Mutagenetix > Incidental Mutation

Incidental Mutation 'R4392:Otog'

326411

Institutional Source

Beutler Lab

Gene Symbol

Otog

Ensembl Gene

ENSMUSG00000009487

Gene Name

otogelin

Synonyms

Otgn

MMRRC Submission

041127-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.844) question?

Stock #

R4392 (G1)

Quality Score

154

Status

Validated

Chromosome

Chromosomal Location

46240987-46311434 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 46285124 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 1369 (Y1369H)

Ref Sequence

ENSEMBL: ENSMUSP00000130949 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164538]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000164538
AA Change: Y1369H

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000130949
Gene: ENSMUSG00000009487
AA Change: Y1369H

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	72	85	N/A	INTRINSIC
VWD	128	288	7.98e-45	SMART
C8	330	404	1.05e-13	SMART
VWC	463	505	1.24e0	SMART
VWD	490	655	4.94e-50	SMART
C8	693	758	1.23e-5	SMART
Pfam:TIL	767	831	3.4e-13	PFAM
VWC	935	983	1.83e0	SMART
VWD	962	1118	6.05e-45	SMART
C8	1153	1227	1.02e-34	SMART
Pfam:AbfB	1270	1384	7.5e-10	PFAM
low complexity region	1488	1513	N/A	INTRINSIC
low complexity region	1524	1536	N/A	INTRINSIC
low complexity region	1560	1578	N/A	INTRINSIC
low complexity region	1637	1644	N/A	INTRINSIC
low complexity region	1677	1696	N/A	INTRINSIC
low complexity region	1731	1748	N/A	INTRINSIC
VWD	2087	2251	2.37e-29	SMART
C8	2287	2356	4.93e-19	SMART
low complexity region	2443	2449	N/A	INTRINSIC
CT	2828	2911	3.46e-28	SMART

