Incidental Mutation 'R4401:Or4k35'
ID 326618
Institutional Source Beutler Lab
Gene Symbol Or4k35
Ensembl Gene ENSMUSG00000074965
Gene Name olfactory receptor family 4 subfamily K member 35
Synonyms MOR248-11, Olfr1277, GA_x6K02T2Q125-72321818-72320907
MMRRC Submission 041132-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R4401 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 111099799-111100710 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111100178 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 178 (F178S)
Ref Sequence ENSEMBL: ENSMUSP00000150703 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099619] [ENSMUST00000214760]
AlphaFold Q8VF41
Predicted Effect probably damaging
Transcript: ENSMUST00000099619
AA Change: F178S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097214
Gene: ENSMUSG00000074965
AA Change: F178S

DomainStartEndE-ValueType
Pfam:7tm_4 31 303 5.5e-50 PFAM
Pfam:7tm_1 41 287 7.2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214760
AA Change: F178S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a A G 5: 8,752,390 (GRCm39) I454V possibly damaging Het
Acvr2a A G 2: 48,789,714 (GRCm39) T486A probably benign Het
Ap3b1 C A 13: 94,554,607 (GRCm39) L248I probably damaging Het
Atad2b T A 12: 4,990,145 (GRCm39) C157S probably damaging Het
Cage1 T A 13: 38,207,078 (GRCm39) I256F probably damaging Het
Cct2 A G 10: 116,893,714 (GRCm39) I287T possibly damaging Het
Cntn4 A G 6: 106,466,625 (GRCm39) T176A possibly damaging Het
Cracd G A 5: 76,996,763 (GRCm39) V74I probably damaging Het
Cyp2c54 T C 19: 40,060,615 (GRCm39) N122S probably benign Het
Cytip T C 2: 58,023,947 (GRCm39) D291G probably benign Het
Eef1d C T 15: 75,774,769 (GRCm39) V213I probably benign Het
Fnbp4 A G 2: 90,577,102 (GRCm39) T145A possibly damaging Het
Fras1 C A 5: 96,790,479 (GRCm39) T951K probably damaging Het
Gm11937 C T 11: 99,500,901 (GRCm39) V39M probably damaging Het
Gm6712 C T 17: 17,538,366 (GRCm39) noncoding transcript Het
Hira A G 16: 18,744,470 (GRCm39) I352V probably damaging Het
Homer3 G A 8: 70,742,793 (GRCm39) probably null Het
Lpcat2 T C 8: 93,599,683 (GRCm39) V217A possibly damaging Het
Mroh2a G T 1: 88,182,657 (GRCm39) R1195L possibly damaging Het
Or2a25 G T 6: 42,889,260 (GRCm39) E268* probably null Het
Or51f5 C T 7: 102,424,006 (GRCm39) R92* probably null Het
Pla2g1b T A 5: 115,608,947 (GRCm39) Y47* probably null Het
Rfng A T 11: 120,673,306 (GRCm39) V245E possibly damaging Het
Rpf2 A G 10: 40,112,124 (GRCm39) V104A possibly damaging Het
Rps6kc1 G T 1: 190,532,155 (GRCm39) H616N probably benign Het
Slc66a1 T C 4: 139,033,854 (GRCm39) I22V probably benign Het
Slc9b2 T C 3: 135,042,305 (GRCm39) V528A probably benign Het
Srgap1 T C 10: 121,640,826 (GRCm39) probably null Het
Trrap A G 5: 144,780,128 (GRCm39) T3240A possibly damaging Het
Vmn2r68 TCC TC 7: 84,870,758 (GRCm39) probably null Het
Zfhx4 C A 3: 5,468,405 (GRCm39) Y2854* probably null Het
Zfp986 C T 4: 145,625,513 (GRCm39) R58C probably benign Het
Other mutations in Or4k35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01552:Or4k35 APN 2 111,100,257 (GRCm39) missense probably damaging 1.00
IGL02550:Or4k35 APN 2 111,100,349 (GRCm39) missense probably damaging 0.99
IGL02661:Or4k35 APN 2 111,099,811 (GRCm39) missense possibly damaging 0.56
IGL02940:Or4k35 APN 2 111,100,073 (GRCm39) missense probably damaging 0.99
R0121:Or4k35 UTSW 2 111,100,659 (GRCm39) missense probably benign 0.01
R0402:Or4k35 UTSW 2 111,100,208 (GRCm39) missense probably damaging 1.00
R0903:Or4k35 UTSW 2 111,100,701 (GRCm39) missense probably benign
R1804:Or4k35 UTSW 2 111,100,275 (GRCm39) missense probably benign
R1806:Or4k35 UTSW 2 111,100,622 (GRCm39) missense possibly damaging 0.65
R1965:Or4k35 UTSW 2 111,099,938 (GRCm39) missense probably damaging 1.00
R3718:Or4k35 UTSW 2 111,100,571 (GRCm39) missense probably benign
R4044:Or4k35 UTSW 2 111,099,927 (GRCm39) missense probably benign 0.01
R4518:Or4k35 UTSW 2 111,100,263 (GRCm39) missense probably benign
R5309:Or4k35 UTSW 2 111,100,655 (GRCm39) missense probably benign 0.00
R5312:Or4k35 UTSW 2 111,100,655 (GRCm39) missense probably benign 0.00
R5367:Or4k35 UTSW 2 111,100,235 (GRCm39) missense possibly damaging 0.81
R5727:Or4k35 UTSW 2 111,100,197 (GRCm39) nonsense probably null
R5772:Or4k35 UTSW 2 111,100,057 (GRCm39) nonsense probably null
R5827:Or4k35 UTSW 2 111,100,266 (GRCm39) missense probably damaging 1.00
R5882:Or4k35 UTSW 2 111,100,484 (GRCm39) missense probably damaging 0.99
R6036:Or4k35 UTSW 2 111,099,957 (GRCm39) missense probably damaging 1.00
R6036:Or4k35 UTSW 2 111,099,957 (GRCm39) missense probably damaging 1.00
R6728:Or4k35 UTSW 2 111,100,018 (GRCm39) missense probably benign 0.00
R7629:Or4k35 UTSW 2 111,100,221 (GRCm39) missense probably benign 0.00
R8377:Or4k35 UTSW 2 111,099,983 (GRCm39) missense probably damaging 1.00
R8870:Or4k35 UTSW 2 111,100,464 (GRCm39) missense possibly damaging 0.61
R9100:Or4k35 UTSW 2 111,100,094 (GRCm39) missense probably benign 0.35
R9668:Or4k35 UTSW 2 111,100,287 (GRCm39) missense probably benign 0.03
R9690:Or4k35 UTSW 2 111,099,822 (GRCm39) missense probably damaging 0.98
R9715:Or4k35 UTSW 2 111,100,623 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTGTGATGTGGGCAGTACAAG -3'
(R):5'- GGTACTGCTTGTATCAATGGC -3'

Sequencing Primer
(F):5'- TAGAGAGAGCTTTGGATGCCCC -3'
(R):5'- CAATGGCTTATGACCGTTATGTAGC -3'
Posted On 2015-07-07