Incidental Mutation 'R4419:Slc22a2'
ID 327022
Institutional Source Beutler Lab
Gene Symbol Slc22a2
Ensembl Gene ENSMUSG00000040966
Gene Name solute carrier family 22 (organic cation transporter), member 2
Synonyms Oct2, Orct2
MMRRC Submission 041140-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4419 (G1)
Quality Score 220
Status Not validated
Chromosome 17
Chromosomal Location 12803076-12847376 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 12831473 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Stop codon at position 421 (S421*)
Ref Sequence ENSEMBL: ENSMUSP00000041186 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046959]
AlphaFold O70577
Predicted Effect probably null
Transcript: ENSMUST00000046959
AA Change: S421*
SMART Domains Protein: ENSMUSP00000041186
Gene: ENSMUSG00000040966
AA Change: S421*

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Pfam:Sugar_tr 80 528 7.6e-37 PFAM
Pfam:MFS_1 134 398 3.5e-21 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knockout allele are viable and fertile and display no obvious phenotypic abnormalities. No significant defects in the renal secretion of a model organic cation are observed. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amdhd2 G A 17: 24,377,652 (GRCm39) P126L probably benign Het
Arfip2 T C 7: 105,288,270 (GRCm39) T44A probably damaging Het
B4galt1 A G 4: 40,853,537 (GRCm39) V90A probably benign Het
Bad C A 19: 6,928,053 (GRCm39) A115E probably benign Het
Bicc1 A G 10: 70,782,804 (GRCm39) L521P possibly damaging Het
Caskin1 T C 17: 24,723,683 (GRCm39) S824P probably damaging Het
Cblb T A 16: 51,867,621 (GRCm39) D76E possibly damaging Het
Celsr3 G T 9: 108,720,443 (GRCm39) A2572S possibly damaging Het
Csmd3 T C 15: 47,567,707 (GRCm39) Q2152R probably damaging Het
D2hgdh T A 1: 93,757,535 (GRCm39) V150E probably damaging Het
Ddn C A 15: 98,703,492 (GRCm39) W600L probably benign Het
Dicer1 A T 12: 104,671,373 (GRCm39) Y966N probably damaging Het
Dsp T A 13: 38,379,108 (GRCm39) I1352N probably damaging Het
Duox1 G A 2: 122,157,607 (GRCm39) A578T probably benign Het
Dysf T C 6: 84,184,224 (GRCm39) probably null Het
Elmo2 T C 2: 165,153,675 (GRCm39) probably null Het
Heg1 A T 16: 33,547,805 (GRCm39) E864V probably benign Het
Hoxb9 T C 11: 96,162,807 (GRCm39) V147A probably benign Het
Kdm1b C T 13: 47,216,553 (GRCm39) R308W probably damaging Het
Ky G A 9: 102,419,909 (GRCm39) V639I probably damaging Het
Med16 G A 10: 79,734,216 (GRCm39) A566V probably benign Het
Mettl17 G T 14: 52,124,729 (GRCm39) G167C possibly damaging Het
Mgat4b T C 11: 50,123,813 (GRCm39) F318L probably damaging Het
Mug2 C A 6: 122,056,589 (GRCm39) A1178D probably damaging Het
Myo3b A G 2: 69,926,706 (GRCm39) D51G probably damaging Het
Naip2 T C 13: 100,297,133 (GRCm39) N968D probably benign Het
Nbea T C 3: 55,917,021 (GRCm39) H820R probably damaging Het
Nqo1 C T 8: 108,118,749 (GRCm39) probably null Het
Or10ak7 A T 4: 118,791,586 (GRCm39) I153N possibly damaging Het
Or6c68 T C 10: 129,157,684 (GRCm39) F64S possibly damaging Het
Or8b51 C T 9: 38,569,365 (GRCm39) V108I probably benign Het
Ppargc1a T C 5: 51,652,044 (GRCm39) D218G probably damaging Het
Rras A G 7: 44,670,003 (GRCm39) D145G probably damaging Het
Scn3a C A 2: 65,297,304 (GRCm39) G1452C probably damaging Het
Slc39a10 A G 1: 46,849,226 (GRCm39) F797L probably benign Het
Spta1 T A 1: 174,074,990 (GRCm39) Y2405* probably null Het
Ss18 A G 18: 14,766,662 (GRCm39) Y359H unknown Het
St14 C T 9: 31,008,224 (GRCm39) C537Y probably damaging Het
Tmem252 T A 19: 24,654,910 (GRCm39) Y96N probably damaging Het
Trafd1 T C 5: 121,511,396 (GRCm39) D474G probably benign Het
Trmt1l A G 1: 151,316,559 (GRCm39) I20M probably damaging Het
Ulk1 C T 5: 110,937,223 (GRCm39) R691Q probably benign Het