Meta Mutation Damage Score

0.6436

Coding Region Coverage

1x: 99.5%
3x: 98.5%
10x: 96.1%
20x: 90.5%

Validation Efficiency

95% (69/73)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness, type 18B. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
PHENOTYPE: Homozygotes for a number of different spontaneous and targeted mutations exhibit vestibular dysfunction, including circling, head tilt, impaired balance, coordination, and placing response. Mutants have impaired hearing, decreased brain stem auditory evoked potential, and ear abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931414P19Rik	C	T	14: 54,584,978 (GRCm38)		probably null	Het
Abca13	A	C	11: 9,309,034 (GRCm38)	K2920T	possibly damaging	Het
Amy2b	T	G	3: 113,149,408 (GRCm38)		noncoding transcript	Het
Anapc1	T	C	2: 128,676,249 (GRCm38)		probably null	Het
Bmp7	T	G	2: 172,916,542 (GRCm38)	D178A	probably benign	Het
Brsk1	T	A	7: 4,698,750 (GRCm38)	I170N	probably damaging	Het
Bub3	C	T	7: 131,566,335 (GRCm38)	A187V	probably benign	Het
Cacna2d2	A	G	9: 107,400,280 (GRCm38)	H71R	possibly damaging	Het
Cdrt4	A	T	11: 62,951,353 (GRCm38)	K20N	probably benign	Het
Clec12a	A	T	6: 129,353,464 (GRCm38)		probably benign	Het
Col12a1	T	A	9: 79,662,488 (GRCm38)	Y1600F	probably damaging	Het
Cyp2a12	T	A	7: 27,029,275 (GRCm38)	I57N	probably damaging	Het
Dip2b	T	C	15: 100,162,036 (GRCm38)	L223P	probably damaging	Het
Dnah5	G	A	15: 28,289,229 (GRCm38)	R1188H	probably benign	Het
Dopey1	T	C	9: 86,503,143 (GRCm38)		probably benign	Het
Efcab5	T	A	11: 77,090,458 (GRCm38)	N1354I	probably damaging	Het
Eif4b	T	A	15: 102,086,641 (GRCm38)		probably null	Het
Elmsan1	A	T	12: 84,173,111 (GRCm38)	D356E	probably benign	Het
Erlec1	A	G	11: 30,943,697 (GRCm38)		probably null	Het
Esp24	T	C	17: 39,040,077 (GRCm38)		probably benign	Het
Esp34	T	C	17: 38,559,491 (GRCm38)	V24A	possibly damaging	Het
Fbxw15	T	A	9: 109,568,232 (GRCm38)		probably benign	Het
Foxc2	T	C	8: 121,117,452 (GRCm38)	S280P	probably damaging	Het
Gm21738	G	C	14: 19,417,178 (GRCm38)	L117V	probably benign	Het
Grk3	A	G	5: 112,920,136 (GRCm38)	F467S	probably damaging	Het
Grwd1	C	T	7: 45,827,780 (GRCm38)	G228S	probably damaging	Het
Gtf2i	T	C	5: 134,260,629 (GRCm38)	E399G	probably damaging	Het
Hjurp	GT	GTT	1: 88,266,524 (GRCm38)		probably null	Het
Homer3	G	A	8: 70,290,143 (GRCm38)		probably null	Het
Lhx4	A	G	1: 155,710,134 (GRCm38)	Y83H	probably damaging	Het
Mdga1	T	C	17: 29,850,656 (GRCm38)	T413A	probably damaging	Het
Mmrn2	T	A	14: 34,397,616 (GRCm38)	L184H	probably damaging	Het
Mroh2a	C	T	1: 88,259,589 (GRCm38)	R133C	probably damaging	Het
Myh13	A	C	11: 67,344,881 (GRCm38)		probably null	Het
Nkain3	C	A	4: 20,282,985 (GRCm38)	R116L	possibly damaging	Het
Nxph2	A	C	2: 23,400,272 (GRCm38)	Q212P	probably damaging	Het
Olfr268-ps1	T	C	2: 111,844,345 (GRCm38)		noncoding transcript	Het
Olfr726	A	G	14: 50,084,603 (GRCm38)	F26S	probably benign	Het
Prl	A	G	13: 27,064,351 (GRCm38)	I131V	possibly damaging	Het
Ptprg	A	T	14: 12,142,467 (GRCm38)	I373F	possibly damaging	Het
Rad18	A	T	6: 112,693,529 (GRCm38)	C25S	probably damaging	Het
Rgs12	A	G	5: 35,032,311 (GRCm38)	T678A	probably damaging	Het
Scaper	T	A	9: 55,858,115 (GRCm38)	E557V	probably damaging	Het
Scube3	C	T	17: 28,164,788 (GRCm38)	P511L	probably null	Het
Sgpl1	A	G	10: 61,104,452 (GRCm38)		probably benign	Het
Slc10a1	C	A	12: 80,967,804 (GRCm38)	E47D	probably damaging	Het
Sptbn4	T	C	7: 27,418,471 (GRCm38)	N369S	probably damaging	Het
Sstr5	T	C	17: 25,491,224 (GRCm38)	T344A	probably benign	Het
Tgm4	C	T	9: 123,066,752 (GRCm38)	T631I	probably benign	Het
Tmprss15	A	G	16: 79,024,438 (GRCm38)	Y457H	probably damaging	Het
Trpm7	A	T	2: 126,848,538 (GRCm38)	W207R	probably damaging	Het
Trpm7	A	T	2: 126,795,509 (GRCm38)		probably null	Het
Ttc26	A	G	6: 38,381,557 (GRCm38)		probably benign	Het
Ugt1a1	CAGAGAGAGAGAGA	CAGAGAGAGAGA	1: 88,211,984 (GRCm38)		probably benign	Het
Ugt1a10	C	T	1: 88,215,123 (GRCm38)	P113L	probably damaging	Het
Usp2	A	T	9: 44,091,259 (GRCm38)	H384L	probably damaging	Het
Vmn2r27	C	T	6: 124,230,176 (GRCm38)	V169I	probably benign	Het
Vopp1	A	C	6: 57,762,476 (GRCm38)	F29C	probably damaging	Het
Wrn	T	C	8: 33,251,832 (GRCm38)	D953G	probably damaging	Het
Zfp759	T	A	13: 67,139,643 (GRCm38)	C419*	probably null	Het

