Incidental Mutation 'R4391:Stmn3'
ID 326357
Institutional Source Beutler Lab
Gene Symbol Stmn3
Ensembl Gene ENSMUSG00000027581
Gene Name stathmin-like 3
Synonyms Sclip, 9330161A03Rik
MMRRC Submission 041682-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.233) question?
Stock # R4391 (G1)
Quality Score 202
Status Validated
Chromosome 2
Chromosomal Location 181306459-181314500 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 181308783 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 77 (R77G)
Ref Sequence ENSEMBL: ENSMUSP00000099334 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103045]
AlphaFold O70166
Predicted Effect probably benign
Transcript: ENSMUST00000103045
AA Change: R77G

PolyPhen 2 Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000099334
Gene: ENSMUSG00000027581
AA Change: R77G

Pfam:Stathmin 41 175 2.7e-56 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.6%
  • 10x: 96.4%
  • 20x: 91.6%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030469F06Rik A T 12: 31,184,623 noncoding transcript Het
A530032D15Rik G A 1: 85,085,131 probably benign Het
Actn2 C T 13: 12,290,748 R394Q probably damaging Het
Atg16l1 A G 1: 87,760,120 D62G probably damaging Het
Atp2b1 A G 10: 99,003,214 T635A probably benign Het
Chil4 G A 3: 106,203,727 P284S possibly damaging Het
Dnah1 G A 14: 31,294,835 T1575I probably damaging Het
Dnah7b A G 1: 46,337,594 probably null Het
Dnajc12 A G 10: 63,407,059 T37A probably benign Het
Efcab5 T A 11: 77,090,458 N1354I probably damaging Het
Epas1 T C 17: 86,809,663 L218P probably benign Het
Fbxw15 T A 9: 109,568,232 probably benign Het
Filip1l C A 16: 57,570,792 S581* probably null Het
Focad T A 4: 88,185,958 I358K probably damaging Het
Gm382 T A X: 127,061,319 S376T probably benign Het
Gpsm1 C T 2: 26,323,997 R179C probably damaging Het
Hjurp A G 1: 88,266,561 probably benign Het
Homer3 G A 8: 70,290,143 probably null Het
Krt39 C T 11: 99,514,752 A441T probably benign Het
Nrd1 T A 4: 109,046,644 N662K probably damaging Het
Obox5 C T 7: 15,757,974 Q105* probably null Het
Olfr312 T A 11: 58,832,015 V287D possibly damaging Het
Olfr681 T A 7: 105,121,586 M43K possibly damaging Het
Olfr891 A T 9: 38,180,349 V158D probably damaging Het
Pcdhb5 T A 18: 37,322,736 L723Q possibly damaging Het
Pou3f3 G T 1: 42,697,458 A105S unknown Het
Ppp1r3d C T 2: 178,414,087 D41N probably damaging Het
Ppp4r1 A G 17: 65,824,754 N497S probably benign Het
Rad54b T G 4: 11,615,570 N859K probably benign Het
Sh3bp2 C T 5: 34,549,718 S29L probably benign Het
Smarcad1 A T 6: 65,056,459 N142I probably benign Het
Stat3 G A 11: 100,905,552 probably benign Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,211,984 probably benign Het
Vmn2r79 A G 7: 87,001,891 H166R possibly damaging Het
Xlr3a T C X: 73,091,844 I87V possibly damaging Het
Other mutations in Stmn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
Translucent UTSW 2 181308780 missense possibly damaging 0.81
IGL03147:Stmn3 UTSW 2 181309200 missense possibly damaging 0.63
R1916:Stmn3 UTSW 2 181307280 missense possibly damaging 0.86
R4113:Stmn3 UTSW 2 181307296 missense possibly damaging 0.87
R4910:Stmn3 UTSW 2 181308837 missense probably damaging 0.99
R5903:Stmn3 UTSW 2 181308780 missense possibly damaging 0.81
R6047:Stmn3 UTSW 2 181309159 missense possibly damaging 0.94
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-07-06