Incidental Mutation 'R4419:Or8b51'
ID 327002
Institutional Source Beutler Lab
Gene Symbol Or8b51
Ensembl Gene ENSMUSG00000094701
Gene Name olfactory receptor family 8 subfamily B member 51
Synonyms Olfr916, MOR168-1, GA_x6K02T2PVTD-32360710-32359778
MMRRC Submission 041140-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.344) question?
Stock # R4419 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38568754-38569686 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 38569365 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 108 (V108I)
Ref Sequence ENSEMBL: ENSMUSP00000149578 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081196] [ENSMUST00000213714] [ENSMUST00000214093] [ENSMUST00000215291]
AlphaFold Q8VG53
Predicted Effect probably benign
Transcript: ENSMUST00000081196
AA Change: V108I

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000079959
Gene: ENSMUSG00000094701
AA Change: V108I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.3e-45 PFAM
Pfam:7tm_1 41 290 1.3e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213714
AA Change: V108I

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect probably benign
Transcript: ENSMUST00000214093
AA Change: V108I

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect probably benign
Transcript: ENSMUST00000215291
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217596
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amdhd2 G A 17: 24,377,652 (GRCm39) P126L probably benign Het
Arfip2 T C 7: 105,288,270 (GRCm39) T44A probably damaging Het
B4galt1 A G 4: 40,853,537 (GRCm39) V90A probably benign Het
Bad C A 19: 6,928,053 (GRCm39) A115E probably benign Het
Bicc1 A G 10: 70,782,804 (GRCm39) L521P possibly damaging Het
Caskin1 T C 17: 24,723,683 (GRCm39) S824P probably damaging Het
Cblb T A 16: 51,867,621 (GRCm39) D76E possibly damaging Het
Celsr3 G T 9: 108,720,443 (GRCm39) A2572S possibly damaging Het
Csmd3 T C 15: 47,567,707 (GRCm39) Q2152R probably damaging Het
D2hgdh T A 1: 93,757,535 (GRCm39) V150E probably damaging Het
Ddn C A 15: 98,703,492 (GRCm39) W600L probably benign Het
Dicer1 A T 12: 104,671,373 (GRCm39) Y966N probably damaging Het
Dsp T A 13: 38,379,108 (GRCm39) I1352N probably damaging Het
Duox1 G A 2: 122,157,607 (GRCm39) A578T probably benign Het
Dysf T C 6: 84,184,224 (GRCm39) probably null Het
Elmo2 T C 2: 165,153,675 (GRCm39) probably null Het
Heg1 A T 16: 33,547,805 (GRCm39) E864V probably benign Het
Hoxb9 T C 11: 96,162,807 (GRCm39) V147A probably benign Het
Kdm1b C T 13: 47,216,553 (GRCm39) R308W probably damaging Het
Ky G A 9: 102,419,909 (GRCm39) V639I probably damaging Het
Med16 G A 10: 79,734,216 (GRCm39) A566V probably benign Het
Mettl17 G T 14: 52,124,729 (GRCm39) G167C possibly damaging Het
Mgat4b T C 11: 50,123,813 (GRCm39) F318L probably damaging Het
Mug2 C A 6: 122,056,589 (GRCm39) A1178D probably damaging Het
Myo3b A G 2: 69,926,706 (GRCm39) D51G probably damaging Het
Naip2 T C 13: 100,297,133 (GRCm39) N968D probably benign Het