Other mutations in Otog

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00516:Otog	APN	7	46,251,282 (GRCm38)	missense	probably damaging	1.00
IGL00725:Otog	APN	7	46,274,092 (GRCm38)	missense	probably damaging	1.00
IGL00757:Otog	APN	7	46,290,128 (GRCm38)	missense	probably damaging	1.00
IGL00822:Otog	APN	7	46,295,880 (GRCm38)	missense	probably benign	0.24
IGL01354:Otog	APN	7	46,289,726 (GRCm38)	missense	probably damaging	1.00
IGL01567:Otog	APN	7	46,276,615 (GRCm38)	splice site	probably benign
IGL02034:Otog	APN	7	46,295,993 (GRCm38)	nonsense	probably null
IGL02090:Otog	APN	7	46,300,147 (GRCm38)	missense	probably damaging	1.00
IGL02132:Otog	APN	7	46,305,479 (GRCm38)	missense	probably damaging	0.99
IGL02148:Otog	APN	7	46,300,587 (GRCm38)	missense	probably damaging	1.00
IGL02173:Otog	APN	7	46,276,741 (GRCm38)	splice site	probably benign
IGL02199:Otog	APN	7	46,277,351 (GRCm38)	missense	possibly damaging	0.90
IGL02216:Otog	APN	7	46,301,468 (GRCm38)	missense	probably damaging	1.00
IGL02322:Otog	APN	7	46,301,457 (GRCm38)	missense	probably benign	0.01
IGL02330:Otog	APN	7	46,288,069 (GRCm38)	missense	possibly damaging	0.84
IGL02529:Otog	APN	7	46,259,957 (GRCm38)	missense	probably damaging	0.99
IGL02898:Otog	APN	7	46,310,138 (GRCm38)	missense	probably damaging	1.00
IGL02970:Otog	APN	7	46,295,867 (GRCm38)	missense	probably benign	0.11
IGL03085:Otog	APN	7	46,305,922 (GRCm38)	critical splice donor site	probably null
IGL03108:Otog	APN	7	46,251,338 (GRCm38)	missense	probably damaging	1.00
IGL03275:Otog	APN	7	46,306,230 (GRCm38)	missense	probably damaging	1.00
R0282_Otog_616	UTSW	7	46,277,493 (GRCm38)	missense	possibly damaging	0.93
R0636_otog_678	UTSW	7	46,264,228 (GRCm38)	critical splice donor site	probably null
R1029_otog_141	UTSW	7	46,274,595 (GRCm38)	missense	probably damaging	1.00
BB010:Otog	UTSW	7	46,310,147 (GRCm38)	missense	probably damaging	1.00
BB020:Otog	UTSW	7	46,310,147 (GRCm38)	missense	probably damaging	1.00
I1329:Otog	UTSW	7	46,246,503 (GRCm38)	missense	probably benign	0.02
IGL02984:Otog	UTSW	7	46,305,508 (GRCm38)	missense	probably damaging	0.98
PIT4472001:Otog	UTSW	7	46,295,849 (GRCm38)	missense	probably damaging	1.00
R0032:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0032:Otog	UTSW	7	46,288,213 (GRCm38)	nonsense	probably null
R0105:Otog	UTSW	7	46,288,366 (GRCm38)	missense	possibly damaging	0.79
R0164:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0164:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0165:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0166:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0167:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0240:Otog	UTSW	7	46,264,032 (GRCm38)	splice site	probably null
R0240:Otog	UTSW	7	46,264,032 (GRCm38)	splice site	probably null
R0242:Otog	UTSW	7	46,267,381 (GRCm38)	missense	probably damaging	0.98
R0242:Otog	UTSW	7	46,267,381 (GRCm38)	missense	probably damaging	0.98
R0282:Otog	UTSW	7	46,277,493 (GRCm38)	missense	possibly damaging	0.93
R0392:Otog	UTSW	7	46,250,075 (GRCm38)	missense	probably benign	0.00
