Incidental Mutation 'R4394:Mgst2'
ID 326516
Institutional Source Beutler Lab
Gene Symbol Mgst2
Ensembl Gene ENSMUSG00000074604
Gene Name microsomal glutathione S-transferase 2
Synonyms GST2, MGST-II
MMRRC Submission 041683-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.224) question?
Stock # R4394 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 51567781-51590098 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 51571949 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 26 (V26I)
Ref Sequence ENSEMBL: ENSMUSP00000096705 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099106] [ENSMUST00000159554] [ENSMUST00000161590]
AlphaFold A2RST1
Predicted Effect probably damaging
Transcript: ENSMUST00000099106
AA Change: V26I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000096705
Gene: ENSMUSG00000074604
AA Change: V26I

DomainStartEndE-ValueType
Pfam:MAPEG 8 124 8.8e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000159554
AA Change: V26I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000141745
Gene: ENSMUSG00000074604
AA Change: V26I

DomainStartEndE-ValueType
Pfam:MAPEG 8 80 3.8e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160753
Predicted Effect possibly damaging
Transcript: ENSMUST00000161590
AA Change: V26I

PolyPhen 2 Score 0.805 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000125670
Gene: ENSMUSG00000074604
AA Change: V26I

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161627
Meta Mutation Damage Score 0.5879 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.8%
  • 10x: 96.8%
  • 20x: 93.4%
Validation Efficiency 99% (69/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trap allele display resistance to induced ER stress related cell death and mortality. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb1 A G 6: 88,813,566 (GRCm39) F391L probably damaging Het
AC140205.10 C A 8: 21,323,181 (GRCm39) T192K probably benign Het
Arid4b T A 13: 14,329,557 (GRCm39) probably null Het
Bahd1 G A 2: 118,753,004 (GRCm39) R757H probably damaging Het
Brip1 A T 11: 85,965,124 (GRCm39) N855K possibly damaging Het
Ces2f A G 8: 105,677,586 (GRCm39) N197S probably damaging Het
Chd4 A G 6: 125,098,581 (GRCm39) T1520A probably damaging Het
Cltc A C 11: 86,624,456 (GRCm39) N159K probably damaging Het
Cntn1 C T 15: 92,189,645 (GRCm39) T656I probably damaging Het
Crybg3 A G 16: 59,380,458 (GRCm39) probably benign Het
Dzip1l T A 9: 99,521,907 (GRCm39) L181H probably damaging Het
Fam3b C A 16: 97,282,986 (GRCm39) probably null Het
Fat1 T A 8: 45,405,383 (GRCm39) N711K probably damaging Het
Fat3 A G 9: 15,834,088 (GRCm39) I4168T probably benign Het
Fbxw20 T C 9: 109,061,398 (GRCm39) D117G probably benign Het
Gm8122 A G 14: 43,091,525 (GRCm39) L81P unknown Het
Hal T C 10: 93,332,421 (GRCm39) probably benign Het
Hgf T A 5: 16,823,949 (GRCm39) Y715* probably null Het
Hid1 T A 11: 115,258,468 (GRCm39) probably benign Het
Hyou1 T A 9: 44,293,169 (GRCm39) V125E probably damaging Het
Jrkl G A 9: 13,245,146 (GRCm39) Q172* probably null Het
Lamc3 A G 2: 31,821,964 (GRCm39) E1304G probably benign Het
Lman2l A C 1: 36,478,804 (GRCm39) C103G probably damaging Het
Lrfn5 T C 12: 61,890,276 (GRCm39) S522P probably damaging Het
Mark3 A T 12: 111,570,957 (GRCm39) I86L possibly damaging Het
Mfsd13a C T 19: 46,360,431 (GRCm39) R328C probably damaging Het
Neb A T 2: 52,077,525 (GRCm39) Y158* probably null Het
Nipbl T C 15: 8,391,345 (GRCm39) I210V probably benign Het
Or7g18 A T 9: 18,786,907 (GRCm39) I95L probably damaging Het
Or8j3b C T 2: 86,205,523 (GRCm39) A78T possibly damaging Het
Pcdhb8 C T 18: 37,489,935 (GRCm39) P538S probably damaging Het
Postn A G 3: 54,278,376 (GRCm39) D295G probably damaging Het
Prss38 T C 11: 59,263,854 (GRCm39) Y286C probably damaging Het
Psen2 A T 1: 180,068,347 (GRCm39) V102E probably damaging Het
Ptpn9 A T 9: 56,943,847 (GRCm39) K126N possibly damaging Het
Ptprd A G 4: 76,046,922 (GRCm39) I435T probably damaging Het
Rab39 T C 9: 53,597,950 (GRCm39) K105R probably benign Het
Robo2 C A 16: 73,745,267 (GRCm39) R840L probably benign Het
Rps6ka5 T A 12: 100,547,578 (GRCm39) I311F probably damaging Het
Ryr1 G T 7: 28,793,667 (GRCm39) T1267K possibly damaging Het
Sis G A 3: 72,863,482 (GRCm39) T252I probably damaging Het
Slc41a3 A T 6: 90,612,312 (GRCm39) S201C probably damaging Het
Slitrk1 A C 14: 109,148,735 (GRCm39) S659A probably benign Het
Snx25 A T 8: 46,488,715 (GRCm39) M880K probably damaging Het
Tbxas1 C T 6: 39,004,713 (GRCm39) T320I probably benign Het
Tex44 T C 1: 86,355,489 (GRCm39) V466A probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Tnxb C T 17: 34,897,636 (GRCm39) Q804* probably null Het
Tpst1 T A 5: 130,131,343 (GRCm39) M271K probably benign Het
Trank1 C T 9: 111,194,265 (GRCm39) T763I possibly damaging Het
Trip12 A T 1: 84,703,462 (GRCm39) H729Q probably damaging Het
Tshz3 A T 7: 36,469,030 (GRCm39) T340S probably damaging Het
Ttc5 T C 14: 51,018,962 (GRCm39) K52E probably benign Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Vmn2r79 A G 7: 86,651,099 (GRCm39) H166R possibly damaging Het
Wsb2 T G 5: 117,501,643 (GRCm39) probably benign Het
Other mutations in Mgst2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00824:Mgst2 APN 3 51,589,999 (GRCm39) missense probably benign 0.00
IGL01712:Mgst2 APN 3 51,571,992 (GRCm39) missense probably damaging 1.00
IGL03401:Mgst2 APN 3 51,571,933 (GRCm39) missense possibly damaging 0.89
R0294:Mgst2 UTSW 3 51,589,251 (GRCm39) missense probably damaging 1.00
R2867:Mgst2 UTSW 3 51,571,954 (GRCm39) synonymous silent
R5149:Mgst2 UTSW 3 51,589,958 (GRCm39) missense probably benign 0.02
R5878:Mgst2 UTSW 3 51,568,651 (GRCm39) utr 5 prime probably benign
R6703:Mgst2 UTSW 3 51,572,033 (GRCm39) critical splice donor site probably null
R7946:Mgst2 UTSW 3 51,584,991 (GRCm39) missense probably damaging 1.00
R9108:Mgst2 UTSW 3 51,589,233 (GRCm39) missense probably damaging 1.00
Z1177:Mgst2 UTSW 3 51,568,691 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAAGGACTTGTGTTCAATCCC -3'
(R):5'- CCAGAGTAACTTGTGGTTGGTAAC -3'

Sequencing Primer
(F):5'- CCTGTAATCCCAGGGCTAGAGAG -3'
(R):5'- CTGAAAATGAATTTAGGGCCTTCTG -3'
Posted On 2015-07-06