Mutagenetix > Incidental Mutation

Incidental Mutation 'R4392:Fbxw15'

326420

Institutional Source

Beutler Lab

Gene Symbol

Fbxw15

Ensembl Gene

ENSMUSG00000074060

Gene Name

F-box and WD-40 domain protein 15

Synonyms

Fbxo12J

MMRRC Submission

041127-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

R4392 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

109552602-109568262 bp(-) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

T to A at 109568232 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143385 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056745] [ENSMUST00000198112] [ENSMUST00000198397]

AlphaFold

L7N1X6

Predicted Effect

probably benign
Transcript: ENSMUST00000056745

SMART Domains

Protein: ENSMUSP00000058175
Gene: ENSMUSG00000074060

Domain	Start	End	E-Value	Type
FBOX	8	45	3.25e-4	SMART
SCOP:d1flga_	73	413	3e-7	SMART
Blast:WD40	137	176	5e-6	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000198112

SMART Domains

Protein: ENSMUSP00000142894
Gene: ENSMUSG00000074060

Domain	Start	End	E-Value	Type
FBOX	8	45	2.1e-6	SMART
SCOP:d1tbga_	73	196	3e-5	SMART
Blast:WD40	84	123	1e-5	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000198397

SMART Domains

Protein: ENSMUSP00000143385
Gene: ENSMUSG00000074060

Domain	Start	End	E-Value	Type
FBOX	8	45	3.25e-4	SMART
SCOP:d1tbga_	116	240	1e-3	SMART
Blast:WD40	137	176	6e-6	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198533

Coding Region Coverage

1x: 99.5%
3x: 98.5%
10x: 96.1%
20x: 90.5%

Validation Efficiency

95% (69/73)

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931414P19Rik	C	T	14: 54,584,978		probably null	Het
Abca13	A	C	11: 9,309,034	K2920T	possibly damaging	Het
Amy2b	T	G	3: 113,149,408		noncoding transcript	Het
Anapc1	T	C	2: 128,676,249		probably null	Het
Bmp7	T	G	2: 172,916,542	D178A	probably benign	Het
Brsk1	T	A	7: 4,698,750	I170N	probably damaging	Het
Bub3	C	T	7: 131,566,335	A187V	probably benign	Het
Cacna2d2	A	G	9: 107,400,280	H71R	possibly damaging	Het
Cdrt4	A	T	11: 62,951,353	K20N	probably benign	Het
Clec12a	A	T	6: 129,353,464		probably benign	Het
Col12a1	T	A	9: 79,662,488	Y1600F	probably damaging	Het
Cyp2a12	T	A	7: 27,029,275	I57N	probably damaging	Het
Dip2b	T	C	15: 100,162,036	L223P	probably damaging	Het
Dnah5	G	A	15: 28,289,229	R1188H	probably benign	Het
Dopey1	T	C	9: 86,503,143		probably benign	Het
Efcab5	T	A	11: 77,090,458	N1354I	probably damaging	Het
Eif4b	T	A	15: 102,086,641		probably null	Het
Elmsan1	A	T	12: 84,173,111	D356E	probably benign	Het
Erlec1	A	G	11: 30,943,697		probably null	Het
Esp24	T	C	17: 39,040,077		probably benign	Het
Esp34	T	C	17: 38,559,491	V24A	possibly damaging	Het
Foxc2	T	C	8: 121,117,452	S280P	probably damaging	Het
Gm21738	G	C	14: 19,417,178	L117V	probably benign	Het
Grk3	A	G	5: 112,920,136	F467S	probably damaging	Het
Grwd1	C	T	7: 45,827,780	G228S	probably damaging	Het
Gtf2i	T	C	5: 134,260,629	E399G	probably damaging	Het
Hjurp	GT	GTT	1: 88,266,524		probably null	Het
Homer3	G	A	8: 70,290,143		probably null	Het
Lhx4	A	G	1: 155,710,134	Y83H	probably damaging	Het
Mdga1	T	C	17: 29,850,656	T413A	probably damaging	Het
Mmrn2	T	A	14: 34,397,616	L184H	probably damaging	Het
Mroh2a	C	T	1: 88,259,589	R133C	probably damaging	Het
Myh13	A	C	11: 67,344,881		probably null	Het
Nkain3	C	A	4: 20,282,985	R116L	possibly damaging	Het
Nxph2	A	C	2: 23,400,272	Q212P	probably damaging	Het
Olfr268-ps1	T	C	2: 111,844,345		noncoding transcript	Het
Olfr726	A	G	14: 50,084,603	F26S	probably benign	Het
Otog	T	C	7: 46,285,124	Y1369H	probably damaging	Het
Prl	A	G	13: 27,064,351	I131V	possibly damaging	Het
Ptprg	A	T	14: 12,142,467	I373F	possibly damaging	Het
Rad18	A	T	6: 112,693,529	C25S	probably damaging	Het
Rgs12	A	G	5: 35,032,311	T678A	probably damaging	Het
Scaper	T	A	9: 55,858,115	E557V	probably damaging	Het
Scube3	C	T	17: 28,164,788	P511L	probably null	Het
Sgpl1	A	G	10: 61,104,452		probably benign	Het
Slc10a1	C	A	12: 80,967,804	E47D	probably damaging	Het
Sptbn4	T	C	7: 27,418,471	N369S	probably damaging	Het
Sstr5	T	C	17: 25,491,224	T344A	probably benign	Het
Tgm4	C	T	9: 123,066,752	T631I	probably benign	Het
Tmprss15	A	G	16: 79,024,438	Y457H	probably damaging	Het
Trpm7	A	T	2: 126,848,538	W207R	probably damaging	Het
Trpm7	A	T	2: 126,795,509		probably null	Het
Ttc26	A	G	6: 38,381,557		probably benign	Het
Ugt1a1	CAGAGAGAGAGAGA	CAGAGAGAGAGA	1: 88,211,984		probably benign	Het
Ugt1a10	C	T	1: 88,215,123	P113L	probably damaging	Het
Usp2	A	T	9: 44,091,259	H384L	probably damaging	Het
Vmn2r27	C	T	6: 124,230,176	V169I	probably benign	Het
Vopp1	A	C	6: 57,762,476	F29C	probably damaging	Het
Wrn	T	C	8: 33,251,832	D953G	probably damaging	Het
Zfp759	T	A	13: 67,139,643	C419*	probably null	Het