R0436:Otog	UTSW	7	46,265,936 (GRCm38)	splice site	probably benign
R0441:Otog	UTSW	7	46,305,877 (GRCm38)	missense	probably damaging	1.00
R0499:Otog	UTSW	7	46,273,832 (GRCm38)	missense	probably damaging	1.00
R0530:Otog	UTSW	7	46,298,244 (GRCm38)	missense	probably damaging	0.98
R0541:Otog	UTSW	7	46,269,249 (GRCm38)	splice site	probably benign
R0600:Otog	UTSW	7	46,251,395 (GRCm38)	splice site	probably benign
R0626:Otog	UTSW	7	46,271,373 (GRCm38)	missense	possibly damaging	0.95
R0636:Otog	UTSW	7	46,264,228 (GRCm38)	critical splice donor site	probably null
R0764:Otog	UTSW	7	46,300,494 (GRCm38)	missense	probably benign	0.00
R0833:Otog	UTSW	7	46,269,362 (GRCm38)	missense	possibly damaging	0.94
R0836:Otog	UTSW	7	46,269,362 (GRCm38)	missense	possibly damaging	0.94
R0844:Otog	UTSW	7	46,287,828 (GRCm38)	missense	possibly damaging	0.53
R1029:Otog	UTSW	7	46,274,595 (GRCm38)	missense	probably damaging	1.00
R1116:Otog	UTSW	7	46,300,601 (GRCm38)	splice site	probably benign
R1134:Otog	UTSW	7	46,298,514 (GRCm38)	missense	probably damaging	1.00
R1183:Otog	UTSW	7	46,289,755 (GRCm38)	missense	probably benign	0.41
R1204:Otog	UTSW	7	46,259,911 (GRCm38)	missense	probably benign	0.16
R1301:Otog	UTSW	7	46,289,689 (GRCm38)	missense	probably damaging	1.00
R1344:Otog	UTSW	7	46,274,615 (GRCm38)	missense	probably damaging	1.00
R1384:Otog	UTSW	7	46,273,695 (GRCm38)	splice site	probably benign
R1418:Otog	UTSW	7	46,274,615 (GRCm38)	missense	probably damaging	1.00
R1432:Otog	UTSW	7	46,300,583 (GRCm38)	missense	probably damaging	1.00
R1479:Otog	UTSW	7	46,295,978 (GRCm38)	missense	possibly damaging	0.75
R1521:Otog	UTSW	7	46,259,264 (GRCm38)	missense	possibly damaging	0.71
R1589:Otog	UTSW	7	46,283,908 (GRCm38)	missense	probably benign	0.18
R1671:Otog	UTSW	7	46,261,786 (GRCm38)	missense	probably damaging	1.00
R1773:Otog	UTSW	7	46,288,159 (GRCm38)	missense	probably benign	0.28
R1806:Otog	UTSW	7	46,290,937 (GRCm38)	critical splice acceptor site	probably null
R1843:Otog	UTSW	7	46,246,283 (GRCm38)	missense	probably damaging	1.00
R1873:Otog	UTSW	7	46,269,343 (GRCm38)	missense	probably damaging	1.00
R1923:Otog	UTSW	7	46,246,283 (GRCm38)	missense	probably damaging	1.00
R1927:Otog	UTSW	7	46,246,283 (GRCm38)	missense	probably damaging	1.00
R2008:Otog	UTSW	7	46,264,074 (GRCm38)	missense	probably benign	0.43
R2048:Otog	UTSW	7	46,287,639 (GRCm38)	missense	probably damaging	1.00
R2131:Otog	UTSW	7	46,250,100 (GRCm38)	missense	probably damaging	1.00
R2153:Otog	UTSW	7	46,302,904 (GRCm38)	missense	probably damaging	1.00
R2240:Otog	UTSW	7	46,241,029 (GRCm38)	start codon destroyed	probably null
R2278:Otog	UTSW	7	46,300,044 (GRCm38)	missense	probably damaging	1.00
R2407:Otog	UTSW	7	46,241,540 (GRCm38)	missense	probably benign	0.10
R2424:Otog	UTSW	7	46,298,169 (GRCm38)	nonsense	probably null
R2513:Otog	UTSW	7	46,305,590 (GRCm38)	critical splice donor site	probably null
R2863:Otog	UTSW	7	46,269,306 (GRCm38)	missense	probably damaging	1.00
R3148:Otog	UTSW	7	46,290,169 (GRCm38)	missense	probably damaging	1.00
R3732:Otog	UTSW	7	46,288,368 (GRCm38)	missense	probably benign	0.03