Vmn1r43 A G 6: 89,846,629 (GRCm39) S286P probably benign Het
Other mutations in Slc22a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Slc22a2 APN 17 12,827,305 (GRCm39) missense possibly damaging 0.79
IGL00658:Slc22a2 APN 17 12,834,202 (GRCm39) missense probably benign 0.37
IGL01073:Slc22a2 APN 17 12,803,236 (GRCm39) missense probably benign 0.00
IGL01573:Slc22a2 APN 17 12,824,848 (GRCm39) missense probably damaging 0.99
IGL02000:Slc22a2 APN 17 12,803,270 (GRCm39) missense possibly damaging 0.77
IGL02943:Slc22a2 APN 17 12,828,948 (GRCm39) missense probably damaging 1.00
IGL03301:Slc22a2 APN 17 12,824,926 (GRCm39) missense probably damaging 1.00
R0492:Slc22a2 UTSW 17 12,834,159 (GRCm39) missense probably benign 0.00
R0835:Slc22a2 UTSW 17 12,831,318 (GRCm39) missense probably benign 0.01
R1330:Slc22a2 UTSW 17 12,805,699 (GRCm39) missense possibly damaging 0.94
R1432:Slc22a2 UTSW 17 12,803,195 (GRCm39) missense possibly damaging 0.89
R1559:Slc22a2 UTSW 17 12,803,298 (GRCm39) missense probably damaging 1.00
R1855:Slc22a2 UTSW 17 12,805,699 (GRCm39) missense probably damaging 0.99
R1884:Slc22a2 UTSW 17 12,833,713 (GRCm39) splice site probably benign
R2042:Slc22a2 UTSW 17 12,818,012 (GRCm39) missense probably benign 0.01
R2197:Slc22a2 UTSW 17 12,817,949 (GRCm39) missense probably damaging 1.00
R2255:Slc22a2 UTSW 17 12,818,062 (GRCm39) missense probably damaging 1.00
R2271:Slc22a2 UTSW 17 12,805,692 (GRCm39) missense probably benign
R4003:Slc22a2 UTSW 17 12,831,337 (GRCm39) missense probably benign 0.01
R4021:Slc22a2 UTSW 17 12,803,376 (GRCm39) missense probably damaging 1.00
R4093:Slc22a2 UTSW 17 12,831,281 (GRCm39) missense probably damaging 1.00
R4404:Slc22a2 UTSW 17 12,833,651 (GRCm39) missense probably damaging 1.00
R4564:Slc22a2 UTSW 17 12,828,943 (GRCm39) missense probably benign 0.08
R4866:Slc22a2 UTSW 17 12,803,316 (GRCm39) missense probably damaging 1.00
R4877:Slc22a2 UTSW 17 12,833,702 (GRCm39) missense possibly damaging 0.53
R5224:Slc22a2 UTSW 17 12,805,719 (GRCm39) missense probably damaging 0.97
R5668:Slc22a2 UTSW 17 12,827,296 (GRCm39) missense probably benign
R6326:Slc22a2 UTSW 17 12,831,297 (GRCm39) nonsense probably null
R7137:Slc22a2 UTSW 17 12,803,228 (GRCm39) missense probably benign
R7211:Slc22a2 UTSW 17 12,805,770 (GRCm39) critical splice donor site probably null
R7378:Slc22a2 UTSW 17 12,831,278 (GRCm39) missense probably damaging 1.00
R7521:Slc22a2 UTSW 17 12,805,710 (GRCm39) missense probably benign 0.14
R7524:Slc22a2 UTSW 17 12,824,944 (GRCm39) missense possibly damaging 0.87
R7735:Slc22a2 UTSW 17 12,828,917 (GRCm39) missense probably damaging 0.99
R8136:Slc22a2 UTSW 17 12,824,917 (GRCm39) missense probably damaging 1.00
R8671:Slc22a2 UTSW 17 12,824,863 (GRCm39) nonsense probably null
R8799:Slc22a2 UTSW 17 12,831,425 (GRCm39) missense probably benign 0.14
R8874:Slc22a2 UTSW 17 12,828,866 (GRCm39) missense probably benign 0.37
R9046:Slc22a2 UTSW 17 12,834,234 (GRCm39) missense probably null 0.15
R9220:Slc22a2 UTSW 17 12,838,757 (GRCm39) missense probably benign 0.03
R9367:Slc22a2 UTSW 17 12,824,837 (GRCm39) missense probably benign 0.19
R9410:Slc22a2 UTSW 17 12,805,732 (GRCm39) missense probably damaging 0.99
R9511:Slc22a2 UTSW 17 12,828,916 (GRCm39) missense probably damaging 0.98
R9580:Slc22a2 UTSW 17 12,803,177 (GRCm39) missense probably benign 0.00
Z1088:Slc22a2 UTSW 17 12,833,663 (GRCm39) missense probably benign 0.36
Z1176:Slc22a2 UTSW 17 12,803,512 (GRCm39) missense possibly damaging 0.79
Z1177:Slc22a2 UTSW 17 12,824,897 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCATCATGCACATGGGCCTC -3'
(R):5'- CTCCACATGGCTAAAAGGATTTG -3'

Sequencing Primer
(F):5'- TCGCAGGGGACAACATCTACTTG -3'
(R):5'- GGCTAAAAGGATTTGTTTCACTGCC -3'
Posted On 2015-07-07