Nbea T C 3: 55,917,021 (GRCm39) H820R probably damaging Het
Nqo1 C T 8: 108,118,749 (GRCm39) probably null Het
Or10ak7 A T 4: 118,791,586 (GRCm39) I153N possibly damaging Het
Or6c68 T C 10: 129,157,684 (GRCm39) F64S possibly damaging Het
Ppargc1a T C 5: 51,652,044 (GRCm39) D218G probably damaging Het
Rras A G 7: 44,670,003 (GRCm39) D145G probably damaging Het
Scn3a C A 2: 65,297,304 (GRCm39) G1452C probably damaging Het
Slc22a2 C A 17: 12,831,473 (GRCm39) S421* probably null Het
Slc39a10 A G 1: 46,849,226 (GRCm39) F797L probably benign Het
Spta1 T A 1: 174,074,990 (GRCm39) Y2405* probably null Het
Ss18 A G 18: 14,766,662 (GRCm39) Y359H unknown Het
St14 C T 9: 31,008,224 (GRCm39) C537Y probably damaging Het
Tmem252 T A 19: 24,654,910 (GRCm39) Y96N probably damaging Het
Trafd1 T C 5: 121,511,396 (GRCm39) D474G probably benign Het
Trmt1l A G 1: 151,316,559 (GRCm39) I20M probably damaging Het
Ulk1 C T 5: 110,937,223 (GRCm39) R691Q probably benign Het
Vmn1r43 A G 6: 89,846,629 (GRCm39) S286P probably benign Het
Other mutations in Or8b51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01965:Or8b51 APN 9 38,568,918 (GRCm39) missense probably benign 0.00
IGL02313:Or8b51 APN 9 38,569,362 (GRCm39) missense probably damaging 0.97
IGL03221:Or8b51 APN 9 38,569,661 (GRCm39) missense probably damaging 0.99
R0479:Or8b51 UTSW 9 38,569,478 (GRCm39) missense probably damaging 1.00
R1507:Or8b51 UTSW 9 38,569,310 (GRCm39) missense probably damaging 1.00
R1521:Or8b51 UTSW 9 38,569,014 (GRCm39) missense probably damaging 0.99
R1860:Or8b51 UTSW 9 38,569,661 (GRCm39) missense probably damaging 0.99
R3107:Or8b51 UTSW 9 38,569,307 (GRCm39) missense possibly damaging 0.48
R3964:Or8b51 UTSW 9 38,569,023 (GRCm39) missense probably benign 0.42
R3965:Or8b51 UTSW 9 38,569,023 (GRCm39) missense probably benign 0.42
R5249:Or8b51 UTSW 9 38,569,374 (GRCm39) missense possibly damaging 0.88
R5481:Or8b51 UTSW 9 38,568,916 (GRCm39) missense probably benign 0.00
R6299:Or8b51 UTSW 9 38,569,073 (GRCm39) missense possibly damaging 0.94
R6555:Or8b51 UTSW 9 38,569,585 (GRCm39) missense probably benign 0.00
R6702:Or8b51 UTSW 9 38,569,073 (GRCm39) missense possibly damaging 0.94
R6703:Or8b51 UTSW 9 38,569,073 (GRCm39) missense possibly damaging 0.94
R6851:Or8b51 UTSW 9 38,569,481 (GRCm39) missense probably benign 0.31
R6895:Or8b51 UTSW 9 38,569,385 (GRCm39) missense probably damaging 0.97
R8688:Or8b51 UTSW 9 38,569,047 (GRCm39) missense probably benign 0.24
R8985:Or8b51 UTSW 9 38,569,621 (GRCm39) nonsense probably null
R9259:Or8b51 UTSW 9 38,569,642 (GRCm39) splice site probably benign
R9292:Or8b51 UTSW 9 38,569,071 (GRCm39) missense probably damaging 1.00
R9634:Or8b51 UTSW 9 38,568,869 (GRCm39) missense probably benign 0.06
R9641:Or8b51 UTSW 9 38,568,915 (GRCm39) missense probably benign 0.00
R9772:Or8b51 UTSW 9 38,568,964 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCTCATTATGCAAACAGTGTGAGC -3'
(R):5'- TGGCAATGTACCTAGTCACTGC -3'

Sequencing Primer
(F):5'- GTGTGAGCCACAGACTCAG -3'
(R):5'- CAATGTACCTAGTCACTGCATTGGG -3'
Posted On 2015-07-07