Incidental Mutation 'R4400:Or6b6'
ID 326587
Institutional Source Beutler Lab
Gene Symbol Or6b6
Ensembl Gene ENSMUSG00000045013
Gene Name olfactory receptor family 6 subfamily B member 6
Synonyms MOR103-4, Olfr711, GA_x6K02T2PBJ9-9352783-9351839
MMRRC Submission 041131-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R4400 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 106969694-106975453 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106972002 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 114 (L114P)
Ref Sequence ENSEMBL: ENSMUSP00000149016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051715] [ENSMUST00000207200] [ENSMUST00000216335]
AlphaFold Q9EPG2
Predicted Effect probably damaging
Transcript: ENSMUST00000051715
AA Change: L114P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000055724
Gene: ENSMUSG00000045013
AA Change: L114P

Pfam:7tm_4 31 307 1.5e-58 PFAM
Pfam:7tm_1 41 290 1.2e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207200
AA Change: L114P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216335
AA Change: L114P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp4b A G 8: 13,388,810 (GRCm38) F189L probably damaging Het
Atp8a1 A T 5: 67,764,878 (GRCm38) Y372N probably benign Het
Bves T C 10: 45,369,293 (GRCm38) V354A probably benign Het
Cd79b A T 11: 106,312,010 (GRCm38) Y195* probably null Het
Cog6 A C 3: 53,012,941 (GRCm38) D131E probably benign Het
Elp3 C T 14: 65,548,090 (GRCm38) E421K possibly damaging Het
Fbxw28 A T 9: 109,328,310 (GRCm38) F237Y probably damaging Het
Fezf1 T C 6: 23,247,710 (GRCm38) N122S probably benign Het
Galnt2 A G 8: 124,324,303 (GRCm38) K157E probably damaging Het
Git2 T C 5: 114,733,909 (GRCm38) E141G possibly damaging Het
Gm26888 T C 11: 119,154,027 (GRCm38) silent Het
Gnrhr T C 5: 86,182,249 (GRCm38) probably null Het
Hoxd13 A T 2: 74,670,015 (GRCm38) D300V probably damaging Het
Hspg2 G A 4: 137,548,122 (GRCm38) A2748T probably benign Het
Hyal2 A G 9: 107,570,853 (GRCm38) N235S probably damaging Het
Itgam T G 7: 128,081,658 (GRCm38) L253R probably damaging Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 52,725,906 (GRCm38) 74 probably benign Het
Matr3 A T 18: 35,583,916 (GRCm38) K591N possibly damaging Het
Mep1a T A 17: 43,475,006 (GRCm38) I731F possibly damaging Het
Mrtfa G A 15: 81,020,923 (GRCm38) Q103* probably null Het
Muc5b A G 7: 141,861,387 (GRCm38) D2690G possibly damaging Het
Nlrc5 A G 8: 94,494,353 (GRCm38) Q1140R probably benign Het
Or14c39 A G 7: 86,694,590 (GRCm38) I45V probably benign Het
Or5ac23 C T 16: 59,328,598 (GRCm38) V304I probably benign Het
Plcl1 T C 1: 55,715,577 (GRCm38) F1028L probably damaging Het
Plpp2 A G 10: 79,527,493 (GRCm38) V106A possibly damaging Het
Prpf8 A G 11: 75,490,702 (GRCm38) T255A possibly damaging Het
Shoc2 A G 19: 54,031,229 (GRCm38) I568V probably benign Het
Spopl C T 2: 23,517,945 (GRCm38) V241M probably damaging Het
Ssrp1 A T 2: 85,037,941 (GRCm38) D9V probably damaging Het
Strn3 A T 12: 51,648,100 (GRCm38) D293E possibly damaging Het
Tbx3 G T 5: 119,680,571 (GRCm38) D404Y probably damaging Het
Tdrd7 T C 4: 46,005,540 (GRCm38) S416P possibly damaging Het
Trim60 G T 8: 65,001,212 (GRCm38) Y128* probably null Het
Tspoap1 T C 11: 87,775,603 (GRCm38) S947P probably damaging Het
Ttn A T 2: 76,782,395 (GRCm38) S17113R probably damaging Het
Ubqln1 T A 13: 58,193,388 (GRCm38) N183I probably damaging Het
Ubr4 A G 4: 139,461,856 (GRCm38) N3917D possibly damaging Het
Ucp2 A G 7: 100,499,350 (GRCm38) *310W probably null Het
Wdr76 A G 2: 121,528,833 (GRCm38) M218V probably damaging Het
Zranb3 A C 1: 127,956,655 (GRCm38) L998R possibly damaging Het
Zxdc G A 6: 90,369,810 (GRCm38) G51E probably damaging Het
Other mutations in Or6b6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02600:Or6b6 APN 7 106,971,549 (GRCm38) missense possibly damaging 0.51
R0087:Or6b6 UTSW 7 106,972,116 (GRCm38) missense probably benign 0.01
R0580:Or6b6 UTSW 7 106,972,240 (GRCm38) missense probably damaging 1.00
R1375:Or6b6 UTSW 7 106,972,098 (GRCm38) missense probably damaging 1.00
R1538:Or6b6 UTSW 7 106,971,983 (GRCm38) nonsense probably null
R1875:Or6b6 UTSW 7 106,972,182 (GRCm38) missense possibly damaging 0.86
R2156:Or6b6 UTSW 7 106,971,568 (GRCm38) missense probably damaging 1.00
R4290:Or6b6 UTSW 7 106,971,711 (GRCm38) missense probably damaging 0.97
R4332:Or6b6 UTSW 7 106,972,147 (GRCm38) missense probably benign 0.00
R4688:Or6b6 UTSW 7 106,971,861 (GRCm38) missense probably benign 0.02
R4868:Or6b6 UTSW 7 106,971,767 (GRCm38) missense probably benign
R4970:Or6b6 UTSW 7 106,971,571 (GRCm38) missense probably benign 0.35
R5006:Or6b6 UTSW 7 106,971,601 (GRCm38) missense probably damaging 1.00
R5082:Or6b6 UTSW 7 106,971,664 (GRCm38) missense probably benign 0.00
R5121:Or6b6 UTSW 7 106,972,231 (GRCm38) missense probably benign
R6465:Or6b6 UTSW 7 106,972,212 (GRCm38) missense possibly damaging 0.63
R6541:Or6b6 UTSW 7 106,972,203 (GRCm38) missense probably benign 0.20
R7419:Or6b6 UTSW 7 106,972,146 (GRCm38) missense probably benign 0.01
R8048:Or6b6 UTSW 7 106,972,464 (GRCm38) start gained probably benign
R9310:Or6b6 UTSW 7 106,971,471 (GRCm38) missense probably damaging 1.00
R9470:Or6b6 UTSW 7 106,972,254 (GRCm38) missense probably benign 0.26
R9603:Or6b6 UTSW 7 106,971,896 (GRCm38) nonsense probably null
Z1177:Or6b6 UTSW 7 106,971,915 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-07-07