|Institutional Source||Beutler Lab|
|Gene Name||protein tyrosine phosphatase, receptor type, G|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4392 (G1)|
|Chromosomal Location||11553532-12242041 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 12142467 bp (GRCm38)|
|Amino Acid Change||Isoleucine to Phenylalanine at position 373 (I373F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000022264 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000022264] [ENSMUST00000142917]|
|AlphaFold||no structure available at present|
AA Change: I373F
PolyPhen 2 Score 0.797 (Sensitivity: 0.84; Specificity: 0.93)
AA Change: I373F
|Meta Mutation Damage Score||0.1328|
|Coding Region Coverage||
|Validation Efficiency||95% (69/73)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ptprg||
(F):5'- CCAGAGTTGGGATCTTACCGTAG -3'
(R):5'- CAATCTTGTCCTGGCTAGCTG -3'
(F):5'- GATCCATTTCCTGAAGTCAGAGG -3'
(R):5'- TGCCTGCTTCCATGGATC -3'