R3732:Otog	UTSW	7	46,288,368 (GRCm38)	missense	probably benign	0.03
R3733:Otog	UTSW	7	46,288,368 (GRCm38)	missense	probably benign	0.03
R3734:Otog	UTSW	7	46,288,368 (GRCm38)	missense	probably benign	0.03
R3855:Otog	UTSW	7	46,273,760 (GRCm38)	missense	possibly damaging	0.65
R3880:Otog	UTSW	7	46,288,021 (GRCm38)	missense	possibly damaging	0.93
R4081:Otog	UTSW	7	46,288,299 (GRCm38)	missense	possibly damaging	0.92
R4349:Otog	UTSW	7	46,274,189 (GRCm38)	missense	probably damaging	0.99
R4382:Otog	UTSW	7	46,289,698 (GRCm38)	missense	probably damaging	1.00
R4520:Otog	UTSW	7	46,241,053 (GRCm38)	unclassified	probably benign
R4569:Otog	UTSW	7	46,310,147 (GRCm38)	missense	probably damaging	1.00
R4580:Otog	UTSW	7	46,287,801 (GRCm38)	missense	possibly damaging	0.78
R4672:Otog	UTSW	7	46,289,786 (GRCm38)	missense	probably damaging	0.98
R4764:Otog	UTSW	7	46,288,519 (GRCm38)	missense	probably benign	0.29
R4910:Otog	UTSW	7	46,298,534 (GRCm38)	missense	probably damaging	1.00
R4910:Otog	UTSW	7	46,264,062 (GRCm38)	missense	probably damaging	1.00
R4913:Otog	UTSW	7	46,264,102 (GRCm38)	missense	probably benign	0.31
R4975:Otog	UTSW	7	46,287,991 (GRCm38)	missense	probably benign	0.00
R4996:Otog	UTSW	7	46,305,510 (GRCm38)	nonsense	probably null
R4996:Otog	UTSW	7	46,298,606 (GRCm38)	missense	possibly damaging	0.51
R5116:Otog	UTSW	7	46,273,767 (GRCm38)	missense	probably benign	0.34
R5138:Otog	UTSW	7	46,250,006 (GRCm38)	missense	possibly damaging	0.61
R5169:Otog	UTSW	7	46,298,148 (GRCm38)	missense	probably benign	0.06
R5239:Otog	UTSW	7	46,287,435 (GRCm38)	missense	probably benign	0.15
R5277:Otog	UTSW	7	46,246,621 (GRCm38)	missense	possibly damaging	0.89
R5287:Otog	UTSW	7	46,269,329 (GRCm38)	missense	probably damaging	0.98
R5299:Otog	UTSW	7	46,288,851 (GRCm38)	missense	probably benign	0.16
R5378:Otog	UTSW	7	46,255,004 (GRCm38)	missense	probably damaging	1.00
R5382:Otog	UTSW	7	46,249,004 (GRCm38)	missense	probably damaging	1.00
R5487:Otog	UTSW	7	46,288,768 (GRCm38)	missense	probably benign	0.27
R5507:Otog	UTSW	7	46,261,699 (GRCm38)	missense	probably damaging	1.00
R5517:Otog	UTSW	7	46,274,571 (GRCm38)	missense	probably damaging	1.00
R5643:Otog	UTSW	7	46,287,447 (GRCm38)	missense	probably damaging	1.00
R5757:Otog	UTSW	7	46,241,121 (GRCm38)	critical splice donor site	probably null
R5910:Otog	UTSW	7	46,298,598 (GRCm38)	missense	possibly damaging	0.94
R6019:Otog	UTSW	7	46,288,950 (GRCm38)	missense	probably benign	0.00
R6150:Otog	UTSW	7	46,264,059 (GRCm38)	missense	possibly damaging	0.82
R6225:Otog	UTSW	7	46,249,034 (GRCm38)	missense	possibly damaging	0.67
R6271:Otog	UTSW	7	46,252,040 (GRCm38)	missense	probably damaging	1.00
R6317:Otog	UTSW	7	46,301,215 (GRCm38)	missense	probably damaging	1.00
R6454:Otog	UTSW	7	46,305,817 (GRCm38)	missense	probably damaging	1.00
R6640:Otog	UTSW	7	46,261,743 (GRCm38)	missense	possibly damaging	0.92
R6753:Otog	UTSW	7	46,249,071 (GRCm38)	missense	probably benign	0.06
R6788:Otog	UTSW	7	46,298,317 (GRCm38)	missense	probably damaging	1.00
