
Het |
| Ndufb4 |
T |
C |
16: 37,468,032 (GRCm39) |
N126S |
probably benign |
Het |
| Nlrp4e |
A |
G |
7: 23,020,652 (GRCm39) |
I380V |
probably benign |
Het |
| Nptn |
A |
G |
9: 58,551,055 (GRCm39) |
K361E |
probably damaging |
Het |
| Or5an1c |
A |
G |
19: 12,218,503 (GRCm39) |
V174A |
probably damaging |
Het |
| Orc2 |
T |
C |
1: 58,514,020 (GRCm39) |
D332G |
probably benign |
Het |
| Pcdha4 |
T |
C |
18: 37,087,842 (GRCm39) |
V675A |
probably benign |
Het |
| Rpl7a-ps3 |
G |
A |
15: 36,308,429 (GRCm39) |
|
noncoding transcript |
Het |
| Slc13a1 |
A |
T |
6: 24,092,397 (GRCm39) |
|
probably null |
Het |
| Tec |
A |
G |
5: 72,939,350 (GRCm39) |
Y222H |
probably benign |
Het |
| Ttll2 |
T |
A |
17: 7,618,599 (GRCm39) |
R443* |
probably null |
Het |
| Zfp189 |
A |
G |
4: 49,529,934 (GRCm39) |
R346G |
probably damaging |
Het |
|
| Other mutations in Vmn1r66 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02957:Vmn1r66
|
APN |
7 |
10,008,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03236:Vmn1r66
|
APN |
7 |
10,008,990 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0380:Vmn1r66
|
UTSW |
7 |
10,008,670 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1625:Vmn1r66
|
UTSW |
7 |
10,008,316 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3745:Vmn1r66
|
UTSW |
7 |
10,008,248 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R4081:Vmn1r66
|
UTSW |
7 |
10,008,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Vmn1r66
|
UTSW |
7 |
10,008,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Vmn1r66
|
UTSW |
7 |
10,008,269 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6164:Vmn1r66
|
UTSW |
7 |
10,008,329 (GRCm39) |
nonsense |
probably null |
|
|
R6792:Vmn1r66
|
UTSW |
7 |
10,008,412 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6843:Vmn1r66
|
UTSW |
7 |
10,008,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7013:Vmn1r66
|
UTSW |
7 |
10,008,683 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7173:Vmn1r66
|
UTSW |
7 |
10,008,482 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7400:Vmn1r66
|
UTSW |
7 |
10,008,874 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9092:Vmn1r66
|
UTSW |
7 |
10,008,110 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
Z1176:Vmn1r66
|
UTSW |
7 |
10,008,212 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACTAATGCTGCATAAACTGAGTG -3'
(R):5'- TTGATTCTCATGCACCTCTGGG -3'
Sequencing Primer
(F):5'- TGGTTAACATAGGAGCAGTACTC -3'
(R):5'- GGAGCCAATGCCTTGATAGTTC -3'
|
| Posted On |
2015-07-06 |
Incidental Mutation