Incidental Mutation 'R4402:Pla2g1b'
ID 326666
Institutional Source Beutler Lab
Gene Symbol Pla2g1b
Ensembl Gene ENSMUSG00000029522
Gene Name phospholipase A2, group IB, pancreas
Synonyms Pla2a, sPLA2IB
MMRRC Submission 042003-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R4402 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 115604321-115612781 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 115608947 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 47 (Y47*)
Ref Sequence ENSEMBL: ENSMUSP00000138683 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031495] [ENSMUST00000112071] [ENSMUST00000125568] [ENSMUST00000145785]
AlphaFold Q9Z0Y2
Predicted Effect probably null
Transcript: ENSMUST00000031495
AA Change: Y47*
SMART Domains Protein: ENSMUSP00000031495
Gene: ENSMUSG00000029522
AA Change: Y47*

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
PA2c 23 146 1.34e-66 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112071
AA Change: Y47*
SMART Domains Protein: ENSMUSP00000107702
Gene: ENSMUSG00000029522
AA Change: Y47*

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
PA2c 23 82 2.08e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000125568
AA Change: Y46*
SMART Domains Protein: ENSMUSP00000120743
Gene: ENSMUSG00000029522
AA Change: Y46*

DomainStartEndE-ValueType
low complexity region 3 15 N/A INTRINSIC
PA2c 22 124 2.58e-45 SMART
Predicted Effect probably null
Transcript: ENSMUST00000145785
AA Change: Y47*
SMART Domains Protein: ENSMUSP00000138683
Gene: ENSMUSG00000029522
AA Change: Y47*