R6859:Otog	UTSW	7	46,273,781 (GRCm38)	missense	probably damaging	0.96
R7033:Otog	UTSW	7	46,267,398 (GRCm38)	critical splice donor site	probably null
R7071:Otog	UTSW	7	46,267,323 (GRCm38)	missense	probably damaging	1.00
R7084:Otog	UTSW	7	46,298,566 (GRCm38)	nonsense	probably null
R7116:Otog	UTSW	7	46,298,265 (GRCm38)	missense	probably damaging	0.99
R7202:Otog	UTSW	7	46,288,050 (GRCm38)	missense	probably damaging	0.97
R7365:Otog	UTSW	7	46,298,308 (GRCm38)	missense	probably damaging	1.00
R7468:Otog	UTSW	7	46,264,119 (GRCm38)	missense	probably benign
R7475:Otog	UTSW	7	46,267,276 (GRCm38)	missense	probably damaging	0.99
R7502:Otog	UTSW	7	46,298,615 (GRCm38)	missense	probably damaging	1.00
R7558:Otog	UTSW	7	46,303,160 (GRCm38)	missense	probably damaging	0.99
R7577:Otog	UTSW	7	46,287,855 (GRCm38)	missense	possibly damaging	0.62
R7651:Otog	UTSW	7	46,241,761 (GRCm38)	missense	probably benign	0.00
R7689:Otog	UTSW	7	46,252,056 (GRCm38)	missense	probably damaging	1.00
R7806:Otog	UTSW	7	46,285,776 (GRCm38)	missense	probably benign
R7933:Otog	UTSW	7	46,310,147 (GRCm38)	missense	probably damaging	1.00
R8021:Otog	UTSW	7	46,267,342 (GRCm38)	missense	probably damaging	0.98
R8082:Otog	UTSW	7	46,289,719 (GRCm38)	missense	probably damaging	1.00
R8531:Otog	UTSW	7	46,252,049 (GRCm38)	missense	probably damaging	0.99
R8772:Otog	UTSW	7	46,284,928 (GRCm38)	missense	probably damaging	1.00
R8816:Otog	UTSW	7	46,301,481 (GRCm38)	missense	possibly damaging	0.92
R8842:Otog	UTSW	7	46,246,524 (GRCm38)	missense	probably damaging	1.00
R8987:Otog	UTSW	7	46,287,454 (GRCm38)	missense	probably benign	0.43
R8988:Otog	UTSW	7	46,310,147 (GRCm38)	missense	probably damaging	1.00
R9010:Otog	UTSW	7	46,300,470 (GRCm38)	missense	probably benign	0.00
R9025:Otog	UTSW	7	46,288,096 (GRCm38)	missense	probably benign	0.13
R9131:Otog	UTSW	7	46,303,173 (GRCm38)	nonsense	probably null
R9179:Otog	UTSW	7	46,288,461 (GRCm38)	missense	possibly damaging	0.65
R9334:Otog	UTSW	7	46,259,929 (GRCm38)	missense	possibly damaging	0.95
R9365:Otog	UTSW	7	46,271,264 (GRCm38)	missense	probably damaging	1.00
R9408:Otog	UTSW	7	46,267,297 (GRCm38)	missense	possibly damaging	0.79
R9418:Otog	UTSW	7	46,288,600 (GRCm38)	missense	probably benign	0.41
R9465:Otog	UTSW	7	46,305,875 (GRCm38)	missense	possibly damaging	0.80
R9496:Otog	UTSW	7	46,241,081 (GRCm38)	missense	unknown
R9632:Otog	UTSW	7	46,265,719 (GRCm38)	missense	probably benign	0.27
R9656:Otog	UTSW	7	46,310,143 (GRCm38)	missense	probably damaging	1.00
RF024:Otog	UTSW	7	46,287,669 (GRCm38)	missense	probably damaging	1.00
X0062:Otog	UTSW	7	46,259,921 (GRCm38)	missense	probably damaging	1.00
Z1177:Otog	UTSW	7	46,289,740 (GRCm38)	missense	probably damaging	1.00
Z1177:Otog	UTSW	7	46,274,538 (GRCm38)	missense	probably damaging	1.00
Z1177:Otog	UTSW	7	46,262,852 (GRCm38)	missense	possibly damaging	0.80
Z1177:Otog	UTSW	7	46,309,985 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GACAGACCCAACTTCTTCCTG -3'
(R):5'- GAGATCAGACCACCTCCTGTTC -3'

Sequencing Primer
(F):5'- ACTTCTTCCTGCACACCACAG -3'
(R):5'- GTAAACCCCAGGGAGCCCTC -3'

Posted On

2015-07-06