Other mutations in Fbxw15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02094:Fbxw15	APN	9	109558240	missense	possibly damaging	0.87
IGL02239:Fbxw15	APN	9	109559837	missense	probably benign	0.01
IGL02343:Fbxw15	APN	9	109552655	utr 3 prime	probably benign
IGL02748:Fbxw15	APN	9	109558210	missense	possibly damaging	0.66
IGL03206:Fbxw15	APN	9	109565362	missense	possibly damaging	0.90
IGL03370:Fbxw15	APN	9	109555151	missense	probably benign	0.00
lagging	UTSW	9	109555673	splice site	probably null
R0321:Fbxw15	UTSW	9	109565385	missense	probably benign	0.03
R0742:Fbxw15	UTSW	9	109555556	splice site	probably null
R1141:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1143:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1276:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1282:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1283:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1321:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1324:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1341:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1716:Fbxw15	UTSW	9	109557136	missense	probably benign	0.00
R1750:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1757:Fbxw15	UTSW	9	109557279	missense	probably damaging	0.99
R1765:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1799:Fbxw15	UTSW	9	109558246	missense	probably damaging	0.99
R1826:Fbxw15	UTSW	9	109559714	splice site	probably null
R1897:Fbxw15	UTSW	9	109558203	nonsense	probably null
R2237:Fbxw15	UTSW	9	109555235	missense	probably damaging	0.99
R2346:Fbxw15	UTSW	9	109565432	missense	probably damaging	1.00
R4391:Fbxw15	UTSW	9	109568232	start gained	probably benign
R4812:Fbxw15	UTSW	9	109559922	missense	probably benign	0.01
R5198:Fbxw15	UTSW	9	109558174	missense	probably benign	0.00
R5278:Fbxw15	UTSW	9	109555684	missense	probably benign	0.03
R5541:Fbxw15	UTSW	9	109565430	missense	probably benign	0.23
R5899:Fbxw15	UTSW	9	109555673	splice site	probably null
R5975:Fbxw15	UTSW	9	109555252	missense	probably damaging	1.00
R6065:Fbxw15	UTSW	9	109568178	missense	probably damaging	1.00
R6285:Fbxw15	UTSW	9	109557166	missense	probably benign	0.09
R7357:Fbxw15	UTSW	9	109558240	missense	probably benign	0.28
R7781:Fbxw15	UTSW	9	109557262	missense	possibly damaging	0.71
R8145:Fbxw15	UTSW	9	109555590	missense	probably benign	0.01
R8182:Fbxw15	UTSW	9	109555710	missense	probably benign	0.00
R8272:Fbxw15	UTSW	9	109559760	missense	probably benign	0.18
R8713:Fbxw15	UTSW	9	109555599	missense	possibly damaging	0.93
R9069:Fbxw15	UTSW	9	109565400	nonsense	probably null
R9496:Fbxw15	UTSW	9	109568223	missense	probably benign	0.01
X0026:Fbxw15	UTSW	9	109558187	missense	probably damaging	0.99

Predicted Primers

Posted On

2015-07-06