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
PA2c 23 76 2.16e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202822
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency 98% (61/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
PHENOTYPE: Mice homozygous for disruptions in this gene display abnormalities in lipid absorption, increased insulin sensitivity and improved glucose tolerance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik T A 11: 58,771,020 (GRCm39) H167Q probably benign Het
Adamts20 T C 15: 94,277,827 (GRCm39) T212A probably benign Het
Ap3b1 C A 13: 94,554,607 (GRCm39) L248I probably damaging Het
Atl1 T G 12: 70,005,973 (GRCm39) D426E probably benign Het
Cage1 T A 13: 38,207,078 (GRCm39) I256F probably damaging Het
Calcr A T 6: 3,708,484 (GRCm39) probably null Het
Canx T C 11: 50,195,265 (GRCm39) T268A probably benign Het
Chd7 A T 4: 8,866,353 (GRCm39) M842L possibly damaging Het
Clca4a T C 3: 144,658,609 (GRCm39) T787A probably benign Het
Clstn3 T C 6: 124,433,939 (GRCm39) Y407C probably damaging Het
Copa C A 1: 171,929,791 (GRCm39) T286N probably damaging Het
Cyb5a G A 18: 84,889,718 (GRCm39) R49Q possibly damaging Het
Def6 A G 17: 28,438,950 (GRCm39) K219E probably damaging Het
Eif4g1 G T 16: 20,497,593 (GRCm39) probably benign Het
Eif5 A T 12: 111,508,183 (GRCm39) K161N probably benign Het
Fras1 C A 5: 96,790,479 (GRCm39) T951K probably damaging Het
Gen1 A T 12: 11,292,363 (GRCm39) N475K possibly damaging Het
Gm14569 T C X: 35,697,146 (GRCm39) Y521C probably benign Het
Gm6124 T A 7: 38,870,529 (GRCm39) noncoding transcript Het
Gpt2 A T 8: 86,252,188 (GRCm39) D501V probably benign Het
Gstm2 T C 3: 107,893,370 (GRCm39) K31R probably benign Het
Homer3 G A 8: 70,742,793 (GRCm39) probably null Het
Itga1 T A 13: 115,138,102 (GRCm39) M428L probably benign Het
Kalrn C T 16: 33,810,180 (GRCm39) D2525N possibly damaging Het
Kcnn4 T C 7: 24,076,867 (GRCm39) W139R probably benign Het
Kdm7a T A 6: 39,143,602 (GRCm39) R380W probably null Het
Khdrbs1 T G 4: 129,635,889 (GRCm39) D22A possibly damaging Het
Liph A T 16: 21,795,000 (GRCm39) I204N probably damaging Het
Loxhd1 A G 18: 77,529,456 (GRCm39) E2033G possibly damaging Het
M6pr C T 6: 122,291,982 (GRCm39) probably benign Het
Mrm1 A G 11: 84,709,915 (GRCm39) I95T probably damaging Het
Mroh2a G T 1: 88,182,657 (GRCm39) R1195L possibly damaging Het
Mug1 C A 6: 121,856,311 (GRCm39) F1030L probably damaging Het
Naca C T 10: 127,879,341 (GRCm39) probably benign Het
Nob1 A T 8: 108,145,120 (GRCm39) probably benign Het
Nutm1 A C 2: 112,080,154 (GRCm39) I587R probably damaging Het
Or1e26 A G 11: 73,480,081 (GRCm39) V161A probably benign Het
Pcdhb2 A G 18: 37,428,455 (GRCm39) K143E probably benign Het
Pcnt T C 10: 76,228,227 (GRCm39) Q1646R probably benign Het
Piwil2 A T 14: 70,646,365 (GRCm39) D390E probably benign Het
Pkhd1 A G 1: 20,309,635 (GRCm39) L2771P probably damaging Het
Plekhn1 T C 4: 156,309,813 (GRCm39) T135A probably damaging Het
Pola1 T C X: 92,605,029 (GRCm39) Y968C probably damaging Het
Ppp1r26 C A 2: 28,341,618 (GRCm39) T416K probably benign Het
Psmd1 A G 1: 86,003,673 (GRCm39) I153V possibly damaging Het
Rcan2 A G 17: 44,264,361 (GRCm39) D7G probably benign Het
Rexo5 T C 7: 119,433,599 (GRCm39) I326T possibly damaging Het
Rps6kc1 A G 1: 190,530,802 (GRCm39) probably benign Het
Shc1 T C 3: 89,333,985 (GRCm39) S273P probably benign Het
Slc9b2 T C 3: 135,042,305 (GRCm39) V528A probably benign Het
Tas2r118 T C 6: 23,969,293 (GRCm39) K256R probably benign Het
Tma16 C T 8: 66,936,823 (GRCm39) probably null Het
Tnfaip2 T C 12: 111,416,285 (GRCm39) F516L probably benign Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Ugt1a10 C T 1: 88,142,845 (GRCm39) P113L probably damaging Het
Wdr35 A G 12: 9,039,981 (GRCm39) D362G probably damaging Het
Wwp2 T C 8: 108,184,610 (GRCm39) V106A probably benign Het
Zfp40 T A 17: 23,395,693 (GRCm39) H230L possibly damaging Het
Zkscan17 T A 11: 59,393,848 (GRCm39) M1L possibly damaging Het
Other mutations in Pla2g1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03282:Pla2g1b APN 5 115,608,939 (GRCm39) missense probably damaging 0.99
IGL03367:Pla2g1b APN 5 115,610,173 (GRCm39) missense probably damaging 1.00
R4401:Pla2g1b UTSW 5 115,608,947 (GRCm39) nonsense probably null
R4403:Pla2g1b UTSW 5 115,608,947 (GRCm39) nonsense probably null
R4958:Pla2g1b UTSW 5 115,608,885 (GRCm39) missense probably damaging 0.97
R9177:Pla2g1b UTSW 5 115,612,595 (GRCm39) missense probably damaging 1.00
R9214:Pla2g1b UTSW 5 115,610,107 (GRCm39) missense possibly damaging 0.49
Predicted Primers PCR Primer
(F):5'- GCACATTAGTAGGCTTCTGGG -3'
(R):5'- AATACACACGACGCTCAGGG -3'

Sequencing Primer
(F):5'- TCCCGAGGCAGCAACTGATAG -3'
(R):5'- AGGGACTGTGCATGCCTC -3'
Posted On 2015-07-07